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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TTC23 |
 Gene summary |
| Gene information | Gene symbol | TTC23 | Gene ID | 64927 |
| Gene name | tetratricopeptide repeat domain 23 | |
| Synonyms | HCC-8 | |
| Cytomap | 15q26.3 | |
| Type of gene | protein-coding | |
| Description | tetratricopeptide repeat protein 23TPR repeat protein 23cervical cancer proto-oncogene 8 protein | |
| Modification date | 20200320 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TTC23 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000103852
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| TC | UP | ENST00000560860.5 | TTC23-218:protein_coding:TTC23 | 5.033224e+00 | 1.270872e+00 | 5.851607e-09 | 5.753564e-07 |
| TC | UP | ENST00000558078.5 | TTC23-212:protein_coding:TTC23 | 1.745703e+00 | 9.043404e-01 | 1.145335e-03 | 1.098352e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TTC23 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_101869 | chr15 | 99228533:99228732:99234988:99235080:99241365:99241559 | 99234988:99235080 |
| exon_skip_107763 | chr15 | 99137942:99138127:99139317:99139467:99156148:99156279 | 99139317:99139467 |
| exon_skip_111723 | chr15 | 99241387:99241559:99245389:99245510:99249171:99249581 | 99245389:99245510 |
| exon_skip_135901 | chr15 | 99148586:99148709:99151293:99151386:99156148:99156279 | 99151293:99151386 |
| exon_skip_137089 | chr15 | 99228553:99228732:99241365:99241559:99245389:99245510 | 99241365:99241559 |
| exon_skip_146990 | chr15 | 99228553:99228732:99241365:99241559:99245389:99245486 | 99241365:99241559 |
| exon_skip_169329 | chr15 | 99245389:99245510:99248188:99248310:99249417:99249445 | 99248188:99248310 |
| exon_skip_178049 | chr15 | 99161740:99161867:99175050:99175155:99199919:99200096 | 99175050:99175155 |
| exon_skip_187236 | chr15 | 99228553:99228732:99234988:99235080:99241365:99241510 | 99234988:99235080 |
| exon_skip_190047 | chr15 | 99228553:99228732:99234988:99235080:99241365:99241559 | 99234988:99235080 |
| exon_skip_191788 | chr15 | 99228553:99228732:99241365:99241559:99249417:99249445 | 99241365:99241559 |
| exon_skip_214581 | chr15 | 99228533:99228732:99234988:99235080:99241365:99241510 | 99234988:99235080 |
| exon_skip_243268 | chr15 | 99228553:99228732:99245389:99245510:99249417:99249445 | 99245389:99245510 |
| exon_skip_245168 | chr15 | 99137942:99138127:99139317:99139399:99156148:99156279 | 99139317:99139399 |
| exon_skip_249479 | chr15 | 99137942:99138127:99139137:99139266:99156148:99156297 | 99139137:99139266 |
| exon_skip_280677 | chr15 | 99137942:99138127:99139137:99139266:99156148:99156279 | 99139137:99139266 |
| exon_skip_50174 | chr15 | 99241387:99241559:99245389:99245510:99249622:99249799 | 99245389:99245510 |
| exon_skip_55697 | chr15 | 99228553:99228732:99241365:99241559:99245389:99245436 | 99241365:99241559 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TTC23 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000394132 | 99234988 | 99235080 | 3UTR-3UTR |
| ENST00000394132 | 99245389 | 99245510 | 3UTR-3UTR |
| ENST00000394132 | 99139317 | 99139399 | Frame-shift |
| ENST00000394135 | 99139317 | 99139399 | Frame-shift |
| ENST00000558663 | 99139317 | 99139399 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000394132 | 99234988 | 99235080 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000394132 | 99234988 | 99235080 | 3UTR-3UTR |
| ENST00000394132 | 99245389 | 99245510 | 3UTR-3UTR |
| ENST00000394132 | 99139317 | 99139399 | Frame-shift |
| ENST00000394135 | 99139317 | 99139399 | Frame-shift |
| ENST00000558663 | 99139317 | 99139399 | Frame-shift |
| ENST00000394132 | 99175050 | 99175155 | Frame-shift |
| ENST00000394135 | 99175050 | 99175155 | Frame-shift |
| ENST00000558663 | 99175050 | 99175155 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for TTC23 |
p-ENSG00000103852_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in TTC23 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000394132 | 99245389 | 99245510 | hsa-miR-1976 | chr15:99245418-99245425 | 8mer-1a | chr15:99245404-99245425 | 148.00 | -20.90 |
| Mayo | ENST00000394132 | 99245389 | 99245510 | hsa-miR-4294 | chr15:99245502-99245509 | 8mer-1a | chr15:99245486-99245510 | 148.00 | -17.21 |
| Mayo | ENST00000394132 | 99234988 | 99235080 | hsa-miR-3160-3p | chr15:99235031-99235038 | 8mer-1a | chr15:99235021-99235042 | 152.00 | -28.19 |
| Mayo | ENST00000394132 | 99245389 | 99245510 | hsa-miR-6747-3p | chr15:99245416-99245423 | 8mer-1a | chr15:99245401-99245423 | 153.00 | -23.72 |
| Mayo | ENST00000394132 | 99245389 | 99245510 | hsa-miR-6879-3p | chr15:99245489-99245496 | 8mer-1a | chr15:99245486-99245510 | 148.00 | -17.21 |
| Mayo | ENST00000394132 | 99245389 | 99245510 | hsa-miR-6773-3p | chr15:99245491-99245498 | 8mer-1a | chr15:99245486-99245510 | 148.00 | -17.21 |
| Mayo | ENST00000394132 | 99234988 | 99235080 | hsa-miR-7854-3p | chr15:99235026-99235033 | 8mer-1a | chr15:99235021-99235042 | 152.00 | -28.19 |
| Mayo | ENST00000394132 | 99245389 | 99245510 | hsa-miR-6778-3p | chr15:99245439-99245446 | 8mer-1a | chr15:99245435-99245457 | 162.00 | -26.79 |
| Mayo | ENST00000394132 | 99234988 | 99235080 | hsa-miR-4776-3p | chr15:99235064-99235071 | 8mer-1a | chr15:99235053-99235074 | 159.00 | -18.11 |
| Mayo | ENST00000394132 | 99245389 | 99245510 | hsa-miR-4284 | chr15:99245456-99245463 | 8mer-1a | chr15:99245446-99245463 | 151.00 | -16.70 |
| Mayo | ENST00000394132 | 99234988 | 99235080 | hsa-miR-4659a-5p | chr15:99235063-99235070 | 8mer-1a | chr15:99235053-99235074 | 159.00 | -18.11 |
| Mayo | ENST00000394132 | 99234988 | 99235080 | hsa-miR-4659b-5p | chr15:99235063-99235070 | 8mer-1a | chr15:99235053-99235074 | 159.00 | -18.11 |
| Mayo | ENST00000394132 | 99245389 | 99245510 | hsa-miR-500b-3p | chr15:99245487-99245494 | 8mer-1a | chr15:99245476-99245494 | 155.00 | -22.37 |
| MSBB | ENST00000394132 | 99234988 | 99235080 | hsa-miR-3160-3p | chr15:99235031-99235038 | 8mer-1a | chr15:99235021-99235042 | 152.00 | -28.19 |
| MSBB | ENST00000394132 | 99234988 | 99235080 | hsa-miR-7854-3p | chr15:99235026-99235033 | 8mer-1a | chr15:99235021-99235042 | 152.00 | -28.19 |
| MSBB | ENST00000394132 | 99234988 | 99235080 | hsa-miR-4776-3p | chr15:99235064-99235071 | 8mer-1a | chr15:99235053-99235074 | 159.00 | -18.11 |
| MSBB | ENST00000394132 | 99234988 | 99235080 | hsa-miR-4659a-5p | chr15:99235063-99235070 | 8mer-1a | chr15:99235053-99235074 | 159.00 | -18.11 |
| MSBB | ENST00000394132 | 99234988 | 99235080 | hsa-miR-4659b-5p | chr15:99235063-99235070 | 8mer-1a | chr15:99235053-99235074 | 159.00 | -18.11 |
| ROSMAP | ENST00000394132 | 99245389 | 99245510 | hsa-miR-1976 | chr15:99245418-99245425 | 8mer-1a | chr15:99245404-99245425 | 148.00 | -20.90 |
| ROSMAP | ENST00000394132 | 99245389 | 99245510 | hsa-miR-4294 | chr15:99245502-99245509 | 8mer-1a | chr15:99245486-99245510 | 148.00 | -17.21 |
| ROSMAP | ENST00000394132 | 99234988 | 99235080 | hsa-miR-3160-3p | chr15:99235031-99235038 | 8mer-1a | chr15:99235021-99235042 | 152.00 | -28.19 |
| ROSMAP | ENST00000394132 | 99245389 | 99245510 | hsa-miR-6747-3p | chr15:99245416-99245423 | 8mer-1a | chr15:99245401-99245423 | 153.00 | -23.72 |
| ROSMAP | ENST00000394132 | 99245389 | 99245510 | hsa-miR-6879-3p | chr15:99245489-99245496 | 8mer-1a | chr15:99245486-99245510 | 148.00 | -17.21 |
| ROSMAP | ENST00000394132 | 99245389 | 99245510 | hsa-miR-6773-3p | chr15:99245491-99245498 | 8mer-1a | chr15:99245486-99245510 | 148.00 | -17.21 |
| ROSMAP | ENST00000394132 | 99234988 | 99235080 | hsa-miR-7854-3p | chr15:99235026-99235033 | 8mer-1a | chr15:99235021-99235042 | 152.00 | -28.19 |
| ROSMAP | ENST00000394132 | 99245389 | 99245510 | hsa-miR-6778-3p | chr15:99245439-99245446 | 8mer-1a | chr15:99245435-99245457 | 162.00 | -26.79 |
| ROSMAP | ENST00000394132 | 99234988 | 99235080 | hsa-miR-4776-3p | chr15:99235064-99235071 | 8mer-1a | chr15:99235053-99235074 | 159.00 | -18.11 |
| ROSMAP | ENST00000394132 | 99245389 | 99245510 | hsa-miR-4284 | chr15:99245456-99245463 | 8mer-1a | chr15:99245446-99245463 | 151.00 | -16.70 |
| ROSMAP | ENST00000394132 | 99234988 | 99235080 | hsa-miR-4659a-5p | chr15:99235063-99235070 | 8mer-1a | chr15:99235053-99235074 | 159.00 | -18.11 |
| ROSMAP | ENST00000394132 | 99234988 | 99235080 | hsa-miR-4659b-5p | chr15:99235063-99235070 | 8mer-1a | chr15:99235053-99235074 | 159.00 | -18.11 |
| ROSMAP | ENST00000394132 | 99245389 | 99245510 | hsa-miR-500b-3p | chr15:99245487-99245494 | 8mer-1a | chr15:99245476-99245494 | 155.00 | -22.37 |
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SNVs in the skipped exons for TTC23 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TTC23 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TTC23 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TTC23 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for TTC23 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TTC23 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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