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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for STK3 |
 Gene summary |
| Gene information | Gene symbol | STK3 | Gene ID | 6788 |
| Gene name | serine/threonine kinase 3 | |
| Synonyms | KRS1|MST2 | |
| Cytomap | 8q22.2 | |
| Type of gene | protein-coding | |
| Description | serine/threonine-protein kinase 3KB-1458E12.1MST-2STE20-like kinase MST2epididymis secretory sperm binding proteinmammalian STE20-like protein kinase 2serine/threonine kinase 3 (STE20 homolog, yeast)serine/threonine kinase 3 (Ste20, yeast homolog) | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| STK3 | GO:0006468 | protein phosphorylation | 8566796|19525978|20086174|20231902 |
| STK3 | GO:0032092 | positive regulation of protein binding | 22292086 |
| STK3 | GO:0035329 | hippo signaling | 20412773 |
| STK3 | GO:0035556 | intracellular signal transduction | 8566796 |
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Gene structures and expression levels for STK3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000104375
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000617590.1 | STK3-219:protein_coding:STK3 | 2.794497e+01 | -1.160734e+00 | 1.324734e-02 | 4.363900e-02 |
| TC | DOWN | ENST00000617590.1 | STK3-219:protein_coding:STK3 | 2.397203e+01 | -2.655948e+00 | 9.841294e-06 | 2.562425e-04 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for STK3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_114603 | chr8 | 98596032:98596169:98638460:98638560:98706467:98706634 | 98638460:98638560 |
| exon_skip_144554 | chr8 | 98594973:98595118:98595602:98595750:98596032:98596169 | 98595602:98595750 |
| exon_skip_182348 | chr8 | 98579759:98579789:98594861:98595045:98596032:98596392 | 98594861:98595045 |
| exon_skip_203076 | chr8 | 98371355:98371678:98379153:98379207:98388192:98388247 | 98379153:98379207 |
| exon_skip_233385 | chr8 | 98548091:98548161:98579664:98579789:98596032:98596169 | 98579664:98579789 |
| exon_skip_235497 | chr8 | 98595330:98596169:98638460:98638560:98706467:98706634 | 98638460:98638560 |
| exon_skip_251445 | chr8 | 98707147:98707311:98749276:98749390:98767243:98767371 | 98749276:98749390 |
| exon_skip_82963 | chr8 | 98707147:98707311:98721074:98721160:98722743:98722969 | 98721074:98721160 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for STK3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000419617 | 98749276 | 98749390 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000419617 | 98579664 | 98579789 | In-frame |
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Infer the effects of exon skipping event on protein functional features for STK3 |
p-ENSG00000104375_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000419617 | 2843 | 491 | 98579664 | 98579789 | 964 | 1088 | 274 | 315 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13188 | 274 | 315 | 1 | 491 | Chain | ID=PRO_0000086689;Note=Serine/threonine-protein kinase 3 |
| Q13188 | 274 | 315 | 1 | 322 | Chain | ID=PRO_0000413713;Note=Serine/threonine-protein kinase 3 36kDa subunit |
| Q13188 | 274 | 315 | 287 | 328 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q13188 | 274 | 315 | 308 | 314 | Compositional bias | Note=Poly-Glu |
| Q13188 | 274 | 315 | 27 | 278 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q13188 | 274 | 315 | 276 | 279 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG4 |
| Q13188 | 274 | 315 | 284 | 287 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG4 |
| Q13188 | 274 | 315 | 288 | 306 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4LG4 |
| Q13188 | 274 | 315 | 303 | 303 | Sequence conflict | Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q13188 | 274 | 315 | 308 | 311 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:6AO5 |
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3'-UTR located exon skipping events that lost miRNA binding sites in STK3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for STK3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for STK3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for STK3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for STK3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for STK3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q13188 | approved|investigational | DB12010 | Fostamatinib | small molecule | Q13188 |
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RelatedDiseases for STK3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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