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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for RPS6KA2 |
 Gene summary |
| Gene information | Gene symbol | RPS6KA2 | Gene ID | 6196 |
| Gene name | ribosomal protein S6 kinase A2 | |
| Synonyms | HU-2|MAPKAPK1C|RSK|RSK3|S6K-alpha|S6K-alpha2|p90-RSK3|p90RSK2|pp90RSK3 | |
| Cytomap | 6q27 | |
| Type of gene | protein-coding | |
| Description | ribosomal protein S6 kinase alpha-2MAP kinase-activated protein kinase 1cMAPK-activated protein kinase 1cMAPKAP kinase 1Cmitogen-activated protein kinase-activated protein kinase 1Cribosomal S6 kinase 3ribosomal protein S6 kinase, 90kDa, polypeptide | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| RPS6KA2 | GO:0008285 | negative regulation of cell proliferation | 16878154 |
| RPS6KA2 | GO:0043065 | positive regulation of apoptotic process | 16878154 |
| RPS6KA2 | GO:0045786 | negative regulation of cell cycle | 16878154 |
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Gene structures and expression levels for RPS6KA2 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000071242
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000511034.1 | RPS6KA2-212:protein_coding:RPS6KA2 | 1.500124e+00 | 8.633657e-01 | 1.281992e-03 | 6.361836e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for RPS6KA2 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_135431 | chr6 | 166419882:166419958:166423256:166423417:166430453:166430611 | 166423256:166423417 |
| exon_skip_153881 | chr6 | 166498611:166498650:166500887:166500924:166504506:166504612 | 166500887:166500924 |
| exon_skip_156535 | chr6 | 166488833:166488921:166490671:166490741:166498508:166498650 | 166490671:166490741 |
| exon_skip_197045 | chr6 | 166538668:166538784:166770863:166770913:166858200:166858259 | 166770863:166770913 |
| exon_skip_210689 | chr6 | 166430453:166430611:166432401:166432490:166448724:166448849 | 166432401:166432490 |
| exon_skip_245219 | chr6 | 166448724:166448849:166451103:166451233:166459449:166459551 | 166451103:166451233 |
| exon_skip_61317 | chr6 | 166418225:166418342:166419882:166419958:166423256:166423417 | 166419882:166419958 |
| exon_skip_82993 | chr6 | 166413794:166413931:166418225:166418342:166419882:166419958 | 166418225:166418342 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for RPS6KA2 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000265678 | 166418225 | 166418342 | Frame-shift |
| ENST00000265678 | 166500887 | 166500924 | Frame-shift |
| ENST00000265678 | 166432401 | 166432490 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000265678 | 166418225 | 166418342 | Frame-shift |
| ENST00000265678 | 166432401 | 166432490 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000265678 | 166418225 | 166418342 | Frame-shift |
| ENST00000265678 | 166419882 | 166419958 | Frame-shift |
| ENST00000265678 | 166451103 | 166451233 | Frame-shift |
| ENST00000265678 | 166490671 | 166490741 | Frame-shift |
| ENST00000265678 | 166500887 | 166500924 | Frame-shift |
| ENST00000265678 | 166423256 | 166423417 | In-frame |
| ENST00000265678 | 166432401 | 166432490 | In-frame |
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Infer the effects of exon skipping event on protein functional features for RPS6KA2 |
p-ENSG00000071242_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000265678 | 5841 | 733 | 166432401 | 166432490 | 1557 | 1645 | 444 | 473 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000265678 | 5841 | 733 | 166432401 | 166432490 | 1557 | 1645 | 444 | 473 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000265678 | 5841 | 733 | 166432401 | 166432490 | 1557 | 1645 | 444 | 473 |
| ENST00000265678 | 5841 | 733 | 166423256 | 166423417 | 1806 | 1966 | 527 | 580 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q15349 | 444 | 473 | 444 | 444 | Binding site | Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q15349 | 444 | 473 | 1 | 733 | Chain | ID=PRO_0000086201;Note=Ribosomal protein S6 kinase alpha-2 |
| Q15349 | 444 | 473 | 415 | 672 | Domain | Note=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q15349 | 444 | 473 | 447 | 447 | Sequence conflict | Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q15349 | 444 | 473 | 444 | 444 | Binding site | Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q15349 | 444 | 473 | 1 | 733 | Chain | ID=PRO_0000086201;Note=Ribosomal protein S6 kinase alpha-2 |
| Q15349 | 444 | 473 | 415 | 672 | Domain | Note=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q15349 | 444 | 473 | 447 | 447 | Sequence conflict | Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q15349 | 444 | 473 | 444 | 444 | Binding site | Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q15349 | 444 | 473 | 1 | 733 | Chain | ID=PRO_0000086201;Note=Ribosomal protein S6 kinase alpha-2 |
| Q15349 | 444 | 473 | 415 | 672 | Domain | Note=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q15349 | 444 | 473 | 447 | 447 | Sequence conflict | Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q15349 | 527 | 580 | 532 | 532 | Active site | Note=Proton acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q15349 | 527 | 580 | 1 | 733 | Chain | ID=PRO_0000086201;Note=Ribosomal protein S6 kinase alpha-2 |
| Q15349 | 527 | 580 | 415 | 672 | Domain | Note=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
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3'-UTR located exon skipping events that lost miRNA binding sites in RPS6KA2 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for RPS6KA2 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for RPS6KA2 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RPS6KA2 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for RPS6KA2 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for RPS6KA2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RPS6KA2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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