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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for RGS7 |
Gene summary |
Gene information | Gene symbol | RGS7 | Gene ID | 6000 |
Gene name | regulator of G protein signaling 7 | |
Synonyms | - | |
Cytomap | 1q43|1q23.1 | |
Type of gene | protein-coding | |
Description | regulator of G-protein signaling 7regulator of G-protein signaling RGS7regulator of G-protein signalling 7 | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
RGS7 | GO:0043547 | positive regulation of GTPase activity | 10521509 |
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Gene structures and expression levels for RGS7 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for RGS7 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_143578 | chr1 | 240775515:240776213:240800641:240800721:240802904:240802993 | 240800641:240800721 |
exon_skip_145956 | chr1 | 240775515:240776213:240802904:240802993:240806140:240806326 | 240802904:240802993 |
exon_skip_181437 | chr1 | 240775515:240776213:240801455:240801508:240802904:240802993 | 240801455:240801508 |
exon_skip_202302 | chr1 | 240811918:240812043:240813618:240813728:240814716:240814777 | 240813618:240813728 |
exon_skip_208886 | chr1 | 240800641:240800721:240801455:240801508:240802904:240802993 | 240801455:240801508 |
exon_skip_214872 | chr1 | 240930717:240930768:240936600:240936706:240983079:240983129 | 240936600:240936706 |
exon_skip_295405 | chr1 | 240802904:240802993:240806140:240806326:240811918:240812043 | 240806140:240806326 |
exon_skip_58551 | chr1 | 240870055:240870119:240930717:240930768:240936600:240936706 | 240930717:240930768 |
exon_skip_59485 | chr1 | 240775515:240776213:240800641:240800721:240801455:240801508 | 240800641:240800721 |
exon_skip_59618 | chr1 | 240868776:240868852:240870055:240870119:240930717:240930768 | 240870055:240870119 |
exon_skip_95886 | chr1 | 240806140:240806326:240811918:240812043:240813618:240813728 | 240811918:240812043 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for RGS7 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for RGS7 |
p-ENSG00000182901_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in RGS7 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for RGS7 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for RGS7 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RGS7 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for RGS7 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
CB | NUP42 | exon_skip_59485 | 4.639767e-01 | 1.058349e-09 |
CB | PCBP4 | exon_skip_143578 | 4.127684e-01 | 7.065681e-08 |
CB | NUP42 | exon_skip_143578 | 5.049376e-01 | 1.329434e-11 |
CB | PTBP1 | exon_skip_143578 | -4.510334e-01 | 2.727213e-09 |
CB | DAZAP1 | exon_skip_202302 | -4.180811e-01 | 5.084837e-08 |
CB | CNOT4 | exon_skip_202302 | -4.378317e-01 | 9.790544e-09 |
CB | FUBP1 | exon_skip_202302 | -4.606788e-01 | 1.270925e-09 |
CB | PTBP1 | exon_skip_202302 | -4.695732e-01 | 5.506521e-10 |
TC | KHDRBS2 | exon_skip_143578 | 4.946876e-01 | 3.408563e-11 |
TC | NUP42 | exon_skip_143578 | 4.095003e-01 | 8.332226e-08 |
TC | RALYL | exon_skip_143578 | 4.265863e-01 | 2.060205e-08 |
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RelatedDrugs for RGS7 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RGS7 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |