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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ZSCAN31 |
 Gene summary |
| Gene information | Gene symbol | ZSCAN31 | Gene ID | 64288 |
| Gene name | zinc finger and SCAN domain containing 31 | |
| Synonyms | ZNF20-Lp|ZNF310P|ZNF323 | |
| Cytomap | 6p22.1|6p22.3-p22.1 | |
| Type of gene | protein-coding | |
| Description | zinc finger and SCAN domain-containing protein 31zinc finger protein 323 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ZSCAN31 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000235109
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000426434.1 | ZSCAN31-205:protein_coding:ZSCAN31 | 1.126671e+01 | 9.606477e-01 | 6.944753e-05 | 5.436750e-04 |
| CB | UP | ENST00000446222.5 | ZSCAN31-213:protein_coding:ZSCAN31 | 8.418211e+00 | 1.219069e+00 | 8.785815e-04 | 4.631609e-03 |
| CB | UP | ENST00000447021.1 | ZSCAN31-215:protein_coding:ZSCAN31 | 1.716672e+00 | 1.138388e+00 | 9.666478e-03 | 3.379494e-02 |
| CB | UP | ENST00000344279.10 | ZSCAN31-201:protein_coding:ZSCAN31 | 1.138727e+02 | 9.668013e-01 | 1.069843e-02 | 3.673636e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZSCAN31 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_107424 | chr6 | 28336900:28336943:28341746:28341795:28353862:28353952 | 28341746:28341795 |
| exon_skip_122695 | chr6 | 28327472:28327533:28329303:28329778:28336082:28336134 | 28329303:28329778 |
| exon_skip_126863 | chr6 | 28327472:28327533:28329303:28329778:28335830:28335936 | 28329303:28329778 |
| exon_skip_128297 | chr6 | 28336900:28336943:28337799:28337893:28353862:28353952 | 28337799:28337893 |
| exon_skip_138193 | chr6 | 28327472:28327533:28329303:28329714:28336790:28336943 | 28329303:28329714 |
| exon_skip_170313 | chr6 | 28327472:28327533:28329303:28329714:28336082:28336198 | 28329303:28329714 |
| exon_skip_187916 | chr6 | 28336790:28336943:28337799:28337893:28353862:28354065 | 28337799:28337893 |
| exon_skip_190695 | chr6 | 28327383:28327533:28329303:28329778:28335830:28336134 | 28329303:28329778 |
| exon_skip_217254 | chr6 | 28336900:28336943:28337756:28337893:28341746:28341751 | 28337756:28337893 |
| exon_skip_239499 | chr6 | 28327472:28327533:28329303:28329714:28335830:28335936 | 28329303:28329714 |
| exon_skip_24151 | chr6 | 28327472:28327533:28329303:28329714:28336082:28336134 | 28329303:28329714 |
| exon_skip_250337 | chr6 | 28329632:28329714:28336790:28336943:28353862:28353952 | 28336790:28336943 |
| exon_skip_262128 | chr6 | 28336790:28336943:28337799:28337893:28353862:28353952 | 28337799:28337893 |
| exon_skip_47069 | chr6 | 28336900:28336943:28353318:28353482:28353862:28353952 | 28353318:28353482 |
| exon_skip_66392 | chr6 | 28329374:28329778:28336790:28336943:28353862:28353952 | 28336790:28336943 |
| exon_skip_7083 | chr6 | 28337799:28337893:28341746:28341792:28353862:28353952 | 28341746:28341792 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ZSCAN31 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000344279 | 28329303 | 28329778 | 3UTR-3CDS |
| ENST00000396838 | 28329303 | 28329714 | 3UTR-3CDS |
| ENST00000414429 | 28329303 | 28329714 | 3UTR-3CDS |
| ENST00000439158 | 28329303 | 28329778 | 3UTR-3CDS |
| ENST00000414429 | 28341746 | 28341795 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000344279 | 28329303 | 28329778 | 3UTR-3CDS |
| ENST00000396838 | 28329303 | 28329714 | 3UTR-3CDS |
| ENST00000414429 | 28329303 | 28329714 | 3UTR-3CDS |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000344279 | 28329303 | 28329778 | 3UTR-3CDS |
| ENST00000396838 | 28329303 | 28329714 | 3UTR-3CDS |
| ENST00000414429 | 28329303 | 28329714 | 3UTR-3CDS |
| ENST00000439158 | 28329303 | 28329778 | 3UTR-3CDS |
| ENST00000396838 | 28337756 | 28337893 | 3UTR-3UTR |
| ENST00000396838 | 28341746 | 28341792 | 3UTR-3UTR |
| ENST00000414429 | 28341746 | 28341795 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for ZSCAN31 |
p-ENSG00000235109_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ZSCAN31 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000396838 | 28337756 | 28337893 | hsa-miR-4425 | chr6:28337807-28337814 | 8mer-1a | chr6:28337791-28337814 | 158.00 | -23.40 |
| Mayo | ENST00000396838 | 28337756 | 28337893 | hsa-miR-7151-3p | chr6:28337799-28337806 | 8mer-1a | chr6:28337791-28337814 | 158.00 | -23.40 |
| Mayo | ENST00000396838 | 28337756 | 28337893 | hsa-miR-3184-3p | chr6:28337771-28337778 | 8mer-1a | chr6:28337767-28337788 | 147.00 | -19.47 |
| Mayo | ENST00000396838 | 28337756 | 28337893 | hsa-miR-5089-5p | chr6:28337805-28337812 | 8mer-1a | chr6:28337791-28337814 | 158.00 | -23.40 |
| Mayo | ENST00000396838 | 28337756 | 28337893 | hsa-miR-520g-3p | chr6:28337813-28337820 | 8mer-1a | chr6:28337806-28337827 | 146.00 | -18.12 |
| Mayo | ENST00000396838 | 28337756 | 28337893 | hsa-miR-520h | chr6:28337813-28337820 | 8mer-1a | chr6:28337806-28337827 | 146.00 | -18.12 |
| Mayo | ENST00000396838 | 28337756 | 28337893 | hsa-miR-3690 | chr6:28337847-28337854 | 8mer-1a | chr6:28337834-28337854 | 150.00 | -17.68 |
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SNVs in the skipped exons for ZSCAN31 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ZSCAN31 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZSCAN31 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ZSCAN31 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ZSCAN31 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZSCAN31 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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