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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for RPL5 |
 Gene summary |
| Gene information | Gene symbol | RPL5 | Gene ID | 6125 |
| Gene name | ribosomal protein L5 | |
| Synonyms | L5|MSTP030|PPP1R135|uL18 | |
| Cytomap | 1p22.1 | |
| Type of gene | protein-coding | |
| Description | 60S ribosomal protein L5large ribosomal subunit protein uL18protein phosphatase 1, regulatory subunit 135 | |
| Modification date | 20200313 | |
| UniProtAcc | A0A2R8Y4A2, | |
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| RPL5 | GO:0010628 | positive regulation of gene expression | 18560357 |
| RPL5 | GO:0045727 | positive regulation of translation | 16213212 |
| RPL5 | GO:1904667 | negative regulation of ubiquitin protein ligase activity | 18560357 |
| RPL5 | GO:2000059 | negative regulation of ubiquitin-dependent protein catabolic process | 18560357 |
| RPL5 | GO:2000435 | negative regulation of protein neddylation | 18560357 |
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Gene structures and expression levels for RPL5 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000122406
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PCC | UP | ENST00000645300.1 | RPL5-209:protein_coding:RPL5 | 4.904114e+01 | 8.316365e-01 | 1.247076e-05 | 1.480629e-03 |
| CB | DOWN | ENST00000644549.1 | RPL5-207:retained_intron:RPL5 | 6.943964e+02 | -1.880923e+00 | 9.321653e-15 | 3.307936e-12 |
| CB | UP | ENST00000645300.1 | RPL5-209:protein_coding:RPL5 | 4.640565e+02 | 1.149803e+00 | 5.647243e-13 | 9.277145e-11 |
| TC | DOWN | ENST00000644549.1 | RPL5-207:retained_intron:RPL5 | 4.838262e+02 | -1.395502e+00 | 1.886143e-10 | 3.352070e-08 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for RPL5 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_183196 | chr1 | 92832086:92832117:92833389:92833458:92833545:92833660 | 92833389:92833458 |
| exon_skip_186687 | chr1 | 92832086:92832117:92833389:92833458:92833545:92833621 | 92833389:92833458 |
| exon_skip_20005 | chr1 | 92833545:92833660:92834779:92834913:92836190:92836271 | 92834779:92834913 |
| exon_skip_204632 | chr1 | 92833545:92833660:92833796:92833949:92834779:92834794 | 92833796:92833949 |
| exon_skip_208552 | chr1 | 92833545:92833660:92833796:92833949:92834779:92834913 | 92833796:92833949 |
| exon_skip_222217 | chr1 | 92832086:92832117:92833389:92833458:92833545:92833614 | 92833389:92833458 |
| exon_skip_39682 | chr1 | 92832098:92832117:92833389:92833458:92833545:92833660 | 92833389:92833458 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for RPL5 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370321 | 92833389 | 92833458 | Frame-shift |
| ENST00000370321 | 92834779 | 92834913 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370321 | 92833389 | 92833458 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370321 | 92833389 | 92833458 | Frame-shift |
| ENST00000370321 | 92834779 | 92834913 | In-frame |
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Infer the effects of exon skipping event on protein functional features for RPL5 |
p-ENSG00000122406_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000370321 | 1045 | 297 | 92834779 | 92834913 | 266 | 399 | 63 | 108 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000370321 | 1045 | 297 | 92834779 | 92834913 | 266 | 399 | 63 | 108 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P46777 | 63 | 108 | 2 | 297 | Chain | ID=PRO_0000131431;Note=60S ribosomal protein L5 |
| P46777 | 63 | 108 | 78 | 78 | Sequence conflict | Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P46777 | 63 | 108 | 2 | 297 | Chain | ID=PRO_0000131431;Note=60S ribosomal protein L5 |
| P46777 | 63 | 108 | 78 | 78 | Sequence conflict | Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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3'-UTR located exon skipping events that lost miRNA binding sites in RPL5 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for RPL5 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for RPL5 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | ROSMAP | HCC | exon_skip_183196 | -3.344956e-01 | 1.470000e-08 | chr1 | + | 92832086 | 92832117 | 92833389 | 92833458 | 92833545 | 92833660 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RPL5 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for RPL5 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for RPL5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RPL5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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