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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for ST3GAL1 |
Gene summary |
Gene information | Gene symbol | ST3GAL1 | Gene ID | 6482 |
Gene name | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | |
Synonyms | Gal-NAc6S|SIAT4A|SIATFL|ST3GalA|ST3GalA.1|ST3GalIA|ST3GalIA,1|ST3O | |
Cytomap | 8q24.22 | |
Type of gene | protein-coding | |
Description | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferaseSIAT4-AST3GalIalpha 2,3-ST 1beta-galactoside alpha-2,3-sialyltransferase 1sialyltransferase 4A (beta-galactosidase alpha-2,3-sialy | |
Modification date | 20200313 | |
UniProtAcc | ||
Context | - 26017559(1950 MHz Electromagnetic Fields Ameliorate Abeta Pathology in Alzheimer's Disease Mice) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ST3GAL1 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | UP | ENST00000518298.5 | ST3GAL1-203:lncRNA:ST3GAL1 | 6.536846e+00 | 1.279098e+00 | 2.559807e-07 | 4.699881e-06 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ST3GAL1 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_108397 | chr8 | 133476523:133476600:133499135:133499189:133507199:133507321 | 133499135:133499189 |
exon_skip_111389 | chr8 | 133476523:133476600:133499135:133499189:133539637:133539729 | 133499135:133499189 |
exon_skip_137165 | chr8 | 133476523:133476600:133545774:133545926:133571693:133571746 | 133545774:133545926 |
exon_skip_16830 | chr8 | 133476523:133476600:133499135:133499189:133545774:133545926 | 133499135:133499189 |
exon_skip_227455 | chr8 | 133465894:133466090:133475719:133476600:133499135:133499189 | 133475719:133476600 |
exon_skip_227851 | chr8 | 133458873:133459937:133461875:133461994:133463414:133463459 | 133461875:133461994 |
exon_skip_245473 | chr8 | 133499135:133499189:133539637:133539729:133545774:133545926 | 133539637:133539729 |
exon_skip_246909 | chr8 | 133499135:133499189:133545774:133545926:133571693:133571746 | 133545774:133545926 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ST3GAL1 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000521180 | 133475719 | 133476600 | 3UTR-3CDS |
ENST00000521180 | 133499135 | 133499189 | 3UTR-3UTR |
ENST00000522652 | 133499135 | 133499189 | 3UTR-3UTR |
ENST00000521180 | 133545774 | 133545926 | 3UTR-3UTR |
ENST00000399640 | 133461875 | 133461994 | In-frame |
ENST00000521180 | 133461875 | 133461994 | In-frame |
ENST00000522652 | 133461875 | 133461994 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000521180 | 133499135 | 133499189 | 3UTR-3UTR |
ENST00000522652 | 133499135 | 133499189 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000521180 | 133499135 | 133499189 | 3UTR-3UTR |
ENST00000522652 | 133499135 | 133499189 | 3UTR-3UTR |
ENST00000521180 | 133545774 | 133545926 | 3UTR-3UTR |
ENST00000399640 | 133461875 | 133461994 | In-frame |
ENST00000521180 | 133461875 | 133461994 | In-frame |
ENST00000522652 | 133461875 | 133461994 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ST3GAL1 |
p-ENSG00000008513_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000399640 | 6781 | 340 | 133461875 | 133461994 | 1555 | 1673 | 243 | 282 |
ENST00000521180 | 6968 | 340 | 133461875 | 133461994 | 1747 | 1865 | 243 | 282 |
ENST00000522652 | 2597 | 340 | 133461875 | 133461994 | 1468 | 1586 | 243 | 282 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000399640 | 6781 | 340 | 133461875 | 133461994 | 1555 | 1673 | 243 | 282 |
ENST00000521180 | 6968 | 340 | 133461875 | 133461994 | 1747 | 1865 | 243 | 282 |
ENST00000522652 | 2597 | 340 | 133461875 | 133461994 | 1468 | 1586 | 243 | 282 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q11201 | 243 | 282 | 266 | 266 | Binding site | Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
Q11201 | 243 | 282 | 266 | 266 | Binding site | Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
Q11201 | 243 | 282 | 266 | 266 | Binding site | Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
Q11201 | 243 | 282 | 270 | 270 | Binding site | Note=Substrate%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
Q11201 | 243 | 282 | 270 | 270 | Binding site | Note=Substrate%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
Q11201 | 243 | 282 | 270 | 270 | Binding site | Note=Substrate%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
Q11201 | 243 | 282 | 1 | 340 | Chain | ID=PRO_0000149253;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 1 |
Q11201 | 243 | 282 | 1 | 340 | Chain | ID=PRO_0000149253;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 1 |
Q11201 | 243 | 282 | 1 | 340 | Chain | ID=PRO_0000149253;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 1 |
Q11201 | 243 | 282 | 142 | 281 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
Q11201 | 243 | 282 | 142 | 281 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
Q11201 | 243 | 282 | 142 | 281 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
Q11201 | 243 | 282 | 35 | 340 | Topological domain | Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q11201 | 243 | 282 | 35 | 340 | Topological domain | Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q11201 | 243 | 282 | 35 | 340 | Topological domain | Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q11201 | 243 | 282 | 266 | 266 | Binding site | Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
Q11201 | 243 | 282 | 266 | 266 | Binding site | Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
Q11201 | 243 | 282 | 266 | 266 | Binding site | Note=Substrate;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
Q11201 | 243 | 282 | 270 | 270 | Binding site | Note=Substrate%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
Q11201 | 243 | 282 | 270 | 270 | Binding site | Note=Substrate%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
Q11201 | 243 | 282 | 270 | 270 | Binding site | Note=Substrate%3B via amide nitrogen;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
Q11201 | 243 | 282 | 1 | 340 | Chain | ID=PRO_0000149253;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 1 |
Q11201 | 243 | 282 | 1 | 340 | Chain | ID=PRO_0000149253;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 1 |
Q11201 | 243 | 282 | 1 | 340 | Chain | ID=PRO_0000149253;Note=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2%2C3-sialyltransferase 1 |
Q11201 | 243 | 282 | 142 | 281 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
Q11201 | 243 | 282 | 142 | 281 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
Q11201 | 243 | 282 | 142 | 281 | Disulfide bond | Ontology_term=ECO:0000250;evidence=ECO:0000250 |
Q11201 | 243 | 282 | 35 | 340 | Topological domain | Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q11201 | 243 | 282 | 35 | 340 | Topological domain | Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
Q11201 | 243 | 282 | 35 | 340 | Topological domain | Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in ST3GAL1 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000521180 | 133545774 | 133545926 | hsa-miR-3942-3p | chr8:133545909-133545916 | 8mer-1a | chr8:133545897-133545916 | 149.00 | -9.67 |
Mayo | ENST00000521180 | 133545774 | 133545926 | hsa-miR-5000-3p | chr8:133545819-133545826 | 8mer-1a | chr8:133545807-133545826 | 157.00 | -20.16 |
Mayo | ENST00000521180 | 133545774 | 133545926 | hsa-miR-4436a | chr8:133545819-133545826 | 8mer-1a | chr8:133545807-133545826 | 157.00 | -20.16 |
Mayo | ENST00000521180 | 133545774 | 133545926 | hsa-miR-6810-5p | chr8:133545804-133545811 | 8mer-1a | chr8:133545788-133545811 | 157.00 | -26.24 |
Mayo | ENST00000521180 | 133545774 | 133545926 | hsa-miR-1263 | chr8:133545919-133545926 | 8mer-1a | chr8:133545905-133545926 | 142.00 | -10.47 |
Mayo | ENST00000521180 | 133545774 | 133545926 | hsa-miR-3144-5p | chr8:133545803-133545810 | 8mer-1a | chr8:133545788-133545811 | 157.00 | -26.24 |
Mayo | ENST00000521180 | 133545774 | 133545926 | hsa-miR-450a-2-3p | chr8:133545805-133545812 | 8mer-1a | chr8:133545791-133545812 | 145.00 | -14.82 |
ROSMAP | ENST00000521180 | 133545774 | 133545926 | hsa-miR-3942-3p | chr8:133545909-133545916 | 8mer-1a | chr8:133545897-133545916 | 149.00 | -9.67 |
ROSMAP | ENST00000521180 | 133545774 | 133545926 | hsa-miR-5000-3p | chr8:133545819-133545826 | 8mer-1a | chr8:133545807-133545826 | 157.00 | -20.16 |
ROSMAP | ENST00000521180 | 133545774 | 133545926 | hsa-miR-4436a | chr8:133545819-133545826 | 8mer-1a | chr8:133545807-133545826 | 157.00 | -20.16 |
ROSMAP | ENST00000521180 | 133545774 | 133545926 | hsa-miR-6810-5p | chr8:133545804-133545811 | 8mer-1a | chr8:133545788-133545811 | 157.00 | -26.24 |
ROSMAP | ENST00000521180 | 133545774 | 133545926 | hsa-miR-1263 | chr8:133545919-133545926 | 8mer-1a | chr8:133545905-133545926 | 142.00 | -10.47 |
ROSMAP | ENST00000521180 | 133545774 | 133545926 | hsa-miR-3144-5p | chr8:133545803-133545810 | 8mer-1a | chr8:133545788-133545811 | 157.00 | -26.24 |
ROSMAP | ENST00000521180 | 133545774 | 133545926 | hsa-miR-450a-2-3p | chr8:133545805-133545812 | 8mer-1a | chr8:133545791-133545812 | 145.00 | -14.82 |
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SNVs in the skipped exons for ST3GAL1 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ST3GAL1 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ST3GAL1 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ST3GAL1 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | TRA2A | exon_skip_16830 | -4.070063e-01 | 2.048081e-06 |
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RelatedDrugs for ST3GAL1 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ST3GAL1 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |