 Gene summary |
| Gene information | Gene symbol | BMP5 |
Gene ID | 653 | | Gene name | bone morphogenetic protein 5 |
| Synonyms | - |
| Cytomap | 6p12.1 |
| Type of gene | protein-coding |
| Description | bone morphogenetic protein 5 |
| Modification date | 20200313 |
| UniProtAcc | M9VUD0, P22003, |
| Context | |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
ENSG00000112175
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
***cutpoints = c(0, 0.0001, 0.001, 0.01, 1), symbols = c("****", "***", "**", "ns")
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| DLPFC | UP | 2.003360e+00 | 9.301491e-01 | 3.766748e-04 | 7.123170e-03 |
| STG | UP | 1.516134e+01 | 1.148139e+00 | 5.945139e-04 | 1.465910e-02 |
| PG | UP | 1.545536e+01 | 1.105385e+00 | 4.647718e-06 | 7.971492e-05 |
| CB | UP | 1.034159e+01 | 1.283321e+00 | 1.317402e-07 | 1.890922e-06 |
| TC | UP | 8.315885e+01 | 4.471331e+00 | 1.312809e-38 | 2.332271e-34 |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| DLPFC | UP | ENST00000370830.4 | BMP5-201:protein_coding:BMP5 | 1.986576e+00 | 9.071475e-01 | 5.888638e-04 | 2.359703e-02 |
| STG | UP | ENST00000370830.4 | BMP5-201:protein_coding:BMP5 | 1.482710e+01 | 1.139033e+00 | 8.786298e-04 | 3.581202e-02 |
| PG | UP | ENST00000370830.4 | BMP5-201:protein_coding:BMP5 | 1.484417e+01 | 1.096288e+00 | 5.702668e-06 | 3.321344e-04 |
| CB | UP | ENST00000370830.4 | BMP5-201:protein_coding:BMP5 | 1.010686e+01 | 1.259193e+00 | 3.112769e-07 | 5.553374e-06 |
| TC | UP | ENST00000370830.4 | BMP5-201:protein_coding:BMP5 | 8.176479e+01 | 4.460178e+00 | 1.465706e-38 | 2.520209e-34 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_165022 | chr6 | 55755560:55755682:55759005:55759115:55760457:55760533 | 55759005:55759115 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370830 | 55759005 | 55759115 | In-frame |
p-ENSG00000112175_img4.png
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| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000370830 | 3969 | 454 | 55759005 | 55759115 | 1804 | 1913 | 368 | 404 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P22003 | 368 | 404 | 369 | 405 | Alternative sequence | ID=VSP_056841;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P22003 | 368 | 404 | 317 | 454 | Chain | ID=PRO_0000033867;Note=Bone morphogenetic protein 5 |
| P22003 | 368 | 404 | 353 | 419 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P22003 | 368 | 404 | 382 | 451 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P22003 | 368 | 404 | 386 | 453 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P22003 | 368 | 404 | 395 | 395 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Diseases associated with this gene.
(DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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