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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for STAT5B |
 Gene summary |
| Gene information | Gene symbol | STAT5B | Gene ID | 6777 |
| Gene name | signal transducer and activator of transcription 5B | |
| Synonyms | STAT5 | |
| Cytomap | 17q21.2 | |
| Type of gene | protein-coding | |
| Description | signal transducer and activator of transcription 5Btranscription factor STAT5B | |
| Modification date | 20200313 | |
| UniProtAcc | C9J4I3, P51692, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| STAT5B | GO:0032355 | response to estradiol | 12552091 |
| STAT5B | GO:0032870 | cellular response to hormone stimulus | 12552091 |
| STAT5B | GO:0045648 | positive regulation of erythrocyte differentiation | 20702587 |
| STAT5B | GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway | 12552091 |
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Gene structures and expression levels for STAT5B |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000173757
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000481253.2 | STAT5B-205:retained_intron:STAT5B | 3.357638e+00 | 1.345965e+00 | 1.791524e-03 | 2.209019e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for STAT5B |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_115248 | chr17 | 42202340:42202447:42202757:42202808:42207558:42207728 | 42202757:42202808 |
| exon_skip_198783 | chr17 | 42218151:42218330:42218723:42218878:42219312:42219463 | 42218723:42218878 |
| exon_skip_238579 | chr17 | 42223463:42223556:42224779:42224868:42227529:42227657 | 42224779:42224868 |
| exon_skip_294416 | chr17 | 42217377:42217464:42218151:42218330:42218723:42218878 | 42218151:42218330 |
| exon_skip_69167 | chr17 | 42224779:42224868:42227529:42227685:42232000:42232137 | 42227529:42227685 |
| exon_skip_81106 | chr17 | 42218151:42218330:42218723:42218878:42219312:42219460 | 42218723:42218878 |
| exon_skip_83586 | chr17 | 42211984:42212190:42216014:42216106:42217160:42217282 | 42216014:42216106 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for STAT5B |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000293328 | 42227529 | 42227685 | Frame-shift |
| ENST00000293328 | 42216014 | 42216106 | In-frame |
| ENST00000293328 | 42218723 | 42218878 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000293328 | 42227529 | 42227685 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000293328 | 42202757 | 42202808 | Frame-shift |
| ENST00000293328 | 42227529 | 42227685 | Frame-shift |
| ENST00000293328 | 42216014 | 42216106 | In-frame |
| ENST00000293328 | 42218151 | 42218330 | In-frame |
| ENST00000293328 | 42218723 | 42218878 | In-frame |
| ENST00000293328 | 42224779 | 42224868 | In-frame |
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Infer the effects of exon skipping event on protein functional features for STAT5B |
p-ENSG00000173757_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000293328 | 5120 | 787 | 42218723 | 42218878 | 1003 | 1157 | 278 | 329 |
| ENST00000293328 | 5120 | 787 | 42216014 | 42216106 | 1550 | 1641 | 460 | 490 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000293328 | 5120 | 787 | 42224779 | 42224868 | 455 | 543 | 95 | 124 |
| ENST00000293328 | 5120 | 787 | 42218723 | 42218878 | 1003 | 1157 | 278 | 329 |
| ENST00000293328 | 5120 | 787 | 42218151 | 42218330 | 1159 | 1337 | 330 | 389 |
| ENST00000293328 | 5120 | 787 | 42216014 | 42216106 | 1550 | 1641 | 460 | 490 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P51692 | 278 | 329 | 1 | 787 | Chain | ID=PRO_0000182429;Note=Signal transducer and activator of transcription 5B |
| P51692 | 278 | 329 | 232 | 321 | Region | Note=Required for interaction with NMI;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9989503;Dbxref=PMID:9989503 |
| P51692 | 460 | 490 | 1 | 787 | Chain | ID=PRO_0000182429;Note=Signal transducer and activator of transcription 5B |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P51692 | 95 | 124 | 1 | 787 | Chain | ID=PRO_0000182429;Note=Signal transducer and activator of transcription 5B |
| P51692 | 278 | 329 | 1 | 787 | Chain | ID=PRO_0000182429;Note=Signal transducer and activator of transcription 5B |
| P51692 | 278 | 329 | 232 | 321 | Region | Note=Required for interaction with NMI;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9989503;Dbxref=PMID:9989503 |
| P51692 | 330 | 389 | 1 | 787 | Chain | ID=PRO_0000182429;Note=Signal transducer and activator of transcription 5B |
| P51692 | 460 | 490 | 1 | 787 | Chain | ID=PRO_0000182429;Note=Signal transducer and activator of transcription 5B |
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3'-UTR located exon skipping events that lost miRNA binding sites in STAT5B |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for STAT5B |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for STAT5B |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for STAT5B |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for STAT5B |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for STAT5B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P51692 | approved|investigational | DB01254 | Dasatinib | small molecule | P51692 |
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RelatedDiseases for STAT5B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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