|
Open reading frame (ORF) annotation in the exon skipping event | |
3'-UTR located exon skipping events lost miRNA binding sites | |
Splicing Quantitative Trait Loci (sQTLs) in the skipped exons | |
Gene summary for RANBP2 |
Gene summary |
Gene information | Gene symbol | RANBP2 | Gene ID | 5903 |
Gene name | RAN binding protein 2 | |
Synonyms | ADANE|ANE1|IIAE3|NUP358|TRP1|TRP2 | |
Cytomap | 2q13 | |
Type of gene | protein-coding | |
Description | E3 SUMO-protein ligase RanBP2358 kDa nucleoporinE3 SUMO-protein transferase RanBP2P270acute necrotizing encephalopathy 1 (autosomal dominant)nuclear pore complex protein Nup358nucleoporin 358nucleoporin Nup358ran-binding protein 2transformation-r | |
Modification date | 20200313 | |
UniProtAcc | F8WBP7, P49792, | |
Context |
Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Gene | GO ID | GO term | PubMed ID |
RANBP2 | GO:0016925 | protein sumoylation | 17264123|22155184 |
Top |
Gene structures and expression levels for RANBP2 |
Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Differentially expressed gene analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
Landscape of isoform expressions across multiple brain tissues between AD and control. |
Top |
Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for RANBP2 |
Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
All exon skipping events in AD cohorts. |
Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
exon_skip_1019 | chr2 | 108772489:108772581:108772868:108773046:108775732:108775936 | 108772868:108773046 |
exon_skip_107667 | chr2 | 108758413:108758548:108762101:108762195:108763237:108765672 | 108762101:108762195 |
exon_skip_121596 | chr2 | 108729135:108729199:108730774:108730885:108731322:108731337 | 108730774:108730885 |
exon_skip_134557 | chr2 | 108758413:108758548:108762101:108762195:108763237:108766047 | 108762101:108762195 |
exon_skip_166836 | chr2 | 108751528:108751703:108751871:108751994:108752998:108753097 | 108751871:108751994 |
exon_skip_22979 | chr2 | 108740489:108740681:108746711:108746798:108748920:108749129 | 108746711:108746798 |
exon_skip_270299 | chr2 | 108758413:108758548:108762101:108762195:108763237:108765318 | 108762101:108762195 |
exon_skip_275426 | chr2 | 108758413:108758548:108762101:108762195:108763237:108768388 | 108762101:108762195 |
exon_skip_41138 | chr2 | 108762101:108762195:108763237:108768388:108771701:108771871 | 108763237:108768388 |
exon_skip_98413 | chr2 | 108736104:108736249:108740489:108740681:108746711:108746798 | 108740489:108740681 |
Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
Top |
Open reading frame (ORF) annotation in the exon skipping event for RANBP2 |
Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000283195 | 108746711 | 108746798 | Frame-shift |
ENST00000283195 | 108751871 | 108751994 | Frame-shift |
ENST00000283195 | 108762101 | 108762195 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000283195 | 108730774 | 108730885 | Frame-shift |
ENST00000283195 | 108746711 | 108746798 | Frame-shift |
ENST00000283195 | 108751871 | 108751994 | Frame-shift |
ENST00000283195 | 108762101 | 108762195 | Frame-shift |
Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
ENST | Start of skipped exon | End of skipped exon | ORF |
ENST00000283195 | 108740489 | 108740681 | Frame-shift |
ENST00000283195 | 108746711 | 108746798 | Frame-shift |
ENST00000283195 | 108751871 | 108751994 | Frame-shift |
ENST00000283195 | 108762101 | 108762195 | Frame-shift |
ENST00000283195 | 108763237 | 108768388 | Frame-shift |
ENST00000283195 | 108772868 | 108773046 | Frame-shift |
Top |
Infer the effects of exon skipping event on protein functional features for RANBP2 |
p-ENSG00000153201_img4.png |
Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
Lost protein functional features of individual exon skipping events in ROSMAP. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in MSBB. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Lost protein functional features of individual exon skipping events in Mayo. |
UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Top |
3'-UTR located exon skipping events that lost miRNA binding sites in RANBP2 |
3'-UTR exon skipping evnets lost miRNA binding. |
Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
Top |
SNVs in the skipped exons for RANBP2 |
- Differential PSIs between mutated versus non-mutated samples. |
- Depth of Coverage in the skipped exon of the mutated samples. |
- Sashimi plot in the skipped exon of the mutated samples. |
- Non-synonymous mutations located in the skipped exons. |
Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
- Non-synonymous mutations located in the skipped exons in CCLE. |
Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
AD stage-associated exon skippint events for RANBP2 |
Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RANBP2 |
sQTL information located at the skipped exons. |
Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
Top |
Correlation with RNA binding proteins (RBPs) for RANBP2 |
Correlated RBP and related information. |
Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
Top |
RelatedDrugs for RANBP2 |
Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for RANBP2 |
Diseases associated with this gene. (DisGeNet 4.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |