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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for SGK1 |
Gene summary |
Gene information | Gene symbol | SGK1 | Gene ID | 6446 |
Gene name | serum/glucocorticoid regulated kinase 1 | |
Synonyms | SGK | |
Cytomap | 6q23.2 | |
Type of gene | protein-coding | |
Description | serine/threonine-protein kinase Sgk1Sgk1 variant i3serine/threonine protein kinase SGK | |
Modification date | 20200329 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for SGK1 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PCC | UP | ENST00000477460.6 | SGK1-213:retained_intron:SGK1 | 1.937055e+01 | 2.086063e+00 | 7.203439e-05 | 4.885327e-03 |
PG | UP | ENST00000237305.11 | SGK1-201:protein_coding:SGK1 | 4.124337e+02 | 8.536715e-01 | 7.278592e-06 | 3.971997e-04 |
PG | UP | ENST00000533224.1 | SGK1-229:protein_coding:SGK1 | 4.555865e+00 | 9.050226e-01 | 2.136962e-04 | 4.784811e-03 |
PG | UP | ENST00000477460.6 | SGK1-213:retained_intron:SGK1 | 2.725109e+01 | 1.012887e+00 | 4.525901e-03 | 4.262224e-02 |
CB | DOWN | ENST00000477460.6 | SGK1-213:retained_intron:SGK1 | 3.446680e+02 | -1.281706e+00 | 6.120605e-07 | 9.879070e-06 |
CB | UP | ENST00000534658.5 | SGK1-230:retained_intron:SGK1 | 1.274758e+00 | 1.107544e+00 | 7.739414e-03 | 2.817653e-02 |
TC | DOWN | ENST00000477460.6 | SGK1-213:retained_intron:SGK1 | 4.147403e+02 | -2.170563e+00 | 6.935419e-17 | 8.915967e-14 |
TC | UP | ENST00000534658.5 | SGK1-230:retained_intron:SGK1 | 4.575183e+00 | 1.055485e+00 | 1.397641e-04 | 2.106495e-03 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for SGK1 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_101155 | chr6 | 134172662:134172774:134173023:134173154:134173274:134173357 | 134173023:134173154 |
exon_skip_41486 | chr6 | 134172726:134172774:134173023:134173154:134173274:134173357 | 134173023:134173154 |
exon_skip_58237 | chr6 | 134174511:134174586:134207356:134207431:134261933:134262017 | 134207356:134207431 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for SGK1 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000237305 | 134173023 | 134173154 | In-frame |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000237305 | 134173023 | 134173154 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SGK1 |
p-ENSG00000118515_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000237305 | 2418 | 431 | 134173023 | 134173154 | 507 | 637 | 139 | 182 |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
ENST00000237305 | 2418 | 431 | 134173023 | 134173154 | 507 | 637 | 139 | 182 |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
O00141 | 139 | 182 | 162 | 167 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R5T |
O00141 | 139 | 182 | 169 | 177 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R5T |
O00141 | 139 | 182 | 1 | 431 | Chain | ID=PRO_0000086642;Note=Serine/threonine-protein kinase Sgk1 |
O00141 | 139 | 182 | 131 | 141 | Compositional bias | Note=Glu/Lys-rich |
O00141 | 139 | 182 | 98 | 355 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
O00141 | 139 | 182 | 131 | 141 | Motif | Note=Nuclear localization signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12631736;Dbxref=PMID:12631736 |
O00141 | 139 | 182 | 152 | 152 | Sequence conflict | Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
O00141 | 139 | 182 | 162 | 167 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R5T |
O00141 | 139 | 182 | 169 | 177 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2R5T |
O00141 | 139 | 182 | 1 | 431 | Chain | ID=PRO_0000086642;Note=Serine/threonine-protein kinase Sgk1 |
O00141 | 139 | 182 | 131 | 141 | Compositional bias | Note=Glu/Lys-rich |
O00141 | 139 | 182 | 98 | 355 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
O00141 | 139 | 182 | 131 | 141 | Motif | Note=Nuclear localization signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12631736;Dbxref=PMID:12631736 |
O00141 | 139 | 182 | 152 | 152 | Sequence conflict | Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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3'-UTR located exon skipping events that lost miRNA binding sites in SGK1 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for SGK1 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for SGK1 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SGK1 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for SGK1 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for SGK1 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SGK1 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |