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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for RRBP1 |
 Gene summary |
| Gene information | Gene symbol | RRBP1 | Gene ID | 6238 |
| Gene name | ribosome binding protein 1 | |
| Synonyms | ES/130|ES130|RRp|hES | |
| Cytomap | 20p12.1 | |
| Type of gene | protein-coding | |
| Description | ribosome-binding protein 1180 kDa ribosome receptor homologES/130-related proteinribosome binding protein 1 homolog 180kDa (dog)ribosome receptor protein | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context | - 31951107(Novel Alzheimer risk genes determine the microglia response to amyloid-beta but not to TAU pathology) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for RRBP1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000125844
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000398782.2 | RRBP1-205:protein_coding:RRBP1 | 3.420234e+01 | 8.481868e-01 | 4.246550e-07 | 4.639896e-05 |
| CB | DOWN | ENST00000470422.5 | RRBP1-208:protein_coding:RRBP1 | 2.552693e+01 | -9.820734e-01 | 1.486613e-06 | 2.099529e-05 |
| TC | DOWN | ENST00000470422.5 | RRBP1-208:protein_coding:RRBP1 | 2.762244e+01 | -1.218816e+00 | 5.312586e-07 | 2.422201e-05 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for RRBP1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_108139 | chr20 | 17659980:17660528:17679999:17680075:17682028:17682060 | 17679999:17680075 |
| exon_skip_193 | chr20 | 17636577:17636729:17641797:17641919:17642979:17643085 | 17641797:17641919 |
| exon_skip_21703 | chr20 | 17615431:17615529:17615926:17616009:17616732:17616839 | 17615926:17616009 |
| exon_skip_219145 | chr20 | 17621855:17621947:17624576:17624668:17625512:17625602 | 17624576:17624668 |
| exon_skip_237925 | chr20 | 17615926:17616009:17616732:17616839:17618596:17618679 | 17616732:17616839 |
| exon_skip_36375 | chr20 | 17660501:17660528:17679999:17680075:17682028:17682060 | 17679999:17680075 |
| exon_skip_44314 | chr20 | 17633460:17633613:17635546:17635664:17636577:17636729 | 17635546:17635664 |
| exon_skip_99535 | chr20 | 17625512:17625602:17627348:17627382:17627504:17627682 | 17627348:17627382 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for RRBP1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000377813 | 17679999 | 17680075 | 3UTR-3UTR |
| ENST00000246043 | 17627348 | 17627382 | Frame-shift |
| ENST00000377813 | 17627348 | 17627382 | Frame-shift |
| ENST00000246043 | 17615926 | 17616009 | In-frame |
| ENST00000377813 | 17615926 | 17616009 | In-frame |
| ENST00000246043 | 17616732 | 17616839 | In-frame |
| ENST00000377813 | 17616732 | 17616839 | In-frame |
| ENST00000246043 | 17641797 | 17641919 | In-frame |
| ENST00000377813 | 17641797 | 17641919 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000377813 | 17679999 | 17680075 | 3UTR-3UTR |
| ENST00000246043 | 17616732 | 17616839 | In-frame |
| ENST00000377813 | 17616732 | 17616839 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000377813 | 17679999 | 17680075 | 3UTR-3UTR |
| ENST00000246043 | 17627348 | 17627382 | Frame-shift |
| ENST00000377813 | 17627348 | 17627382 | Frame-shift |
| ENST00000246043 | 17635546 | 17635664 | Frame-shift |
| ENST00000377813 | 17635546 | 17635664 | Frame-shift |
| ENST00000246043 | 17616732 | 17616839 | In-frame |
| ENST00000377813 | 17616732 | 17616839 | In-frame |
| ENST00000246043 | 17624576 | 17624668 | In-frame |
| ENST00000377813 | 17624576 | 17624668 | In-frame |
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Infer the effects of exon skipping event on protein functional features for RRBP1 |
p-ENSG00000125844_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000246043 | 4754 | 1410 | 17641797 | 17641919 | 2062 | 2183 | 687 | 727 |
| ENST00000377813 | 5058 | 1410 | 17641797 | 17641919 | 2366 | 2487 | 687 | 727 |
| ENST00000246043 | 4754 | 1410 | 17616732 | 17616839 | 3760 | 3866 | 1253 | 1288 |
| ENST00000377813 | 5058 | 1410 | 17616732 | 17616839 | 4064 | 4170 | 1253 | 1288 |
| ENST00000246043 | 4754 | 1410 | 17615926 | 17616009 | 3868 | 3950 | 1289 | 1316 |
| ENST00000377813 | 5058 | 1410 | 17615926 | 17616009 | 4172 | 4254 | 1289 | 1316 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000246043 | 4754 | 1410 | 17616732 | 17616839 | 3760 | 3866 | 1253 | 1288 |
| ENST00000377813 | 5058 | 1410 | 17616732 | 17616839 | 4064 | 4170 | 1253 | 1288 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000246043 | 4754 | 1410 | 17624576 | 17624668 | 3055 | 3146 | 1018 | 1048 |
| ENST00000377813 | 5058 | 1410 | 17624576 | 17624668 | 3359 | 3450 | 1018 | 1048 |
| ENST00000246043 | 4754 | 1410 | 17616732 | 17616839 | 3760 | 3866 | 1253 | 1288 |
| ENST00000377813 | 5058 | 1410 | 17616732 | 17616839 | 4064 | 4170 | 1253 | 1288 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9P2E9 | 687 | 727 | 1 | 1410 | Chain | ID=PRO_0000097441;Note=Ribosome-binding protein 1 |
| Q9P2E9 | 687 | 727 | 1 | 1410 | Chain | ID=PRO_0000097441;Note=Ribosome-binding protein 1 |
| Q9P2E9 | 687 | 727 | 29 | 1410 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P2E9 | 687 | 727 | 29 | 1410 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P2E9 | 1253 | 1288 | 1 | 1410 | Chain | ID=PRO_0000097441;Note=Ribosome-binding protein 1 |
| Q9P2E9 | 1253 | 1288 | 1 | 1410 | Chain | ID=PRO_0000097441;Note=Ribosome-binding protein 1 |
| Q9P2E9 | 1253 | 1288 | 1276 | 1276 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648 |
| Q9P2E9 | 1253 | 1288 | 1276 | 1276 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648 |
| Q9P2E9 | 1253 | 1288 | 1277 | 1277 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:24275569 |
| Q9P2E9 | 1253 | 1288 | 1277 | 1277 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:24275569 |
| Q9P2E9 | 1253 | 1288 | 29 | 1410 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P2E9 | 1253 | 1288 | 29 | 1410 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P2E9 | 1289 | 1316 | 1 | 1410 | Chain | ID=PRO_0000097441;Note=Ribosome-binding protein 1 |
| Q9P2E9 | 1289 | 1316 | 1 | 1410 | Chain | ID=PRO_0000097441;Note=Ribosome-binding protein 1 |
| Q9P2E9 | 1289 | 1316 | 1312 | 1312 | Sequence conflict | Note=T->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9P2E9 | 1289 | 1316 | 1312 | 1312 | Sequence conflict | Note=T->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9P2E9 | 1289 | 1316 | 29 | 1410 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P2E9 | 1289 | 1316 | 29 | 1410 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9P2E9 | 1253 | 1288 | 1 | 1410 | Chain | ID=PRO_0000097441;Note=Ribosome-binding protein 1 |
| Q9P2E9 | 1253 | 1288 | 1 | 1410 | Chain | ID=PRO_0000097441;Note=Ribosome-binding protein 1 |
| Q9P2E9 | 1253 | 1288 | 1276 | 1276 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648 |
| Q9P2E9 | 1253 | 1288 | 1276 | 1276 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648 |
| Q9P2E9 | 1253 | 1288 | 1277 | 1277 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:24275569 |
| Q9P2E9 | 1253 | 1288 | 1277 | 1277 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:24275569 |
| Q9P2E9 | 1253 | 1288 | 29 | 1410 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P2E9 | 1253 | 1288 | 29 | 1410 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9P2E9 | 1018 | 1048 | 1 | 1410 | Chain | ID=PRO_0000097441;Note=Ribosome-binding protein 1 |
| Q9P2E9 | 1018 | 1048 | 1 | 1410 | Chain | ID=PRO_0000097441;Note=Ribosome-binding protein 1 |
| Q9P2E9 | 1018 | 1048 | 1043 | 1043 | Sequence conflict | Note=L->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9P2E9 | 1018 | 1048 | 1043 | 1043 | Sequence conflict | Note=L->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9P2E9 | 1018 | 1048 | 1043 | 1043 | Sequence conflict | Note=L->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9P2E9 | 1018 | 1048 | 1043 | 1043 | Sequence conflict | Note=L->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9P2E9 | 1018 | 1048 | 1043 | 1043 | Sequence conflict | Note=L->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9P2E9 | 1018 | 1048 | 1043 | 1043 | Sequence conflict | Note=L->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9P2E9 | 1018 | 1048 | 1043 | 1043 | Sequence conflict | Note=L->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9P2E9 | 1018 | 1048 | 1043 | 1043 | Sequence conflict | Note=L->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9P2E9 | 1018 | 1048 | 29 | 1410 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P2E9 | 1018 | 1048 | 29 | 1410 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P2E9 | 1253 | 1288 | 1 | 1410 | Chain | ID=PRO_0000097441;Note=Ribosome-binding protein 1 |
| Q9P2E9 | 1253 | 1288 | 1 | 1410 | Chain | ID=PRO_0000097441;Note=Ribosome-binding protein 1 |
| Q9P2E9 | 1253 | 1288 | 1276 | 1276 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648 |
| Q9P2E9 | 1253 | 1288 | 1276 | 1276 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648 |
| Q9P2E9 | 1253 | 1288 | 1277 | 1277 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:24275569 |
| Q9P2E9 | 1253 | 1288 | 1277 | 1277 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:24275569;Dbxref=PMID:18669648,PMID:24275569 |
| Q9P2E9 | 1253 | 1288 | 29 | 1410 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P2E9 | 1253 | 1288 | 29 | 1410 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in RRBP1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000377813 | 17679999 | 17680075 | hsa-miR-4254 | chr20:17680046-17680053 | 8mer-1a | chr20:17680046-17680066 | 160.00 | -25.13 |
| Mayo | ENST00000377813 | 17679999 | 17680075 | hsa-miR-7162-3p | chr20:17680053-17680060 | 8mer-1a | chr20:17680046-17680066 | 160.00 | -25.13 |
| Mayo | ENST00000377813 | 17679999 | 17680075 | hsa-miR-1267 | chr20:17680024-17680031 | 8mer-1a | chr20:17680011-17680031 | 158.00 | -14.95 |
| Mayo | ENST00000377813 | 17679999 | 17680075 | hsa-miR-642a-5p | chr20:17680031-17680038 | 8mer-1a | chr20:17680029-17680050 | 164.00 | -23.03 |
| Mayo | ENST00000377813 | 17679999 | 17680075 | hsa-miR-12119 | chr20:17680054-17680061 | 8mer-1a | chr20:17680046-17680066 | 160.00 | -25.13 |
| Mayo | ENST00000377813 | 17679999 | 17680075 | hsa-miR-6892-3p | chr20:17680030-17680037 | 8mer-1a | chr20:17680029-17680050 | 164.00 | -23.03 |
| Mayo | ENST00000377813 | 17679999 | 17680075 | hsa-miR-671-3p | chr20:17680059-17680066 | 8mer-1a | chr20:17680046-17680066 | 160.00 | -25.13 |
| Mayo | ENST00000377813 | 17679999 | 17680075 | hsa-miR-6851-5p | chr20:17680043-17680050 | 8mer-1a | chr20:17680029-17680050 | 164.00 | -23.03 |
| Mayo | ENST00000377813 | 17679999 | 17680075 | hsa-miR-3689d | chr20:17680043-17680050 | 8mer-1a | chr20:17680029-17680050 | 164.00 | -23.03 |
| MSBB | ENST00000377813 | 17679999 | 17680075 | hsa-miR-4254 | chr20:17680046-17680053 | 8mer-1a | chr20:17680046-17680066 | 160.00 | -25.13 |
| MSBB | ENST00000377813 | 17679999 | 17680075 | hsa-miR-7162-3p | chr20:17680053-17680060 | 8mer-1a | chr20:17680046-17680066 | 160.00 | -25.13 |
| MSBB | ENST00000377813 | 17679999 | 17680075 | hsa-miR-1267 | chr20:17680024-17680031 | 8mer-1a | chr20:17680011-17680031 | 158.00 | -14.95 |
| MSBB | ENST00000377813 | 17679999 | 17680075 | hsa-miR-642a-5p | chr20:17680031-17680038 | 8mer-1a | chr20:17680029-17680050 | 164.00 | -23.03 |
| MSBB | ENST00000377813 | 17679999 | 17680075 | hsa-miR-12119 | chr20:17680054-17680061 | 8mer-1a | chr20:17680046-17680066 | 160.00 | -25.13 |
| MSBB | ENST00000377813 | 17679999 | 17680075 | hsa-miR-6892-3p | chr20:17680030-17680037 | 8mer-1a | chr20:17680029-17680050 | 164.00 | -23.03 |
| MSBB | ENST00000377813 | 17679999 | 17680075 | hsa-miR-671-3p | chr20:17680059-17680066 | 8mer-1a | chr20:17680046-17680066 | 160.00 | -25.13 |
| MSBB | ENST00000377813 | 17679999 | 17680075 | hsa-miR-6851-5p | chr20:17680043-17680050 | 8mer-1a | chr20:17680029-17680050 | 164.00 | -23.03 |
| MSBB | ENST00000377813 | 17679999 | 17680075 | hsa-miR-3689d | chr20:17680043-17680050 | 8mer-1a | chr20:17680029-17680050 | 164.00 | -23.03 |
| ROSMAP | ENST00000377813 | 17679999 | 17680075 | hsa-miR-4254 | chr20:17680046-17680053 | 8mer-1a | chr20:17680046-17680066 | 160.00 | -25.13 |
| ROSMAP | ENST00000377813 | 17679999 | 17680075 | hsa-miR-7162-3p | chr20:17680053-17680060 | 8mer-1a | chr20:17680046-17680066 | 160.00 | -25.13 |
| ROSMAP | ENST00000377813 | 17679999 | 17680075 | hsa-miR-1267 | chr20:17680024-17680031 | 8mer-1a | chr20:17680011-17680031 | 158.00 | -14.95 |
| ROSMAP | ENST00000377813 | 17679999 | 17680075 | hsa-miR-642a-5p | chr20:17680031-17680038 | 8mer-1a | chr20:17680029-17680050 | 164.00 | -23.03 |
| ROSMAP | ENST00000377813 | 17679999 | 17680075 | hsa-miR-12119 | chr20:17680054-17680061 | 8mer-1a | chr20:17680046-17680066 | 160.00 | -25.13 |
| ROSMAP | ENST00000377813 | 17679999 | 17680075 | hsa-miR-6892-3p | chr20:17680030-17680037 | 8mer-1a | chr20:17680029-17680050 | 164.00 | -23.03 |
| ROSMAP | ENST00000377813 | 17679999 | 17680075 | hsa-miR-671-3p | chr20:17680059-17680066 | 8mer-1a | chr20:17680046-17680066 | 160.00 | -25.13 |
| ROSMAP | ENST00000377813 | 17679999 | 17680075 | hsa-miR-6851-5p | chr20:17680043-17680050 | 8mer-1a | chr20:17680029-17680050 | 164.00 | -23.03 |
| ROSMAP | ENST00000377813 | 17679999 | 17680075 | hsa-miR-3689d | chr20:17680043-17680050 | 8mer-1a | chr20:17680029-17680050 | 164.00 | -23.03 |
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SNVs in the skipped exons for RRBP1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for RRBP1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RRBP1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for RRBP1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TRA2A | exon_skip_108139 | -4.107781e-01 | 9.108024e-08 |
| IFG | RBM25 | exon_skip_108139 | 4.801125e-01 | 1.514205e-02 |
| IFG | SFPQ | exon_skip_108139 | 4.445772e-01 | 2.597112e-02 |
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RelatedDrugs for RRBP1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RRBP1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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