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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CDH22 |
 Gene summary |
| Gene information | Gene symbol | CDH22 | Gene ID | 64405 |
| Gene name | cadherin 22 | |
| Synonyms | C20orf25|dJ998H6.1 | |
| Cytomap | 20q13.12 | |
| Type of gene | protein-coding | |
| Description | cadherin-22PB-cadherincadherin 22, type 2cadherin-like 22ortholog of rat PB-cadherinpituitary and brain cadherin | |
| Modification date | 20200313 | |
| UniProtAcc | Q49AS4, Q9UJ99, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for CDH22 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000149654
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| STG | UP | ENST00000474438.1 | CDH22-201:lncRNA:CDH22 | 8.120296e+00 | 8.348549e-01 | 5.253469e-04 | 2.771448e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CDH22 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_106301 | chr20 | 46186826:46186947:46199423:46199559:46210307:46210560 | 46199423:46199559 |
| exon_skip_119365 | chr20 | 46212995:46213188:46216826:46216993:46227508:46227610 | 46216826:46216993 |
| exon_skip_22494 | chr20 | 46216826:46216993:46227508:46227627:46240963:46241257 | 46227508:46227627 |
| exon_skip_237008 | chr20 | 46173739:46175077:46177946:46178197:46186588:46186705 | 46177946:46178197 |
| exon_skip_253706 | chr20 | 46186588:46186705:46186826:46186947:46199423:46199559 | 46186826:46186947 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CDH22 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000537909 | 46177946 | 46178197 | In-frame |
| ENST00000537909 | 46216826 | 46216993 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000537909 | 46177946 | 46178197 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000537909 | 46186826 | 46186947 | Frame-shift |
| ENST00000537909 | 46199423 | 46199559 | Frame-shift |
| ENST00000537909 | 46177946 | 46178197 | In-frame |
| ENST00000537909 | 46216826 | 46216993 | In-frame |
| ENST00000537909 | 46227508 | 46227627 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CDH22 |
p-ENSG00000149654_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000537909 | 3919 | 828 | 46216826 | 46216993 | 1314 | 1480 | 223 | 279 |
| ENST00000537909 | 3919 | 828 | 46177946 | 46178197 | 2307 | 2557 | 554 | 638 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000537909 | 3919 | 828 | 46177946 | 46178197 | 2307 | 2557 | 554 | 638 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000537909 | 3919 | 828 | 46227508 | 46227627 | 1194 | 1312 | 183 | 223 |
| ENST00000537909 | 3919 | 828 | 46216826 | 46216993 | 1314 | 1480 | 223 | 279 |
| ENST00000537909 | 3919 | 828 | 46177946 | 46178197 | 2307 | 2557 | 554 | 638 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UJ99 | 223 | 279 | 35 | 828 | Chain | ID=PRO_0000003821;Note=Cadherin-22 |
| Q9UJ99 | 223 | 279 | 169 | 277 | Domain | Note=Cadherin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043 |
| Q9UJ99 | 223 | 279 | 278 | 394 | Domain | Note=Cadherin 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043 |
| Q9UJ99 | 223 | 279 | 36 | 624 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9UJ99 | 554 | 638 | 35 | 828 | Chain | ID=PRO_0000003821;Note=Cadherin-22 |
| Q9UJ99 | 554 | 638 | 499 | 616 | Domain | Note=Cadherin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043 |
| Q9UJ99 | 554 | 638 | 612 | 612 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9UJ99 | 554 | 638 | 36 | 624 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9UJ99 | 554 | 638 | 625 | 645 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UJ99 | 554 | 638 | 35 | 828 | Chain | ID=PRO_0000003821;Note=Cadherin-22 |
| Q9UJ99 | 554 | 638 | 499 | 616 | Domain | Note=Cadherin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043 |
| Q9UJ99 | 554 | 638 | 612 | 612 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9UJ99 | 554 | 638 | 36 | 624 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9UJ99 | 554 | 638 | 625 | 645 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UJ99 | 183 | 223 | 35 | 828 | Chain | ID=PRO_0000003821;Note=Cadherin-22 |
| Q9UJ99 | 183 | 223 | 169 | 277 | Domain | Note=Cadherin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043 |
| Q9UJ99 | 183 | 223 | 36 | 624 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9UJ99 | 223 | 279 | 35 | 828 | Chain | ID=PRO_0000003821;Note=Cadherin-22 |
| Q9UJ99 | 223 | 279 | 169 | 277 | Domain | Note=Cadherin 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043 |
| Q9UJ99 | 223 | 279 | 278 | 394 | Domain | Note=Cadherin 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043 |
| Q9UJ99 | 223 | 279 | 36 | 624 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9UJ99 | 554 | 638 | 35 | 828 | Chain | ID=PRO_0000003821;Note=Cadherin-22 |
| Q9UJ99 | 554 | 638 | 499 | 616 | Domain | Note=Cadherin 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00043 |
| Q9UJ99 | 554 | 638 | 612 | 612 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9UJ99 | 554 | 638 | 36 | 624 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9UJ99 | 554 | 638 | 625 | 645 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in CDH22 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for CDH22 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CDH22 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CDH22 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CDH22 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for CDH22 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDH22 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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