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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for RPS24 |
 Gene summary |
| Gene information | Gene symbol | RPS24 | Gene ID | 6229 |
| Gene name | ribosomal protein S24 | |
| Synonyms | DBA3|S24|eS24 | |
| Cytomap | 10q22.3 | |
| Type of gene | protein-coding | |
| Description | 40S ribosomal protein S24small ribosomal subunit protein eS24 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for RPS24 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000138326
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for RPS24 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_100729 | chr10 | 78037198:78037304:78037965:78037982:78040204:78040225 | 78037965:78037982 |
| exon_skip_109275 | chr10 | 78035352:78035417:78035511:78035720:78037194:78037218 | 78035511:78035720 |
| exon_skip_125395 | chr10 | 78037194:78037304:78040615:78040747:78048981:78049164 | 78040615:78040747 |
| exon_skip_132654 | chr10 | 78037251:78037304:78037965:78037993:78040204:78040225 | 78037965:78037993 |
| exon_skip_140381 | chr10 | 78037194:78037304:78037965:78037993:78040204:78040225 | 78037965:78037993 |
| exon_skip_143142 | chr10 | 78037257:78037304:78040615:78040747:78048981:78049164 | 78040615:78040747 |
| exon_skip_157298 | chr10 | 78037251:78037304:78040204:78040225:78040615:78040696 | 78040204:78040225 |
| exon_skip_162676 | chr10 | 78033891:78033904:78035352:78035417:78035511:78035720 | 78035352:78035417 |
| exon_skip_173990 | chr10 | 78037251:78037304:78037439:78037441:78037965:78037982 | 78037439:78037441 |
| exon_skip_184826 | chr10 | 78037275:78037304:78037965:78037982:78040204:78040225 | 78037965:78037982 |
| exon_skip_185919 | chr10 | 78037194:78037304:78040615:78040747:78048981:78049225 | 78040615:78040747 |
| exon_skip_196416 | chr10 | 78037194:78037304:78040204:78040225:78040615:78040696 | 78040204:78040225 |
| exon_skip_200228 | chr10 | 78037194:78037304:78037439:78037441:78037965:78037982 | 78037439:78037441 |
| exon_skip_206173 | chr10 | 78037194:78037304:78040201:78040225:78040615:78040696 | 78040201:78040225 |
| exon_skip_206600 | chr10 | 78037275:78037304:78037965:78037993:78040204:78040225 | 78037965:78037993 |
| exon_skip_209200 | chr10 | 78037194:78037304:78037439:78037441:78040204:78040225 | 78037439:78037441 |
| exon_skip_212855 | chr10 | 78037194:78037304:78037439:78040225:78040615:78040696 | 78037439:78040225 |
| exon_skip_222548 | chr10 | 78035707:78035720:78037194:78037304:78040204:78040225 | 78037194:78037304 |
| exon_skip_23657 | chr10 | 78037275:78037304:78040204:78040225:78040615:78040696 | 78040204:78040225 |
| exon_skip_243250 | chr10 | 78037198:78037304:78037965:78037993:78040204:78040225 | 78037965:78037993 |
| exon_skip_250318 | chr10 | 78037251:78037304:78037439:78037441:78040204:78040225 | 78037439:78037441 |
| exon_skip_268851 | chr10 | 78037275:78037304:78040201:78040225:78040615:78040696 | 78040201:78040225 |
| exon_skip_29241 | chr10 | 78037194:78037304:78037965:78037982:78040204:78040225 | 78037965:78037982 |
| exon_skip_293549 | chr10 | 78033891:78033904:78035352:78035417:78035511:78035552 | 78035352:78035417 |
| exon_skip_33142 | chr10 | 78037275:78037304:78037439:78037441:78037965:78037982 | 78037439:78037441 |
| exon_skip_41106 | chr10 | 78037251:78037304:78040201:78040225:78040615:78040696 | 78040201:78040225 |
| exon_skip_5165 | chr10 | 78037251:78037304:78037965:78037982:78040204:78040225 | 78037965:78037982 |
| exon_skip_54172 | chr10 | 78037275:78037304:78037439:78037441:78040204:78040225 | 78037439:78037441 |
| exon_skip_82348 | chr10 | 78037439:78037441:78037965:78037982:78040204:78040225 | 78037965:78037982 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_82348 | MSBB_PG | 3.853731e-01 | 4.863636e-01 | -1.009905e-01 | 7.512549e-03 |
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Open reading frame (ORF) annotation in the exon skipping event for RPS24 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000613865 | 78035352 | 78035417 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000613865 | 78035352 | 78035417 | In-frame |
| ENST00000613865 | 78035511 | 78035720 | In-frame |
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Infer the effects of exon skipping event on protein functional features for RPS24 |
p-ENSG00000138326_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000613865 | 651 | 133 | 78035352 | 78035417 | 147 | 211 | 1 | 23 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000613865 | 651 | 133 | 78035352 | 78035417 | 147 | 211 | 1 | 23 |
| ENST00000613865 | 651 | 133 | 78035511 | 78035720 | 213 | 421 | 23 | 93 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P62847 | 1 | 23 | 1 | 133 | Chain | ID=PRO_0000137623;Note=40S ribosomal protein S24 |
| P62847 | 1 | 23 | 1 | 1 | Modified residue | Note=N-acetylmethionine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:19413330,ECO:0000244|PubMed:22223895,ECO:0000244|PubMed:22814378,ECO:0000269|Ref.9;Dbxref=PMID:19413330,PMID:22223895,PMID:22814378 |
| P62847 | 1 | 23 | 9 | 9 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P62847 | 1 | 23 | 1 | 133 | Chain | ID=PRO_0000137623;Note=40S ribosomal protein S24 |
| P62847 | 1 | 23 | 1 | 1 | Modified residue | Note=N-acetylmethionine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:19413330,ECO:0000244|PubMed:22223895,ECO:0000244|PubMed:22814378,ECO:0000269|Ref.9;Dbxref=PMID:19413330,PMID:22223895,PMID:22814378 |
| P62847 | 1 | 23 | 9 | 9 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231 |
| P62847 | 23 | 93 | 1 | 133 | Chain | ID=PRO_0000137623;Note=40S ribosomal protein S24 |
| P62847 | 23 | 93 | 37 | 37 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
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3'-UTR located exon skipping events that lost miRNA binding sites in RPS24 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for RPS24 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for RPS24 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RPS24 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for RPS24 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | TRA2A | exon_skip_29241 | 4.861082e-01 | 8.270420e-11 |
| CB | SRSF4 | exon_skip_29241 | 4.839356e-01 | 1.031166e-10 |
| CB | TRA2A | exon_skip_82348 | 5.402238e-01 | 1.993232e-13 |
| CB | SRSF4 | exon_skip_82348 | 5.575043e-01 | 2.294798e-14 |
| DLPFC | NUP42 | exon_skip_5165 | 4.654220e-01 | 1.608230e-14 |
| DLPFC | SRSF4 | exon_skip_5165 | 4.783291e-01 | 2.351518e-15 |
| HCC | PABPN1 | exon_skip_200228 | -4.411187e-01 | 1.994175e-14 |
| HCC | RBM5 | exon_skip_200228 | -4.296200e-01 | 1.091078e-13 |
| HCC | TRA2A | exon_skip_200228 | -4.650609e-01 | 4.684230e-16 |
| HCC | NUP42 | exon_skip_200228 | -4.376770e-01 | 3.339002e-14 |
| HCC | PABPC4 | exon_skip_200228 | -4.485083e-01 | 6.464039e-15 |
| HCC | PABPN1 | exon_skip_82348 | -4.197418e-01 | 4.929922e-13 |
| HCC | SRSF4 | exon_skip_82348 | -4.608700e-01 | 1.041666e-15 |
| IFG | TRA2A | exon_skip_82348 | -4.727976e-01 | 1.106044e-02 |
| IFG | PABPC4 | exon_skip_82348 | -5.890099e-01 | 9.749533e-04 |
| STG | NUP42 | exon_skip_82348 | 4.241600e-01 | 3.438458e-05 |
| TC | NUP42 | exon_skip_184826 | 4.515142e-01 | 2.066195e-09 |
| TC | NUP42 | exon_skip_82348 | 5.522442e-01 | 3.731744e-14 |
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RelatedDrugs for RPS24 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RPS24 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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