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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for RPL10 |
 Gene summary |
| Gene information | Gene symbol | RPL10 | Gene ID | 6134 |
| Gene name | ribosomal protein L10 | |
| Synonyms | AUTSX5|DXS648|DXS648E|L10|MRXS35|NOV|QM | |
| Cytomap | Xq28 | |
| Type of gene | protein-coding | |
| Description | 60S ribosomal protein L10Wilms tumor-related proteinlaminin receptor homologlarge ribosomal subunit protein uL16tumor suppressor QM | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for RPL10 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000147403
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000489200.5 | RPL10-215:retained_intron:RPL10 | 1.678968e+01 | -1.548154e+00 | 7.359602e-04 | 3.993131e-03 |
| CB | DOWN | ENST00000618723.4 | RPL10-218:protein_coding:RPL10 | 1.553532e+01 | -1.242028e+00 | 1.169683e-03 | 5.895137e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for RPL10 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_12522 | chrX | 154399803:154399941:154400464:154400626:154400702:154400781 | 154400464:154400626 |
| exon_skip_145792 | chrX | 154399803:154399941:154400464:154400626:154400702:154400715 | 154400464:154400626 |
| exon_skip_188790 | chrX | 154399803:154399941:154400464:154400626:154400702:154400739 | 154400464:154400626 |
| exon_skip_193304 | chrX | 154399338:154399396:154399487:154399594:154399803:154399848 | 154399487:154399594 |
| exon_skip_209637 | chrX | 154399366:154399396:154399487:154399594:154399803:154399941 | 154399487:154399594 |
| exon_skip_216254 | chrX | 154399338:154399396:154399487:154399594:154399803:154399941 | 154399487:154399594 |
| exon_skip_266699 | chrX | 154399803:154399941:154400464:154400626:154400702:154400917 | 154400464:154400626 |
| exon_skip_289585 | chrX | 154399803:154399941:154400464:154400626:154400702:154400740 | 154400464:154400626 |
| exon_skip_42522 | chrX | 154399803:154399941:154400464:154400626:154400702:154400736 | 154400464:154400626 |
| exon_skip_78981 | chrX | 154399338:154399396:154399487:154399594:154399803:154399821 | 154399487:154399594 |
| exon_skip_82351 | chrX | 154399338:154399396:154399487:154399594:154399803:154399829 | 154399487:154399594 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for RPL10 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000369817 | 154400464 | 154400626 | Frame-shift |
| ENST00000424325 | 154400464 | 154400626 | Frame-shift |
| ENST00000369817 | 154399487 | 154399594 | In-frame |
| ENST00000424325 | 154399487 | 154399594 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000369817 | 154400464 | 154400626 | Frame-shift |
| ENST00000424325 | 154400464 | 154400626 | Frame-shift |
| ENST00000369817 | 154399487 | 154399594 | In-frame |
| ENST00000424325 | 154399487 | 154399594 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000369817 | 154400464 | 154400626 | Frame-shift |
| ENST00000424325 | 154400464 | 154400626 | Frame-shift |
| ENST00000369817 | 154399487 | 154399594 | In-frame |
| ENST00000424325 | 154399487 | 154399594 | In-frame |
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Infer the effects of exon skipping event on protein functional features for RPL10 |
p-ENSG00000147403_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000369817 | 1301 | 214 | 154399487 | 154399594 | 660 | 766 | 28 | 63 |
| ENST00000424325 | 2335 | 214 | 154399487 | 154399594 | 272 | 378 | 28 | 63 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000369817 | 1301 | 214 | 154399487 | 154399594 | 660 | 766 | 28 | 63 |
| ENST00000424325 | 2335 | 214 | 154399487 | 154399594 | 272 | 378 | 28 | 63 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000369817 | 1301 | 214 | 154399487 | 154399594 | 660 | 766 | 28 | 63 |
| ENST00000424325 | 2335 | 214 | 154399487 | 154399594 | 272 | 378 | 28 | 63 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P27635 | 28 | 63 | 48 | 54 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2 |
| P27635 | 28 | 63 | 48 | 54 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2 |
| P27635 | 28 | 63 | 58 | 61 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2 |
| P27635 | 28 | 63 | 58 | 61 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2 |
| P27635 | 28 | 63 | 2 | 214 | Chain | ID=PRO_0000147105;Note=60S ribosomal protein L10 |
| P27635 | 28 | 63 | 2 | 214 | Chain | ID=PRO_0000147105;Note=60S ribosomal protein L10 |
| P27635 | 28 | 63 | 62 | 80 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2 |
| P27635 | 28 | 63 | 62 | 80 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2 |
| P27635 | 28 | 63 | 32 | 32 | Modified residue | Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P27635 | 28 | 63 | 32 | 32 | Modified residue | Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P27635 | 28 | 63 | 43 | 45 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2 |
| P27635 | 28 | 63 | 43 | 45 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P27635 | 28 | 63 | 48 | 54 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2 |
| P27635 | 28 | 63 | 48 | 54 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2 |
| P27635 | 28 | 63 | 58 | 61 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2 |
| P27635 | 28 | 63 | 58 | 61 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2 |
| P27635 | 28 | 63 | 2 | 214 | Chain | ID=PRO_0000147105;Note=60S ribosomal protein L10 |
| P27635 | 28 | 63 | 2 | 214 | Chain | ID=PRO_0000147105;Note=60S ribosomal protein L10 |
| P27635 | 28 | 63 | 62 | 80 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2 |
| P27635 | 28 | 63 | 62 | 80 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2 |
| P27635 | 28 | 63 | 32 | 32 | Modified residue | Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P27635 | 28 | 63 | 32 | 32 | Modified residue | Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P27635 | 28 | 63 | 43 | 45 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2 |
| P27635 | 28 | 63 | 43 | 45 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P27635 | 28 | 63 | 48 | 54 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2 |
| P27635 | 28 | 63 | 48 | 54 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2 |
| P27635 | 28 | 63 | 58 | 61 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2 |
| P27635 | 28 | 63 | 58 | 61 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2 |
| P27635 | 28 | 63 | 2 | 214 | Chain | ID=PRO_0000147105;Note=60S ribosomal protein L10 |
| P27635 | 28 | 63 | 2 | 214 | Chain | ID=PRO_0000147105;Note=60S ribosomal protein L10 |
| P27635 | 28 | 63 | 62 | 80 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2 |
| P27635 | 28 | 63 | 62 | 80 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2 |
| P27635 | 28 | 63 | 32 | 32 | Modified residue | Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P27635 | 28 | 63 | 32 | 32 | Modified residue | Note=Citrulline;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| P27635 | 28 | 63 | 43 | 45 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2 |
| P27635 | 28 | 63 | 43 | 45 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2PA2 |
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3'-UTR located exon skipping events that lost miRNA binding sites in RPL10 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for RPL10 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for RPL10 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RPL10 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for RPL10 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for RPL10 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RPL10 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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