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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for SLN |
Gene summary |
Gene information | Gene symbol | SLN | Gene ID | 6588 |
Gene name | sarcolipin | |
Synonyms | - | |
Cytomap | 11q22.3 | |
Type of gene | protein-coding | |
Description | sarcolipin | |
Modification date | 20200315 | |
UniProtAcc | A0A158RFT9, O00631, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
SLN | GO:1901894 | regulation of calcium-transporting ATPase activity | 11781085 |
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Gene structures and expression levels for SLN |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
PG | DOWN | 2.785513e+00 | -9.787720e-01 | 1.161843e-04 | 1.037406e-03 |
TC | DOWN | 2.175210e+01 | -1.142791e+00 | 7.590490e-08 | 2.305109e-06 |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PG | DOWN | ENST00000305991.3 | SLN-201:protein_coding:SLN | 2.136534e+00 | -1.084833e+00 | 1.118590e-03 | 1.585831e-02 |
TC | DOWN | ENST00000305991.3 | SLN-201:protein_coding:SLN | 1.984945e+01 | -1.156136e+00 | 6.580194e-07 | 2.870743e-05 |
TC | DOWN | ENST00000563941.5 | MSLN-205:protein_coding:MSLN | 8.619547e+00 | -1.400343e+00 | 1.064208e-04 | 1.694699e-03 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for SLN |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_288901 | chr11 | 107707612:107708005:107711963:107712162:107719616:107719657 | 107711963:107712162 |
exon_skip_97558 | chr11 | 107707612:107708005:107711963:107712162:107719616:107719693 | 107711963:107712162 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for SLN |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000531293 | 107711963 | 107712162 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000531293 | 107711963 | 107712162 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for SLN |
p-ENSG00000170290_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in SLN |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000531293 | 107711963 | 107712162 | hsa-miR-3972 | chr11:107712099-107712106 | 8mer-1a | chr11:107712093-107712116 | 158.00 | -23.57 |
Mayo | ENST00000531293 | 107711963 | 107712162 | hsa-miR-3913-3p | chr11:107712113-107712120 | 8mer-1a | chr11:107712100-107712121 | 155.00 | -21.33 |
Mayo | ENST00000531293 | 107711963 | 107712162 | hsa-miR-665 | chr11:107712060-107712067 | 8mer-1a | chr11:107712046-107712067 | 151.00 | -22.44 |
Mayo | ENST00000531293 | 107711963 | 107712162 | hsa-miR-6883-5p | chr11:107712041-107712048 | 8mer-1a | chr11:107712026-107712048 | 173.00 | -34.08 |
Mayo | ENST00000531293 | 107711963 | 107712162 | hsa-miR-4728-5p | chr11:107712041-107712048 | 8mer-1a | chr11:107712026-107712048 | 173.00 | -34.08 |
Mayo | ENST00000531293 | 107711963 | 107712162 | hsa-miR-6785-5p | chr11:107712041-107712048 | 8mer-1a | chr11:107712026-107712048 | 173.00 | -34.08 |
Mayo | ENST00000531293 | 107711963 | 107712162 | hsa-miR-5190 | chr11:107712117-107712124 | 8mer-1a | chr11:107712108-107712125 | 153.00 | -19.01 |
Mayo | ENST00000531293 | 107711963 | 107712162 | hsa-miR-3681-3p | chr11:107712108-107712115 | 8mer-1a | chr11:107712093-107712116 | 158.00 | -23.57 |
Mayo | ENST00000531293 | 107711963 | 107712162 | hsa-miR-216a-3p | chr11:107712108-107712115 | 8mer-1a | chr11:107712093-107712116 | 158.00 | -23.57 |
Mayo | ENST00000531293 | 107711963 | 107712162 | hsa-miR-128-3p | chr11:107712108-107712115 | 8mer-1a | chr11:107712093-107712116 | 158.00 | -23.57 |
Mayo | ENST00000531293 | 107711963 | 107712162 | hsa-miR-149-3p | chr11:107712041-107712048 | 8mer-1a | chr11:107712026-107712048 | 173.00 | -34.08 |
Mayo | ENST00000531293 | 107711963 | 107712162 | hsa-miR-1202 | chr11:107712099-107712106 | 8mer-1a | chr11:107712093-107712116 | 158.00 | -23.57 |
Mayo | ENST00000531293 | 107711963 | 107712162 | hsa-miR-6874-5p | chr11:107712024-107712031 | 8mer-1a | chr11:107712020-107712043 | 156.00 | -18.43 |
ROSMAP | ENST00000531293 | 107711963 | 107712162 | hsa-miR-3972 | chr11:107712099-107712106 | 8mer-1a | chr11:107712093-107712116 | 158.00 | -23.57 |
ROSMAP | ENST00000531293 | 107711963 | 107712162 | hsa-miR-3913-3p | chr11:107712113-107712120 | 8mer-1a | chr11:107712100-107712121 | 155.00 | -21.33 |
ROSMAP | ENST00000531293 | 107711963 | 107712162 | hsa-miR-665 | chr11:107712060-107712067 | 8mer-1a | chr11:107712046-107712067 | 151.00 | -22.44 |
ROSMAP | ENST00000531293 | 107711963 | 107712162 | hsa-miR-6883-5p | chr11:107712041-107712048 | 8mer-1a | chr11:107712026-107712048 | 173.00 | -34.08 |
ROSMAP | ENST00000531293 | 107711963 | 107712162 | hsa-miR-4728-5p | chr11:107712041-107712048 | 8mer-1a | chr11:107712026-107712048 | 173.00 | -34.08 |
ROSMAP | ENST00000531293 | 107711963 | 107712162 | hsa-miR-6785-5p | chr11:107712041-107712048 | 8mer-1a | chr11:107712026-107712048 | 173.00 | -34.08 |
ROSMAP | ENST00000531293 | 107711963 | 107712162 | hsa-miR-5190 | chr11:107712117-107712124 | 8mer-1a | chr11:107712108-107712125 | 153.00 | -19.01 |
ROSMAP | ENST00000531293 | 107711963 | 107712162 | hsa-miR-3681-3p | chr11:107712108-107712115 | 8mer-1a | chr11:107712093-107712116 | 158.00 | -23.57 |
ROSMAP | ENST00000531293 | 107711963 | 107712162 | hsa-miR-216a-3p | chr11:107712108-107712115 | 8mer-1a | chr11:107712093-107712116 | 158.00 | -23.57 |
ROSMAP | ENST00000531293 | 107711963 | 107712162 | hsa-miR-128-3p | chr11:107712108-107712115 | 8mer-1a | chr11:107712093-107712116 | 158.00 | -23.57 |
ROSMAP | ENST00000531293 | 107711963 | 107712162 | hsa-miR-149-3p | chr11:107712041-107712048 | 8mer-1a | chr11:107712026-107712048 | 173.00 | -34.08 |
ROSMAP | ENST00000531293 | 107711963 | 107712162 | hsa-miR-1202 | chr11:107712099-107712106 | 8mer-1a | chr11:107712093-107712116 | 158.00 | -23.57 |
ROSMAP | ENST00000531293 | 107711963 | 107712162 | hsa-miR-6874-5p | chr11:107712024-107712031 | 8mer-1a | chr11:107712020-107712043 | 156.00 | -18.43 |
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SNVs in the skipped exons for SLN |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for SLN |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SLN |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for SLN |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for SLN |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLN |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |