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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for STAU1 |
Gene summary |
Gene information | Gene symbol | STAU1 | Gene ID | 6780 |
Gene name | staufen double-stranded RNA binding protein 1 | |
Synonyms | PPP1R150|STAU | |
Cytomap | 20q13.13 | |
Type of gene | protein-coding | |
Description | double-stranded RNA-binding protein Staufen homolog 1protein phosphatase 1, regulatory subunit 150staufen, RNA binding protein, homolog 1 | |
Modification date | 20200322 | |
UniProtAcc | ||
Context | - 30140277(Multi-omic Directed Networks Describe Features of Gene Regulation in Aged Brains and Expand the Set of Genes Driving Cognitive Decline) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for STAU1 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | DOWN | ENST00000614381.4 | STAU1-210:protein_coding:STAU1 | 3.802310e+02 | -2.011112e+00 | 9.097030e-03 | 3.218190e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for STAU1 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_163622 | chr20 | 49120021:49120128:49123092:49123235:49124375:49124587 | 49123092:49123235 |
exon_skip_184032 | chr20 | 49120021:49120128:49123092:49123229:49124375:49124587 | 49123092:49123229 |
exon_skip_20014 | chr20 | 49174195:49174269:49179122:49179244:49188116:49188367 | 49179122:49179244 |
exon_skip_206595 | chr20 | 49151582:49151747:49153933:49154071:49174195:49174263 | 49153933:49154071 |
exon_skip_208424 | chr20 | 49115782:49115867:49117126:49117248:49117777:49118096 | 49117126:49117248 |
exon_skip_282402 | chr20 | 49153933:49154071:49165997:49166285:49174195:49174263 | 49165997:49166285 |
exon_skip_8599 | chr20 | 49153933:49154071:49158437:49158497:49158939:49159146 | 49158437:49158497 |
exon_skip_99079 | chr20 | 49153933:49154071:49174195:49174269:49188116:49188367 | 49174195:49174269 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for STAU1 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000371856 | 49165997 | 49166285 | 3UTR-3CDS |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000371856 | 49165997 | 49166285 | 3UTR-3CDS |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000371856 | 49165997 | 49166285 | 3UTR-3CDS |
ENST00000371856 | 49117126 | 49117248 | In-frame |
ENST00000371856 | 49123092 | 49123235 | In-frame |
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Infer the effects of exon skipping event on protein functional features for STAU1 |
p-ENSG00000124214_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000371856 | 3701 | 577 | 49123092 | 49123235 | 1234 | 1376 | 274 | 321 |
ENST00000371856 | 3701 | 577 | 49117126 | 49117248 | 1921 | 2042 | 503 | 543 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
O95793 | 274 | 321 | 2 | 577 | Chain | ID=PRO_0000072243;Note=Double-stranded RNA-binding protein Staufen homolog 1 |
O95793 | 274 | 321 | 286 | 354 | Domain | Note=DRBM 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00266 |
O95793 | 274 | 321 | 278 | 278 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
O95793 | 503 | 543 | 504 | 509 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKK |
O95793 | 503 | 543 | 517 | 523 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKK |
O95793 | 503 | 543 | 525 | 527 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKK |
O95793 | 503 | 543 | 529 | 537 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKK |
O95793 | 503 | 543 | 2 | 577 | Chain | ID=PRO_0000072243;Note=Double-stranded RNA-binding protein Staufen homolog 1 |
O95793 | 503 | 543 | 538 | 553 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4DKK |
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3'-UTR located exon skipping events that lost miRNA binding sites in STAU1 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for STAU1 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for STAU1 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for STAU1 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
DLPFC | exon_skip_282402 | rs238150 | chr20:49235382 | 3.849024e-04 | 2.621087e-02 |
DLPFC | exon_skip_282402 | rs3021 | chr20:49257468 | 3.849024e-04 | 2.621087e-02 |
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Correlation with RNA binding proteins (RBPs) for STAU1 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
IFG | IGF2BP3 | exon_skip_282402 | -4.390110e-01 | 1.942936e-02 |
TC | NOVA1 | exon_skip_282402 | 4.236379e-01 | 2.381193e-08 |
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RelatedDrugs for STAU1 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STAU1 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |