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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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3'-UTR located exon skipping events lost miRNA binding sites

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SNVs in the skipped exons with depth of coverage

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AD stage-associated exon skipping events

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Correlation with RNA binding proteins (RBPs)

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Related drugs with this gene

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Related diseases with this gene

Gene summary for WNK1

check button Gene summary
Gene informationGene symbol

WNK1

Gene ID

65125

Gene nameWNK lysine deficient protein kinase 1
SynonymsHSAN2|HSN2|KDP|PPP1R167|PRKWNK1|PSK|p65
Cytomap

12p13.33

Type of geneprotein-coding
Descriptionserine/threonine-protein kinase WNK1WNK lysine deficient protein kinase 1 isoformerythrocyte 65 kDa proteinprostate-derived sterile 20-like kinaseprotein kinase with no lysine 1protein phosphatase 1, regulatory subunit 167serine/threonine-protein ki
Modification date20200327
UniProtAcc

A0A0B4J299,

A5D8Z4,

A5XEH6,

A5XEH7,

A5XEH8,

A5XEH9,

D3DUP1,

D3DUP2,

F5GWT4,

F6UYG0,

H0YF81,

H0YFF1,

H0YFK5,

H0YFP5,

H0YH68,

H0YH79,

I3L251,

L8EA38,

Q9H4A3,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
WNK1

GO:0006468

protein phosphorylation

10660600

WNK1

GO:0010923

negative regulation of phosphatase activity

19389623

WNK1

GO:0023016

signal transduction by trans-phosphorylation

16669787

WNK1

GO:0035556

intracellular signal transduction

10660600


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Gene structures and expression levels for WNK1

check buttonSkipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

ENSG00000060237
check button Differentially expressed gene analysis across multiple brain tissues between AD and control.
Tissue typeDEG directionBase mean exp.log2FC(AD/control)P-valueAdj. p-value

check button Differentially expressed isoform analysis across multiple brain tissues between AD and control.
gencode gene structure
Tissue typeDEG directionENSTTranscript info.Base mean exp.log2FC(AD/control)P-valueAdjc. p-value
PGUPENST00000535572.5WNK1-206:protein_coding:WNK12.278201e+038.400909e-011.145322e-069.818537e-05
PGDOWNENST00000530271.6WNK1-204:protein_coding:WNK11.853886e+02-9.022651e-013.195393e-046.418920e-03
CBUPENST00000542424.1WNK1-213:retained_intron:WNK18.132109e+011.033134e+002.888544e-162.153417e-13
CBUPENST00000545285.5WNK1-219:protein_coding:WNK11.749635e+011.773415e+001.149008e-094.886996e-08
CBUPENST00000540360.5WNK1-211:lncRNA:WNK11.307733e+011.265578e+001.420499e-084.059549e-07
CBDOWNENST00000340908.8WNK1-202:protein_coding:WNK11.744015e+02-9.091824e-011.015542e-072.151307e-06
CBUPENST00000535698.1WNK1-207:protein_coding:WNK13.858956e+008.965560e-011.522200e-051.505670e-04
CBUPENST00000534872.1WNK1-205:protein_coding:WNK15.141459e+001.705004e+002.677499e-052.424641e-04

check button Landscape of isoform expressions across multiple brain tissues between AD and control.
gencode gene structure

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for WNK1

check button Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).
boxplot

check button All exon skipping events in AD cohorts.
Exon skip IDchrExons involved in exon skippingSkipped exon
exon_skip_116052chr12889140:889223:890453:890510:894562:894635890453:890510
exon_skip_123062chr12881934:882073:882943:883059:883395:883419882943:883059
exon_skip_128310chr12862235:862270:878212:878361:881692:881789878212:878361
exon_skip_128631chr12900598:900670:901561:901653:904453:904487901561:901653
exon_skip_136971chr12862235:862270:871265:871348:878215:878361871265:871348
exon_skip_145420chr12900598:900670:907847:908034:908475:909033907847:908034
exon_skip_158915chr12878313:878361:880721:880999:881692:881789880721:880999
exon_skip_176300chr12868568:869104:871265:871348:878212:878312871265:871348
exon_skip_178110chr12878215:878361:880721:880999:881692:881789880721:880999
exon_skip_180240chr12897598:897681:900476:900670:907847:907956900476:900670
exon_skip_184965chr12878215:878361:879573:880031:880721:880783879573:880031
exon_skip_186733chr12857161:857249:859245:859464:861013:861135859245:859464
exon_skip_187939chr12862235:862270:867866:869104:871265:871348867866:869104
exon_skip_188258chr12883395:883568:883774:883831:884121:884243883774:883831
exon_skip_190833chr12901561:901632:904453:904494:907847:907956904453:904494
exon_skip_216782chr12900598:900670:904453:904494:907847:907956904453:904494
exon_skip_217286chr12900598:900670:907847:908034:908475:911300907847:908034
exon_skip_2335chr12897479:897681:900476:900670:907847:907956900476:900670
exon_skip_239434chr12862235:862270:867866:869104:871265:871318867866:869104
exon_skip_248174chr12889140:889223:890453:890513:894562:894635890453:890513
exon_skip_251166chr12878215:878361:879573:880031:880721:880814879573:880031
exon_skip_257643chr12878313:878361:879573:880031:880721:880814879573:880031
exon_skip_270261chr12878272:878361:880721:880999:881692:881789880721:880999
exon_skip_278862chr12878272:878361:879573:880031:880721:880814879573:880031
exon_skip_289725chr12881911:882073:882943:883059:883395:883419882943:883059
exon_skip_291878chr12879573:880031:880721:880999:881692:881789880721:880999
exon_skip_293790chr12862235:862270:871265:871348:878212:878243871265:871348
exon_skip_29586chr12890453:890513:894562:894635:896071:896732894562:894635
exon_skip_35191chr12900598:900670:901561:901632:904453:904487901561:901632
exon_skip_44786chr12862235:862270:871265:871348:878212:878312871265:871348
exon_skip_82655chr12862235:862270:871265:871348:878215:878243871265:871348
exon_skip_83347chr12887221:887304:889140:889223:890453:890510889140:889223

check button Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.
psi tcga
Exon skipping informationTissue typeAvg(PSIs) in ADAvg(PSIs) in controlDifference (PSI)Adj. p-value
exon_skip_187939MSBB_PG1.168702e-012.169091e-01-1.000389e-012.712669e-03
exon_skip_270261Mayo_CB5.026829e-013.985333e-011.041496e-015.495597e-04
exon_skip_190833Mayo_CB5.724390e-016.990625e-01-1.266235e-013.022195e-06


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Open reading frame (ORF) annotation in the exon skipping event for WNK1

check button Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000315939859245859464Frame-shift
ENST00000315939883774883831Frame-shift
ENST00000315939890453890513Frame-shift
ENST00000315939894562894635Frame-shift
ENST00000315939907847908034Frame-shift
ENST00000315939871265871348In-frame
ENST00000315939879573880031In-frame
ENST00000315939880721880999In-frame
ENST00000315939882943883059In-frame
ENST00000315939889140889223In-frame
ENST00000315939900476900670In-frame

check button Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000315939859245859464Frame-shift
ENST00000315939883774883831Frame-shift
ENST00000315939890453890513Frame-shift
ENST00000315939871265871348In-frame
ENST00000315939879573880031In-frame
ENST00000315939880721880999In-frame
ENST00000315939882943883059In-frame
ENST00000315939900476900670In-frame

check button Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000315939859245859464Frame-shift
ENST00000315939883774883831Frame-shift
ENST00000315939890453890513Frame-shift
ENST00000315939894562894635Frame-shift
ENST00000315939871265871348In-frame
ENST00000315939879573880031In-frame
ENST00000315939880721880999In-frame
ENST00000315939882943883059In-frame
ENST00000315939889140889223In-frame
ENST00000315939900476900670In-frame

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Infer the effects of exon skipping event on protein functional features for WNK1

p-ENSG00000060237_img4.png
boxplot

check button Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000031593910469238287126587134827842866713741
ENST0000031593910469238287957388003130183475791944
ENST00000315939104692382880721880999347737549441037
ENST000003159391046923828829438830594017413211241163
ENST000003159391046923828891408892236009609117881816
ENST000003159391046923829004769006707093728621502214

check button Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000031593910469238287126587134827842866713741
ENST0000031593910469238287957388003130183475791944
ENST00000315939104692382880721880999347737549441037
ENST000003159391046923828829438830594017413211241163
ENST000003159391046923829004769006707093728621502214

check button Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000031593910469238287126587134827842866713741
ENST0000031593910469238287957388003130183475791944
ENST00000315939104692382880721880999347737549441037
ENST000003159391046923828829438830594017413211241163
ENST000003159391046923828891408892236009609117881816
ENST000003159391046923829004769006707093728621502214

check button Lost protein functional features of individual exon skipping events in ROSMAP.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q9H4A3713741713713Alternative sequenceID=VSP_040267;Note=In isoform 5 and isoform 6. V->VPQSMAHPCGGTPTYPESQIFFPTIHERPVSFSPPPTCPPKVAISQRRKSTSFLEAQTHHFQPLLRTVGQSLLPPGGSPTNWTPEAVVMLGTTASRVTGESCEIQVHPMFEPSQVYSDYRPGLVLPEEAHYFIPQEAVYVAGVHYQARVAEQYEGIPYNSSVLSSPMKQIPEQKPVQGGPTSSSVFEFPSGQAFLVGHLQNLRLD
Q9H4A37137417141037Alternative sequenceID=VSP_040268;Note=In isoform 4. AQGQSQGQPSSSSLTGVSSSQPIQHPQQQQGIQQTAPPQQTVQYSLSQTSTSSEATTAQPVSQPQAPQVLPQVSAGKQLPVSQPVPTIQGEPQIPVATQPSVVPVHSGAHFLPVGQPLPTPLLPQYPVSQIPISTPHVSTAQTGFSSLPITMAAGITQPLLTLASSATTAAIPGVSTVVPSQLPTLLQPVTQLPSQVHPQLLQPAVQSMGIPANLGQAAEVP
Q9H4A3713741740740Alternative sequenceID=VSP_040269;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9205841;Dbxref=PMID:9205841
Q9H4A371374112382ChainID=PRO_0000086819;Note=Serine/threonine-protein kinase WNK1
Q9H4A37919447141037Alternative sequenceID=VSP_040268;Note=In isoform 4. AQGQSQGQPSSSSLTGVSSSQPIQHPQQQQGIQQTAPPQQTVQYSLSQTSTSSEATTAQPVSQPQAPQVLPQVSAGKQLPVSQPVPTIQGEPQIPVATQPSVVPVHSGAHFLPVGQPLPTPLLPQYPVSQIPISTPHVSTAQTGFSSLPITMAAGITQPLLTLASSATTAAIPGVSTVVPSQLPTLLQPVTQLPSQVHPQLLQPAVQSMGIPANLGQAAEVP
Q9H4A37919447921037Alternative sequenceID=VSP_050638;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9205841;Dbxref=PMID:9205841
Q9H4A3791944792944Alternative sequenceID=VSP_040270;Note=In isoform 5. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9H4A379194412382ChainID=PRO_0000086819;Note=Serine/threonine-protein kinase WNK1
Q9H4A3791944823823Natural variantID=VAR_041315;Note=H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56015776,PMID:17344846
Q9H4A394410377141037Alternative sequenceID=VSP_040268;Note=In isoform 4. AQGQSQGQPSSSSLTGVSSSQPIQHPQQQQGIQQTAPPQQTVQYSLSQTSTSSEATTAQPVSQPQAPQVLPQVSAGKQLPVSQPVPTIQGEPQIPVATQPSVVPVHSGAHFLPVGQPLPTPLLPQYPVSQIPISTPHVSTAQTGFSSLPITMAAGITQPLLTLASSATTAAIPGVSTVVPSQLPTLLQPVTQLPSQVHPQLLQPAVQSMGIPANLGQAAEVP
Q9H4A394410377921037Alternative sequenceID=VSP_050638;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9205841;Dbxref=PMID:9205841
Q9H4A39441037792944Alternative sequenceID=VSP_040270;Note=In isoform 5. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9H4A3944103712382ChainID=PRO_0000086819;Note=Serine/threonine-protein kinase WNK1
Q9H4A31124116312382ChainID=PRO_0000086819;Note=Serine/threonine-protein kinase WNK1
Q9H4A31788181612382ChainID=PRO_0000086819;Note=Serine/threonine-protein kinase WNK1
Q9H4A31788181617991799Natural variantID=VAR_035641;Note=In breast cancer samples%3B infiltrating ductal carcinoma%3B somatic mutation. Q->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16959974,ECO:0000269|PubMed:17344846;Dbxref=PMID:16959974,PMID:17344846
Q9H4A31788181618081808Natural variantID=VAR_041317;Note=M->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11571656,ECO:0000269|PubMed:17344846,ECO:0000269|Ref.3;Dbxref=dbSNP:rs12828016,PMID:11571656,PMID:17344846
Q9H4A32150221412382ChainID=PRO_0000086819;Note=Serine/threonine-protein kinase WNK1
Q9H4A32150221421902190Natural variantID=VAR_041320;Note=In a breast pleomorphic lobular carcinoma sample%3B somatic mutation. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846

check button Lost protein functional features of individual exon skipping events in MSBB.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q9H4A3713741713713Alternative sequenceID=VSP_040267;Note=In isoform 5 and isoform 6. V->VPQSMAHPCGGTPTYPESQIFFPTIHERPVSFSPPPTCPPKVAISQRRKSTSFLEAQTHHFQPLLRTVGQSLLPPGGSPTNWTPEAVVMLGTTASRVTGESCEIQVHPMFEPSQVYSDYRPGLVLPEEAHYFIPQEAVYVAGVHYQARVAEQYEGIPYNSSVLSSPMKQIPEQKPVQGGPTSSSVFEFPSGQAFLVGHLQNLRLD
Q9H4A37137417141037Alternative sequenceID=VSP_040268;Note=In isoform 4. AQGQSQGQPSSSSLTGVSSSQPIQHPQQQQGIQQTAPPQQTVQYSLSQTSTSSEATTAQPVSQPQAPQVLPQVSAGKQLPVSQPVPTIQGEPQIPVATQPSVVPVHSGAHFLPVGQPLPTPLLPQYPVSQIPISTPHVSTAQTGFSSLPITMAAGITQPLLTLASSATTAAIPGVSTVVPSQLPTLLQPVTQLPSQVHPQLLQPAVQSMGIPANLGQAAEVP
Q9H4A3713741740740Alternative sequenceID=VSP_040269;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9205841;Dbxref=PMID:9205841
Q9H4A371374112382ChainID=PRO_0000086819;Note=Serine/threonine-protein kinase WNK1
Q9H4A37919447141037Alternative sequenceID=VSP_040268;Note=In isoform 4. AQGQSQGQPSSSSLTGVSSSQPIQHPQQQQGIQQTAPPQQTVQYSLSQTSTSSEATTAQPVSQPQAPQVLPQVSAGKQLPVSQPVPTIQGEPQIPVATQPSVVPVHSGAHFLPVGQPLPTPLLPQYPVSQIPISTPHVSTAQTGFSSLPITMAAGITQPLLTLASSATTAAIPGVSTVVPSQLPTLLQPVTQLPSQVHPQLLQPAVQSMGIPANLGQAAEVP
Q9H4A37919447921037Alternative sequenceID=VSP_050638;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9205841;Dbxref=PMID:9205841
Q9H4A3791944792944Alternative sequenceID=VSP_040270;Note=In isoform 5. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9H4A379194412382ChainID=PRO_0000086819;Note=Serine/threonine-protein kinase WNK1
Q9H4A3791944823823Natural variantID=VAR_041315;Note=H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56015776,PMID:17344846
Q9H4A394410377141037Alternative sequenceID=VSP_040268;Note=In isoform 4. AQGQSQGQPSSSSLTGVSSSQPIQHPQQQQGIQQTAPPQQTVQYSLSQTSTSSEATTAQPVSQPQAPQVLPQVSAGKQLPVSQPVPTIQGEPQIPVATQPSVVPVHSGAHFLPVGQPLPTPLLPQYPVSQIPISTPHVSTAQTGFSSLPITMAAGITQPLLTLASSATTAAIPGVSTVVPSQLPTLLQPVTQLPSQVHPQLLQPAVQSMGIPANLGQAAEVP
Q9H4A394410377921037Alternative sequenceID=VSP_050638;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9205841;Dbxref=PMID:9205841
Q9H4A39441037792944Alternative sequenceID=VSP_040270;Note=In isoform 5. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9H4A3944103712382ChainID=PRO_0000086819;Note=Serine/threonine-protein kinase WNK1
Q9H4A31124116312382ChainID=PRO_0000086819;Note=Serine/threonine-protein kinase WNK1
Q9H4A32150221412382ChainID=PRO_0000086819;Note=Serine/threonine-protein kinase WNK1
Q9H4A32150221421902190Natural variantID=VAR_041320;Note=In a breast pleomorphic lobular carcinoma sample%3B somatic mutation. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846

check button Lost protein functional features of individual exon skipping events in Mayo.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q9H4A3713741713713Alternative sequenceID=VSP_040267;Note=In isoform 5 and isoform 6. V->VPQSMAHPCGGTPTYPESQIFFPTIHERPVSFSPPPTCPPKVAISQRRKSTSFLEAQTHHFQPLLRTVGQSLLPPGGSPTNWTPEAVVMLGTTASRVTGESCEIQVHPMFEPSQVYSDYRPGLVLPEEAHYFIPQEAVYVAGVHYQARVAEQYEGIPYNSSVLSSPMKQIPEQKPVQGGPTSSSVFEFPSGQAFLVGHLQNLRLD
Q9H4A37137417141037Alternative sequenceID=VSP_040268;Note=In isoform 4. AQGQSQGQPSSSSLTGVSSSQPIQHPQQQQGIQQTAPPQQTVQYSLSQTSTSSEATTAQPVSQPQAPQVLPQVSAGKQLPVSQPVPTIQGEPQIPVATQPSVVPVHSGAHFLPVGQPLPTPLLPQYPVSQIPISTPHVSTAQTGFSSLPITMAAGITQPLLTLASSATTAAIPGVSTVVPSQLPTLLQPVTQLPSQVHPQLLQPAVQSMGIPANLGQAAEVP
Q9H4A3713741740740Alternative sequenceID=VSP_040269;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9205841;Dbxref=PMID:9205841
Q9H4A371374112382ChainID=PRO_0000086819;Note=Serine/threonine-protein kinase WNK1
Q9H4A37919447141037Alternative sequenceID=VSP_040268;Note=In isoform 4. AQGQSQGQPSSSSLTGVSSSQPIQHPQQQQGIQQTAPPQQTVQYSLSQTSTSSEATTAQPVSQPQAPQVLPQVSAGKQLPVSQPVPTIQGEPQIPVATQPSVVPVHSGAHFLPVGQPLPTPLLPQYPVSQIPISTPHVSTAQTGFSSLPITMAAGITQPLLTLASSATTAAIPGVSTVVPSQLPTLLQPVTQLPSQVHPQLLQPAVQSMGIPANLGQAAEVP
Q9H4A37919447921037Alternative sequenceID=VSP_050638;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9205841;Dbxref=PMID:9205841
Q9H4A3791944792944Alternative sequenceID=VSP_040270;Note=In isoform 5. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9H4A379194412382ChainID=PRO_0000086819;Note=Serine/threonine-protein kinase WNK1
Q9H4A3791944823823Natural variantID=VAR_041315;Note=H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs56015776,PMID:17344846
Q9H4A394410377141037Alternative sequenceID=VSP_040268;Note=In isoform 4. AQGQSQGQPSSSSLTGVSSSQPIQHPQQQQGIQQTAPPQQTVQYSLSQTSTSSEATTAQPVSQPQAPQVLPQVSAGKQLPVSQPVPTIQGEPQIPVATQPSVVPVHSGAHFLPVGQPLPTPLLPQYPVSQIPISTPHVSTAQTGFSSLPITMAAGITQPLLTLASSATTAAIPGVSTVVPSQLPTLLQPVTQLPSQVHPQLLQPAVQSMGIPANLGQAAEVP
Q9H4A394410377921037Alternative sequenceID=VSP_050638;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9205841;Dbxref=PMID:9205841
Q9H4A39441037792944Alternative sequenceID=VSP_040270;Note=In isoform 5. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9H4A3944103712382ChainID=PRO_0000086819;Note=Serine/threonine-protein kinase WNK1
Q9H4A31124116312382ChainID=PRO_0000086819;Note=Serine/threonine-protein kinase WNK1
Q9H4A31788181612382ChainID=PRO_0000086819;Note=Serine/threonine-protein kinase WNK1
Q9H4A31788181617991799Natural variantID=VAR_035641;Note=In breast cancer samples%3B infiltrating ductal carcinoma%3B somatic mutation. Q->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16959974,ECO:0000269|PubMed:17344846;Dbxref=PMID:16959974,PMID:17344846
Q9H4A31788181618081808Natural variantID=VAR_041317;Note=M->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11571656,ECO:0000269|PubMed:17344846,ECO:0000269|Ref.3;Dbxref=dbSNP:rs12828016,PMID:11571656,PMID:17344846
Q9H4A32150221412382ChainID=PRO_0000086819;Note=Serine/threonine-protein kinase WNK1
Q9H4A32150221421902190Natural variantID=VAR_041320;Note=In a breast pleomorphic lobular carcinoma sample%3B somatic mutation. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846


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3'-UTR located exon skipping events that lost miRNA binding sites in WNK1

check button 3'-UTR exon skipping evnets lost miRNA binding.
Tissue typeENSTExon skip startExon skip endmicroRNABinding site by TargetScanBinding type by TargetScanBdinding site by miRandaScore of miRandaEnergy by miRanda

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SNVs in the skipped exons for WNK1

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Depth of Coverage in the skipped exon of the mutated samples.

check button - Sashimi plot in the skipped exon of the mutated samples.

check button - Non-synonymous mutations located in the skipped exons.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange

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AD stage-associated exon skippint events for WNK1

check button Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).
AD stage infoCohortTissueSE idCoefficient P-valueChromosomeStrandE1 startE1 endSkipped startSkipped endE2 startE2 end
ADstageMSBBIFGexon_skip_187939-3.861741e-014.237818e-02chr12+862235862270867866869104871265871348
CDRMSBBIFGexon_skip_187939-4.031855e-013.338398e-02chr12+862235862270867866869104871265871348
CDRMSBBSTGexon_skip_216782-3.294274e-011.262275e-03chr12+900598900670904453904494907847907956

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for WNK1

check button sQTL information located at the skipped exons.
Tissue typeExon skip IDSNP idLocationP-valueFDR
HCCexon_skip_128631rs6489750chr12:8238715.241350e-055.251787e-03

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Correlation with RNA binding proteins (RBPs) for WNK1

check button Correlated RBP and related information.
Tissue typeRBP nameExon skip IDCorrelation coeifficientP-value
CBSRSF2exon_skip_1879395.706445e-011.352826e-14
CBRBMS1exon_skip_1879394.147558e-019.808611e-08
CBRBM25exon_skip_1879394.970703e-016.333427e-11
CBRBM6exon_skip_187939-4.974346e-016.103131e-11
CBSRSF11exon_skip_1879394.396639e-011.300335e-08
CBTIA1exon_skip_1879395.780500e-015.123929e-15
CBRBM3exon_skip_1879396.231233e-017.895482e-18
CBHNRNPKexon_skip_1879394.666857e-011.198749e-09
CBUNKexon_skip_1879394.181639e-017.510693e-08
CBFUBP3exon_skip_1879395.373625e-017.980342e-13
CBHNRNPA0exon_skip_1879394.057532e-011.957587e-07
CBHNRNPDLexon_skip_1879397.069850e-011.750073e-24
CBRBM45exon_skip_1879396.677160e-014.244803e-21
CBHNRNPDexon_skip_1879396.132412e-013.568974e-17
CBNUP42exon_skip_1879395.927478e-016.927177e-16
CBRALYLexon_skip_1879394.768079e-014.646245e-10
CBPTBP3exon_skip_1879394.949109e-017.881209e-11
CBPABPC1exon_skip_1879395.819864e-013.027776e-15
CBSRSF9exon_skip_1879394.901911e-011.264267e-10
CBSRSF5exon_skip_1879394.301648e-012.864826e-08
CBHNRNPH2exon_skip_1879394.695420e-019.203017e-10
CBRBM4exon_skip_187939-4.476159e-016.586946e-09
CBELAVL1exon_skip_2702615.313079e-018.130061e-13
CBSRSF11exon_skip_2702614.023735e-011.751406e-07
CBCNOT4exon_skip_2702614.494673e-013.526974e-09
CBTIA1exon_skip_2702614.208383e-014.065642e-08
CBRBM5exon_skip_2702614.364799e-011.099636e-08
CBTRNAU1APexon_skip_2702614.293550e-012.011378e-08
CBFXR2exon_skip_2702616.101021e-012.217964e-17
CBPCBP1exon_skip_2702615.034789e-011.805138e-11
CBILF2exon_skip_2702614.402972e-017.911145e-09
CBHNRNPKexon_skip_2702614.456709e-014.942031e-09
CBPCBP2exon_skip_2702615.137072e-015.967383e-12
CBRALYLexon_skip_2702614.626598e-011.057092e-09
CBHNRNPLexon_skip_2702614.979636e-013.229829e-11
CBRBM23exon_skip_2702615.886573e-015.149656e-16
CBEWSR1exon_skip_2702615.399586e-012.923761e-13
CBSRSF1exon_skip_2702614.386151e-019.151072e-09
CBSRSF4exon_skip_2702614.979295e-013.241372e-11
CBSRSF9exon_skip_2702614.226854e-013.495901e-08
CBHNRNPH2exon_skip_2702614.763732e-012.857961e-10
CBRBM41exon_skip_2702614.715845e-014.542363e-10
CBHNRNPFexon_skip_2702614.190395e-014.705526e-08
CBCNOT4exon_skip_116052-4.906735e-018.681354e-10
CBPCBP2exon_skip_2335-4.025834e-011.435409e-07
CBTRA2Aexon_skip_74325-4.359839e-013.048094e-08
CBTARDBPexon_skip_2236505.633513e-011.073106e-14
CBTRA2Aexon_skip_2236505.118664e-015.356095e-12
CBEWSR1exon_skip_2236504.880795e-016.761138e-11
CBSRSF1exon_skip_2236505.698378e-014.537035e-15
CBSRSF9exon_skip_2236504.604158e-011.019951e-09
CBTARDBPexon_skip_82790-4.210345e-017.468665e-07
CBNUP42exon_skip_827904.229437e-016.573371e-07
CBHNRNPFexon_skip_82790-4.000055e-012.897216e-06
CBNUP42exon_skip_1654667.193524e-011.260836e-26
CBRALYLexon_skip_1654665.941195e-011.519505e-16
CBPABPC4exon_skip_1654664.217598e-013.081544e-08
CBSRSF9exon_skip_1654666.164514e-015.141903e-18
CBEIF4Bexon_skip_1654664.962844e-012.882277e-11
CBILF2exon_skip_1427444.167131e-014.663268e-08
CBNUP42exon_skip_1427444.886277e-016.391249e-11
CBRALYLexon_skip_1427444.920683e-014.479570e-11
CBEWSR1exon_skip_1427444.324754e-011.249728e-08
CBSRSF9exon_skip_1427445.501200e-015.868475e-14
CBEIF4Bexon_skip_1427444.862048e-018.189458e-11
CBNUP42exon_skip_2756184.369434e-013.495492e-07
CBNUP42exon_skip_2167826.708926e-013.853323e-22
CBSRSF9exon_skip_2167826.438520e-015.482180e-20
CBEIF4Bexon_skip_2167825.427116e-011.471289e-13
CBILF2exon_skip_1432534.315285e-011.355197e-08
CBNUP42exon_skip_1432535.773011e-011.645629e-15
CBSRSF9exon_skip_1432536.207310e-012.605042e-18
CBEIF4Bexon_skip_1432535.441103e-011.239035e-13
CBTRA2Aexon_skip_65051-5.312440e-011.108675e-10
CBNUP42exon_skip_650514.924023e-013.557084e-09
CBTRA2Aexon_skip_190833-6.136779e-011.788352e-16
CBNUP42exon_skip_1908334.985916e-011.508959e-10
CBTRA2Aexon_skip_171545-5.265069e-011.438609e-11
CBNUP42exon_skip_1715454.600135e-017.469243e-09
CBTRA2Aexon_skip_203507-5.222880e-018.038801e-10
CBNUP42exon_skip_2035074.533844e-011.768413e-07
CBTRA2Aexon_skip_259749-5.401175e-014.672574e-10
CBNUP42exon_skip_2597494.619702e-012.025091e-07
DLPFCEIF4Bexon_skip_1432534.951191e-011.722057e-22
DLPFCSRSF11exon_skip_187939-4.386478e-015.805529e-16
DLPFCRC3H1exon_skip_1879395.136521e-013.341055e-22
DLPFCKHDRBS2exon_skip_1879395.814851e-012.398230e-29
DLPFCEIF4Bexon_skip_2167824.834575e-012.242274e-21
DLPFCSRSF11exon_skip_178110-4.079654e-014.561049e-15
DLPFCRC3H1exon_skip_1781104.226132e-013.673706e-16
FLSRSF2exon_skip_1879394.332474e-014.759813e-10
FLMSI1exon_skip_187939-4.342433e-014.299625e-10
FLELAVL4exon_skip_1879395.548604e-011.185160e-16
FLRBM3exon_skip_1879394.210459e-011.611050e-09
FLFXR2exon_skip_1879394.205980e-011.683250e-09
FLILF2exon_skip_1879394.780074e-013.507029e-12
FLHNRNPKexon_skip_1879394.248369e-011.108776e-09
FLRBM24exon_skip_1879394.055721e-017.061993e-09
FLHNRNPA0exon_skip_1879394.373696e-013.118038e-10
FLRALYLexon_skip_1879394.245641e-011.139162e-09
FLHNRNPH2exon_skip_1879395.631590e-013.307661e-17
FLSRSF2exon_skip_1781105.530464e-012.449575e-17
FLMSI1exon_skip_178110-5.131917e-019.168264e-15
FLELAVL4exon_skip_1781106.568951e-015.942093e-26
FLRBM25exon_skip_1781104.035920e-013.403244e-09
FLSRSF11exon_skip_1781104.524980e-011.948986e-11
FLTIA1exon_skip_1781105.337096e-014.785143e-16
FLTRNAU1APexon_skip_1781104.630522e-015.718269e-12
FLFXR2exon_skip_1781105.036402e-013.392131e-14
FLILF2exon_skip_1781105.390508e-012.145830e-16
FLHNRNPKexon_skip_1781105.795893e-012.987386e-19
FLPCBP2exon_skip_1781104.704563e-012.358468e-12
FLRC3H1exon_skip_1781104.354646e-011.293211e-10
FLRBM24exon_skip_1781106.174556e-012.656020e-22
FLFUBP1exon_skip_1781105.538938e-012.140903e-17
FLENOX1exon_skip_1781105.326374e-015.611458e-16
FLRALYLexon_skip_1781106.757852e-016.673131e-28
FLPTBP3exon_skip_1781104.529966e-011.841027e-11
FLHNRNPLexon_skip_1781105.040300e-013.218325e-14
FLRBM23exon_skip_1781105.220885e-012.611107e-15
FLSRSF1exon_skip_1781105.731197e-019.072835e-19
FLSRSF9exon_skip_1781105.229320e-012.313556e-15
FLHNRNPH2exon_skip_1781104.107751e-011.677534e-09
FLRBM41exon_skip_1781104.509333e-012.329273e-11
FLNOVA1exon_skip_1781105.571612e-011.269139e-17
FLMBNL1exon_skip_1654665.241893e-012.272611e-15
FLILF2exon_skip_1654665.536200e-012.691957e-17
FLNUP42exon_skip_1654664.591120e-011.024911e-11
FLRALYLexon_skip_1654666.467358e-017.663736e-25
FLSRSF1exon_skip_1654664.939630e-011.413123e-13
FLSRSF9exon_skip_1654665.420410e-011.623714e-16
FLEIF4Bexon_skip_1654665.154321e-017.844194e-15
FLESRP1exon_skip_1654664.356367e-011.413674e-10
FLNOVA1exon_skip_1654665.792155e-013.920001e-19
FLILF2exon_skip_2167825.375973e-013.778187e-16
FLNUP42exon_skip_2167824.629605e-017.393841e-12
FLSRSF9exon_skip_2167825.244071e-012.593330e-15
FLEIF4Bexon_skip_2167824.915699e-012.217757e-13
HCCDAZAP1exon_skip_187939-5.391183e-015.511924e-22
HCCRBMS2exon_skip_187939-5.649280e-012.035857e-24
HCCMSI1exon_skip_187939-5.906992e-014.546979e-27
HCCPABPN1exon_skip_187939-5.234797e-011.307488e-20
HCCSFPQexon_skip_187939-5.458343e-011.344148e-22
HCCZNF638exon_skip_187939-4.493039e-015.716370e-15
HCCRBM6exon_skip_187939-5.613334e-014.574383e-24
HCCSRSF11exon_skip_187939-4.683404e-012.737711e-16
HCCU2AF2exon_skip_187939-4.770679e-016.372883e-17
HCCTIA1exon_skip_187939-4.265222e-011.705967e-13
HCCRBM5exon_skip_187939-5.135333e-019.010849e-20
HCCTRNAU1APexon_skip_187939-4.424808e-011.623571e-14
HCCPCBP1exon_skip_187939-4.204173e-014.062165e-13
HCCUNKexon_skip_187939-4.337341e-015.983848e-14
HCCTRA2Aexon_skip_187939-4.194801e-014.633716e-13
HCCSF1exon_skip_187939-4.351197e-014.878879e-14
HCCFUBP1exon_skip_187939-4.547561e-012.440608e-15
HCCENOX1exon_skip_187939-4.282653e-011.327374e-13
HCCHNRNPA2B1exon_skip_187939-5.000675e-011.113990e-18
HCCRBM45exon_skip_187939-4.273141e-011.522426e-13
HCCPTBP1exon_skip_187939-6.399692e-017.428296e-33
HCCSNRNP70exon_skip_187939-4.666008e-013.642756e-16
HCCSRSF4exon_skip_187939-5.330206e-011.931900e-21
HCCHNRNPFexon_skip_187939-5.689460e-018.140376e-25
HCCRBM4exon_skip_187939-5.048932e-014.581827e-19
HCCPCBP4exon_skip_251166-5.998787e-018.870233e-28
HCCSRSF5exon_skip_251166-4.979750e-012.513723e-18
HCCMSI1exon_skip_178110-4.630551e-016.487474e-16
HCCRBM6exon_skip_178110-4.718543e-011.529947e-16
HCCRBM5exon_skip_178110-4.401078e-012.321565e-14
HCCPTBP1exon_skip_178110-5.171389e-014.508556e-20
HCCSRSF4exon_skip_178110-4.395386e-012.528446e-14
HCCHNRNPFexon_skip_178110-4.464438e-018.879511e-15
HCCZNF326exon_skip_165466-5.553032e-011.740368e-23
HCCHNRNPFexon_skip_165466-5.243506e-011.100817e-20
HCCZNF326exon_skip_142744-5.255624e-018.657382e-21
HCCHNRNPFexon_skip_142744-4.997517e-011.180112e-18
HCCTRA2Aexon_skip_216782-4.127267e-011.182208e-12
HCCPABPC4exon_skip_216782-4.560202e-011.999200e-15
HCCHNRNPFexon_skip_216782-5.685322e-018.951499e-25
HCCHNRNPFexon_skip_143253-4.240377e-012.433480e-13
IFGSRSF2exon_skip_1879394.043317e-013.283811e-02
IFGELAVL4exon_skip_1879395.534547e-012.249967e-03
IFGFXR2exon_skip_1879395.554496e-012.152052e-03
IFGILF2exon_skip_1879394.402418e-011.905250e-02
IFGKHDRBS2exon_skip_1879394.989042e-016.881998e-03
IFGNUP42exon_skip_1879394.114589e-012.960302e-02
IFGRALYLexon_skip_1879396.326763e-013.030773e-04
IFGHNRNPH2exon_skip_1879396.206149e-014.258199e-04
IFGRBM23exon_skip_1369714.465756e-011.720698e-02
IFGELAVL4exon_skip_1781105.402226e-013.001872e-03
IFGIGF2BP2exon_skip_178110-4.568332e-011.453226e-02
IFGFXR2exon_skip_1781104.761518e-011.042709e-02
IFGRBM24exon_skip_1781104.758125e-011.048974e-02
IFGRALYLexon_skip_1781106.166925e-014.741948e-04
IFGNOVA1exon_skip_1781104.682022e-011.198006e-02
IFGEWSR1exon_skip_351914.710083e-011.141124e-02
IFGSRSF9exon_skip_351914.082001e-013.104864e-02
IFGEWSR1exon_skip_1286314.526651e-011.557421e-02
IFGNOVA1exon_skip_1286314.528641e-011.552310e-02
PCCRBMS2exon_skip_239434-6.381899e-017.111597e-26
PCCRBMS1exon_skip_239434-4.968860e-019.608646e-15
PCCMSI1exon_skip_239434-4.351272e-012.682251e-11
PCCELAVL4exon_skip_2394345.773221e-012.039117e-20
PCCRBM6exon_skip_239434-4.960366e-011.083683e-14
PCCTRNAU1APexon_skip_239434-4.218715e-011.207659e-10
PCCTRA2Aexon_skip_239434-4.094992e-014.641970e-10
PCCRALYLexon_skip_2394344.320980e-013.804836e-11
PCCPTBP1exon_skip_239434-7.054274e-011.572155e-33
PCCPABPC1exon_skip_239434-4.863508e-014.173579e-14
PCCSRSF4exon_skip_239434-4.009202e-011.143865e-09
PCCHNRNPFexon_skip_239434-6.079507e-015.128809e-23
PCCRBMS2exon_skip_68613-4.694860e-015.096379e-13
PCCRBM6exon_skip_68613-4.184053e-012.156383e-10
PCCPTBP1exon_skip_68613-5.778038e-012.812588e-20
PCCHNRNPFexon_skip_68613-4.677669e-016.352491e-13
PCCELAVL4exon_skip_1781105.214885e-012.162192e-16
PCCRBM6exon_skip_178110-4.848626e-014.463504e-14
PCCPCBP4exon_skip_178110-4.526702e-012.939425e-12
PCCPTBP1exon_skip_178110-6.619475e-011.763664e-28
PCCHNRNPFexon_skip_178110-5.561656e-017.423611e-19
PCCRALYLexon_skip_2918784.088929e-015.175165e-09
PCCZNF326exon_skip_165466-4.953112e-011.040618e-14
PCCRALYLexon_skip_1654665.026419e-013.635622e-15
PCCHNRNPFexon_skip_165466-5.545699e-019.780620e-19
PCCZNF326exon_skip_142744-4.091576e-014.382769e-10
PCCHNRNPFexon_skip_142744-4.167815e-011.918630e-10
PCCHNRNPFexon_skip_216782-5.549138e-019.217429e-19
PCCHNRNPFexon_skip_143253-4.177006e-011.734317e-10
PGSRSF2exon_skip_1879394.339556e-016.102166e-10
PGMSI1exon_skip_187939-4.029230e-011.186614e-08
PGELAVL4exon_skip_1879397.596238e-013.215827e-36
PGRBM25exon_skip_1879394.256726e-011.387976e-09
PGELAVL1exon_skip_1879394.463367e-011.712943e-10
PGRBM3exon_skip_1879394.428062e-012.473668e-10
PGMBNL1exon_skip_1879394.289861e-011.001764e-09
PGFXR2exon_skip_1879396.520604e-016.734280e-24
PGPCBP1exon_skip_1879395.158253e-014.899297e-14
PGILF2exon_skip_1879395.364302e-012.989525e-15
PGHNRNPKexon_skip_1879395.378740e-012.439863e-15
PGKHDRBS2exon_skip_1879395.305175e-016.801126e-15
PGRBM24exon_skip_1879395.876541e-011.172503e-18
PGHNRNPA0exon_skip_1879395.423574e-011.290263e-15
PGHNRNPDLexon_skip_1879394.858946e-012.064615e-12
PGHNRNPDexon_skip_1879394.501483e-011.146487e-10
PGNUP42exon_skip_1879394.434666e-012.310060e-10
PGRALYLexon_skip_1879396.874013e-012.355461e-27
PGRBM42exon_skip_1879394.405823e-013.111277e-10
PGHNRNPLexon_skip_1879395.228086e-011.939487e-14
PGCELF1exon_skip_1879395.191796e-013.147572e-14
PGEWSR1exon_skip_1879394.768321e-015.976081e-12
PGSRSF5exon_skip_1879394.387334e-013.760074e-10
PGHNRNPH2exon_skip_1879397.051080e-012.808818e-29
PGNOVA1exon_skip_1879395.228513e-011.928392e-14
PGFXR2exon_skip_2511664.344002e-014.989822e-09
PGRALYLexon_skip_2511664.560732e-016.617721e-10
PGHNRNPH2exon_skip_2511664.350324e-014.713627e-09
PGSRSF2exon_skip_1781105.020316e-011.021648e-13
PGMSI1exon_skip_178110-4.619121e-011.364030e-11
PGELAVL4exon_skip_1781106.947819e-013.778183e-29
PGRBM25exon_skip_1781104.816613e-011.327643e-12
PGELAVL1exon_skip_1781105.092933e-013.927022e-14
PGSRSF11exon_skip_1781104.553324e-012.869213e-11
PGCNOT4exon_skip_1781104.143265e-012.098254e-09
PGTRNAU1APexon_skip_1781104.416923e-011.275439e-10
PGFXR2exon_skip_1781106.320741e-016.361151e-23
PGPCBP1exon_skip_1781105.202141e-018.927711e-15
PGILF2exon_skip_1781105.422269e-013.816687e-16
PGHNRNPKexon_skip_1781105.819733e-016.921000e-19
PGRC3H1exon_skip_1781104.230686e-018.812392e-10
PGRBM24exon_skip_1781106.418365e-018.492758e-24
PGFUBP1exon_skip_1781104.008914e-017.588954e-09
PGENOX1exon_skip_1781104.397777e-011.564316e-10
PGHNRNPDLexon_skip_1781104.985298e-011.607158e-13
PGRALYLexon_skip_1781106.818797e-019.671477e-28
PGHNRNPLexon_skip_1781105.329798e-011.475480e-15
PGRBM23exon_skip_1781104.889356e-015.417301e-13
PGEWSR1exon_skip_1781104.065608e-014.442092e-09
PGSRSF1exon_skip_1781104.310682e-013.897277e-10
PGSRSF9exon_skip_1781104.202147e-011.172949e-09
PGSRSF5exon_skip_1781104.142175e-012.120744e-09
PGHNRNPH2exon_skip_1781106.358827e-012.924844e-23
PGNOVA1exon_skip_1781105.642558e-011.281450e-17
PGMBNL1exon_skip_1654664.814324e-011.365154e-12
PGILF2exon_skip_1654665.715978e-013.905549e-18
PGNUP42exon_skip_1654664.904306e-014.493956e-13
PGRALYLexon_skip_1654667.392282e-011.250767e-34
PGSRSF1exon_skip_1654664.672923e-017.338180e-12
PGSRSF9exon_skip_1654665.082844e-014.491011e-14
PGEIF4Bexon_skip_1654664.732674e-013.639365e-12
PGNOVA1exon_skip_1654666.188096e-018.769876e-22
PGILF2exon_skip_2167825.520273e-016.015353e-17
PGNUP42exon_skip_2167825.408232e-013.307685e-16
PGSRSF9exon_skip_2167824.951568e-011.858336e-13
PGEIF4Bexon_skip_2167824.849552e-016.750180e-13
STGSRSF2exon_skip_1879394.122477e-016.581355e-05
STGMSI1exon_skip_187939-5.432124e-014.543422e-08
STGELAVL4exon_skip_1879396.770687e-014.411311e-13
STGIGF2BP2exon_skip_187939-4.520436e-019.816775e-06
STGFXR2exon_skip_1879394.513102e-011.018948e-05
STGPCBP1exon_skip_1879394.211262e-014.393644e-05
STGILF2exon_skip_1879394.638015e-015.337785e-06
STGHNRNPKexon_skip_1879394.268383e-013.367408e-05
STGKHDRBS2exon_skip_1879394.640659e-015.263765e-06
STGRBM24exon_skip_1879394.413275e-011.677871e-05
STGHNRNPA0exon_skip_1879395.664104e-018.825310e-09
STGHNRNPDLexon_skip_1879394.604301e-016.371418e-06
STGRALYLexon_skip_1879396.191957e-011.270690e-10
STGHNRNPLexon_skip_1879394.099911e-017.280158e-05
STGHNRNPH2exon_skip_1879396.215581e-011.031547e-10
STGESRP2exon_skip_187939-4.268474e-013.365963e-05
STGNOVA1exon_skip_1879394.422272e-011.605138e-05
STGMSI1exon_skip_178110-4.033470e-016.702149e-05
STGELAVL4exon_skip_1781105.437702e-012.123594e-08
STGPCBP1exon_skip_1781104.729707e-011.927455e-06
STGRBM24exon_skip_1781104.937275e-015.702091e-07
STGFUBP1exon_skip_1781104.119087e-014.512874e-05
STGENOX1exon_skip_1781104.260059e-012.297702e-05
STGRALYLexon_skip_1781105.497185e-011.384624e-08
STGHNRNPH2exon_skip_1781104.873069e-018.382618e-07
STGNOVA1exon_skip_1781104.909396e-016.747074e-07
STGPABPN1Lexon_skip_216782-4.266706e-012.001298e-05
STGILF2exon_skip_2167824.842151e-018.759851e-07
STGNUP42exon_skip_2167825.061577e-012.268091e-07
STGSRSF9exon_skip_2167825.061428e-012.270251e-07
STGEIF4Bexon_skip_2167824.857047e-018.015665e-07
TCSRSF2exon_skip_1879395.789787e-011.061162e-15
TCELAVL4exon_skip_1879398.237768e-018.721228e-41
TCRBM25exon_skip_1879395.539641e-012.996156e-14
TCELAVL1exon_skip_1879394.590377e-011.027747e-09
TCRBM6exon_skip_187939-4.307270e-011.305672e-08
TCSRSF11exon_skip_1879394.633990e-016.802559e-10
TCCNOT4exon_skip_1879395.112276e-014.925347e-12
TCTIA1exon_skip_1879394.086385e-018.119178e-08
TCRBM3exon_skip_1879394.615783e-018.087153e-10
TCMBNL1exon_skip_1879395.440826e-011.039931e-13
TCFXR2exon_skip_1879394.857547e-017.471295e-11
TCPCBP1exon_skip_1879394.203760e-013.125117e-08
TCILF2exon_skip_1879395.794295e-019.965326e-16
TCHNRNPKexon_skip_1879395.424994e-011.264616e-13
TCKHDRBS2exon_skip_1879398.444874e-011.066376e-44
TCRBM24exon_skip_1879397.382523e-018.187226e-29
TCENOX1exon_skip_1879394.429465e-014.484415e-09
TCKHSRPexon_skip_1879394.176780e-013.904682e-08
TCHNRNPA0exon_skip_1879397.667246e-013.187072e-32
TCHNRNPDLexon_skip_1879395.586112e-011.645096e-14
TCRBM45exon_skip_1879394.802211e-011.310166e-10
TCPUF60exon_skip_1879394.139557e-015.292204e-08
TCHNRNPDexon_skip_1879397.208684e-016.089324e-27
TCNUP42exon_skip_1879397.256593e-011.919407e-27
TCRALYLexon_skip_1879398.075840e-014.561836e-38
TCPTBP3exon_skip_1879396.445386e-013.707001e-20
TCHNRNPLexon_skip_1879394.292933e-011.476031e-08
TCCELF1exon_skip_1879396.454695e-013.146743e-20
TCEWSR1exon_skip_1879394.411346e-015.268511e-09
TCSRSF1exon_skip_1879394.432902e-014.348917e-09
TCSRSF9exon_skip_1879394.655867e-015.518517e-10
TCSRSF5exon_skip_1879394.816945e-011.129274e-10
TCHNRNPH2exon_skip_1879397.759746e-011.946653e-33
TCESRP1exon_skip_1879396.637334e-011.122483e-21
TCNOVA1exon_skip_1879396.227630e-011.465865e-18
TCFXR2exon_skip_2576434.103776e-017.769967e-08
TCRALYLexon_skip_2576435.977290e-018.947932e-17
TCPTBP3exon_skip_2576434.554411e-011.620260e-09
TCHNRNPH2exon_skip_2576434.366653e-018.706026e-09
TCELAVL4exon_skip_1589156.031774e-013.158744e-17
TCRBM25exon_skip_1589154.057878e-011.018222e-07
TCILF2exon_skip_1589154.002083e-011.576380e-07
TCHNRNPKexon_skip_1589154.012141e-011.457798e-07
TCRBM24exon_skip_1589155.692975e-013.997879e-15
TCRALYLexon_skip_1589155.767277e-011.450143e-15
TCPTBP3exon_skip_1589154.494375e-012.498059e-09
TCHNRNPH2exon_skip_1589155.344351e-013.371738e-13
TCESRP1exon_skip_1589154.925292e-013.704839e-11
TCNOVA1exon_skip_1589154.766776e-011.867470e-10
TCNOVA1exon_skip_351914.090218e-018.655180e-08
TCRALYLexon_skip_1286315.939782e-011.934119e-16
TCILF2exon_skip_1654665.091640e-016.191251e-12
TCNUP42exon_skip_1654667.024103e-014.192583e-25
TCRALYLexon_skip_1654668.127300e-016.666488e-39
TCEWSR1exon_skip_1654664.054476e-011.045962e-07
TCESRP1exon_skip_1654666.411177e-016.736460e-20
TCNOVA1exon_skip_1654666.532610e-017.806432e-21
TCMBNL1exon_skip_1427444.142557e-015.164819e-08
TCILF2exon_skip_1427444.673348e-014.664072e-10
TCNUP42exon_skip_1427446.238774e-011.222912e-18
TCRALYLexon_skip_1427447.868643e-016.073587e-35
TCSRSF9exon_skip_1427444.074628e-018.916098e-08
TCESRP1exon_skip_1427445.945055e-011.151337e-16
TCNOVA1exon_skip_1427445.363859e-012.666044e-13
TCILF2exon_skip_2167825.082622e-016.838881e-12
TCNUP42exon_skip_2167826.705590e-013.039114e-22
TCESRP1exon_skip_2167825.737100e-012.195945e-15
TCILF2exon_skip_1432534.730561e-012.671554e-10
TCNUP42exon_skip_1432536.246177e-011.083764e-18
TCSRSF9exon_skip_1432534.127042e-015.857040e-08
TCESRP1exon_skip_1432536.013788e-014.143928e-17

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RelatedDrugs for WNK1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for WNK1

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource