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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for TNS3 |
 Gene summary |
| Gene information | Gene symbol | TNS3 | Gene ID | 64759 |
| Gene name | tensin 3 | |
| Synonyms | TEM6|TENS1 | |
| Cytomap | 7p12.3 | |
| Type of gene | protein-coding | |
| Description | tensin-3tensin-like SH2 domain containing 1tensin-like SH2 domain-containing protein 1thyroid specific PTB domain proteintumor endothelial marker 6 | |
| Modification date | 20200327 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for TNS3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000136205
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PCC | UP | ENST00000428457.1 | TNS3-204:protein_coding:TNS3 | 6.183764e+02 | 9.861846e-01 | 3.756927e-04 | 1.374007e-02 |
| HCC | UP | ENST00000428457.1 | TNS3-204:protein_coding:TNS3 | 2.420791e+02 | 1.077072e+00 | 1.375847e-07 | 5.234553e-05 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TNS3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_139137 | chr7 | 47297082:47297213:47302186:47302272:47302950:47303584 | 47302186:47302272 |
| exon_skip_150889 | chr7 | 47400901:47400914:47405498:47405559:47411727:47411802 | 47405498:47405559 |
| exon_skip_177625 | chr7 | 47280164:47280190:47280286:47280354:47283697:47283865 | 47280286:47280354 |
| exon_skip_23689 | chr7 | 47435282:47435404:47437263:47437313:47439487:47439658 | 47437263:47437313 |
| exon_skip_247748 | chr7 | 47293733:47293828:47297082:47297213:47302186:47302272 | 47297082:47297213 |
| exon_skip_251243 | chr7 | 47506907:47506944:47529036:47529147:47582051:47582099 | 47529036:47529147 |
| exon_skip_39850 | chr7 | 47442003:47442055:47481103:47481141:47506907:47506944 | 47481103:47481141 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for TNS3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000311160 | 47481103 | 47481141 | 3UTR-3UTR |
| ENST00000311160 | 47280286 | 47280354 | In-frame |
| ENST00000311160 | 47297082 | 47297213 | In-frame |
| ENST00000311160 | 47302186 | 47302272 | In-frame |
| ENST00000311160 | 47437263 | 47437313 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000311160 | 47481103 | 47481141 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000311160 | 47481103 | 47481141 | 3UTR-3UTR |
| ENST00000311160 | 47529036 | 47529147 | 3UTR-3UTR |
| ENST00000311160 | 47280286 | 47280354 | In-frame |
| ENST00000311160 | 47302186 | 47302272 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TNS3 |
p-ENSG00000136205_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000311160 | 7635 | 1445 | 47437263 | 47437313 | 509 | 558 | 50 | 66 |
| ENST00000311160 | 7635 | 1445 | 47302186 | 47302272 | 3816 | 3901 | 1152 | 1181 |
| ENST00000311160 | 7635 | 1445 | 47297082 | 47297213 | 3903 | 4033 | 1181 | 1225 |
| ENST00000311160 | 7635 | 1445 | 47280286 | 47280354 | 4456 | 4523 | 1366 | 1388 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000311160 | 7635 | 1445 | 47302186 | 47302272 | 3816 | 3901 | 1152 | 1181 |
| ENST00000311160 | 7635 | 1445 | 47280286 | 47280354 | 4456 | 4523 | 1366 | 1388 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q68CZ2 | 50 | 66 | 1 | 1445 | Chain | ID=PRO_0000295915;Note=Tensin-3 |
| Q68CZ2 | 50 | 66 | 1 | 170 | Domain | Note=Phosphatase tensin-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00590 |
| Q68CZ2 | 1152 | 1181 | 251 | 1445 | Alternative sequence | ID=VSP_027125;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q68CZ2 | 1152 | 1181 | 392 | 1445 | Alternative sequence | ID=VSP_027127;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q68CZ2 | 1152 | 1181 | 1 | 1445 | Chain | ID=PRO_0000295915;Note=Tensin-3 |
| Q68CZ2 | 1152 | 1181 | 1172 | 1282 | Domain | Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191 |
| Q68CZ2 | 1152 | 1181 | 1154 | 1154 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:24275569 |
| Q68CZ2 | 1181 | 1225 | 251 | 1445 | Alternative sequence | ID=VSP_027125;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q68CZ2 | 1181 | 1225 | 392 | 1445 | Alternative sequence | ID=VSP_027127;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q68CZ2 | 1181 | 1225 | 1 | 1445 | Chain | ID=PRO_0000295915;Note=Tensin-3 |
| Q68CZ2 | 1181 | 1225 | 1172 | 1282 | Domain | Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191 |
| Q68CZ2 | 1366 | 1388 | 251 | 1445 | Alternative sequence | ID=VSP_027125;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q68CZ2 | 1366 | 1388 | 392 | 1445 | Alternative sequence | ID=VSP_027127;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q68CZ2 | 1366 | 1388 | 1 | 1445 | Chain | ID=PRO_0000295915;Note=Tensin-3 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q68CZ2 | 1152 | 1181 | 251 | 1445 | Alternative sequence | ID=VSP_027125;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q68CZ2 | 1152 | 1181 | 392 | 1445 | Alternative sequence | ID=VSP_027127;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q68CZ2 | 1152 | 1181 | 1 | 1445 | Chain | ID=PRO_0000295915;Note=Tensin-3 |
| Q68CZ2 | 1152 | 1181 | 1172 | 1282 | Domain | Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191 |
| Q68CZ2 | 1152 | 1181 | 1154 | 1154 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:20068231,PMID:24275569 |
| Q68CZ2 | 1366 | 1388 | 251 | 1445 | Alternative sequence | ID=VSP_027125;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q68CZ2 | 1366 | 1388 | 392 | 1445 | Alternative sequence | ID=VSP_027127;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q68CZ2 | 1366 | 1388 | 1 | 1445 | Chain | ID=PRO_0000295915;Note=Tensin-3 |
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3'-UTR located exon skipping events that lost miRNA binding sites in TNS3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000311160 | 47529036 | 47529147 | hsa-miR-3658 | chr7:47529110-47529117 | 8mer-1a | chr7:47529101-47529121 | 145.00 | -17.62 |
| Mayo | ENST00000311160 | 47529036 | 47529147 | hsa-miR-3150b-5p | chr7:47529130-47529137 | 8mer-1a | chr7:47529125-47529145 | 162.00 | -18.60 |
| Mayo | ENST00000311160 | 47529036 | 47529147 | hsa-miR-3150a-5p | chr7:47529130-47529137 | 8mer-1a | chr7:47529125-47529145 | 162.00 | -18.60 |
| Mayo | ENST00000311160 | 47529036 | 47529147 | hsa-miR-3911 | chr7:47529079-47529086 | 8mer-1a | chr7:47529068-47529087 | 145.00 | -17.94 |
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SNVs in the skipped exons for TNS3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for TNS3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TNS3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for TNS3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for TNS3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TNS3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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