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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for AURKA |
Gene summary |
Gene information | Gene symbol | AURKA | Gene ID | 6790 |
Gene name | aurora kinase A | |
Synonyms | AIK|ARK1|AURA|BTAK|PPP1R47|STK15|STK6|STK7 | |
Cytomap | 20q13.2 | |
Type of gene | protein-coding | |
Description | aurora kinase Aaurora 2aurora/IPL1-like kinaseaurora/IPL1-related kinase 1breast tumor-amplified kinaseprotein phosphatase 1, regulatory subunit 47serine/threonine protein kinase 15serine/threonine-protein kinase 6serine/threonine-protein kinase a | |
Modification date | 20200329 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
AURKA | GO:0006468 | protein phosphorylation | 21600873|21820309 |
AURKA | GO:0009611 | response to wounding | 19435814 |
AURKA | GO:0032091 | negative regulation of protein binding | 21820309 |
AURKA | GO:0097421 | liver regeneration | 19435814 |
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Gene structures and expression levels for AURKA |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for AURKA |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_131743 | chr20 | 56388156:56388202:56388687:56388784:56392168:56392196 | 56388687:56388784 |
exon_skip_171628 | chr20 | 56388156:56388202:56390556:56390665:56392154:56392215 | 56390556:56390665 |
exon_skip_231928 | chr20 | 56388156:56388202:56388687:56388784:56390556:56390665 | 56388687:56388784 |
exon_skip_269004 | chr20 | 56388156:56388202:56390556:56390665:56392168:56392196 | 56390556:56390665 |
exon_skip_270672 | chr20 | 56383111:56383176:56384270:56384324:56386257:56386533 | 56384270:56384324 |
exon_skip_54896 | chr20 | 56388687:56388784:56390556:56390665:56392168:56392196 | 56390556:56390665 |
exon_skip_58080 | chr20 | 56370485:56370659:56373408:56373556:56381433:56381571 | 56373408:56373556 |
exon_skip_72093 | chr20 | 56388156:56388202:56390556:56390665:56392168:56392215 | 56390556:56390665 |
exon_skip_87301 | chr20 | 56388156:56388202:56388687:56388784:56392154:56392215 | 56388687:56388784 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for AURKA |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000371356 | 56388687 | 56388784 | 3UTR-3UTR |
ENST00000395911 | 56388687 | 56388784 | 3UTR-3UTR |
ENST00000312783 | 56390556 | 56390665 | 3UTR-3UTR |
ENST00000312783 | 56373408 | 56373556 | Frame-shift |
ENST00000347343 | 56373408 | 56373556 | Frame-shift |
ENST00000371356 | 56373408 | 56373556 | Frame-shift |
ENST00000395911 | 56373408 | 56373556 | Frame-shift |
ENST00000395913 | 56373408 | 56373556 | Frame-shift |
ENST00000395914 | 56373408 | 56373556 | Frame-shift |
ENST00000395915 | 56373408 | 56373556 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000371356 | 56388687 | 56388784 | 3UTR-3UTR |
ENST00000312783 | 56390556 | 56390665 | 3UTR-3UTR |
ENST00000312783 | 56384270 | 56384324 | Frame-shift |
ENST00000347343 | 56384270 | 56384324 | Frame-shift |
ENST00000371356 | 56384270 | 56384324 | Frame-shift |
ENST00000395911 | 56384270 | 56384324 | Frame-shift |
ENST00000395913 | 56384270 | 56384324 | Frame-shift |
ENST00000395914 | 56384270 | 56384324 | Frame-shift |
ENST00000395915 | 56384270 | 56384324 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for AURKA |
p-ENSG00000087586_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in AURKA |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000371356 | 56388687 | 56388784 | hsa-miR-4695-3p | chr20:56388760-56388767 | 8mer-1a | chr20:56388744-56388767 | 162.00 | -28.39 |
Mayo | ENST00000371356 | 56388687 | 56388784 | hsa-miR-1976 | chr20:56388716-56388723 | 8mer-1a | chr20:56388703-56388723 | 149.00 | -24.39 |
Mayo | ENST00000371356 | 56388687 | 56388784 | hsa-miR-6742-3p | chr20:56388733-56388740 | 8mer-1a | chr20:56388733-56388755 | 154.00 | -19.41 |
Mayo | ENST00000371356 | 56388687 | 56388784 | hsa-miR-7162-5p | chr20:56388737-56388744 | 8mer-1a | chr20:56388733-56388755 | 154.00 | -19.41 |
Mayo | ENST00000371356 | 56388687 | 56388784 | hsa-miR-1343-3p | chr20:56388734-56388741 | 8mer-1a | chr20:56388733-56388755 | 154.00 | -19.41 |
Mayo | ENST00000312783 | 56390556 | 56390665 | hsa-miR-3161 | chr20:56390620-56390627 | 8mer-1a | chr20:56390598-56390627 | 152.00 | -19.50 |
Mayo | ENST00000371356 | 56388687 | 56388784 | hsa-miR-6747-3p | chr20:56388714-56388721 | 8mer-1a | chr20:56388703-56388723 | 149.00 | -24.39 |
Mayo | ENST00000312783 | 56390556 | 56390665 | hsa-miR-4493 | chr20:56390603-56390610 | 8mer-1a | chr20:56390594-56390611 | 162.00 | -27.28 |
Mayo | ENST00000312783 | 56390556 | 56390665 | hsa-miR-4706 | chr20:56390631-56390638 | 8mer-1a | chr20:56390630-56390651 | 144.00 | -36.36 |
Mayo | ENST00000371356 | 56388687 | 56388784 | hsa-miR-629-5p | chr20:56388730-56388737 | 8mer-1a | chr20:56388730-56388751 | 143.00 | -25.80 |
Mayo | ENST00000371356 | 56388687 | 56388784 | hsa-miR-6783-3p | chr20:56388734-56388741 | 8mer-1a | chr20:56388733-56388755 | 154.00 | -19.41 |
Mayo | ENST00000371356 | 56388687 | 56388784 | hsa-miR-6787-3p | chr20:56388757-56388764 | 8mer-1a | chr20:56388740-56388764 | 166.00 | -28.48 |
Mayo | ENST00000312783 | 56390556 | 56390665 | hsa-miR-4749-5p | chr20:56390631-56390638 | 8mer-1a | chr20:56390630-56390651 | 144.00 | -36.36 |
Mayo | ENST00000371356 | 56388687 | 56388784 | hsa-miR-516b-3p | chr20:56388737-56388744 | 8mer-1a | chr20:56388733-56388755 | 154.00 | -19.41 |
Mayo | ENST00000371356 | 56388687 | 56388784 | hsa-miR-516a-3p | chr20:56388737-56388744 | 8mer-1a | chr20:56388733-56388755 | 154.00 | -19.41 |
Mayo | ENST00000312783 | 56390556 | 56390665 | hsa-miR-4276 | chr20:56390608-56390615 | 8mer-1a | chr20:56390598-56390627 | 152.00 | -19.50 |
Mayo | ENST00000371356 | 56388687 | 56388784 | hsa-miR-504-3p | chr20:56388775-56388782 | 8mer-1a | chr20:56388763-56388784 | 159.00 | -28.97 |
ROSMAP | ENST00000395911 | 56388687 | 56388784 | hsa-miR-4695-3p | chr20:56388760-56388767 | 8mer-1a | chr20:56388744-56388767 | 162.00 | -28.39 |
ROSMAP | ENST00000395911 | 56388687 | 56388784 | hsa-miR-1976 | chr20:56388716-56388723 | 8mer-1a | chr20:56388703-56388723 | 149.00 | -24.39 |
ROSMAP | ENST00000395911 | 56388687 | 56388784 | hsa-miR-6742-3p | chr20:56388733-56388740 | 8mer-1a | chr20:56388733-56388755 | 154.00 | -19.41 |
ROSMAP | ENST00000395911 | 56388687 | 56388784 | hsa-miR-7162-5p | chr20:56388737-56388744 | 8mer-1a | chr20:56388733-56388755 | 154.00 | -19.41 |
ROSMAP | ENST00000395911 | 56388687 | 56388784 | hsa-miR-1343-3p | chr20:56388734-56388741 | 8mer-1a | chr20:56388733-56388755 | 154.00 | -19.41 |
ROSMAP | ENST00000312783 | 56390556 | 56390665 | hsa-miR-3161 | chr20:56390620-56390627 | 8mer-1a | chr20:56390598-56390627 | 152.00 | -19.50 |
ROSMAP | ENST00000395911 | 56388687 | 56388784 | hsa-miR-6747-3p | chr20:56388714-56388721 | 8mer-1a | chr20:56388703-56388723 | 149.00 | -24.39 |
ROSMAP | ENST00000312783 | 56390556 | 56390665 | hsa-miR-4493 | chr20:56390603-56390610 | 8mer-1a | chr20:56390594-56390611 | 162.00 | -27.28 |
ROSMAP | ENST00000312783 | 56390556 | 56390665 | hsa-miR-4706 | chr20:56390631-56390638 | 8mer-1a | chr20:56390630-56390651 | 144.00 | -36.36 |
ROSMAP | ENST00000395911 | 56388687 | 56388784 | hsa-miR-629-5p | chr20:56388730-56388737 | 8mer-1a | chr20:56388730-56388751 | 143.00 | -25.80 |
ROSMAP | ENST00000395911 | 56388687 | 56388784 | hsa-miR-6783-3p | chr20:56388734-56388741 | 8mer-1a | chr20:56388733-56388755 | 154.00 | -19.41 |
ROSMAP | ENST00000395911 | 56388687 | 56388784 | hsa-miR-6787-3p | chr20:56388757-56388764 | 8mer-1a | chr20:56388740-56388764 | 166.00 | -28.48 |
ROSMAP | ENST00000312783 | 56390556 | 56390665 | hsa-miR-4749-5p | chr20:56390631-56390638 | 8mer-1a | chr20:56390630-56390651 | 144.00 | -36.36 |
ROSMAP | ENST00000395911 | 56388687 | 56388784 | hsa-miR-516b-3p | chr20:56388737-56388744 | 8mer-1a | chr20:56388733-56388755 | 154.00 | -19.41 |
ROSMAP | ENST00000395911 | 56388687 | 56388784 | hsa-miR-516a-3p | chr20:56388737-56388744 | 8mer-1a | chr20:56388733-56388755 | 154.00 | -19.41 |
ROSMAP | ENST00000312783 | 56390556 | 56390665 | hsa-miR-4276 | chr20:56390608-56390615 | 8mer-1a | chr20:56390598-56390627 | 152.00 | -19.50 |
ROSMAP | ENST00000395911 | 56388687 | 56388784 | hsa-miR-504-3p | chr20:56388775-56388782 | 8mer-1a | chr20:56388763-56388784 | 159.00 | -28.97 |
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SNVs in the skipped exons for AURKA |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for AURKA |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for AURKA |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for AURKA |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for AURKA |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
O14965 | approved|investigational | DB12010 | Fostamatinib | small molecule | O14965 |
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RelatedDiseases for AURKA |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |