|
||||||
|
 | |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| 3'-UTR located exon skipping events lost miRNA binding sites |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| |
| |
|
Gene summary for TMEM267 |
 Gene summary |
| Gene information | Gene symbol | TMEM267 | Gene ID | 64417 |
| Gene name | transmembrane protein 267 | |
| Synonyms | C5orf28 | |
| Cytomap | 5p12 | |
| Type of gene | protein-coding | |
| Description | transmembrane protein 267transmembrane protein C5orf28 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
Gene structures and expression levels for TMEM267 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
ENSG00000151881
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
 |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for TMEM267 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_104002 | chr5 | 43446380:43446557:43479890:43479987:43483822:43483836 | 43479890:43479987 |
| exon_skip_111233 | chr5 | 43446380:43446557:43453658:43454043:43476114:43476234 | 43453658:43454043 |
| exon_skip_15048 | chr5 | 43446380:43446557:43453658:43454043:43476114:43476258 | 43453658:43454043 |
| exon_skip_165457 | chr5 | 43453658:43454043:43454455:43454605:43483822:43483891 | 43454455:43454605 |
| exon_skip_204886 | chr5 | 43446380:43446557:43453658:43454043:43483822:43483836 | 43453658:43454043 |
| exon_skip_248644 | chr5 | 43453658:43454043:43479890:43479987:43483822:43483836 | 43479890:43479987 |
| exon_skip_25239 | chr5 | 43453658:43454043:43454455:43454605:43483822:43483836 | 43454455:43454605 |
| exon_skip_277622 | chr5 | 43453658:43454043:43476114:43476258:43479890:43479987 | 43476114:43476258 |
| exon_skip_48246 | chr5 | 43445979:43446557:43453658:43454043:43479890:43479987 | 43453658:43454043 |
| exon_skip_56840 | chr5 | 43445979:43446557:43479890:43479987:43483822:43483836 | 43479890:43479987 |
| exon_skip_90495 | chr5 | 43446380:43446557:43453658:43454043:43479890:43479987 | 43453658:43454043 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Top |
Open reading frame (ORF) annotation in the exon skipping event for TMEM267 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000397080 | 43453658 | 43454043 | 3UTR-3CDS |
| ENST00000500337 | 43453658 | 43454043 | 3UTR-3CDS |
| ENST00000512085 | 43454455 | 43454605 | 3UTR-3UTR |
| ENST00000500337 | 43476114 | 43476258 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000397080 | 43453658 | 43454043 | 3UTR-3CDS |
| ENST00000500337 | 43453658 | 43454043 | 3UTR-3CDS |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000397080 | 43453658 | 43454043 | 3UTR-3CDS |
| ENST00000500337 | 43453658 | 43454043 | 3UTR-3CDS |
| ENST00000512085 | 43454455 | 43454605 | 3UTR-3UTR |
Top |
Infer the effects of exon skipping event on protein functional features for TMEM267 |
p-ENSG00000151881_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in TMEM267 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000512085 | 43454455 | 43454605 | hsa-miR-4684-5p | chr5:43454554-43454561 | 8mer-1a | chr5:43454549-43454571 | 148.00 | -17.52 |
| Mayo | ENST00000512085 | 43454455 | 43454605 | hsa-miR-5584-5p | chr5:43454471-43454478 | 8mer-1a | chr5:43454457-43454478 | 176.00 | -26.27 |
| Mayo | ENST00000512085 | 43454455 | 43454605 | hsa-miR-24-3p | chr5:43454516-43454523 | 8mer-1a | chr5:43454512-43454537 | 149.00 | -25.61 |
| Mayo | ENST00000512085 | 43454455 | 43454605 | hsa-miR-28-3p | chr5:43454492-43454499 | 8mer-1a | chr5:43454490-43454511 | 168.00 | -17.57 |
| Mayo | ENST00000512085 | 43454455 | 43454605 | hsa-miR-12115 | chr5:43454587-43454594 | 8mer-1a | chr5:43454574-43454594 | 149.00 | -25.26 |
| Mayo | ENST00000512085 | 43454455 | 43454605 | hsa-miR-3978 | chr5:43454533-43454540 | 8mer-1a | chr5:43454517-43454540 | 142.00 | -11.49 |
| ROSMAP | ENST00000512085 | 43454455 | 43454605 | hsa-miR-4684-5p | chr5:43454554-43454561 | 8mer-1a | chr5:43454549-43454571 | 148.00 | -17.52 |
| ROSMAP | ENST00000512085 | 43454455 | 43454605 | hsa-miR-5584-5p | chr5:43454471-43454478 | 8mer-1a | chr5:43454457-43454478 | 176.00 | -26.27 |
| ROSMAP | ENST00000500337 | 43476114 | 43476258 | hsa-miR-4296 | chr5:43476194-43476201 | 8mer-1a | chr5:43476181-43476201 | 163.00 | -27.95 |
| ROSMAP | ENST00000500337 | 43476114 | 43476258 | hsa-miR-4306 | chr5:43476170-43476177 | 8mer-1a | chr5:43476168-43476185 | 158.00 | -19.63 |
| ROSMAP | ENST00000500337 | 43476114 | 43476258 | hsa-miR-4516 | chr5:43476178-43476185 | 8mer-1a | chr5:43476177-43476199 | 162.00 | -26.01 |
| ROSMAP | ENST00000500337 | 43476114 | 43476258 | hsa-miR-4722-5p | chr5:43476232-43476239 | 8mer-1a | chr5:43476219-43476241 | 151.00 | -24.30 |
| ROSMAP | ENST00000500337 | 43476114 | 43476258 | hsa-miR-4322 | chr5:43476194-43476201 | 8mer-1a | chr5:43476181-43476201 | 163.00 | -27.95 |
| ROSMAP | ENST00000512085 | 43454455 | 43454605 | hsa-miR-24-3p | chr5:43454516-43454523 | 8mer-1a | chr5:43454512-43454537 | 149.00 | -25.61 |
| ROSMAP | ENST00000500337 | 43476114 | 43476258 | hsa-miR-4531 | chr5:43476179-43476186 | 8mer-1a | chr5:43476177-43476199 | 162.00 | -26.01 |
| ROSMAP | ENST00000500337 | 43476114 | 43476258 | hsa-miR-4434 | chr5:43476178-43476185 | 8mer-1a | chr5:43476177-43476199 | 162.00 | -26.01 |
| ROSMAP | ENST00000500337 | 43476114 | 43476258 | hsa-miR-4265 | chr5:43476194-43476201 | 8mer-1a | chr5:43476181-43476201 | 163.00 | -27.95 |
| ROSMAP | ENST00000500337 | 43476114 | 43476258 | hsa-miR-5703 | chr5:43476178-43476185 | 8mer-1a | chr5:43476177-43476199 | 162.00 | -26.01 |
| ROSMAP | ENST00000500337 | 43476114 | 43476258 | hsa-miR-185-5p | chr5:43476170-43476177 | 8mer-1a | chr5:43476168-43476185 | 158.00 | -19.63 |
| ROSMAP | ENST00000512085 | 43454455 | 43454605 | hsa-miR-28-3p | chr5:43454492-43454499 | 8mer-1a | chr5:43454490-43454511 | 168.00 | -17.57 |
| ROSMAP | ENST00000512085 | 43454455 | 43454605 | hsa-miR-12115 | chr5:43454587-43454594 | 8mer-1a | chr5:43454574-43454594 | 149.00 | -25.26 |
| ROSMAP | ENST00000500337 | 43476114 | 43476258 | hsa-miR-12131 | chr5:43476180-43476187 | 8mer-1a | chr5:43476177-43476199 | 162.00 | -26.01 |
| ROSMAP | ENST00000500337 | 43476114 | 43476258 | hsa-miR-4644 | chr5:43476170-43476177 | 8mer-1a | chr5:43476168-43476185 | 158.00 | -19.63 |
| ROSMAP | ENST00000512085 | 43454455 | 43454605 | hsa-miR-3978 | chr5:43454533-43454540 | 8mer-1a | chr5:43454517-43454540 | 142.00 | -11.49 |
Top |
SNVs in the skipped exons for TMEM267 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for TMEM267 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TMEM267 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for TMEM267 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
Top |
RelatedDrugs for TMEM267 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TMEM267 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|