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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for SP1 |
Gene summary |
Gene information | Gene symbol | SP1 | Gene ID | 6667 |
Gene name | Sp1 transcription factor | |
Synonyms | - | |
Cytomap | 12q13.13 | |
Type of gene | protein-coding | |
Description | transcription factor Sp1specificity protein 1 | |
Modification date | 20200329 | |
UniProtAcc | ||
Context | - 26807343(Transcription Factor Sp1 Inhibition, Memory, and Cytokines in a Mouse Model of Alzheimer's Disease) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
SP1 | GO:0006355 | regulation of transcription, DNA-templated | 12169688|12560508 |
SP1 | GO:0043923 | positive regulation by host of viral transcription | 2833704 |
SP1 | GO:0045893 | positive regulation of transcription, DNA-templated | 12771217|14580349 |
SP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 2833704|12169688|16691198|19263243|21659522|27030318 |
SP1 | GO:1904828 | positive regulation of hydrogen sulfide biosynthetic process | 21659522 |
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Gene structures and expression levels for SP1 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
STG | UP | ENST00000646274.1 | CLASP1-216:protein_coding:CLASP1 | 7.541049e+01 | 7.635680e+00 | 7.193475e-10 | 9.073185e-07 |
PG | UP | ENST00000296280.10 | MASP1-202:protein_coding:MASP1 | 8.437510e+01 | 9.456542e-01 | 8.698492e-09 | 2.299679e-06 |
PG | UP | ENST00000337774.9 | MASP1-203:protein_coding:MASP1 | 9.758323e+00 | 8.696269e-01 | 6.920438e-06 | 3.825907e-04 |
PG | UP | ENST00000483719.1 | MASP1-213:retained_intron:MASP1 | 1.798680e+00 | 1.197309e+00 | 5.923371e-05 | 1.866887e-03 |
PG | UP | ENST00000460839.5 | MASP1-209:retained_intron:MASP1 | 6.509907e+00 | 8.336469e-01 | 3.687644e-03 | 3.696519e-02 |
CB | DOWN | ENST00000616743.1 | BASP1-203:protein_coding:BASP1 | 1.617929e+02 | -1.992742e+00 | 3.221914e-11 | 2.505431e-09 |
CB | UP | ENST00000472776.1 | CLASP1-210:retained_intron:CLASP1 | 5.725222e+01 | 8.078072e-01 | 4.119561e-11 | 3.023564e-09 |
CB | UP | ENST00000465381.5 | TASP1-204:lncRNA:TASP1 | 4.514920e+00 | 1.229143e+00 | 7.051560e-07 | 1.113930e-05 |
CB | UP | ENST00000463621.3 | CLASP1-209:retained_intron:CLASP1 | 9.827009e+00 | 1.066638e+00 | 2.324220e-06 | 3.071023e-05 |
CB | DOWN | ENST00000337774.9 | MASP1-203:protein_coding:MASP1 | 1.146019e+01 | -8.105789e-01 | 1.092015e-05 | 1.135198e-04 |
CB | DOWN | ENST00000392472.6 | MASP1-205:protein_coding:MASP1 | 6.693374e+01 | -1.004885e+00 | 5.591226e-05 | 4.520505e-04 |
CB | DOWN | ENST00000377868.6 | BFSP1-201:protein_coding:BFSP1 | 3.225563e+01 | -1.202912e+00 | 2.750096e-04 | 1.742108e-03 |
CB | UP | ENST00000526511.5 | CASP1-205:retained_intron:CASP1 | 3.038827e+00 | 9.131613e-01 | 3.872638e-03 | 1.592739e-02 |
CB | DOWN | ENST00000435347.7 | LASP1-204:protein_coding:LASP1 | 1.046639e+01 | -6.998867e+00 | 4.939375e-03 | 1.947897e-02 |
CB | UP | ENST00000561530.5 | CARHSP1-203:protein_coding:CARHSP1 | 2.168385e+01 | 1.029836e+00 | 5.891976e-03 | 2.253905e-02 |
TC | DOWN | ENST00000435347.7 | LASP1-204:protein_coding:LASP1 | 8.181339e+01 | -8.920091e+00 | 5.538388e-09 | 5.520569e-07 |
TC | DOWN | ENST00000616743.1 | BASP1-203:protein_coding:BASP1 | 3.189556e+02 | -8.635999e-01 | 2.577368e-05 | 5.461907e-04 |
TC | UP | ENST00000488627.5 | CTDSP1-209:lncRNA:CTDSP1 | 4.873860e+01 | 9.625410e-01 | 1.775533e-03 | 1.532312e-02 |
TC | UP | ENST00000465381.5 | TASP1-204:lncRNA:TASP1 | 1.478481e+00 | 8.059552e-01 | 5.796833e-03 | 3.742206e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for SP1 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for SP1 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for SP1 |
p-ENSG00000185591_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in SP1 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for SP1 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for SP1 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SP1 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for SP1 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for SP1 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Q8N907 | approved|investigational | DB01593 | Zinc | small molecule | Q8N907 |
Q8N907 | approved|investigational | DB14487 | Zinc acetate | small molecule | Q8N907 |
Q8N907 | approved|investigational | DB14533 | Zinc chloride | small molecule | Q8N907 |
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RelatedDiseases for SP1 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |