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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for MAP2K4 |
 Gene summary |
| Gene information | Gene symbol | MAP2K4 | Gene ID | 6416 |
| Gene name | mitogen-activated protein kinase kinase 4 | |
| Synonyms | JNKK|JNKK1|MAPKK4|MEK4|MKK4|PRKMK4|SAPKK-1|SAPKK1|SEK1|SERK1|SKK1 | |
| Cytomap | 17p12 | |
| Type of gene | protein-coding | |
| Description | dual specificity mitogen-activated protein kinase kinase 4JNK-activated kinase 1JNK-activating kinase 1MAP kinase kinase 4MAPK/ERK kinase 4MAPKK 4MEK 4SAPK/ERK kinase 1c-Jun N-terminal kinase kinase 1stress-activated protein kinase kinase 1 | |
| Modification date | 20200329 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for MAP2K4 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000065559
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000579089.5 | MAP2K4-205:lncRNA:MAP2K4 | 4.194408e+00 | 3.074293e+00 | 1.273832e-13 | 2.752936e-11 |
| CB | UP | ENST00000581941.5 | MAP2K4-206:lncRNA:MAP2K4 | 5.479315e+01 | 1.639867e+00 | 1.022092e-11 | 9.888571e-10 |
| CB | UP | ENST00000602686.5 | MAP2K4-214:nonsense_mediated_decay:MAP2K4 | 1.650748e+01 | 2.118801e+00 | 1.160355e-09 | 4.928119e-08 |
| CB | UP | ENST00000602375.5 | MAP2K4-212:nonsense_mediated_decay:MAP2K4 | 7.554440e+00 | 1.007273e+00 | 1.243398e-06 | 1.801957e-05 |
| CB | UP | ENST00000582183.5 | MAP2K4-207:nonsense_mediated_decay:MAP2K4 | 2.892952e+00 | 9.993608e-01 | 5.026217e-05 | 4.130779e-04 |
| CB | UP | ENST00000538465.7 | MAP2K4-204:nonsense_mediated_decay:MAP2K4 | 2.951354e+00 | 3.093548e+00 | 5.959380e-05 | 4.776872e-04 |
| CB | UP | ENST00000585076.1 | MAP2K4-210:retained_intron:MAP2K4 | 1.902100e+00 | 1.095041e+00 | 6.289426e-05 | 4.995187e-04 |
| CB | UP | ENST00000582377.1 | MAP2K4-208:retained_intron:MAP2K4 | 1.478627e+00 | 9.481511e-01 | 8.984285e-05 | 6.766850e-04 |
| TC | UP | ENST00000579089.5 | MAP2K4-205:lncRNA:MAP2K4 | 9.607956e-01 | 1.219415e+00 | 3.473520e-03 | 2.550190e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MAP2K4 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_127554 | chr17 | 12095602:12095694:12110375:12110426:12113233:12113318 | 12110375:12110426 |
| exon_skip_180500 | chr17 | 12020976:12021001:12054889:12054991:12081356:12081530 | 12054889:12054991 |
| exon_skip_183323 | chr17 | 12020976:12021001:12081356:12081530:12095575:12095694 | 12081356:12081530 |
| exon_skip_2340 | chr17 | 12020887:12021001:12054889:12054991:12081356:12081367 | 12054889:12054991 |
| exon_skip_248843 | chr17 | 12020976:12021001:12054889:12054991:12095575:12095694 | 12054889:12054991 |
| exon_skip_250797 | chr17 | 12069756:12069849:12081356:12081530:12095575:12095694 | 12081356:12081530 |
| exon_skip_257176 | chr17 | 12054967:12054991:12081356:12081530:12095575:12095694 | 12081356:12081530 |
| exon_skip_258720 | chr17 | 12095602:12095694:12107790:12107909:12110375:12110426 | 12107790:12107909 |
| exon_skip_263940 | chr17 | 12020976:12021001:12032266:12032298:12054889:12054936 | 12032266:12032298 |
| exon_skip_285057 | chr17 | 12020834:12021001:12032266:12032298:12054889:12054991 | 12032266:12032298 |
| exon_skip_285817 | chr17 | 12054889:12054991:12081356:12081530:12095575:12095694 | 12081356:12081530 |
| exon_skip_42761 | chr17 | 12095575:12095694:12107790:12107909:12110375:12110426 | 12107790:12107909 |
| exon_skip_50492 | chr17 | 12069761:12069849:12081356:12081530:12095575:12095694 | 12081356:12081530 |
| exon_skip_54004 | chr17 | 12129139:12129287:12139839:12139884:12141147:12141260 | 12139839:12139884 |
| exon_skip_55862 | chr17 | 12020976:12021001:12032266:12032298:12054889:12054991 | 12032266:12032298 |
| exon_skip_81019 | chr17 | 12125294:12125371:12129139:12129287:12139839:12139884 | 12129139:12129287 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for MAP2K4 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000353533 | 12054889 | 12054991 | Frame-shift |
| ENST00000353533 | 12081356 | 12081530 | Frame-shift |
| ENST00000353533 | 12129139 | 12129287 | Frame-shift |
| ENST00000353533 | 12107790 | 12107909 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000353533 | 12054889 | 12054991 | Frame-shift |
| ENST00000353533 | 12081356 | 12081530 | Frame-shift |
| ENST00000353533 | 12107790 | 12107909 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000353533 | 12054889 | 12054991 | Frame-shift |
| ENST00000353533 | 12081356 | 12081530 | Frame-shift |
| ENST00000353533 | 12129139 | 12129287 | Frame-shift |
| ENST00000353533 | 12139839 | 12139884 | Frame-shift |
| ENST00000353533 | 12107790 | 12107909 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MAP2K4 |
p-ENSG00000065559_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000353533 | 3843 | 399 | 12107790 | 12107909 | 578 | 696 | 171 | 211 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000353533 | 3843 | 399 | 12107790 | 12107909 | 578 | 696 | 171 | 211 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000353533 | 3843 | 399 | 12107790 | 12107909 | 578 | 696 | 171 | 211 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P45985 | 171 | 211 | 171 | 178 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ALN |
| P45985 | 171 | 211 | 182 | 184 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ALN |
| P45985 | 171 | 211 | 2 | 399 | Chain | ID=PRO_0000086381;Note=Dual specificity mitogen-activated protein kinase kinase 4 |
| P45985 | 171 | 211 | 102 | 367 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P45985 | 171 | 211 | 185 | 194 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ALN |
| P45985 | 171 | 211 | 202 | 223 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ALN |
| P45985 | 171 | 211 | 179 | 179 | Sequence conflict | Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P45985 | 171 | 211 | 171 | 178 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ALN |
| P45985 | 171 | 211 | 182 | 184 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ALN |
| P45985 | 171 | 211 | 2 | 399 | Chain | ID=PRO_0000086381;Note=Dual specificity mitogen-activated protein kinase kinase 4 |
| P45985 | 171 | 211 | 102 | 367 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P45985 | 171 | 211 | 185 | 194 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ALN |
| P45985 | 171 | 211 | 202 | 223 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ALN |
| P45985 | 171 | 211 | 179 | 179 | Sequence conflict | Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P45985 | 171 | 211 | 171 | 178 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ALN |
| P45985 | 171 | 211 | 182 | 184 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ALN |
| P45985 | 171 | 211 | 2 | 399 | Chain | ID=PRO_0000086381;Note=Dual specificity mitogen-activated protein kinase kinase 4 |
| P45985 | 171 | 211 | 102 | 367 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| P45985 | 171 | 211 | 185 | 194 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ALN |
| P45985 | 171 | 211 | 202 | 223 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3ALN |
| P45985 | 171 | 211 | 179 | 179 | Sequence conflict | Note=E->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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3'-UTR located exon skipping events that lost miRNA binding sites in MAP2K4 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MAP2K4 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MAP2K4 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAP2K4 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for MAP2K4 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TRA2A | exon_skip_285817 | -4.737164e-01 | 2.611829e-09 |
| CB | NUP42 | exon_skip_285817 | 5.223803e-01 | 2.598277e-11 |
| CB | PABPC1 | exon_skip_250797 | 4.271267e-01 | 1.410142e-06 |
| CB | DAZAP1 | exon_skip_258720 | -4.567730e-01 | 6.831886e-09 |
| CB | TRA2A | exon_skip_258720 | -6.069631e-01 | 4.629227e-16 |
| CB | FUBP1 | exon_skip_258720 | -5.068713e-01 | 6.660601e-11 |
| TC | KHDRBS2 | exon_skip_257176 | 4.529952e-01 | 7.427645e-09 |
| TC | NUP42 | exon_skip_257176 | 4.395582e-01 | 2.280167e-08 |
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RelatedDrugs for MAP2K4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAP2K4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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