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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for S100A6 |
Gene summary |
Gene information | Gene symbol | S100A6 | Gene ID | 6277 |
Gene name | S100 calcium binding protein A6 | |
Synonyms | 2A9|5B10|CABP|CACY|PRA|S10A6 | |
Cytomap | 1q21.3 | |
Type of gene | protein-coding | |
Description | protein S100-A6MLN 4calcyclingrowth factor-inducible protein 2A9prolactin receptor-associated protein | |
Modification date | 20200313 | |
UniProtAcc | P06703, R4GN98, | |
Context | - 15590066(Astrocytic calcium/zinc Binding Protein S100A6 Over Expression in Alzheimer's Disease and in PS1/APP Transgenic Mice Models) |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for S100A6 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
TC | UP | ENST00000462951.2 | S100A6-204:retained_intron:S100A6 | 5.921589e+00 | 8.383253e-01 | 1.333417e-07 | 7.752305e-06 |
TC | UP | ENST00000462776.2 | S100A6-203:protein_coding:S100A6 | 5.683256e+00 | 1.014886e+00 | 2.312009e-06 | 7.986707e-05 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for S100A6 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_109821 | chr1 | 153535239:153535360:153535789:153535933:153536108:153536244 | 153535789:153535933 |
exon_skip_136641 | chr1 | 153534812:153534830:153535202:153535375:153535949:153535991 | 153535202:153535375 |
exon_skip_179613 | chr1 | 153535252:153535360:153535789:153535933:153536108:153536244 | 153535789:153535933 |
exon_skip_181922 | chr1 | 153534714:153534830:153535202:153535375:153535949:153535991 | 153535202:153535375 |
exon_skip_258355 | chr1 | 153535202:153535360:153535789:153535933:153536108:153536244 | 153535789:153535933 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for S100A6 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000496817 | 153535202 | 153535375 | 3UTR-3CDS |
ENST00000368720 | 153535789 | 153535933 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000368720 | 153535789 | 153535933 | 3UTR-3UTR |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000496817 | 153535202 | 153535375 | 3UTR-3CDS |
ENST00000368720 | 153535789 | 153535933 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for S100A6 |
p-ENSG00000197956_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in S100A6 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000368720 | 153535789 | 153535933 | hsa-miR-4685-5p | chr1:153535911-153535918 | 8mer-1a | chr1:153535898-153535918 | 162.00 | -26.50 |
Mayo | ENST00000368720 | 153535789 | 153535933 | hsa-miR-6762-5p | chr1:153535842-153535849 | 8mer-1a | chr1:153535834-153535855 | 156.00 | -24.28 |
Mayo | ENST00000368720 | 153535789 | 153535933 | hsa-miR-6797-5p | chr1:153535816-153535823 | 8mer-1a | chr1:153535798-153535823 | 154.00 | -24.62 |
Mayo | ENST00000368720 | 153535789 | 153535933 | hsa-miR-6801-3p | chr1:153535874-153535881 | 8mer-1a | chr1:153535872-153535897 | 153.00 | -30.04 |
Mayo | ENST00000368720 | 153535789 | 153535933 | hsa-miR-6810-3p | chr1:153535874-153535881 | 8mer-1a | chr1:153535872-153535897 | 153.00 | -30.04 |
Mayo | ENST00000368720 | 153535789 | 153535933 | hsa-miR-1249-5p | chr1:153535816-153535823 | 8mer-1a | chr1:153535798-153535823 | 154.00 | -24.62 |
Mayo | ENST00000368720 | 153535789 | 153535933 | hsa-miR-6837-5p | chr1:153535911-153535918 | 8mer-1a | chr1:153535898-153535918 | 162.00 | -26.50 |
Mayo | ENST00000368720 | 153535789 | 153535933 | hsa-miR-6845-5p | chr1:153535842-153535849 | 8mer-1a | chr1:153535834-153535855 | 156.00 | -24.28 |
MSBB | ENST00000368720 | 153535789 | 153535933 | hsa-miR-4685-5p | chr1:153535911-153535918 | 8mer-1a | chr1:153535898-153535918 | 162.00 | -26.50 |
MSBB | ENST00000368720 | 153535789 | 153535933 | hsa-miR-6762-5p | chr1:153535842-153535849 | 8mer-1a | chr1:153535834-153535855 | 156.00 | -24.28 |
MSBB | ENST00000368720 | 153535789 | 153535933 | hsa-miR-6797-5p | chr1:153535816-153535823 | 8mer-1a | chr1:153535798-153535823 | 154.00 | -24.62 |
MSBB | ENST00000368720 | 153535789 | 153535933 | hsa-miR-6801-3p | chr1:153535874-153535881 | 8mer-1a | chr1:153535872-153535897 | 153.00 | -30.04 |
MSBB | ENST00000368720 | 153535789 | 153535933 | hsa-miR-6810-3p | chr1:153535874-153535881 | 8mer-1a | chr1:153535872-153535897 | 153.00 | -30.04 |
MSBB | ENST00000368720 | 153535789 | 153535933 | hsa-miR-1249-5p | chr1:153535816-153535823 | 8mer-1a | chr1:153535798-153535823 | 154.00 | -24.62 |
MSBB | ENST00000368720 | 153535789 | 153535933 | hsa-miR-6837-5p | chr1:153535911-153535918 | 8mer-1a | chr1:153535898-153535918 | 162.00 | -26.50 |
MSBB | ENST00000368720 | 153535789 | 153535933 | hsa-miR-6845-5p | chr1:153535842-153535849 | 8mer-1a | chr1:153535834-153535855 | 156.00 | -24.28 |
ROSMAP | ENST00000368720 | 153535789 | 153535933 | hsa-miR-4685-5p | chr1:153535911-153535918 | 8mer-1a | chr1:153535898-153535918 | 162.00 | -26.50 |
ROSMAP | ENST00000368720 | 153535789 | 153535933 | hsa-miR-6762-5p | chr1:153535842-153535849 | 8mer-1a | chr1:153535834-153535855 | 156.00 | -24.28 |
ROSMAP | ENST00000368720 | 153535789 | 153535933 | hsa-miR-6797-5p | chr1:153535816-153535823 | 8mer-1a | chr1:153535798-153535823 | 154.00 | -24.62 |
ROSMAP | ENST00000368720 | 153535789 | 153535933 | hsa-miR-6801-3p | chr1:153535874-153535881 | 8mer-1a | chr1:153535872-153535897 | 153.00 | -30.04 |
ROSMAP | ENST00000368720 | 153535789 | 153535933 | hsa-miR-6810-3p | chr1:153535874-153535881 | 8mer-1a | chr1:153535872-153535897 | 153.00 | -30.04 |
ROSMAP | ENST00000368720 | 153535789 | 153535933 | hsa-miR-1249-5p | chr1:153535816-153535823 | 8mer-1a | chr1:153535798-153535823 | 154.00 | -24.62 |
ROSMAP | ENST00000368720 | 153535789 | 153535933 | hsa-miR-6837-5p | chr1:153535911-153535918 | 8mer-1a | chr1:153535898-153535918 | 162.00 | -26.50 |
ROSMAP | ENST00000368720 | 153535789 | 153535933 | hsa-miR-6845-5p | chr1:153535842-153535849 | 8mer-1a | chr1:153535834-153535855 | 156.00 | -24.28 |
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SNVs in the skipped exons for S100A6 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for S100A6 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for S100A6 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for S100A6 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | RBM4 | exon_skip_181922 | 4.794549e-01 | 2.415328e-10 |
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RelatedDrugs for S100A6 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
P06703 | approved|investigational | DB11093 | Calcium Citrate | small molecule | P06703 |
P06703 | approved | DB11348 | Calcium Phosphate | small molecule | P06703 |
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RelatedDiseases for S100A6 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |