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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for FAM153CP |
 Gene summary |
| Gene information | Gene symbol | FAM153CP | Gene ID | 653316 |
| Gene name | family with sequence similarity 153 member C | |
| Synonyms | FAM153C|NY-REN-7-like | |
| Cytomap | 5q35.3 | |
| Type of gene | pseudo | |
| Description | protein FAM153C | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for FAM153CP |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000204677
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000652464.2 | FAM153CP-238:lncRNA:FAM153CP | 6.745066e+01 | -1.649059e+00 | 7.117467e-14 | 1.756365e-11 |
| CB | DOWN | ENST00000652167.1 | FAM153CP-232:lncRNA:FAM153CP | 3.050980e+02 | -1.285397e+00 | 1.981533e-12 | 2.626496e-10 |
| CB | DOWN | ENST00000651508.1 | FAM153CP-226:lncRNA:FAM153CP | 3.201933e+02 | -8.722057e-01 | 1.151191e-08 | 3.384078e-07 |
| CB | DOWN | ENST00000511511.6 | FAM153CP-209:lncRNA:FAM153CP | 1.214500e+01 | -2.363373e+00 | 9.185489e-07 | 1.394189e-05 |
| CB | DOWN | ENST00000515878.1 | FAM153CP-212:lncRNA:FAM153CP | 1.283840e+00 | -1.590263e+00 | 5.061461e-04 | 2.910632e-03 |
| CB | DOWN | ENST00000663505.1 | FAM153CP-247:lncRNA:FAM153CP | 3.329017e+01 | -1.391028e+00 | 5.878078e-04 | 3.304667e-03 |
| CB | UP | ENST00000651969.2 | FAM153CP-230:lncRNA:FAM153CP | 5.747349e+00 | 4.032667e+00 | 6.531633e-04 | 3.611586e-03 |
| CB | DOWN | ENST00000511819.6 | FAM153CP-210:lncRNA:FAM153CP | 2.431569e+01 | -1.111110e+00 | 4.625864e-03 | 1.846574e-02 |
| TC | DOWN | ENST00000651496.2 | FAM153CP-225:lncRNA:FAM153CP | 9.677858e+00 | -8.550585e-01 | 5.519353e-04 | 6.215983e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for FAM153CP |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_116175 | chr5 | 178053872:178053973:178054738:178054807:178055369:178055559 | 178054738:178054807 |
| exon_skip_11891 | chr5 | 178006405:178006519:178009326:178009381:178035096:178035154 | 178009326:178009381 |
| exon_skip_119232 | chr5 | 178053872:178053973:178054716:178054807:178055369:178055559 | 178054716:178054807 |
| exon_skip_125108 | chr5 | 178006990:178007060:178009326:178009381:178035096:178035154 | 178009326:178009381 |
| exon_skip_128403 | chr5 | 178046414:178046451:178046872:178046939:178047028:178047133 | 178046872:178046939 |
| exon_skip_131154 | chr5 | 178009326:178009381:178016586:178016616:178020260:178020453 | 178016586:178016616 |
| exon_skip_136614 | chr5 | 178049127:178049321:178049869:178049954:178050303:178050437 | 178049869:178049954 |
| exon_skip_139150 | chr5 | 178053937:178053973:178054738:178054807:178055369:178055559 | 178054738:178054807 |
| exon_skip_13920 | chr5 | 178052665:178052687:178052803:178052989:178053840:178053973 | 178052803:178052989 |
| exon_skip_154129 | chr5 | 178053840:178053973:178054738:178054807:178055369:178055559 | 178054738:178054807 |
| exon_skip_168562 | chr5 | 178049869:178049954:178050303:178050437:178052533:178052687 | 178050303:178050437 |
| exon_skip_172138 | chr5 | 178053935:178053973:178054738:178054807:178055369:178055559 | 178054738:178054807 |
| exon_skip_176203 | chr5 | 178053840:178053973:178057649:178057818:178063172:178063321 | 178057649:178057818 |
| exon_skip_186678 | chr5 | 178041693:178041763:178042195:178042225:178046414:178046451 | 178042195:178042225 |
| exon_skip_195224 | chr5 | 178042195:178042225:178046414:178046451:178046872:178046895 | 178046414:178046451 |
| exon_skip_207013 | chr5 | 178052665:178052687:178052909:178052989:178053840:178053973 | 178052909:178052989 |
| exon_skip_210131 | chr5 | 178035096:178035154:178036012:178036036:178038838:178038917 | 178036012:178036036 |
| exon_skip_210541 | chr5 | 178057649:178057818:178060875:178060994:178063172:178063305 | 178060875:178060994 |
| exon_skip_225947 | chr5 | 178047028:178047133:178048665:178049321:178052533:178052687 | 178048665:178049321 |
| exon_skip_240418 | chr5 | 178057649:178057818:178060875:178060994:178063172:178063236 | 178060875:178060994 |
| exon_skip_246028 | chr5 | 178006405:178006519:178009326:178009381:178020260:178020453 | 178009326:178009381 |
| exon_skip_264274 | chr5 | 178053935:178053973:178054716:178054807:178055369:178055559 | 178054716:178054807 |
| exon_skip_269331 | chr5 | 178020260:178020453:178023233:178023332:178035096:178035154 | 178023233:178023332 |
| exon_skip_27921 | chr5 | 178016586:178016616:178020260:178020453:178035096:178035154 | 178020260:178020453 |
| exon_skip_280477 | chr5 | 178035096:178035154:178035988:178036036:178038838:178038917 | 178035988:178036036 |
| exon_skip_29937 | chr5 | 178009326:178009381:178032743:178032886:178035096:178035154 | 178032743:178032886 |
| exon_skip_63815 | chr5 | 178052532:178052687:178052909:178052989:178053840:178053973 | 178052909:178052989 |
| exon_skip_64769 | chr5 | 178046872:178046939:178047028:178047133:178048665:178048762 | 178047028:178047133 |
| exon_skip_66047 | chr5 | 178009326:178009381:178020260:178020453:178035096:178035154 | 178020260:178020453 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_139150 | Mayo_CB | 3.971951e-01 | 6.326316e-01 | -2.354365e-01 | 1.361631e-07 |
| exon_skip_172138 | Mayo_TC | 3.912308e-01 | 5.737879e-01 | -1.825571e-01 | 7.481857e-03 |
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Open reading frame (ORF) annotation in the exon skipping event for FAM153CP |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for FAM153CP |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in FAM153CP |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for FAM153CP |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for FAM153CP |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FAM153CP |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for FAM153CP |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | RBM6 | exon_skip_264274 | -4.743356e-01 | 1.670912e-09 |
| CB | NUP42 | exon_skip_264274 | 4.539169e-01 | 9.800467e-09 |
| CB | RBM6 | exon_skip_139150 | -5.058682e-01 | 1.202557e-11 |
| CB | TRA2A | exon_skip_139150 | -6.467285e-01 | 4.357128e-20 |
| CB | FUBP1 | exon_skip_139150 | -4.749235e-01 | 2.887104e-10 |
| CB | HNRNPC | exon_skip_139150 | -5.167831e-01 | 3.624468e-12 |
| CB | NUP42 | exon_skip_139150 | 4.327766e-01 | 1.355038e-08 |
| CB | PTBP1 | exon_skip_139150 | -4.415070e-01 | 6.369911e-09 |
| TC | PTBP1 | exon_skip_172138 | -4.535738e-01 | 5.310636e-08 |
| TC | NOVA1 | exon_skip_172138 | 4.678824e-01 | 1.752343e-08 |
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RelatedDrugs for FAM153CP |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM153CP |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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