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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for CRTC3 |
Gene summary |
Gene information | Gene symbol | CRTC3 | Gene ID | 64784 |
Gene name | CREB regulated transcription coactivator 3 | |
Synonyms | TORC-3|TORC3 | |
Cytomap | 15q26.1 | |
Type of gene | protein-coding | |
Description | CREB-regulated transcription coactivator 3transducer of regulated CREB protein 3transducer of regulated cAMP response element-binding protein (CREB) 3 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for CRTC3 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CRTC3 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_105657 | chr15 | 90614453:90614488:90617883:90617968:90619741:90619790 | 90617883:90617968 |
exon_skip_132605 | chr15 | 90604385:90604447:90607378:90607478:90614453:90614488 | 90607378:90607478 |
exon_skip_272169 | chr15 | 90607378:90607478:90614453:90614488:90617883:90617968 | 90614453:90614488 |
exon_skip_28811 | chr15 | 90604385:90604447:90607378:90607478:90617883:90617968 | 90607378:90607478 |
exon_skip_34538 | chr15 | 90530063:90530203:90540039:90540137:90593636:90593730 | 90540039:90540137 |
exon_skip_5459 | chr15 | 90617886:90617968:90619741:90619790:90625776:90625786 | 90619741:90619790 |
exon_skip_94023 | chr15 | 90530063:90530203:90540039:90540137:90593636:90593755 | 90540039:90540137 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CRTC3 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000268184 | 90607378 | 90607478 | Frame-shift |
ENST00000268184 | 90617883 | 90617968 | Frame-shift |
ENST00000268184 | 90614453 | 90614488 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000268184 | 90614453 | 90614488 | In-frame |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000268184 | 90607378 | 90607478 | Frame-shift |
ENST00000268184 | 90617883 | 90617968 | Frame-shift |
ENST00000268184 | 90619741 | 90619790 | Frame-shift |
ENST00000268184 | 90614453 | 90614488 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CRTC3 |
p-ENSG00000140577_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000268184 | 2554 | 619 | 90614453 | 90614488 | 583 | 617 | 193 | 204 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000268184 | 2554 | 619 | 90614453 | 90614488 | 583 | 617 | 193 | 204 |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000268184 | 2554 | 619 | 90614453 | 90614488 | 583 | 617 | 193 | 204 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q6UUV7 | 193 | 204 | 1 | 619 | Chain | ID=PRO_0000318531;Note=CREB-regulated transcription coactivator 3 |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q6UUV7 | 193 | 204 | 1 | 619 | Chain | ID=PRO_0000318531;Note=CREB-regulated transcription coactivator 3 |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Q6UUV7 | 193 | 204 | 1 | 619 | Chain | ID=PRO_0000318531;Note=CREB-regulated transcription coactivator 3 |
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3'-UTR located exon skipping events that lost miRNA binding sites in CRTC3 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CRTC3 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CRTC3 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CRTC3 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CRTC3 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for CRTC3 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CRTC3 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |