ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for PTPN12

Gene summary

Gene information	Gene symbol	PTPN12
	Gene ID	5782
	Gene name	protein tyrosine phosphatase non-receptor type 12
	Synonyms	PTP-PEST\|PTPG1
	Cytomap	7q11.23
	Type of gene	protein-coding
	Description	tyrosine-protein phosphatase non-receptor type 12protein-tyrosine phosphatase G1
	Modification date	20200329
	UniProtAcc	C9J1X8, C9JJC1, C9JYA4, F8WB51, H0YB59, H0YC15, H3BM04, Q05209,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
PTPN12	GO:0006470	protein dephosphorylation	27134172
PTPN12	GO:0035335	peptidyl-tyrosine dephosphorylation	27134172

Top

Gene structures and expression levels for PTPN12

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000127947

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
CB	UP	ENST00000519553.1	PTPN12-213:retained_intron:PTPN12	1.997862e+00	1.104129e+00	1.087366e-04	7.948976e-04
CB	UP	ENST00000407343.3	PTPN12-202:protein_coding:PTPN12	1.040179e+01	1.048833e+00	1.688363e-04	1.153248e-03

Landscape of isoform expressions across multiple brain tissues between AD and control.

Top

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PTPN12

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_108325	chr7	77571153:77571186:77581427:77581503:77585543:77585571	77581427:77581503
exon_skip_109776	chr7	77571153:77571186:77583555:77583650:77585543:77585571	77583555:77583650
exon_skip_128406	chr7	77581427:77581503:77583555:77583650:77585543:77585571	77583555:77583650
exon_skip_136764	chr7	77571153:77571186:77581427:77581503:77583555:77583649	77581427:77581503
exon_skip_139053	chr7	77632348:77632425:77635782:77635849:77637018:77637048	77635782:77635849
exon_skip_152872	chr7	77592185:77592256:77597842:77597901:77600664:77600728	77597842:77597901
exon_skip_184588	chr7	77571153:77571186:77581427:77581503:77583555:77583595	77581427:77581503
exon_skip_189162	chr7	77583555:77583650:77585543:77585581:77592185:77592256	77585543:77585581
exon_skip_194335	chr7	77618480:77618565:77626705:77627675:77632348:77632425	77626705:77627675
exon_skip_195079	chr7	77600664:77600806:77607235:77607301:77610765:77610802	77607235:77607301
exon_skip_197178	chr7	77627156:77627675:77632348:77632425:77635782:77635849	77632348:77632425
exon_skip_207891	chr7	77637018:77637048:77638624:77638731:77639219:77639280	77638624:77638731
exon_skip_214111	chr7	77537554:77537645:77571078:77571186:77581427:77581465	77571078:77571186
exon_skip_233454	chr7	77585546:77585581:77592185:77592256:77597842:77597901	77592185:77592256
exon_skip_248469	chr7	77600664:77600806:77604879:77604935:77607235:77607301	77604879:77604935
exon_skip_256732	chr7	77537554:77537645:77563936:77564195:77571078:77571109	77563936:77564195
exon_skip_263834	chr7	77581427:77581503:77583555:77583650:77585543:77585581	77583555:77583650
exon_skip_268637	chr7	77635782:77635849:77637018:77637048:77638624:77638708	77637018:77637048
exon_skip_50398	chr7	77571153:77571186:77581427:77581503:77583555:77583650	77581427:77581503
exon_skip_5122	chr7	77600781:77600806:77604879:77604935:77607235:77607301	77604879:77604935
exon_skip_59084	chr7	77610948:77611046:77618480:77618565:77626705:77627675	77618480:77618565
exon_skip_85417	chr7	77537554:77537645:77563936:77564195:77571078:77571186	77563936:77564195
exon_skip_87283	chr7	77583574:77583650:77585543:77585581:77592185:77592256	77585543:77585581
exon_skip_88758	chr7	77597842:77597901:77600664:77600806:77607235:77607301	77600664:77600806

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information

Tissue type

Avg(PSIs) in AD

Avg(PSIs) in control

Difference (PSI)

Adj. p-value

Top

Open reading frame (ORF) annotation in the exon skipping event for PTPN12

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000248594	77581427	77581503	Frame-shift
ENST00000248594	77600664	77600806	Frame-shift
ENST00000248594	77607235	77607301	Frame-shift
ENST00000248594	77618480	77618565	Frame-shift
ENST00000248594	77635782	77635849	Frame-shift
ENST00000248594	77637018	77637048	Frame-shift
ENST00000248594	77583555	77583650	In-frame
ENST00000248594	77585543	77585581	In-frame
ENST00000248594	77592185	77592256	In-frame
ENST00000248594	77597842	77597901	In-frame
ENST00000248594	77632348	77632425	In-frame
ENST00000248594	77638624	77638731	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000248594	77600664	77600806	Frame-shift
ENST00000248594	77607235	77607301	Frame-shift
ENST00000248594	77637018	77637048	Frame-shift
ENST00000248594	77583555	77583650	In-frame
ENST00000248594	77597842	77597901	In-frame
ENST00000248594	77632348	77632425	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000248594	77581427	77581503	Frame-shift
ENST00000248594	77600664	77600806	Frame-shift
ENST00000248594	77607235	77607301	Frame-shift
ENST00000248594	77618480	77618565	Frame-shift
ENST00000248594	77626705	77627675	Frame-shift
ENST00000248594	77635782	77635849	Frame-shift
ENST00000248594	77637018	77637048	Frame-shift
ENST00000248594	77583555	77583650	In-frame
ENST00000248594	77585543	77585581	In-frame
ENST00000248594	77592185	77592256	In-frame
ENST00000248594	77597842	77597901	In-frame
ENST00000248594	77632348	77632425	In-frame
ENST00000248594	77638624	77638731	In-frame

Top

Infer the effects of exon skipping event on protein functional features for PTPN12

p-ENSG00000127947_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000248594	3423	780	77583555	77583650	559	653	95	127
ENST00000248594	3423	780	77585543	77585581	655	692	127	140
ENST00000248594	3423	780	77592185	77592256	694	764	140	164
ENST00000248594	3423	780	77597842	77597901	766	824	164	184
ENST00000248594	3423	780	77632348	77632425	2270	2346	666	691
ENST00000248594	3423	780	77638624	77638731	2447	2553	725	760

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000248594	3423	780	77583555	77583650	559	653	95	127
ENST00000248594	3423	780	77597842	77597901	766	824	164	184
ENST00000248594	3423	780	77632348	77632425	2270	2346	666	691

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000248594	3423	780	77583555	77583650	559	653	95	127
ENST00000248594	3423	780	77585543	77585581	655	692	127	140
ENST00000248594	3423	780	77592185	77592256	694	764	140	164
ENST00000248594	3423	780	77597842	77597901	766	824	164	184
ENST00000248594	3423	780	77632348	77632425	2270	2346	666	691
ENST00000248594	3423	780	77638624	77638731	2447	2553	725	760

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q05209	95	127	1	130	Alternative sequence	ID=VSP_046274;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q05209	95	127	1	119	Alternative sequence	ID=VSP_054168;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05209	95	127	102	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HDE
Q05209	95	127	1	780	Chain	ID=PRO_0000094771;Note=Tyrosine-protein phosphatase non-receptor type 12
Q05209	95	127	28	293	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00160
Q05209	95	127	114	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HDE
Q05209	95	127	121	121	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05209	95	127	121	121	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05209	95	127	111	113	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HDE
Q05209	127	140	1	130	Alternative sequence	ID=VSP_046274;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q05209	127	140	128	131	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HDE
Q05209	127	140	135	137	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HDE
Q05209	127	140	1	780	Chain	ID=PRO_0000094771;Note=Tyrosine-protein phosphatase non-receptor type 12
Q05209	127	140	28	293	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00160
Q05209	140	164	155	157	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HDE
Q05209	140	164	160	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HDE
Q05209	140	164	1	780	Chain	ID=PRO_0000094771;Note=Tyrosine-protein phosphatase non-receptor type 12
Q05209	140	164	28	293	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00160
Q05209	164	184	160	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HDE
Q05209	164	184	173	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HDE
Q05209	164	184	1	780	Chain	ID=PRO_0000094771;Note=Tyrosine-protein phosphatase non-receptor type 12
Q05209	164	184	28	293	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00160
Q05209	666	691	1	780	Chain	ID=PRO_0000094771;Note=Tyrosine-protein phosphatase non-receptor type 12
Q05209	666	691	673	673	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:16964243,ECO:0000244\|PubMed:18088087,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,E
Q05209	666	691	689	689	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18220336,ECO:0000244\|PubMed:18669648;Dbxref=PMID:18220336,PMID:18669648
Q05209	725	760	1	780	Chain	ID=PRO_0000094771;Note=Tyrosine-protein phosphatase non-receptor type 12

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q05209	95	127	1	130	Alternative sequence	ID=VSP_046274;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q05209	95	127	1	119	Alternative sequence	ID=VSP_054168;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05209	95	127	102	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HDE
Q05209	95	127	1	780	Chain	ID=PRO_0000094771;Note=Tyrosine-protein phosphatase non-receptor type 12
Q05209	95	127	28	293	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00160
Q05209	95	127	114	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HDE
Q05209	95	127	121	121	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05209	95	127	121	121	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05209	95	127	111	113	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HDE
Q05209	164	184	160	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HDE
Q05209	164	184	173	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HDE
Q05209	164	184	1	780	Chain	ID=PRO_0000094771;Note=Tyrosine-protein phosphatase non-receptor type 12
Q05209	164	184	28	293	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00160
Q05209	666	691	1	780	Chain	ID=PRO_0000094771;Note=Tyrosine-protein phosphatase non-receptor type 12
Q05209	666	691	673	673	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:16964243,ECO:0000244\|PubMed:18088087,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,E
Q05209	666	691	689	689	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18220336,ECO:0000244\|PubMed:18669648;Dbxref=PMID:18220336,PMID:18669648

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q05209	95	127	1	130	Alternative sequence	ID=VSP_046274;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q05209	95	127	1	119	Alternative sequence	ID=VSP_054168;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05209	95	127	102	106	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HDE
Q05209	95	127	1	780	Chain	ID=PRO_0000094771;Note=Tyrosine-protein phosphatase non-receptor type 12
Q05209	95	127	28	293	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00160
Q05209	95	127	114	123	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HDE
Q05209	95	127	121	121	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05209	95	127	121	121	Sequence conflict	Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05209	95	127	111	113	Turn	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HDE
Q05209	127	140	1	130	Alternative sequence	ID=VSP_046274;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q05209	127	140	128	131	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HDE
Q05209	127	140	135	137	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HDE
Q05209	127	140	1	780	Chain	ID=PRO_0000094771;Note=Tyrosine-protein phosphatase non-receptor type 12
Q05209	127	140	28	293	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00160
Q05209	140	164	155	157	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HDE
Q05209	140	164	160	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HDE
Q05209	140	164	1	780	Chain	ID=PRO_0000094771;Note=Tyrosine-protein phosphatase non-receptor type 12
Q05209	140	164	28	293	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00160
Q05209	164	184	160	170	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HDE
Q05209	164	184	173	182	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5HDE
Q05209	164	184	1	780	Chain	ID=PRO_0000094771;Note=Tyrosine-protein phosphatase non-receptor type 12
Q05209	164	184	28	293	Domain	Note=Tyrosine-protein phosphatase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00160
Q05209	666	691	1	780	Chain	ID=PRO_0000094771;Note=Tyrosine-protein phosphatase non-receptor type 12
Q05209	666	691	673	673	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:16964243,ECO:0000244\|PubMed:18088087,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163,E
Q05209	666	691	689	689	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18220336,ECO:0000244\|PubMed:18669648;Dbxref=PMID:18220336,PMID:18669648
Q05209	725	760	1	780	Chain	ID=PRO_0000094771;Note=Tyrosine-protein phosphatase non-receptor type 12

Top

3'-UTR located exon skipping events that lost miRNA binding sites in PTPN12

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

Top

SNVs in the skipped exons for PTPN12

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

Top

AD stage-associated exon skippint events for PTPN12

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

Top

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PTPN12

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

Top

Correlation with RNA binding proteins (RBPs) for PTPN12

Correlated RBP and related information.

Tissue type

RBP name

Exon skip ID

Correlation coeifficient

P-value

Top

RelatedDrugs for PTPN12

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for PTPN12

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

Home

Download

Statistics

Landscape

Help

Contact

Gene summary for PTPN12

Gene structures and expression levels for PTPN12

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PTPN12

Open reading frame (ORF) annotation in the exon skipping event for PTPN12

Infer the effects of exon skipping event on protein functional features for PTPN12

3'-UTR located exon skipping events that lost miRNA binding sites in PTPN12

SNVs in the skipped exons for PTPN12

AD stage-associated exon skippint events for PTPN12

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PTPN12

Correlation with RNA binding proteins (RBPs) for PTPN12

RelatedDrugs for PTPN12

RelatedDiseases for PTPN12