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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for DPF2 |
Gene summary |
Gene information | Gene symbol | DPF2 | Gene ID | 5977 |
Gene name | double PHD fingers 2 | |
Synonyms | CSS7|REQ|UBID4|ubi-d4 | |
Cytomap | 11q13.1 | |
Type of gene | protein-coding | |
Description | zinc finger protein ubi-d4BAF45DBRG1-associated factor 45DD4, zinc and double PHD fingers family 2apoptosis response zinc finger proteinprotein requiemrequiem, apoptosis response zinc finger | |
Modification date | 20200313 | |
UniProtAcc | ||
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for DPF2 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
PG | UP | ENST00000415073.6 | DPF2-202:protein_coding:DPF2 | 2.290839e+00 | 3.063574e+00 | 8.311965e-04 | 1.274435e-02 |
CB | DOWN | ENST00000531989.1 | DPF2-208:protein_coding:DPF2 | 2.276274e+02 | -2.337627e+00 | 9.200970e-05 | 6.902326e-04 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for DPF2 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_10707 | chr11 | 65340966:65341073:65341399:65341562:65343745:65343837 | 65341399:65341562 |
exon_skip_158460 | chr11 | 65333877:65333918:65340385:65340545:65340966:65341073 | 65340385:65340545 |
exon_skip_169201 | chr11 | 65333875:65333918:65340385:65340545:65340966:65341073 | 65340385:65340545 |
exon_skip_173544 | chr11 | 65343755:65343837:65343991:65344069:65345666:65345803 | 65343991:65344069 |
exon_skip_48080 | chr11 | 65345930:65346058:65346247:65346359:65348850:65348931 | 65346247:65346359 |
exon_skip_69535 | chr11 | 65343991:65344069:65344580:65344621:65345666:65345706 | 65344580:65344621 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
exon_skip_69535 | ROSMAP_DLPFC | 3.272685e-01 | 4.465812e-01 | -1.193127e-01 | 7.338941e-05 |
exon_skip_69535 | ROSMAP_PCC | 3.904651e-01 | 4.941667e-01 | -1.037016e-01 | 3.304848e-04 |
exon_skip_69535 | Mayo_TC | 2.767073e-01 | 4.044156e-01 | -1.277083e-01 | 8.818273e-05 |
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Open reading frame (ORF) annotation in the exon skipping event for DPF2 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000528416 | 65340385 | 65340545 | Frame-shift |
ENST00000528416 | 65341399 | 65341562 | Frame-shift |
ENST00000528416 | 65346247 | 65346359 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000528416 | 65343991 | 65344069 | Frame-shift |
ENST00000528416 | 65346247 | 65346359 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000528416 | 65340385 | 65340545 | Frame-shift |
ENST00000528416 | 65341399 | 65341562 | Frame-shift |
ENST00000528416 | 65343991 | 65344069 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for DPF2 |
p-ENSG00000133884_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in DPF2 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for DPF2 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for DPF2 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DPF2 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for DPF2 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
DLPFC | KHDRBS2 | exon_skip_69535 | 6.639764e-01 | 1.076379e-43 |
FL | KHDRBS3 | exon_skip_69535 | 5.551379e-01 | 1.678714e-13 |
FL | HNRNPL | exon_skip_69535 | 5.355217e-01 | 1.654835e-12 |
HCC | PCBP1 | exon_skip_69535 | -4.415755e-01 | 1.861492e-14 |
HCC | UNK | exon_skip_69535 | -5.196776e-01 | 2.755173e-20 |
HCC | KHDRBS2 | exon_skip_69535 | 4.835929e-01 | 2.084979e-17 |
HCC | KHDRBS3 | exon_skip_69535 | -4.992472e-01 | 1.293806e-18 |
HCC | HNRNPAB | exon_skip_69535 | -4.636518e-01 | 5.889782e-16 |
IFG | IGF2BP2 | exon_skip_69535 | -5.107858e-01 | 5.477696e-03 |
STG | IGF2BP2 | exon_skip_69535 | -4.044950e-01 | 2.397063e-04 |
STG | KHDRBS2 | exon_skip_69535 | 5.331331e-01 | 5.030143e-07 |
STG | KHDRBS3 | exon_skip_69535 | 5.388174e-01 | 3.599491e-07 |
STG | HNRNPL | exon_skip_69535 | 5.136625e-01 | 1.512843e-06 |
STG | CELF1 | exon_skip_69535 | 4.678068e-01 | 1.570560e-05 |
TC | KHDRBS2 | exon_skip_69535 | 6.700682e-01 | 4.516690e-22 |
TC | KHDRBS3 | exon_skip_69535 | 5.093631e-01 | 7.059520e-12 |
TC | HNRNPL | exon_skip_69535 | 4.193501e-01 | 3.758780e-08 |
TC | CELF1 | exon_skip_69535 | 4.758016e-01 | 2.323249e-10 |
TC | SRSF5 | exon_skip_69535 | 5.522120e-01 | 4.508352e-14 |
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RelatedDrugs for DPF2 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DPF2 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |