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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CAPRIN2 |
 Gene summary |
| Gene information | Gene symbol | CAPRIN2 | Gene ID | 65981 |
| Gene name | caprin family member 2 | |
| Synonyms | C1QDC1|EEG-1|EEG1|RNG140 | |
| Cytomap | 12p11.21 | |
| Type of gene | protein-coding | |
| Description | caprin-2C1q domain-containing protein 1RNA granule protein 140cytoplasmic activation/proliferation-associated protein 2gastric cancer multidrug resistance-associated protein | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CAPRIN2 | GO:0030308 | negative regulation of cell growth | 14593112 |
| CAPRIN2 | GO:0032092 | positive regulation of protein binding | 18762581 |
| CAPRIN2 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 18762581 |
| CAPRIN2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 18762581 |
| CAPRIN2 | GO:0090263 | positive regulation of canonical Wnt signaling pathway | 18762581 |
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Gene structures and expression levels for CAPRIN2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000110888
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| STG | UP | ENST00000454014.6 | CAPRIN2-205:nonsense_mediated_decay:CAPRIN2 | 1.668633e+01 | 7.214038e+00 | 4.849045e-05 | 7.281117e-03 |
| CB | DOWN | ENST00000433722.6 | CAPRIN2-204:protein_coding:CAPRIN2 | 2.589076e+02 | -1.692279e+00 | 2.000290e-13 | 3.953844e-11 |
| CB | UP | ENST00000620681.1 | CAPRIN2-219:lncRNA:CAPRIN2 | 4.067723e+01 | 1.725574e+00 | 3.013984e-08 | 7.695511e-07 |
| CB | UP | ENST00000538387.1 | CAPRIN2-209:lncRNA:CAPRIN2 | 1.267538e+01 | 1.864782e+00 | 8.047472e-08 | 1.766643e-06 |
| CB | UP | ENST00000553026.5 | CAPRIN2-217:retained_intron:CAPRIN2 | 4.173515e+00 | 9.709252e-01 | 2.579975e-04 | 1.651625e-03 |
| CB | UP | ENST00000454014.6 | CAPRIN2-205:nonsense_mediated_decay:CAPRIN2 | 1.016509e+03 | 8.356975e-01 | 2.676595e-04 | 1.704220e-03 |
| CB | DOWN | ENST00000298892.9 | CAPRIN2-201:protein_coding:CAPRIN2 | 1.839778e+02 | -1.181524e+00 | 1.253355e-03 | 6.243140e-03 |
| TC | UP | ENST00000538387.1 | CAPRIN2-209:lncRNA:CAPRIN2 | 1.812022e+00 | 1.308217e+00 | 3.351327e-03 | 2.481270e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CAPRIN2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_125404 | chr12 | 30716623:30716676:30719079:30719225:30720811:30720915 | 30719079:30719225 |
| exon_skip_128247 | chr12 | 30730239:30730282:30731343:30731510:30734968:30735014 | 30731343:30731510 |
| exon_skip_135559 | chr12 | 30713785:30713885:30714959:30715144:30716508:30716676 | 30714959:30715144 |
| exon_skip_136265 | chr12 | 30711566:30711629:30711739:30711782:30713785:30713885 | 30711739:30711782 |
| exon_skip_140469 | chr12 | 30719079:30719225:30720811:30720915:30723259:30723314 | 30720811:30720915 |
| exon_skip_142456 | chr12 | 30711566:30711629:30711739:30711782:30713785:30713869 | 30711739:30711782 |
| exon_skip_150405 | chr12 | 30713785:30713885:30714959:30715081:30716508:30716676 | 30714959:30715081 |
| exon_skip_170666 | chr12 | 30728668:30729325:30730239:30730282:30734968:30735014 | 30730239:30730282 |
| exon_skip_18026 | chr12 | 30741020:30741106:30751071:30751133:30753344:30753538 | 30751071:30751133 |
| exon_skip_229616 | chr12 | 30709553:30710470:30711566:30711629:30713785:30713885 | 30711566:30711629 |
| exon_skip_244437 | chr12 | 30716623:30716676:30719079:30719225:30723259:30723314 | 30719079:30719225 |
| exon_skip_253360 | chr12 | 30724370:30724451:30725966:30726088:30728648:30728778 | 30725966:30726088 |
| exon_skip_255900 | chr12 | 30731470:30731510:30734968:30735206:30741020:30741106 | 30734968:30735206 |
| exon_skip_31464 | chr12 | 30716623:30716676:30720811:30720915:30723259:30723314 | 30720811:30720915 |
| exon_skip_34270 | chr12 | 30716623:30716676:30719079:30720915:30723259:30723314 | 30719079:30720915 |
| exon_skip_51136 | chr12 | 30731470:30731510:30733629:30733711:30734968:30735014 | 30733629:30733711 |
| exon_skip_62371 | chr12 | 30730239:30730282:30731343:30731510:30734968:30735147 | 30731343:30731510 |
| exon_skip_64020 | chr12 | 30751071:30751133:30753344:30753559:30754681:30754853 | 30753344:30753559 |
| exon_skip_6586 | chr12 | 30751071:30751133:30753344:30753559:30754689:30754860 | 30753344:30753559 |
| exon_skip_73158 | chr12 | 30713785:30713885:30714959:30715141:30716508:30716676 | 30714959:30715141 |
| exon_skip_82003 | chr12 | 30751071:30751133:30753344:30753559:30754751:30754939 | 30753344:30753559 |
| exon_skip_90386 | chr12 | 30751071:30751133:30753344:30753559:30754751:30754888 | 30753344:30753559 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_140469 | Mayo_CB | 6.313415e-01 | 7.761039e-01 | -1.447624e-01 | 8.620183e-08 |
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Open reading frame (ORF) annotation in the exon skipping event for CAPRIN2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for CAPRIN2 |
p-ENSG00000110888_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in CAPRIN2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CAPRIN2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CAPRIN2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CAPRIN2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CAPRIN2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TRA2A | exon_skip_265523 | -4.891830e-01 | 8.631856e-10 |
| CB | RBM45 | exon_skip_274378 | 4.334304e-01 | 8.835663e-08 |
| CB | RBM6 | exon_skip_122522 | -4.284229e-01 | 1.764612e-08 |
| CB | TRA2A | exon_skip_122522 | -5.375339e-01 | 2.760080e-13 |
| CB | RBM6 | exon_skip_180752 | -4.338627e-01 | 1.235017e-08 |
| CB | TRA2A | exon_skip_180752 | -4.128229e-01 | 7.034938e-08 |
| CB | RBM45 | exon_skip_72377 | 4.686804e-01 | 5.279747e-10 |
| CB | U2AF2 | exon_skip_34270 | -4.253001e-01 | 2.294967e-08 |
| CB | RBM3 | exon_skip_34270 | 4.196800e-01 | 3.658252e-08 |
| CB | PCBP4 | exon_skip_34270 | 4.924884e-01 | 4.288166e-11 |
| CB | RBM45 | exon_skip_34270 | 6.358666e-01 | 2.158531e-19 |
| CB | NUP42 | exon_skip_34270 | 5.131628e-01 | 4.638272e-12 |
| CB | RBM4 | exon_skip_34270 | -4.722865e-01 | 3.278712e-10 |
| CB | TRA2A | exon_skip_140469 | -5.528028e-01 | 4.183452e-14 |
| CB | CNOT4 | exon_skip_128247 | -4.714393e-01 | 4.606114e-10 |
| CB | TRA2A | exon_skip_128247 | -4.655070e-01 | 8.095276e-10 |
| CB | NUP42 | exon_skip_128247 | 4.821702e-01 | 1.615365e-10 |
| CB | RBM3 | exon_skip_51136 | 5.534719e-01 | 3.842985e-14 |
| CB | NUP42 | exon_skip_51136 | 5.791129e-01 | 1.281496e-15 |
| DLPFC | KHDRBS2 | exon_skip_34270 | 4.429825e-01 | 1.172983e-15 |
| FL | MSI1 | exon_skip_51136 | -4.102270e-01 | 4.563219e-09 |
| FL | RBM3 | exon_skip_51136 | 4.903525e-01 | 7.947089e-13 |
| FL | RALYL | exon_skip_51136 | 4.485287e-01 | 9.638959e-11 |
| FL | HNRNPL | exon_skip_51136 | 4.288183e-01 | 7.451543e-10 |
| FL | EIF4B | exon_skip_51136 | 4.558653e-01 | 4.351338e-11 |
| HCC | RBMS2 | exon_skip_34270 | -4.224713e-01 | 6.771045e-13 |
| HCC | MSI1 | exon_skip_34270 | -4.257841e-01 | 4.282618e-13 |
| HCC | MSI1 | exon_skip_51136 | -4.867218e-01 | 6.263595e-17 |
| HCC | SFPQ | exon_skip_51136 | -5.364771e-01 | 7.458289e-21 |
| HCC | SRSF11 | exon_skip_51136 | -4.591491e-01 | 5.144514e-15 |
| HCC | RBM5 | exon_skip_51136 | -5.613993e-01 | 4.467794e-23 |
| IFG | TARDBP | exon_skip_51136 | -4.275676e-01 | 2.610585e-02 |
| IFG | SFPQ | exon_skip_51136 | -7.258563e-01 | 1.826377e-05 |
| IFG | SRSF11 | exon_skip_51136 | -6.683990e-01 | 1.386407e-04 |
| IFG | RBM5 | exon_skip_51136 | -6.378367e-01 | 3.447843e-04 |
| IFG | IGF2BP3 | exon_skip_51136 | -4.370121e-01 | 2.264854e-02 |
| IFG | IGF2BP2 | exon_skip_51136 | -5.112726e-01 | 6.418736e-03 |
| IFG | SRSF1 | exon_skip_51136 | -4.125920e-01 | 3.245446e-02 |
| PCC | MSI1 | exon_skip_51136 | -4.535105e-01 | 3.954267e-11 |
| PCC | RBM3 | exon_skip_51136 | 4.058086e-01 | 5.234302e-09 |
| PG | MSI1 | exon_skip_51136 | -5.289879e-01 | 1.025536e-13 |
| PG | RBM3 | exon_skip_51136 | 4.908176e-01 | 9.417609e-12 |
| PG | RALYL | exon_skip_51136 | 4.078414e-01 | 3.081401e-08 |
| STG | RBM3 | exon_skip_51136 | 4.129552e-01 | 2.314074e-04 |
| TC | RALYL | exon_skip_18820 | 4.036968e-01 | 2.506297e-07 |
| TC | PTBP1 | exon_skip_18820 | -4.032509e-01 | 2.591072e-07 |
| TC | NOVA1 | exon_skip_18820 | 4.772599e-01 | 5.080630e-10 |
| TC | RBMS2 | exon_skip_34270 | -5.322187e-01 | 1.216132e-12 |
| TC | SRSF2 | exon_skip_34270 | 4.478782e-01 | 5.738959e-09 |
| TC | MSI1 | exon_skip_34270 | -4.584334e-01 | 2.248667e-09 |
| TC | ELAVL4 | exon_skip_34270 | 6.877968e-01 | 6.657706e-23 |
| TC | RBM6 | exon_skip_34270 | -4.254668e-01 | 3.786029e-08 |
| TC | RBM3 | exon_skip_34270 | 4.589106e-01 | 2.153771e-09 |
| TC | MATR3 | exon_skip_34270 | 6.148841e-01 | 2.191199e-17 |
| TC | G3BP2 | exon_skip_34270 | 5.644315e-01 | 2.467411e-14 |
| TC | KHDRBS2 | exon_skip_34270 | 6.938529e-01 | 1.955672e-23 |
| TC | KHDRBS3 | exon_skip_34270 | 5.590755e-01 | 4.857605e-14 |
| TC | RBM24 | exon_skip_34270 | 5.982472e-01 | 2.548716e-16 |
| TC | HNRNPA0 | exon_skip_34270 | 5.345964e-01 | 9.249339e-13 |
| TC | PUM1 | exon_skip_34270 | 4.751143e-01 | 4.786153e-10 |
| TC | RBM45 | exon_skip_34270 | 4.734404e-01 | 5.611177e-10 |
| TC | HNRNPD | exon_skip_34270 | 5.036145e-01 | 2.785410e-11 |
| TC | NUP42 | exon_skip_34270 | 5.890278e-01 | 9.348648e-16 |
| TC | RALYL | exon_skip_34270 | 7.231829e-01 | 3.283741e-26 |
| TC | PTBP1 | exon_skip_34270 | -5.921867e-01 | 6.017005e-16 |
| TC | CPEB1 | exon_skip_34270 | 4.183024e-01 | 6.727004e-08 |
| TC | HNRNPH2 | exon_skip_34270 | 5.900390e-01 | 8.123039e-16 |
| TC | ESRP1 | exon_skip_34270 | 5.512315e-01 | 1.281892e-13 |
| TC | NOVA1 | exon_skip_34270 | 6.503276e-01 | 7.030697e-20 |
| TC | MSI1 | exon_skip_51136 | -4.057946e-01 | 1.778059e-07 |
| TC | RBM3 | exon_skip_51136 | 5.568842e-01 | 6.386523e-14 |
| TC | NUP42 | exon_skip_51136 | 6.710845e-01 | 1.684384e-21 |
| TC | RALYL | exon_skip_51136 | 7.642264e-01 | 9.394147e-31 |
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RelatedDrugs for CAPRIN2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CAPRIN2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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