ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for PTPRB

Gene summary

Gene information	Gene symbol	PTPRB
	Gene ID	5787
	Gene name	protein tyrosine phosphatase receptor type B
	Synonyms	HPTP-BETA\|HPTPB\|PTPB\|R-PTP-BETA\|VEPTP
	Cytomap	12q15
	Type of gene	protein-coding
	Description	receptor-type tyrosine-protein phosphatase betaVE-PTPprotein tyrosine phosphatase, receptor type, beta polypeptidevascular endothelial protein tyrosine phosphatase
	Modification date	20200327
	UniProtAcc	F8VSD5, F8VU56, H0YHE8, P23467, Q6ZR19, Q86VA4,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
PTPRB	GO:0016311	dephosphorylation	19116766\|19136612

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Gene structures and expression levels for PTPRB

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000127329

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
PG	UP	ENST00000261266.9	PTPRB-201:protein_coding:PTPRB	3.111941e+02	8.191548e-01	7.510042e-04	1.183145e-02
CB	UP	ENST00000549400.1	PTPRB-207:retained_intron:PTPRB	2.209496e+00	1.066531e+00	2.449839e-03	1.090249e-02
TC	UP	ENST00000261266.9	PTPRB-201:protein_coding:PTPRB	4.694514e+02	1.250297e+00	6.824488e-04	7.341434e-03

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PTPRB

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_172537	chr12	70544557:70544663:70552777:70553020:70555160:70555309	70552777:70553020
exon_skip_192022	chr12	70521403:70521511:70524471:70524591:70532035:70532170	70524471:70524591
exon_skip_209828	chr12	70524471:70524591:70532035:70532170:70534488:70534651	70532035:70532170
exon_skip_271609	chr12	70539939:70540022:70540858:70540957:70544557:70544663	70540858:70540957
exon_skip_27686	chr12	70571824:70572087:70576382:70576645:70581036:70581302	70576382:70576645
exon_skip_280225	chr12	70563017:70563107:70566435:70566704:70569675:70569938	70566435:70566704
exon_skip_288669	chr12	70587007:70587267:70589964:70590233:70592282:70592545	70589964:70590233
exon_skip_290876	chr12	70587007:70587267:70589964:70590233:70592282:70592402	70589964:70590233
exon_skip_293969	chr12	70589964:70590233:70592282:70592545:70594467:70594724	70592282:70592545
exon_skip_40019	chr12	70538924:70539014:70539625:70539706:70539827:70539844	70539625:70539706
exon_skip_51552	chr12	70562844:70563107:70566435:70566704:70569675:70569938	70566435:70566704
exon_skip_79634	chr12	70536025:70536159:70538155:70538231:70538924:70539014	70538155:70538231
exon_skip_95468	chr12	70581036:70581302:70587007:70587267:70589964:70590233	70587007:70587267

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

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Open reading frame (ORF) annotation in the exon skipping event for PTPRB

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000261266	70524471	70524591	Frame-shift
ENST00000261266	70538155	70538231	Frame-shift
ENST00000261266	70539625	70539706	Frame-shift
ENST00000261266	70540858	70540957	Frame-shift
ENST00000261266	70552777	70553020	Frame-shift
ENST00000261266	70566435	70566704	In-frame
ENST00000261266	70576382	70576645	In-frame
ENST00000261266	70587007	70587267	In-frame
ENST00000261266	70589964	70590233	In-frame
ENST00000261266	70592282	70592545	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000261266	70540858	70540957	Frame-shift
ENST00000261266	70566435	70566704	In-frame
ENST00000261266	70576382	70576645	In-frame
ENST00000261266	70589964	70590233	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000261266	70524471	70524591	Frame-shift
ENST00000261266	70532035	70532170	Frame-shift
ENST00000261266	70538155	70538231	Frame-shift
ENST00000261266	70539625	70539706	Frame-shift
ENST00000261266	70540858	70540957	Frame-shift
ENST00000261266	70552777	70553020	Frame-shift
ENST00000261266	70566435	70566704	In-frame
ENST00000261266	70576382	70576645	In-frame
ENST00000261266	70587007	70587267	In-frame
ENST00000261266	70589964	70590233	In-frame
ENST00000261266	70592282	70592545	In-frame

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Infer the effects of exon skipping event on protein functional features for PTPRB

p-ENSG00000127329_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000261266	6127	1997	70592282	70592545	893	1155	287	375
ENST00000261266	6127	1997	70589964	70590233	1157	1425	375	465
ENST00000261266	6127	1997	70587007	70587267	1427	1686	465	552
ENST00000261266	6127	1997	70576382	70576645	1955	2217	641	729
ENST00000261266	6127	1997	70566435	70566704	3011	3279	993	1083

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000261266	6127	1997	70589964	70590233	1157	1425	375	465
ENST00000261266	6127	1997	70576382	70576645	1955	2217	641	729
ENST00000261266	6127	1997	70566435	70566704	3011	3279	993	1083

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000261266	6127	1997	70592282	70592545	893	1155	287	375
ENST00000261266	6127	1997	70589964	70590233	1157	1425	375	465
ENST00000261266	6127	1997	70587007	70587267	1427	1686	465	552
ENST00000261266	6127	1997	70576382	70576645	1955	2217	641	729
ENST00000261266	6127	1997	70566435	70566704	3011	3279	993	1083

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P23467	287	375	23	1997	Chain	ID=PRO_0000025436;Note=Receptor-type tyrosine-protein phosphatase beta
P23467	287	375	203	288	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	287	375	291	378	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	287	375	321	321	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	287	375	23	1621	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	375	465	377	466	Alternative sequence	ID=VSP_038521;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P23467	375	465	23	1997	Chain	ID=PRO_0000025436;Note=Receptor-type tyrosine-protein phosphatase beta
P23467	375	465	291	378	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	375	465	379	471	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	375	465	414	414	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	375	465	421	421	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	375	465	395	395	Natural variant	ID=VAR_057135;Note=V->A;Dbxref=dbSNP:rs36027530
P23467	375	465	415	415	Natural variant	ID=VAR_057136;Note=D->E;Dbxref=dbSNP:rs2165627
P23467	375	465	23	1621	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	465	552	377	466	Alternative sequence	ID=VSP_038521;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P23467	465	552	23	1997	Chain	ID=PRO_0000025436;Note=Receptor-type tyrosine-protein phosphatase beta
P23467	465	552	379	471	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	465	552	467	552	Domain	Note=Fibronectin type-III 6;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	465	552	479	479	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	465	552	544	544	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	465	552	23	1621	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	641	729	23	1997	Chain	ID=PRO_0000025436;Note=Receptor-type tyrosine-protein phosphatase beta
P23467	641	729	556	641	Domain	Note=Fibronectin type-III 7;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	641	729	642	729	Domain	Note=Fibronectin type-III 8;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	641	729	652	652	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	641	729	721	721	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	641	729	666	666	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
P23467	641	729	23	1621	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	993	1083	997	1086	Alternative sequence	ID=VSP_053944;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P23467	993	1083	23	1997	Chain	ID=PRO_0000025436;Note=Receptor-type tyrosine-protein phosphatase beta
P23467	993	1083	909	1001	Domain	Note=Fibronectin type-III 11;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	993	1083	995	1083	Domain	Note=Fibronectin type-III 12;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	993	1083	1040	1040	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	993	1083	1032	1032	Natural variant	ID=VAR_057138;Note=T->I;Dbxref=dbSNP:rs34902691
P23467	993	1083	23	1621	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P23467	375	465	377	466	Alternative sequence	ID=VSP_038521;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P23467	375	465	23	1997	Chain	ID=PRO_0000025436;Note=Receptor-type tyrosine-protein phosphatase beta
P23467	375	465	291	378	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	375	465	379	471	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	375	465	414	414	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	375	465	421	421	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	375	465	395	395	Natural variant	ID=VAR_057135;Note=V->A;Dbxref=dbSNP:rs36027530
P23467	375	465	415	415	Natural variant	ID=VAR_057136;Note=D->E;Dbxref=dbSNP:rs2165627
P23467	375	465	23	1621	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	641	729	23	1997	Chain	ID=PRO_0000025436;Note=Receptor-type tyrosine-protein phosphatase beta
P23467	641	729	556	641	Domain	Note=Fibronectin type-III 7;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	641	729	642	729	Domain	Note=Fibronectin type-III 8;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	641	729	652	652	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	641	729	721	721	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	641	729	666	666	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
P23467	641	729	23	1621	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	993	1083	997	1086	Alternative sequence	ID=VSP_053944;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P23467	993	1083	23	1997	Chain	ID=PRO_0000025436;Note=Receptor-type tyrosine-protein phosphatase beta
P23467	993	1083	909	1001	Domain	Note=Fibronectin type-III 11;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	993	1083	995	1083	Domain	Note=Fibronectin type-III 12;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	993	1083	1040	1040	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	993	1083	1032	1032	Natural variant	ID=VAR_057138;Note=T->I;Dbxref=dbSNP:rs34902691
P23467	993	1083	23	1621	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
P23467	287	375	23	1997	Chain	ID=PRO_0000025436;Note=Receptor-type tyrosine-protein phosphatase beta
P23467	287	375	203	288	Domain	Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	287	375	291	378	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	287	375	321	321	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	287	375	23	1621	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	375	465	377	466	Alternative sequence	ID=VSP_038521;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P23467	375	465	23	1997	Chain	ID=PRO_0000025436;Note=Receptor-type tyrosine-protein phosphatase beta
P23467	375	465	291	378	Domain	Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	375	465	379	471	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	375	465	414	414	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	375	465	421	421	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	375	465	395	395	Natural variant	ID=VAR_057135;Note=V->A;Dbxref=dbSNP:rs36027530
P23467	375	465	415	415	Natural variant	ID=VAR_057136;Note=D->E;Dbxref=dbSNP:rs2165627
P23467	375	465	23	1621	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	465	552	377	466	Alternative sequence	ID=VSP_038521;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P23467	465	552	23	1997	Chain	ID=PRO_0000025436;Note=Receptor-type tyrosine-protein phosphatase beta
P23467	465	552	379	471	Domain	Note=Fibronectin type-III 5;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	465	552	467	552	Domain	Note=Fibronectin type-III 6;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	465	552	479	479	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	465	552	544	544	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	465	552	23	1621	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	641	729	23	1997	Chain	ID=PRO_0000025436;Note=Receptor-type tyrosine-protein phosphatase beta
P23467	641	729	556	641	Domain	Note=Fibronectin type-III 7;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	641	729	642	729	Domain	Note=Fibronectin type-III 8;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	641	729	652	652	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	641	729	721	721	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	641	729	666	666	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
P23467	641	729	23	1621	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	993	1083	997	1086	Alternative sequence	ID=VSP_053944;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
P23467	993	1083	23	1997	Chain	ID=PRO_0000025436;Note=Receptor-type tyrosine-protein phosphatase beta
P23467	993	1083	909	1001	Domain	Note=Fibronectin type-III 11;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	993	1083	995	1083	Domain	Note=Fibronectin type-III 12;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00316
P23467	993	1083	1040	1040	Glycosylation	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255
P23467	993	1083	1032	1032	Natural variant	ID=VAR_057138;Note=T->I;Dbxref=dbSNP:rs34902691
P23467	993	1083	23	1621	Topological domain	Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255

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3'-UTR located exon skipping events that lost miRNA binding sites in PTPRB

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

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SNVs in the skipped exons for PTPRB

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for PTPRB

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PTPRB

sQTL information located at the skipped exons.

Tissue type	Exon skip ID	SNP id	Location	P-value	FDR
CB	exon_skip_288669	rs10506598	chr12:70622159	2.631370e-04	3.688142e-02

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Correlation with RNA binding proteins (RBPs) for PTPRB

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	TARDBP	exon_skip_79634	-4.356557e-01	1.633154e-08
CB	SAMD4A	exon_skip_79634	-4.913486e-01	9.781750e-11
CB	PCBP4	exon_skip_79634	5.596427e-01	4.523923e-14
CB	RBM4B	exon_skip_79634	-4.593763e-01	2.064895e-09

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RelatedDrugs for PTPRB

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for PTPRB

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for PTPRB

Gene structures and expression levels for PTPRB

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PTPRB

Open reading frame (ORF) annotation in the exon skipping event for PTPRB

Infer the effects of exon skipping event on protein functional features for PTPRB

3'-UTR located exon skipping events that lost miRNA binding sites in PTPRB

SNVs in the skipped exons for PTPRB

AD stage-associated exon skippint events for PTPRB

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PTPRB

Correlation with RNA binding proteins (RBPs) for PTPRB

RelatedDrugs for PTPRB

RelatedDiseases for PTPRB