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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for SRC |
Gene summary |
Gene information | Gene symbol | SRC | Gene ID | 6714 |
Gene name | SRC proto-oncogene, non-receptor tyrosine kinase | |
Synonyms | ASV|SRC1|THC6|c-SRC|p60-Src | |
Cytomap | 20q11.23 | |
Type of gene | protein-coding | |
Description | proto-oncogene tyrosine-protein kinase Srcproto-oncogene c-Srcprotooncogene SRC, Rous sarcomatyrosine kinase pp60c-srctyrosine-protein kinase SRC-1v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog | |
Modification date | 20200327 | |
UniProtAcc | P12931, Q71UK5, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
SRC | GO:0018108 | peptidyl-tyrosine phosphorylation | 12051764|22732588 |
SRC | GO:0035306 | positive regulation of dephosphorylation | 23159740 |
SRC | GO:0035556 | intracellular signal transduction | 15248232 |
SRC | GO:0046777 | protein autophosphorylation | 16441665 |
SRC | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 19059439 |
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Gene structures and expression levels for SRC |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | DOWN | ENST00000477066.5 | SRC-207:lncRNA:SRC | 2.574867e+02 | -1.136721e+00 | 6.175804e-07 | 9.956129e-06 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for SRC |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_186016 | chr20 | 37386075:37386174:37386460:37386477:37393895:37393993 | 37386460:37386477 |
exon_skip_221559 | chr20 | 37365204:37365277:37382619:37382786:37384150:37384403 | 37382619:37382786 |
exon_skip_65766 | chr20 | 37400251:37400294:37401602:37401678:37402435:37402588 | 37401602:37401678 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_186016 | Mayo_TC | 3.819512e-01 | 4.860870e-01 | -1.041357e-01 | 1.716906e-04 |
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Open reading frame (ORF) annotation in the exon skipping event for SRC |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000373578 | 37382619 | 37382786 | 5UTR-5UTR |
ENST00000358208 | 37401602 | 37401678 | Frame-shift |
ENST00000373567 | 37401602 | 37401678 | Frame-shift |
ENST00000373578 | 37401602 | 37401678 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000373578 | 37382619 | 37382786 | 5UTR-5UTR |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000373578 | 37382619 | 37382786 | 5UTR-5UTR |
ENST00000358208 | 37401602 | 37401678 | Frame-shift |
ENST00000373567 | 37401602 | 37401678 | Frame-shift |
ENST00000373578 | 37401602 | 37401678 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for SRC |
p-ENSG00000197122_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in SRC |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for SRC |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for SRC |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SRC |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for SRC |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
HCC | ZNF326 | exon_skip_186016 | -4.381995e-01 | 5.311454e-14 |
HCC | RBM5 | exon_skip_186016 | -4.294122e-01 | 1.888660e-13 |
HCC | HNRNPF | exon_skip_186016 | -4.360104e-01 | 7.310671e-14 |
TC | ILF2 | exon_skip_186016 | 4.662399e-01 | 1.606062e-09 |
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RelatedDrugs for SRC |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
P12931 | approved|investigational | DB01254 | Dasatinib | small molecule | P12931 |
P12931 | approved|nutraceutical|vet_approved | DB04272 | Citric Acid | small molecule | P12931 |
P12931 | approved | DB06616 | Bosutinib | small molecule | P12931 |
P12931 | approved|investigational | DB08901 | Ponatinib | small molecule | P12931 |
P12931 | approved | DB09079 | Nintedanib | small molecule | P12931 |
P12931 | approved|investigational | DB12010 | Fostamatinib | small molecule | P12931 |
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RelatedDiseases for SRC |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |