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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for ZBED8 |
Gene summary |
Gene information | Gene symbol | ZBED8 | Gene ID | 63920 |
Gene name | zinc finger BED-type containing 8 | |
Synonyms | Buster3|C5orf54 | |
Cytomap | 5q33.3 | |
Type of gene | protein-coding | |
Description | protein ZBED8transposon-derived Buster3 transposase-like proteinzinc finger BED domain-containing protein 8 | |
Modification date | 20200313 | |
UniProtAcc | Q8IZ13, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ZBED8 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ZBED8 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_239387 | chr5 | 160393528:160395539:160397442:160397515:160399639:160400036 | 160397442:160397515 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ZBED8 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000523213 | 160397442 | 160397515 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000523213 | 160397442 | 160397515 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000523213 | 160397442 | 160397515 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for ZBED8 |
p-ENSG00000221886_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in ZBED8 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000523213 | 160397442 | 160397515 | hsa-miR-620 | chr5:160397457-160397464 | 8mer-1a | chr5:160397446-160397464 | 156.00 | -14.80 |
Mayo | ENST00000523213 | 160397442 | 160397515 | hsa-miR-432-5p | chr5:160397459-160397466 | 8mer-1a | chr5:160397443-160397466 | 148.00 | -17.94 |
Mayo | ENST00000523213 | 160397442 | 160397515 | hsa-miR-1270 | chr5:160397457-160397464 | 8mer-1a | chr5:160397446-160397464 | 156.00 | -14.80 |
Mayo | ENST00000523213 | 160397442 | 160397515 | hsa-miR-3191-5p | chr5:160397503-160397510 | 8mer-1a | chr5:160397490-160397510 | 149.00 | -15.87 |
Mayo | ENST00000523213 | 160397442 | 160397515 | hsa-miR-6857-5p | chr5:160397477-160397484 | 8mer-1a | chr5:160397463-160397485 | 152.00 | -16.99 |
Mayo | ENST00000523213 | 160397442 | 160397515 | hsa-miR-450a-2-3p | chr5:160397478-160397485 | 8mer-1a | chr5:160397463-160397485 | 152.00 | -16.99 |
MSBB | ENST00000523213 | 160397442 | 160397515 | hsa-miR-620 | chr5:160397457-160397464 | 8mer-1a | chr5:160397446-160397464 | 156.00 | -14.80 |
MSBB | ENST00000523213 | 160397442 | 160397515 | hsa-miR-432-5p | chr5:160397459-160397466 | 8mer-1a | chr5:160397443-160397466 | 148.00 | -17.94 |
MSBB | ENST00000523213 | 160397442 | 160397515 | hsa-miR-1270 | chr5:160397457-160397464 | 8mer-1a | chr5:160397446-160397464 | 156.00 | -14.80 |
MSBB | ENST00000523213 | 160397442 | 160397515 | hsa-miR-3191-5p | chr5:160397503-160397510 | 8mer-1a | chr5:160397490-160397510 | 149.00 | -15.87 |
MSBB | ENST00000523213 | 160397442 | 160397515 | hsa-miR-6857-5p | chr5:160397477-160397484 | 8mer-1a | chr5:160397463-160397485 | 152.00 | -16.99 |
MSBB | ENST00000523213 | 160397442 | 160397515 | hsa-miR-450a-2-3p | chr5:160397478-160397485 | 8mer-1a | chr5:160397463-160397485 | 152.00 | -16.99 |
ROSMAP | ENST00000523213 | 160397442 | 160397515 | hsa-miR-620 | chr5:160397457-160397464 | 8mer-1a | chr5:160397446-160397464 | 156.00 | -14.80 |
ROSMAP | ENST00000523213 | 160397442 | 160397515 | hsa-miR-432-5p | chr5:160397459-160397466 | 8mer-1a | chr5:160397443-160397466 | 148.00 | -17.94 |
ROSMAP | ENST00000523213 | 160397442 | 160397515 | hsa-miR-1270 | chr5:160397457-160397464 | 8mer-1a | chr5:160397446-160397464 | 156.00 | -14.80 |
ROSMAP | ENST00000523213 | 160397442 | 160397515 | hsa-miR-3191-5p | chr5:160397503-160397510 | 8mer-1a | chr5:160397490-160397510 | 149.00 | -15.87 |
ROSMAP | ENST00000523213 | 160397442 | 160397515 | hsa-miR-6857-5p | chr5:160397477-160397484 | 8mer-1a | chr5:160397463-160397485 | 152.00 | -16.99 |
ROSMAP | ENST00000523213 | 160397442 | 160397515 | hsa-miR-450a-2-3p | chr5:160397478-160397485 | 8mer-1a | chr5:160397463-160397485 | 152.00 | -16.99 |
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SNVs in the skipped exons for ZBED8 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ZBED8 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZBED8 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
CB | exon_skip_239387 | rs7717016 | chr5:160399667 | 2.712092e-10 | 2.538038e-07 |
CB | exon_skip_239387 | rs1075059 | chr5:160398791 | 2.491585e-06 | 7.815457e-04 |
CB | exon_skip_239387 | rs13185269 | chr5:160359587 | 1.537155e-04 | 2.433360e-02 |
CB | exon_skip_239387 | rs2961932 | chr5:160391118 | 2.368183e-04 | 3.396640e-02 |
CB | exon_skip_239387 | rs1582418 | chr5:160455790 | 2.862511e-04 | 3.929203e-02 |
CB | exon_skip_239387 | rs2431099 | chr5:160459613 | 2.862511e-04 | 3.929203e-02 |
HCC | exon_skip_239387 | rs7717016 | chr5:160399667 | 1.471085e-07 | 2.857924e-05 |
HCC | exon_skip_239387 | rs12522744 | chr5:160413693 | 6.281857e-06 | 8.393200e-04 |
HCC | exon_skip_239387 | rs1895321 | chr5:160419403 | 9.967950e-06 | 1.248391e-03 |
HCC | exon_skip_239387 | rs17409777 | chr5:160400201 | 1.197227e-05 | 1.470198e-03 |
HCC | exon_skip_239387 | rs17057795 | chr5:160434334 | 1.008583e-04 | 9.196428e-03 |
HCC | exon_skip_239387 | rs11135102 | chr5:160438572 | 8.035845e-04 | 4.921015e-02 |
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Correlation with RNA binding proteins (RBPs) for ZBED8 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ZBED8 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZBED8 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |