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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for S100A4 |
 Gene summary |
| Gene information | Gene symbol | S100A4 | Gene ID | 6275 |
| Gene name | S100 calcium binding protein A4 | |
| Synonyms | 18A2|42A|CAPL|FSP1|MTS1|P9KA|PEL98 | |
| Cytomap | 1q21.3 | |
| Type of gene | protein-coding | |
| Description | protein S100-A4S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog)calcium placental proteinfibroblast-specific protein-1leukemia multidrug resistance associated proteinmalignant transformation suppress | |
| Modification date | 20200327 | |
| UniProtAcc | P26447, | |
| Context | - 16171556(S100-mediated Signal Transduction in the Nervous System and Neurological Diseases) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| S100A4 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 15033494 |
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Gene structures and expression levels for S100A4 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000196154
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| DLPFC | UP | 6.593148e+01 | 1.189530e+00 | 7.274753e-16 | 4.773693e-12 |
| PCC | UP | 4.929124e+01 | 1.253615e+00 | 1.463266e-10 | 2.168463e-07 |
| HCC | UP | 5.260278e+01 | 9.225084e-01 | 1.223116e-08 | 3.796402e-06 |
| STG | UP | 3.806022e+01 | 1.080283e+00 | 2.683472e-05 | 3.034988e-03 |
| PG | UP | 3.405207e+01 | 1.179908e+00 | 2.994273e-10 | 3.671876e-08 |
| CB | UP | 8.303837e+01 | 1.125117e+00 | 7.278973e-14 | 1.396619e-11 |
| TC | UP | 1.526775e+02 | 1.169332e+00 | 5.529325e-11 | 5.309796e-09 |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| DLPFC | UP | ENST00000368716.9 | S100A4-204:protein_coding:S100A4 | 5.595270e+01 | 1.137315e+00 | 9.298175e-14 | 1.105997e-09 |
| DLPFC | UP | ENST00000481009.1 | S100A4-206:lncRNA:S100A4 | 3.361407e+00 | 1.822703e+00 | 1.197601e-10 | 2.584102e-07 |
| DLPFC | UP | ENST00000368715.5 | S100A4-203:protein_coding:S100A4 | 2.953554e+00 | 2.388851e+00 | 1.699984e-10 | 3.499776e-07 |
| DLPFC | UP | ENST00000354332.8 | S100A4-201:protein_coding:S100A4 | 2.706291e+00 | 1.052470e+00 | 7.821469e-04 | 2.849938e-02 |
| DLPFC | UP | ENST00000468373.1 | S100A4-205:lncRNA:S100A4 | 1.783227e+00 | 1.103443e+00 | 1.116543e-03 | 3.615525e-02 |
| PCC | UP | ENST00000481009.1 | S100A4-206:lncRNA:S100A4 | 2.075634e+00 | 2.381932e+00 | 1.040538e-08 | 1.106959e-05 |
| PCC | UP | ENST00000368716.9 | S100A4-204:protein_coding:S100A4 | 4.345119e+01 | 1.197992e+00 | 1.097038e-08 | 1.113019e-05 |
| PCC | UP | ENST00000368715.5 | S100A4-203:protein_coding:S100A4 | 2.177348e+00 | 2.656364e+00 | 3.641680e-08 | 2.599752e-05 |
| PCC | UP | ENST00000354332.8 | S100A4-201:protein_coding:S100A4 | 2.480451e+00 | 1.677919e+00 | 2.180460e-05 | 2.184708e-03 |
| HCC | UP | ENST00000368716.9 | S100A4-204:protein_coding:S100A4 | 4.653600e+01 | 8.778439e-01 | 4.409476e-07 | 1.329690e-04 |
| HCC | UP | ENST00000481009.1 | S100A4-206:lncRNA:S100A4 | 2.837405e+00 | 1.624497e+00 | 7.842193e-07 | 2.127031e-04 |
| HCC | UP | ENST00000368715.5 | S100A4-203:protein_coding:S100A4 | 2.488015e+00 | 1.517499e+00 | 7.378115e-06 | 1.131675e-03 |
| STG | UP | ENST00000368716.9 | S100A4-204:protein_coding:S100A4 | 3.114347e+01 | 1.006963e+00 | 3.896972e-04 | 2.387842e-02 |
| PG | UP | ENST00000368716.9 | S100A4-204:protein_coding:S100A4 | 2.797890e+01 | 1.115485e+00 | 6.357515e-09 | 1.792831e-06 |
| PG | UP | ENST00000481009.1 | S100A4-206:lncRNA:S100A4 | 1.303942e+00 | 1.940717e+00 | 7.573398e-05 | 2.231342e-03 |
| CB | UP | ENST00000368716.9 | S100A4-204:protein_coding:S100A4 | 6.892087e+01 | 1.046492e+00 | 1.004764e-10 | 6.333205e-09 |
| CB | UP | ENST00000481009.1 | S100A4-206:lncRNA:S100A4 | 4.235001e+00 | 1.459063e+00 | 1.122142e-10 | 6.959558e-09 |
| CB | UP | ENST00000368715.5 | S100A4-203:protein_coding:S100A4 | 3.633918e+00 | 1.443131e+00 | 2.767287e-06 | 3.562228e-05 |
| CB | UP | ENST00000354332.8 | S100A4-201:protein_coding:S100A4 | 2.140865e+00 | 1.850905e+00 | 1.852045e-05 | 1.774847e-04 |
| CB | UP | ENST00000468373.1 | S100A4-205:lncRNA:S100A4 | 2.963362e+00 | 1.061903e+00 | 1.625774e-03 | 7.759250e-03 |
| TC | UP | ENST00000368715.5 | S100A4-203:protein_coding:S100A4 | 7.746546e+00 | 2.625701e+00 | 1.334309e-13 | 6.395198e-11 |
| TC | UP | ENST00000481009.1 | S100A4-206:lncRNA:S100A4 | 6.242712e+00 | 2.150011e+00 | 5.783938e-11 | 1.222143e-08 |
| TC | UP | ENST00000368716.9 | S100A4-204:protein_coding:S100A4 | 1.265893e+02 | 1.085565e+00 | 8.201114e-10 | 1.112537e-07 |
| TC | UP | ENST00000468373.1 | S100A4-205:lncRNA:S100A4 | 4.324019e+00 | 1.361953e+00 | 1.487729e-04 | 2.210717e-03 |
| TC | UP | ENST00000354332.8 | S100A4-201:protein_coding:S100A4 | 4.985681e+00 | 1.356030e+00 | 2.433654e-04 | 3.263440e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for S100A4 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_176309 | chr1 | 153544654:153544809:153545470:153545518:153545753:153545802 | 153545470:153545518 |
| exon_skip_24997 | chr1 | 153543621:153543923:153544654:153544809:153545753:153545802 | 153544654:153544809 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for S100A4 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000368716 | 153544654 | 153544809 | 3UTR-3CDS |
| ENST00000354332 | 153545470 | 153545518 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000354332 | 153545470 | 153545518 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000354332 | 153545470 | 153545518 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for S100A4 |
p-ENSG00000196154_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in S100A4 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for S100A4 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for S100A4 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for S100A4 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for S100A4 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for S100A4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| P26447 | approved|investigational | DB00831 | Trifluoperazine | small molecule | P26447 |
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RelatedDiseases for S100A4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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