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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for BCL6 |
 Gene summary |
| Gene information | Gene symbol | BCL6 | Gene ID | 604 |
| Gene name | BCL6 transcription repressor | |
| Synonyms | BCL5|BCL6A|LAZ3|ZBTB27|ZNF51 | |
| Cytomap | 3q27.3 | |
| Type of gene | protein-coding | |
| Description | B-cell lymphoma 6 proteinB cell CLL/lymphoma 6B-cell lymphoma 5 proteinB-cell lymphoma 6 protein transcriptBCL-5BCL-6cys-his2 zinc finger transcription factorlymphoma-associated zinc finger gene on chromosome 3protein LAZ-3zinc finger and BTB dom | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| BCL6 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 11929873|15577913 |
| BCL6 | GO:0006974 | cellular response to DNA damage stimulus | 15577913 |
| BCL6 | GO:0030308 | negative regulation of cell growth | 10490843 |
| BCL6 | GO:0043065 | positive regulation of apoptotic process | 10490843 |
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Gene structures and expression levels for BCL6 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000113916
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| STG | UP | ENST00000232014.8 | BCL6-201:protein_coding:BCL6 | 2.912144e+01 | 6.547639e+00 | 1.033999e-04 | 1.125795e-02 |
| PG | UP | ENST00000496823.1 | BCL6-210:lncRNA:BCL6 | 5.566299e+01 | 8.877049e-01 | 1.036307e-05 | 5.197368e-04 |
| CB | UP | ENST00000430339.5 | BCL6-204:protein_coding:BCL6 | 7.718346e+00 | 1.110305e+00 | 8.329047e-06 | 9.055650e-05 |
| CB | UP | ENST00000232014.8 | BCL6-201:protein_coding:BCL6 | 1.756875e+02 | 1.019442e+00 | 2.054012e-04 | 1.360977e-03 |
| TC | UP | ENST00000232014.8 | BCL6-201:protein_coding:BCL6 | 1.388317e+02 | 1.242772e+00 | 4.769561e-05 | 8.953080e-04 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for BCL6 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_238553 | chr3 | 187731780:187731930:187733533:187733703:187734869:187734882 | 187733533:187733703 |
| exon_skip_252926 | chr3 | 187725499:187725629:187726731:187726898:187728360:187728517 | 187726731:187726898 |
| exon_skip_44494 | chr3 | 187726731:187726898:187728360:187728544:187729050:187730016 | 187728360:187728544 |
| exon_skip_94030 | chr3 | 187725499:187725629:187726731:187726898:187728360:187728544 | 187726731:187726898 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for BCL6 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000232014 | 187726731 | 187726898 | In-frame |
| ENST00000406870 | 187726731 | 187726898 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000232014 | 187726731 | 187726898 | In-frame |
| ENST00000406870 | 187726731 | 187726898 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000232014 | 187733533 | 187733703 | 3UTR-3CDS |
| ENST00000406870 | 187733533 | 187733703 | 3UTR-3CDS |
| ENST00000232014 | 187728360 | 187728544 | Frame-shift |
| ENST00000406870 | 187728360 | 187728544 | Frame-shift |
| ENST00000232014 | 187726731 | 187726898 | In-frame |
| ENST00000406870 | 187726731 | 187726898 | In-frame |
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Infer the effects of exon skipping event on protein functional features for BCL6 |
p-ENSG00000113916_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000232014 | 2727 | 706 | 187726731 | 187726898 | 2070 | 2236 | 513 | 569 |
| ENST00000406870 | 3586 | 706 | 187726731 | 187726898 | 1908 | 2074 | 513 | 569 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000232014 | 2727 | 706 | 187726731 | 187726898 | 2070 | 2236 | 513 | 569 |
| ENST00000406870 | 3586 | 706 | 187726731 | 187726898 | 1908 | 2074 | 513 | 569 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000232014 | 2727 | 706 | 187726731 | 187726898 | 2070 | 2236 | 513 | 569 |
| ENST00000406870 | 3586 | 706 | 187726731 | 187726898 | 1908 | 2074 | 513 | 569 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P41182 | 513 | 569 | 514 | 569 | Alternative sequence | ID=VSP_042709;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5 |
| P41182 | 513 | 569 | 514 | 569 | Alternative sequence | ID=VSP_042709;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5 |
| P41182 | 513 | 569 | 521 | 523 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YRM |
| P41182 | 513 | 569 | 521 | 523 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YRM |
| P41182 | 513 | 569 | 527 | 529 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YRM |
| P41182 | 513 | 569 | 527 | 529 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YRM |
| P41182 | 513 | 569 | 1 | 706 | Chain | ID=PRO_0000047098;Note=B-cell lymphoma 6 protein |
| P41182 | 513 | 569 | 1 | 706 | Chain | ID=PRO_0000047098;Note=B-cell lymphoma 6 protein |
| P41182 | 513 | 569 | 530 | 540 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YRM |
| P41182 | 513 | 569 | 530 | 540 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YRM |
| P41182 | 513 | 569 | 558 | 568 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LCE |
| P41182 | 513 | 569 | 558 | 568 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LCE |
| P41182 | 513 | 569 | 520 | 523 | Mutagenesis | Note=No effect on DNA-binding%2C nuclear localization%2C transcriptional repression activity and interaction with HDAC5. CNEC->GNEG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12504096;Dbxref=PMID:12504096 |
| P41182 | 513 | 569 | 520 | 523 | Mutagenesis | Note=No effect on DNA-binding%2C nuclear localization%2C transcriptional repression activity and interaction with HDAC5. CNEC->GNEG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12504096;Dbxref=PMID:12504096 |
| P41182 | 513 | 569 | 548 | 551 | Mutagenesis | Note=No effect on DNA-binding%2C nuclear localization%2C transcriptional repression activity and interaction with HDAC5. CDRC->GDRG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12504096;Dbxref=PMID:12504096 |
| P41182 | 513 | 569 | 548 | 551 | Mutagenesis | Note=No effect on DNA-binding%2C nuclear localization%2C transcriptional repression activity and interaction with HDAC5. CDRC->GDRG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12504096;Dbxref=PMID:12504096 |
| P41182 | 513 | 569 | 518 | 541 | Zinc finger | Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 |
| P41182 | 513 | 569 | 518 | 541 | Zinc finger | Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 |
| P41182 | 513 | 569 | 546 | 568 | Zinc finger | Note=C2H2-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 |
| P41182 | 513 | 569 | 546 | 568 | Zinc finger | Note=C2H2-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P41182 | 513 | 569 | 514 | 569 | Alternative sequence | ID=VSP_042709;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5 |
| P41182 | 513 | 569 | 514 | 569 | Alternative sequence | ID=VSP_042709;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5 |
| P41182 | 513 | 569 | 521 | 523 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YRM |
| P41182 | 513 | 569 | 521 | 523 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YRM |
| P41182 | 513 | 569 | 527 | 529 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YRM |
| P41182 | 513 | 569 | 527 | 529 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YRM |
| P41182 | 513 | 569 | 1 | 706 | Chain | ID=PRO_0000047098;Note=B-cell lymphoma 6 protein |
| P41182 | 513 | 569 | 1 | 706 | Chain | ID=PRO_0000047098;Note=B-cell lymphoma 6 protein |
| P41182 | 513 | 569 | 530 | 540 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YRM |
| P41182 | 513 | 569 | 530 | 540 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YRM |
| P41182 | 513 | 569 | 558 | 568 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LCE |
| P41182 | 513 | 569 | 558 | 568 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LCE |
| P41182 | 513 | 569 | 520 | 523 | Mutagenesis | Note=No effect on DNA-binding%2C nuclear localization%2C transcriptional repression activity and interaction with HDAC5. CNEC->GNEG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12504096;Dbxref=PMID:12504096 |
| P41182 | 513 | 569 | 520 | 523 | Mutagenesis | Note=No effect on DNA-binding%2C nuclear localization%2C transcriptional repression activity and interaction with HDAC5. CNEC->GNEG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12504096;Dbxref=PMID:12504096 |
| P41182 | 513 | 569 | 548 | 551 | Mutagenesis | Note=No effect on DNA-binding%2C nuclear localization%2C transcriptional repression activity and interaction with HDAC5. CDRC->GDRG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12504096;Dbxref=PMID:12504096 |
| P41182 | 513 | 569 | 548 | 551 | Mutagenesis | Note=No effect on DNA-binding%2C nuclear localization%2C transcriptional repression activity and interaction with HDAC5. CDRC->GDRG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12504096;Dbxref=PMID:12504096 |
| P41182 | 513 | 569 | 518 | 541 | Zinc finger | Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 |
| P41182 | 513 | 569 | 518 | 541 | Zinc finger | Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 |
| P41182 | 513 | 569 | 546 | 568 | Zinc finger | Note=C2H2-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 |
| P41182 | 513 | 569 | 546 | 568 | Zinc finger | Note=C2H2-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P41182 | 513 | 569 | 514 | 569 | Alternative sequence | ID=VSP_042709;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5 |
| P41182 | 513 | 569 | 514 | 569 | Alternative sequence | ID=VSP_042709;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5 |
| P41182 | 513 | 569 | 521 | 523 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YRM |
| P41182 | 513 | 569 | 521 | 523 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YRM |
| P41182 | 513 | 569 | 527 | 529 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YRM |
| P41182 | 513 | 569 | 527 | 529 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YRM |
| P41182 | 513 | 569 | 1 | 706 | Chain | ID=PRO_0000047098;Note=B-cell lymphoma 6 protein |
| P41182 | 513 | 569 | 1 | 706 | Chain | ID=PRO_0000047098;Note=B-cell lymphoma 6 protein |
| P41182 | 513 | 569 | 530 | 540 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YRM |
| P41182 | 513 | 569 | 530 | 540 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2YRM |
| P41182 | 513 | 569 | 558 | 568 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LCE |
| P41182 | 513 | 569 | 558 | 568 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:2LCE |
| P41182 | 513 | 569 | 520 | 523 | Mutagenesis | Note=No effect on DNA-binding%2C nuclear localization%2C transcriptional repression activity and interaction with HDAC5. CNEC->GNEG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12504096;Dbxref=PMID:12504096 |
| P41182 | 513 | 569 | 520 | 523 | Mutagenesis | Note=No effect on DNA-binding%2C nuclear localization%2C transcriptional repression activity and interaction with HDAC5. CNEC->GNEG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12504096;Dbxref=PMID:12504096 |
| P41182 | 513 | 569 | 548 | 551 | Mutagenesis | Note=No effect on DNA-binding%2C nuclear localization%2C transcriptional repression activity and interaction with HDAC5. CDRC->GDRG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12504096;Dbxref=PMID:12504096 |
| P41182 | 513 | 569 | 548 | 551 | Mutagenesis | Note=No effect on DNA-binding%2C nuclear localization%2C transcriptional repression activity and interaction with HDAC5. CDRC->GDRG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12504096;Dbxref=PMID:12504096 |
| P41182 | 513 | 569 | 518 | 541 | Zinc finger | Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 |
| P41182 | 513 | 569 | 518 | 541 | Zinc finger | Note=C2H2-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 |
| P41182 | 513 | 569 | 546 | 568 | Zinc finger | Note=C2H2-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 |
| P41182 | 513 | 569 | 546 | 568 | Zinc finger | Note=C2H2-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00042 |
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3'-UTR located exon skipping events that lost miRNA binding sites in BCL6 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for BCL6 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for BCL6 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for BCL6 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for BCL6 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for BCL6 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BCL6 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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