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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for STAT3 |
 Gene summary |
| Gene information | Gene symbol | STAT3 | Gene ID | 6774 |
| Gene name | signal transducer and activator of transcription 3 | |
| Synonyms | ADMIO|ADMIO1|APRF|HIES | |
| Cytomap | 17q21.2 | |
| Type of gene | protein-coding | |
| Description | signal transducer and activator of transcription 3DNA-binding protein APRFacute-phase response factor | |
| Modification date | 20200329 | |
| UniProtAcc | ||
| Context | - 32507685(Inhibition of STAT3 phosphorylation attenuates impairments in learning and memory in 5XFAD mice, an animal model of Alzheimer's disease) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| STAT3 | GO:0006355 | regulation of transcription, DNA-templated | 15664994|17344214 |
| STAT3 | GO:0006606 | protein import into nucleus | 18234692 |
| STAT3 | GO:0010507 | negative regulation of autophagy | 26962683 |
| STAT3 | GO:0010628 | positive regulation of gene expression | 23820254 |
| STAT3 | GO:0030522 | intracellular receptor signaling pathway | 17324931 |
| STAT3 | GO:0032355 | response to estradiol | 12552091 |
| STAT3 | GO:0032870 | cellular response to hormone stimulus | 12552091 |
| STAT3 | GO:0033210 | leptin-mediated signaling pathway | 17344214 |
| STAT3 | GO:0035278 | miRNA mediated inhibition of translation | 23820254 |
| STAT3 | GO:0044320 | cellular response to leptin stimulus | 17344214 |
| STAT3 | GO:0044321 | response to leptin | 17344214 |
| STAT3 | GO:0045893 | positive regulation of transcription, DNA-templated | 19390056 |
| STAT3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17324931|27050391|31462771 |
| STAT3 | GO:0051726 | regulation of cell cycle | 17344214 |
| STAT3 | GO:0060396 | growth hormone receptor signaling pathway | 10925297 |
| STAT3 | GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway | 12552091 |
| STAT3 | GO:0070102 | interleukin-6-mediated signaling pathway | 12359225|12552091|17324931|24429361 |
| STAT3 | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II | 19390056|23820254 |
| STAT3 | GO:2000637 | positive regulation of gene silencing by miRNA | 23820254 |
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Gene structures and expression levels for STAT3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000168610
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000491272.1 | STAT3-208:retained_intron:STAT3 | 5.324401e+00 | 8.232781e-01 | 8.929051e-05 | 2.522333e-03 |
| PG | UP | ENST00000462286.2 | STAT3-205:retained_intron:STAT3 | 7.485835e+00 | 8.132791e-01 | 2.195989e-04 | 4.877996e-03 |
| CB | UP | ENST00000588969.5 | STAT3-213:protein_coding:STAT3 | 3.748531e+01 | 8.855065e-01 | 6.791417e-04 | 3.731861e-03 |
| TC | UP | ENST00000404395.3 | STAT3-203:protein_coding:STAT3 | 1.310462e+02 | 8.780160e-01 | 2.764682e-08 | 2.110425e-06 |
| TC | UP | ENST00000588969.5 | STAT3-213:protein_coding:STAT3 | 4.477823e+01 | 1.036643e+00 | 6.551575e-05 | 1.157919e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for STAT3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_102485 | chr17 | 42346569:42346713:42348389:42348517:42388279:42388431 | 42348389:42348517 |
| exon_skip_133935 | chr17 | 42329747:42329776:42331472:42331531:42333673:42333765 | 42331472:42331531 |
| exon_skip_141111 | chr17 | 42324963:42325061:42326116:42326199:42329410:42329457 | 42326116:42326199 |
| exon_skip_16098 | chr17 | 42339318:42339409:42345559:42345657:42346569:42346713 | 42345559:42345657 |
| exon_skip_161546 | chr17 | 42346596:42346713:42348389:42348520:42388279:42388414 | 42348389:42348520 |
| exon_skip_175302 | chr17 | 42346596:42346713:42348389:42348517:42388279:42388414 | 42348389:42348517 |
| exon_skip_188870 | chr17 | 42348389:42348517:42374059:42374206:42388279:42388454 | 42374059:42374206 |
| exon_skip_204375 | chr17 | 42348389:42348517:42374059:42374206:42388279:42388414 | 42374059:42374206 |
| exon_skip_262397 | chr17 | 42346569:42346713:42348389:42348520:42388279:42388431 | 42348389:42348520 |
| exon_skip_272637 | chr17 | 42329410:42329457:42329554:42329647:42329747:42329776 | 42329554:42329647 |
| exon_skip_287599 | chr17 | 42338731:42338812:42339314:42339409:42345559:42345657 | 42339314:42339409 |
| exon_skip_64428 | chr17 | 42339314:42339409:42345559:42345657:42346569:42346713 | 42345559:42345657 |
| exon_skip_79921 | chr17 | 42345559:42345657:42346569:42346713:42348389:42348516 | 42346569:42346713 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for STAT3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000588969 | 42348389 | 42348517 | 3UTR-3CDS |
| ENST00000264657 | 42329554 | 42329647 | Frame-shift |
| ENST00000588969 | 42329554 | 42329647 | Frame-shift |
| ENST00000264657 | 42346569 | 42346713 | Frame-shift |
| ENST00000588969 | 42346569 | 42346713 | Frame-shift |
| ENST00000264657 | 42331472 | 42331531 | In-frame |
| ENST00000588969 | 42331472 | 42331531 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000588969 | 42348389 | 42348517 | 3UTR-3CDS |
| ENST00000264657 | 42326116 | 42326199 | In-frame |
| ENST00000588969 | 42326116 | 42326199 | In-frame |
| ENST00000264657 | 42331472 | 42331531 | In-frame |
| ENST00000588969 | 42331472 | 42331531 | In-frame |
| ENST00000264657 | 42339314 | 42339409 | In-frame |
| ENST00000588969 | 42339314 | 42339409 | In-frame |
| ENST00000264657 | 42345559 | 42345657 | In-frame |
| ENST00000588969 | 42345559 | 42345657 | In-frame |
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Infer the effects of exon skipping event on protein functional features for STAT3 |
p-ENSG00000168610_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000264657 | 5064 | 770 | 42331472 | 42331531 | 1363 | 1421 | 350 | 369 |
| ENST00000588969 | 2789 | 770 | 42331472 | 42331531 | 1255 | 1313 | 350 | 369 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000264657 | 5064 | 770 | 42345559 | 42345657 | 587 | 684 | 91 | 123 |
| ENST00000588969 | 2789 | 770 | 42345559 | 42345657 | 479 | 576 | 91 | 123 |
| ENST00000264657 | 5064 | 770 | 42339314 | 42339409 | 686 | 780 | 124 | 155 |
| ENST00000588969 | 2789 | 770 | 42339314 | 42339409 | 578 | 672 | 124 | 155 |
| ENST00000264657 | 5064 | 770 | 42331472 | 42331531 | 1363 | 1421 | 350 | 369 |
| ENST00000588969 | 2789 | 770 | 42331472 | 42331531 | 1255 | 1313 | 350 | 369 |
| ENST00000264657 | 5064 | 770 | 42326116 | 42326199 | 1595 | 1677 | 427 | 454 |
| ENST00000588969 | 2789 | 770 | 42326116 | 42326199 | 1487 | 1569 | 427 | 454 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P40763 | 350 | 369 | 2 | 770 | Chain | ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3 |
| P40763 | 350 | 369 | 2 | 770 | Chain | ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P40763 | 91 | 123 | 2 | 770 | Chain | ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3 |
| P40763 | 91 | 123 | 2 | 770 | Chain | ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3 |
| P40763 | 124 | 155 | 2 | 770 | Chain | ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3 |
| P40763 | 124 | 155 | 2 | 770 | Chain | ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3 |
| P40763 | 124 | 155 | 150 | 162 | Motif | Note=Essential for nuclear import |
| P40763 | 124 | 155 | 150 | 162 | Motif | Note=Essential for nuclear import |
| P40763 | 124 | 155 | 143 | 143 | Natural variant | ID=VAR_018679;Note=M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs17878478 |
| P40763 | 124 | 155 | 143 | 143 | Natural variant | ID=VAR_018679;Note=M->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.5;Dbxref=dbSNP:rs17878478 |
| P40763 | 124 | 155 | 133 | 133 | Sequence conflict | Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P40763 | 124 | 155 | 133 | 133 | Sequence conflict | Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P40763 | 350 | 369 | 2 | 770 | Chain | ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3 |
| P40763 | 350 | 369 | 2 | 770 | Chain | ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3 |
| P40763 | 427 | 454 | 2 | 770 | Chain | ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3 |
| P40763 | 427 | 454 | 2 | 770 | Chain | ID=PRO_0000182417;Note=Signal transducer and activator of transcription 3 |
| P40763 | 427 | 454 | 434 | 435 | Mutagenesis | Note=Inhibits leptin-mediated transactivation of CCND1 promoter. No effect on interaction with INPP5F. EE->AA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344214,ECO:0000269|PubMed:25476455;Dbxref=PMID:17344214,PMID:25476455 |
| P40763 | 427 | 454 | 434 | 435 | Mutagenesis | Note=Inhibits leptin-mediated transactivation of CCND1 promoter. No effect on interaction with INPP5F. EE->AA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17344214,ECO:0000269|PubMed:25476455;Dbxref=PMID:17344214,PMID:25476455 |
| P40763 | 427 | 454 | 437 | 437 | Natural variant | ID=VAR_037372;Note=In AD-HIES%3B loss of function. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17676033;Dbxref=PMID:17676033 |
| P40763 | 427 | 454 | 437 | 437 | Natural variant | ID=VAR_037372;Note=In AD-HIES%3B loss of function. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17676033;Dbxref=PMID:17676033 |
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3'-UTR located exon skipping events that lost miRNA binding sites in STAT3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for STAT3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for STAT3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for STAT3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for STAT3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for STAT3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for STAT3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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