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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for SRSF2 |
Gene summary |
Gene information | Gene symbol | SRSF2 | Gene ID | 6427 |
Gene name | serine and arginine rich splicing factor 2 | |
Synonyms | PR264|SC-35|SC35|SFRS2|SFRS2A|SRp30b | |
Cytomap | 17q25.1 | |
Type of gene | protein-coding | |
Description | serine/arginine-rich splicing factor 2SR splicing factor 2splicing component, 35 kDasplicing factor SC35splicing factor, arginine/serine-rich 2 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context | - 29226865(SIRT1 Deacetylates SC35 and Suppresses Its Function in Tau Exon 10 Inclusion) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for SRSF2 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PCC | UP | ENST00000586778.1 | SRSF2-209:retained_intron:SRSF2 | 2.515997e+01 | 9.756599e-01 | 2.160039e-05 | 2.173060e-03 |
CB | UP | ENST00000585202.5 | SRSF2-208:nonsense_mediated_decay:SRSF2 | 1.519049e+02 | 1.055678e+00 | 5.521464e-10 | 2.685715e-08 |
CB | UP | ENST00000592676.1 | SRSF2-211:retained_intron:SRSF2 | 2.363599e+01 | 1.411419e+00 | 2.500534e-04 | 1.608437e-03 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for SRSF2 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_117790 | chr17 | 76735137:76735158:76735772:76735875:76736154:76736464 | 76735772:76735875 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for SRSF2 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for SRSF2 |
p-ENSG00000161547_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in SRSF2 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for SRSF2 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for SRSF2 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SRSF2 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for SRSF2 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | NUP42 | exon_skip_117790 | 5.639192e-01 | 9.959477e-15 |
CB | RALYL | exon_skip_117790 | 4.000291e-01 | 1.749297e-07 |
DLPFC | RBM3 | exon_skip_117790 | 4.442335e-01 | 5.666484e-18 |
FL | RBM3 | exon_skip_117790 | 4.221617e-01 | 5.837256e-10 |
IFG | TRA2A | exon_skip_117790 | -4.686526e-01 | 1.188720e-02 |
PCC | RBM3 | exon_skip_117790 | 4.092581e-01 | 4.335882e-10 |
STG | RBM3 | exon_skip_117790 | 4.668096e-01 | 3.521307e-06 |
STG | RALYL | exon_skip_117790 | 4.143914e-01 | 4.898152e-05 |
TC | RBM3 | exon_skip_117790 | 4.740574e-01 | 2.420748e-10 |
TC | KHDRBS2 | exon_skip_117790 | 4.152513e-01 | 4.762733e-08 |
TC | RALYL | exon_skip_117790 | 4.335289e-01 | 1.025713e-08 |
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RelatedDrugs for SRSF2 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SRSF2 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |