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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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3'-UTR located exon skipping events lost miRNA binding sites

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SNVs in the skipped exons with depth of coverage

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AD stage-associated exon skipping events

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Correlation with RNA binding proteins (RBPs)

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Related drugs with this gene

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Related diseases with this gene

Gene summary for THADA

check button Gene summary
Gene informationGene symbol

THADA

Gene ID

63892

Gene nameTHADA armadillo repeat containing
SynonymsARMC13|GITA
Cytomap

2p21

Type of geneprotein-coding
Descriptionthyroid adenoma-associated proteindeath receptor-interacting proteingene inducing thyroid adenomas protein
Modification date20200313
UniProtAcc

B5MC89,

B6ZDE5,

F5H3M9,

H0Y3V5,

H7BYZ4,

Q6YHU6,

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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Gene structures and expression levels for THADA

check buttonSkipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

ENSG00000115970
check button Differentially expressed gene analysis across multiple brain tissues between AD and control.
Tissue typeDEG directionBase mean exp.log2FC(AD/control)P-valueAdj. p-value

check button Differentially expressed isoform analysis across multiple brain tissues between AD and control.
gencode gene structure
Tissue typeDEG directionENSTTranscript info.Base mean exp.log2FC(AD/control)P-valueAdjc. p-value
CBDOWNENST00000467668.1THADA-212:lncRNA:THADA7.379593e+00-8.597231e-015.902951e-032.257104e-02
TCUPENST00000497770.1THADA-219:lncRNA:THADA1.416447e+003.198862e+002.000224e-071.084093e-05

check button Landscape of isoform expressions across multiple brain tissues between AD and control.
gencode gene structure

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for THADA

check button Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).
boxplot

check button All exon skipping events in AD cohorts.
Exon skip IDchrExons involved in exon skippingSkipped exon
exon_skip_106811chr243344122:43344237:43370120:43370197:43371965:4337212243370120:43370197
exon_skip_145349chr243574336:43575027:43577022:43577242:43578513:4357860743577022:43577242
exon_skip_156697chr243541159:43541316:43549210:43549368:43551789:4355192243549210:43549368
exon_skip_158871chr243279765:43279896:43286908:43287061:43291696:4329176843286908:43287061
exon_skip_206372chr243232713:43232882:43279765:43279896:43286908:4328706143279765:43279896
exon_skip_210915chr243508648:43508780:43527879:43527988:43541159:4354130343527879:43527988
exon_skip_220574chr243397971:43398139:43428100:43428231:43430213:4343030243428100:43428231
exon_skip_2363chr243527879:43527988:43538429:43538566:43541159:4354122943538429:43538566
exon_skip_239086chr243527879:43527988:43538429:43538566:43541159:4354130343538429:43538566
exon_skip_254695chr243320446:43320540:43344122:43344237:43397971:4339805843344122:43344237
exon_skip_260799chr243232830:43232882:43279765:43279896:43286908:4328706143279765:43279896
exon_skip_26589chr243552204:43552339:43560234:43560385:43566698:4356682143560234:43560385
exon_skip_278906chr243556349:43556555:43560234:43560385:43566698:4356682143560234:43560385
exon_skip_31252chr243527879:43527988:43538429:43538566:43541159:4354123943538429:43538566
exon_skip_76007chr243552204:43552339:43556345:43556555:43560234:4356038143556345:43556555
exon_skip_82313chr243592317:43592416:43592844:43592890:43595931:4359600743592844:43592890
exon_skip_82981chr243430213:43430302:43485234:43485325:43498833:4349895543485234:43485325
exon_skip_83832chr243397971:43398139:43485234:43485325:43498833:4349895543485234:43485325
exon_skip_85749chr243397971:43398139:43430213:43430302:43485234:4348532543430213:43430302

check button Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.
Exon skipping informationTissue typeAvg(PSIs) in ADAvg(PSIs) in controlDifference (PSI)Adj. p-value


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Open reading frame (ORF) annotation in the exon skipping event for THADA

check button Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000004050064328690843287061Frame-shift
ENST000004059754328690843287061Frame-shift
ENST000004050064334412243344237Frame-shift
ENST000004059754334412243344237Frame-shift
ENST000004050064348523443485325Frame-shift
ENST000004059754348523443485325Frame-shift
ENST000004050064355634543556555Frame-shift
ENST000004059754355634543556555Frame-shift
ENST000004050064356023443560385Frame-shift
ENST000004059754356023443560385Frame-shift
ENST000004050064357702243577242Frame-shift
ENST000004059754357702243577242Frame-shift
ENST000004050064327976543279896In-frame
ENST000004059754327976543279896In-frame
ENST000004050064342810043428231In-frame
ENST000004059754342810043428231In-frame

check button Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000004050064348523443485325Frame-shift
ENST000004059754348523443485325Frame-shift
ENST000004050064355634543556555Frame-shift
ENST000004059754355634543556555Frame-shift
ENST000004050064356023443560385Frame-shift
ENST000004059754356023443560385Frame-shift
ENST000004050064357702243577242Frame-shift
ENST000004059754357702243577242Frame-shift
ENST000004050064327976543279896In-frame
ENST000004059754327976543279896In-frame

check button Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000004050064328690843287061Frame-shift
ENST000004059754328690843287061Frame-shift
ENST000004050064334412243344237Frame-shift
ENST000004059754334412243344237Frame-shift
ENST000004050064348523443485325Frame-shift
ENST000004059754348523443485325Frame-shift
ENST000004050064352787943527988Frame-shift
ENST000004059754352787943527988Frame-shift
ENST000004050064355634543556555Frame-shift
ENST000004059754355634543556555Frame-shift
ENST000004050064356023443560385Frame-shift
ENST000004059754356023443560385Frame-shift
ENST000004050064357702243577242Frame-shift
ENST000004059754357702243577242Frame-shift
ENST000004050064327976543279896In-frame
ENST000004059754327976543279896In-frame
ENST000004050064342810043428231In-frame
ENST000004059754342810043428231In-frame
ENST000004050064354921043549368In-frame
ENST000004059754354921043549368In-frame

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Infer the effects of exon skipping event on protein functional features for THADA

p-ENSG00000115970_img4.png
boxplot

check button Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000004050066327195343428100434282314279440913091352
ENST000004059756131195343428100434282314067419713091352
ENST000004050066327195343279765432798965517564717211765
ENST000004059756131195343279765432798965305543517211765

check button Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000004050066327195343279765432798965517564717211765
ENST000004059756131195343279765432798965305543517211765

check button Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST00000405006632719534354921043549368330034579821035
ENST00000405975613119534354921043549368308832459821035
ENST000004050066327195343428100434282314279440913091352
ENST000004059756131195343428100434282314067419713091352
ENST000004050066327195343279765432798965517564717211765
ENST000004059756131195343279765432798965305543517211765

check button Lost protein functional features of individual exon skipping events in ROSMAP.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q6YHU6130913528951953Alternative sequenceID=VSP_054422;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q6YHU6130913528951953Alternative sequenceID=VSP_054422;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q6YHU6130913529381953Alternative sequenceID=VSP_034733;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q6YHU6130913529381953Alternative sequenceID=VSP_034733;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q6YHU61309135212801353Alternative sequenceID=VSP_034735;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q6YHU61309135212801353Alternative sequenceID=VSP_034735;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q6YHU61309135211953ChainID=PRO_0000344057;Note=Thyroid adenoma-associated protein
Q6YHU61309135211953ChainID=PRO_0000344057;Note=Thyroid adenoma-associated protein
Q6YHU61309135213221327Compositional biasNote=Poly-Leu
Q6YHU61309135213221327Compositional biasNote=Poly-Leu
Q6YHU6172117658951953Alternative sequenceID=VSP_054422;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q6YHU6172117658951953Alternative sequenceID=VSP_054422;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q6YHU6172117659381953Alternative sequenceID=VSP_034733;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q6YHU6172117659381953Alternative sequenceID=VSP_034733;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q6YHU61721176511953ChainID=PRO_0000344057;Note=Thyroid adenoma-associated protein
Q6YHU61721176511953ChainID=PRO_0000344057;Note=Thyroid adenoma-associated protein

check button Lost protein functional features of individual exon skipping events in MSBB.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q6YHU6172117658951953Alternative sequenceID=VSP_054422;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q6YHU6172117658951953Alternative sequenceID=VSP_054422;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q6YHU6172117659381953Alternative sequenceID=VSP_034733;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q6YHU6172117659381953Alternative sequenceID=VSP_034733;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q6YHU61721176511953ChainID=PRO_0000344057;Note=Thyroid adenoma-associated protein
Q6YHU61721176511953ChainID=PRO_0000344057;Note=Thyroid adenoma-associated protein

check button Lost protein functional features of individual exon skipping events in Mayo.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q6YHU6982103511279Alternative sequenceID=VSP_034730;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q6YHU6982103511279Alternative sequenceID=VSP_034730;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q6YHU698210358951953Alternative sequenceID=VSP_054422;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q6YHU698210358951953Alternative sequenceID=VSP_054422;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q6YHU698210359381953Alternative sequenceID=VSP_034733;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q6YHU698210359381953Alternative sequenceID=VSP_034733;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q6YHU6982103511953ChainID=PRO_0000344057;Note=Thyroid adenoma-associated protein
Q6YHU6982103511953ChainID=PRO_0000344057;Note=Thyroid adenoma-associated protein
Q6YHU6982103510151015Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q6YHU6982103510151015Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q6YHU6982103510241024Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
Q6YHU6982103510241024Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231
Q6YHU6130913528951953Alternative sequenceID=VSP_054422;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q6YHU6130913528951953Alternative sequenceID=VSP_054422;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q6YHU6130913529381953Alternative sequenceID=VSP_034733;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q6YHU6130913529381953Alternative sequenceID=VSP_034733;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q6YHU61309135212801353Alternative sequenceID=VSP_034735;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q6YHU61309135212801353Alternative sequenceID=VSP_034735;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q6YHU61309135211953ChainID=PRO_0000344057;Note=Thyroid adenoma-associated protein
Q6YHU61309135211953ChainID=PRO_0000344057;Note=Thyroid adenoma-associated protein
Q6YHU61309135213221327Compositional biasNote=Poly-Leu
Q6YHU61309135213221327Compositional biasNote=Poly-Leu
Q6YHU6172117658951953Alternative sequenceID=VSP_054422;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q6YHU6172117658951953Alternative sequenceID=VSP_054422;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q6YHU6172117659381953Alternative sequenceID=VSP_034733;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q6YHU6172117659381953Alternative sequenceID=VSP_034733;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q6YHU61721176511953ChainID=PRO_0000344057;Note=Thyroid adenoma-associated protein
Q6YHU61721176511953ChainID=PRO_0000344057;Note=Thyroid adenoma-associated protein


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3'-UTR located exon skipping events that lost miRNA binding sites in THADA

check button 3'-UTR exon skipping evnets lost miRNA binding.
Tissue typeENSTExon skip startExon skip endmicroRNABinding site by TargetScanBinding type by TargetScanBdinding site by miRandaScore of miRandaEnergy by miRanda

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SNVs in the skipped exons for THADA

check button - Differential PSIs between mutated versus non-mutated samples.
ENSG00000115970.exon_skip_156697.Mayo_TC.WGS.boxplot.svg
boxplot

check button - Depth of Coverage in the skipped exon of the mutated samples.

check button - Sashimi plot in the skipped exon of the mutated samples.

check button - Non-synonymous mutations located in the skipped exons.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange

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AD stage-associated exon skippint events for THADA

check button Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).
AD stage infoCohortTissueSE idCoefficient P-valueChromosomeStrandE1 startE1 endSkipped startSkipped endE2 startE2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for THADA

check button sQTL information located at the skipped exons.
Tissue typeExon skip IDSNP idLocationP-valueFDR

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Correlation with RNA binding proteins (RBPs) for THADA

check button Correlated RBP and related information.
Tissue typeRBP nameExon skip IDCorrelation coeifficientP-value

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RelatedDrugs for THADA

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for THADA

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource