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Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for HIVEP3 |
Gene summary |
Gene information | Gene symbol | HIVEP3 | Gene ID | 59269 |
Gene name | HIVEP zinc finger 3 | |
Synonyms | KBP-1|KBP1|KRC|SHN3|Schnurri-3|ZAS3|ZNF40C | |
Cytomap | 1p34.2 | |
Type of gene | protein-coding | |
Description | transcription factor HIVEP3ZAS family, member 3human immunodeficiency virus type I enhancer binding protein 3kappa-B and V(D)J recombination signal sequences-binding proteinkappa-binding protein 1zinc finger protein ZAS3 | |
Modification date | 20200313 | |
UniProtAcc | Q5T1R4, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
HIVEP3 | GO:0045893 | positive regulation of transcription, DNA-templated | 15790681 |
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Gene structures and expression levels for HIVEP3 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
CB | DOWN | ENST00000643665.1 | HIVEP3-207:protein_coding:HIVEP3 | 1.026763e+02 | -1.483893e+00 | 1.388311e-02 | 4.530954e-02 |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for HIVEP3 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_167625 | chr1 | 41848871:41849089:41918413:41918524:42035807:42035925 | 41918413:41918524 |
exon_skip_173802 | chr1 | 41518402:41518488:41524735:41524910:41575544:41575603 | 41524735:41524910 |
exon_skip_245775 | chr1 | 41847948:41848445:41848871:41849089:41918413:41918524 | 41848871:41849089 |
exon_skip_246892 | chr1 | 41628749:41628947:41700916:41700995:41918413:41918707 | 41700916:41700995 |
exon_skip_27774 | chr1 | 41518402:41518488:41524735:41524910:41575544:41575689 | 41524735:41524910 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for HIVEP3 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000372583 | 41700916 | 41700995 | 3UTR-3UTR |
ENST00000372583 | 41524735 | 41524910 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000372583 | 41700916 | 41700995 | 3UTR-3UTR |
ENST00000372583 | 41524735 | 41524910 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000372583 | 41700916 | 41700995 | 3UTR-3UTR |
ENST00000372583 | 41524735 | 41524910 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for HIVEP3 |
p-ENSG00000127124_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in HIVEP3 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Mayo | ENST00000372583 | 41700916 | 41700995 | hsa-miR-6730-3p | chr1:41700951-41700958 | 8mer-1a | chr1:41700948-41700968 | 163.00 | -17.25 |
Mayo | ENST00000372583 | 41700916 | 41700995 | hsa-miR-8067 | chr1:41700961-41700968 | 8mer-1a | chr1:41700952-41700971 | 161.00 | -22.85 |
Mayo | ENST00000372583 | 41700916 | 41700995 | hsa-miR-301a-5p | chr1:41700953-41700960 | 8mer-1a | chr1:41700952-41700971 | 161.00 | -22.85 |
Mayo | ENST00000372583 | 41700916 | 41700995 | hsa-miR-642a-3p | chr1:41700949-41700956 | 8mer-1a | chr1:41700933-41700956 | 159.00 | -22.46 |
Mayo | ENST00000372583 | 41700916 | 41700995 | hsa-miR-642b-3p | chr1:41700949-41700956 | 8mer-1a | chr1:41700933-41700956 | 159.00 | -22.46 |
Mayo | ENST00000372583 | 41700916 | 41700995 | hsa-miR-515-5p | chr1:41700971-41700978 | 8mer-1a | chr1:41700955-41700978 | 150.00 | -17.22 |
Mayo | ENST00000372583 | 41700916 | 41700995 | hsa-miR-519e-5p | chr1:41700971-41700978 | 8mer-1a | chr1:41700955-41700978 | 150.00 | -17.22 |
Mayo | ENST00000372583 | 41700916 | 41700995 | hsa-miR-4786-5p | chr1:41700933-41700940 | 8mer-1a | chr1:41700919-41700940 | 161.00 | -24.83 |
Mayo | ENST00000372583 | 41700916 | 41700995 | hsa-miR-6508-5p | chr1:41700961-41700968 | 8mer-1a | chr1:41700952-41700971 | 161.00 | -22.85 |
Mayo | ENST00000372583 | 41700916 | 41700995 | hsa-miR-301b-5p | chr1:41700953-41700960 | 8mer-1a | chr1:41700952-41700971 | 161.00 | -22.85 |
Mayo | ENST00000372583 | 41700916 | 41700995 | hsa-miR-591 | chr1:41700939-41700946 | 8mer-1a | chr1:41700933-41700956 | 159.00 | -22.46 |
MSBB | ENST00000372583 | 41700916 | 41700995 | hsa-miR-6730-3p | chr1:41700951-41700958 | 8mer-1a | chr1:41700948-41700968 | 163.00 | -17.25 |
MSBB | ENST00000372583 | 41700916 | 41700995 | hsa-miR-8067 | chr1:41700961-41700968 | 8mer-1a | chr1:41700952-41700971 | 161.00 | -22.85 |
MSBB | ENST00000372583 | 41700916 | 41700995 | hsa-miR-301a-5p | chr1:41700953-41700960 | 8mer-1a | chr1:41700952-41700971 | 161.00 | -22.85 |
MSBB | ENST00000372583 | 41700916 | 41700995 | hsa-miR-642a-3p | chr1:41700949-41700956 | 8mer-1a | chr1:41700933-41700956 | 159.00 | -22.46 |
MSBB | ENST00000372583 | 41700916 | 41700995 | hsa-miR-642b-3p | chr1:41700949-41700956 | 8mer-1a | chr1:41700933-41700956 | 159.00 | -22.46 |
MSBB | ENST00000372583 | 41700916 | 41700995 | hsa-miR-515-5p | chr1:41700971-41700978 | 8mer-1a | chr1:41700955-41700978 | 150.00 | -17.22 |
MSBB | ENST00000372583 | 41700916 | 41700995 | hsa-miR-519e-5p | chr1:41700971-41700978 | 8mer-1a | chr1:41700955-41700978 | 150.00 | -17.22 |
MSBB | ENST00000372583 | 41700916 | 41700995 | hsa-miR-4786-5p | chr1:41700933-41700940 | 8mer-1a | chr1:41700919-41700940 | 161.00 | -24.83 |
MSBB | ENST00000372583 | 41700916 | 41700995 | hsa-miR-6508-5p | chr1:41700961-41700968 | 8mer-1a | chr1:41700952-41700971 | 161.00 | -22.85 |
MSBB | ENST00000372583 | 41700916 | 41700995 | hsa-miR-301b-5p | chr1:41700953-41700960 | 8mer-1a | chr1:41700952-41700971 | 161.00 | -22.85 |
MSBB | ENST00000372583 | 41700916 | 41700995 | hsa-miR-591 | chr1:41700939-41700946 | 8mer-1a | chr1:41700933-41700956 | 159.00 | -22.46 |
ROSMAP | ENST00000372583 | 41700916 | 41700995 | hsa-miR-6730-3p | chr1:41700951-41700958 | 8mer-1a | chr1:41700948-41700968 | 163.00 | -17.25 |
ROSMAP | ENST00000372583 | 41700916 | 41700995 | hsa-miR-8067 | chr1:41700961-41700968 | 8mer-1a | chr1:41700952-41700971 | 161.00 | -22.85 |
ROSMAP | ENST00000372583 | 41700916 | 41700995 | hsa-miR-301a-5p | chr1:41700953-41700960 | 8mer-1a | chr1:41700952-41700971 | 161.00 | -22.85 |
ROSMAP | ENST00000372583 | 41700916 | 41700995 | hsa-miR-642a-3p | chr1:41700949-41700956 | 8mer-1a | chr1:41700933-41700956 | 159.00 | -22.46 |
ROSMAP | ENST00000372583 | 41700916 | 41700995 | hsa-miR-642b-3p | chr1:41700949-41700956 | 8mer-1a | chr1:41700933-41700956 | 159.00 | -22.46 |
ROSMAP | ENST00000372583 | 41700916 | 41700995 | hsa-miR-515-5p | chr1:41700971-41700978 | 8mer-1a | chr1:41700955-41700978 | 150.00 | -17.22 |
ROSMAP | ENST00000372583 | 41700916 | 41700995 | hsa-miR-519e-5p | chr1:41700971-41700978 | 8mer-1a | chr1:41700955-41700978 | 150.00 | -17.22 |
ROSMAP | ENST00000372583 | 41700916 | 41700995 | hsa-miR-4786-5p | chr1:41700933-41700940 | 8mer-1a | chr1:41700919-41700940 | 161.00 | -24.83 |
ROSMAP | ENST00000372583 | 41700916 | 41700995 | hsa-miR-6508-5p | chr1:41700961-41700968 | 8mer-1a | chr1:41700952-41700971 | 161.00 | -22.85 |
ROSMAP | ENST00000372583 | 41700916 | 41700995 | hsa-miR-301b-5p | chr1:41700953-41700960 | 8mer-1a | chr1:41700952-41700971 | 161.00 | -22.85 |
ROSMAP | ENST00000372583 | 41700916 | 41700995 | hsa-miR-591 | chr1:41700939-41700946 | 8mer-1a | chr1:41700933-41700956 | 159.00 | -22.46 |
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SNVs in the skipped exons for HIVEP3 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for HIVEP3 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for HIVEP3 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for HIVEP3 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for HIVEP3 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HIVEP3 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |