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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for STYX |
 Gene summary |
| Gene information | Gene symbol | STYX | Gene ID | 6815 |
| Gene name | serine/threonine/tyrosine interacting protein | |
| Synonyms | - | |
| Cytomap | 14q22.1 | |
| Type of gene | protein-coding | |
| Description | serine/threonine/tyrosine-interacting proteininactive tyrosine-protein phosphatase STYXphosphoserine/threonine/tyrosine interaction proteinprotein tyrosine phosphatase-like protein | |
| Modification date | 20200313 | |
| UniProtAcc | Q8WUJ0, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| STYX | GO:0032091 | negative regulation of protein binding | 28007894 |
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Gene structures and expression levels for STYX |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000198252
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for STYX |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_181362 | chr14 | 52744852:52744884:52746426:52746479:52750683:52750780 | 52746426:52746479 |
| exon_skip_217478 | chr14 | 52757743:52757782:52757874:52757924:52759682:52759754 | 52757874:52757924 |
| exon_skip_230084 | chr14 | 52750683:52750780:52756551:52756611:52757319:52757355 | 52756551:52756611 |
| exon_skip_35592 | chr14 | 52757319:52757355:52757743:52757782:52757874:52757924 | 52757743:52757782 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for STYX |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000354586 | 52756551 | 52756611 | Frame-shift |
| ENST00000442123 | 52756551 | 52756611 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000354586 | 52756551 | 52756611 | Frame-shift |
| ENST00000442123 | 52756551 | 52756611 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000354586 | 52756551 | 52756611 | Frame-shift |
| ENST00000442123 | 52756551 | 52756611 | Frame-shift |
| ENST00000354586 | 52757743 | 52757782 | Frame-shift |
| ENST00000442123 | 52757743 | 52757782 | Frame-shift |
| ENST00000354586 | 52746426 | 52746479 | In-frame |
| ENST00000442123 | 52746426 | 52746479 | In-frame |
| ENST00000354586 | 52757874 | 52757924 | In-frame |
| ENST00000442123 | 52757874 | 52757924 | In-frame |
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Infer the effects of exon skipping event on protein functional features for STYX |
p-ENSG00000198252_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000354586 | 4874 | 223 | 52746426 | 52746479 | 385 | 437 | 30 | 48 |
| ENST00000442123 | 4571 | 223 | 52746426 | 52746479 | 139 | 191 | 30 | 48 |
| ENST00000354586 | 4874 | 223 | 52757874 | 52757924 | 675 | 724 | 127 | 143 |
| ENST00000442123 | 4571 | 223 | 52757874 | 52757924 | 429 | 478 | 127 | 143 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8WUJ0 | 30 | 48 | 30 | 33 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B |
| Q8WUJ0 | 30 | 48 | 30 | 33 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B |
| Q8WUJ0 | 30 | 48 | 36 | 39 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B |
| Q8WUJ0 | 30 | 48 | 36 | 39 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B |
| Q8WUJ0 | 30 | 48 | 1 | 223 | Chain | ID=PRO_0000094950;Note=Serine/threonine/tyrosine-interacting protein |
| Q8WUJ0 | 30 | 48 | 1 | 223 | Chain | ID=PRO_0000094950;Note=Serine/threonine/tyrosine-interacting protein |
| Q8WUJ0 | 30 | 48 | 41 | 44 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B |
| Q8WUJ0 | 30 | 48 | 41 | 44 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B |
| Q8WUJ0 | 30 | 48 | 46 | 48 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B |
| Q8WUJ0 | 30 | 48 | 46 | 48 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B |
| Q8WUJ0 | 127 | 143 | 1 | 223 | Chain | ID=PRO_0000094950;Note=Serine/threonine/tyrosine-interacting protein |
| Q8WUJ0 | 127 | 143 | 1 | 223 | Chain | ID=PRO_0000094950;Note=Serine/threonine/tyrosine-interacting protein |
| Q8WUJ0 | 127 | 143 | 96 | 167 | Domain | Note=Tyrosine-protein phosphatase |
| Q8WUJ0 | 127 | 143 | 96 | 167 | Domain | Note=Tyrosine-protein phosphatase |
| Q8WUJ0 | 127 | 143 | 126 | 139 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B |
| Q8WUJ0 | 127 | 143 | 126 | 139 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B |
| Q8WUJ0 | 127 | 143 | 143 | 153 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B |
| Q8WUJ0 | 127 | 143 | 143 | 153 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R0B |
| Q8WUJ0 | 127 | 143 | 142 | 144 | Mutagenesis | Note=Increases interaction with FBXW7. KYR->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28007894;Dbxref=PMID:28007894 |
| Q8WUJ0 | 127 | 143 | 142 | 144 | Mutagenesis | Note=Increases interaction with FBXW7. KYR->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28007894;Dbxref=PMID:28007894 |
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3'-UTR located exon skipping events that lost miRNA binding sites in STYX |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for STYX |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for STYX |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for STYX |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for STYX |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for STYX |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STYX |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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