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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ANKRD36B |
 Gene summary |
| Gene information | Gene symbol | ANKRD36B | Gene ID | 57730 |
| Gene name | ankyrin repeat domain 36B | |
| Synonyms | KIAA1641 | |
| Cytomap | 2q11.2 | |
| Type of gene | protein-coding | |
| Description | ankyrin repeat domain-containing protein 36BCLL-associated antigen KW-1melanoma-associated antigen | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ANKRD36B |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000196912
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000419390.2 | ANKRD36B-203:nonsense_mediated_decay:ANKRD36B | 2.515636e+01 | 8.541260e-01 | 2.092057e-07 | 3.968585e-06 |
| CB | UP | ENST00000359901.8 | ANKRD36B-202:protein_coding:ANKRD36B | 1.056040e+02 | 1.364641e+00 | 6.781586e-04 | 3.727017e-03 |
| CB | DOWN | ENST00000497329.6 | ANKRD36B-207:protein_coding:ANKRD36B | 1.439467e+01 | -1.034143e+00 | 1.015115e-02 | 3.518618e-02 |
| TC | DOWN | ENST00000488634.2 | ANKRD36B-206:retained_intron:ANKRD36B | 1.011268e+01 | -8.522850e-01 | 6.128763e-04 | 6.746004e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ANKRD36B |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_109737 | chr2 | 97558966:97558994:97560665:97560737:97560832:97560860 | 97560665:97560737 |
| exon_skip_129966 | chr2 | 97560832:97560860:97578906:97579043:97580462:97580568 | 97578906:97579043 |
| exon_skip_143973 | chr2 | 97560832:97560860:97584944:97585117:97585284:97585398 | 97584944:97585117 |
| exon_skip_155858 | chr2 | 97507564:97507657:97507995:97508065:97509581:97509729 | 97507995:97508065 |
| exon_skip_180951 | chr2 | 97511569:97512052:97513180:97513363:97515732:97515945 | 97513180:97513363 |
| exon_skip_204541 | chr2 | 97555226:97555254:97556937:97557009:97557104:97557132 | 97556937:97557009 |
| exon_skip_204748 | chr2 | 97576379:97576446:97578906:97579043:97580462:97580568 | 97578906:97579043 |
| exon_skip_240148 | chr2 | 97492667:97492855:97507036:97507065:97507564:97507657 | 97507036:97507065 |
| exon_skip_247051 | chr2 | 97511138:97512052:97513180:97513363:97515732:97515945 | 97513180:97513363 |
| exon_skip_265753 | chr2 | 97507564:97507657:97507995:97508065:97509581:97509733 | 97507995:97508065 |
| exon_skip_277600 | chr2 | 97560832:97560860:97576379:97576446:97578906:97579043 | 97576379:97576446 |
| exon_skip_281481 | chr2 | 97507036:97507065:97507564:97508065:97509581:97509733 | 97507564:97508065 |
| exon_skip_39793 | chr2 | 97549586:97549614:97551289:97551361:97551452:97551480 | 97551289:97551361 |
| exon_skip_55438 | chr2 | 97511906:97512052:97513180:97513363:97515732:97515945 | 97513180:97513363 |
| exon_skip_58209 | chr2 | 97560832:97560860:97576379:97576446:97578906:97578982 | 97576379:97576446 |
| exon_skip_89806 | chr2 | 97547703:97547731:97549419:97549491:97549586:97549614 | 97549419:97549491 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
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| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
| exon_skip_155858 | MSBB_IFG | 4.770588e-01 | 6.181818e-01 | -1.411230e-01 | 3.228745e-02 |
| exon_skip_109737 | MSBB_IFG | 5.400000e-01 | 8.100000e-01 | -2.700000e-01 | 4.000162e-02 |
| exon_skip_265753 | Mayo_CB | 4.295122e-01 | 6.681579e-01 | -2.386457e-01 | 1.384226e-07 |
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Open reading frame (ORF) annotation in the exon skipping event for ANKRD36B |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000359901 | 97507036 | 97507065 | 5CDS-5UTR |
| ENST00000258459 | 97507995 | 97508065 | Frame-shift |
| ENST00000359901 | 97507995 | 97508065 | Frame-shift |
| ENST00000258459 | 97513180 | 97513363 | Frame-shift |
| ENST00000359901 | 97513180 | 97513363 | Frame-shift |
| ENST00000258459 | 97560665 | 97560737 | Frame-shift |
| ENST00000359901 | 97560665 | 97560737 | Frame-shift |
| ENST00000258459 | 97576379 | 97576446 | Frame-shift |
| ENST00000359901 | 97576379 | 97576446 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000359901 | 97507036 | 97507065 | 5CDS-5UTR |
| ENST00000258459 | 97507995 | 97508065 | Frame-shift |
| ENST00000359901 | 97507995 | 97508065 | Frame-shift |
| ENST00000258459 | 97513180 | 97513363 | Frame-shift |
| ENST00000359901 | 97513180 | 97513363 | Frame-shift |
| ENST00000258459 | 97549419 | 97549491 | Frame-shift |
| ENST00000359901 | 97549419 | 97549491 | Frame-shift |
| ENST00000258459 | 97556937 | 97557009 | Frame-shift |
| ENST00000359901 | 97556937 | 97557009 | Frame-shift |
| ENST00000258459 | 97560665 | 97560737 | Frame-shift |
| ENST00000359901 | 97560665 | 97560737 | Frame-shift |
| ENST00000258459 | 97576379 | 97576446 | Frame-shift |
| ENST00000359901 | 97576379 | 97576446 | Frame-shift |
| ENST00000258459 | 97578906 | 97579043 | In-frame |
| ENST00000359901 | 97578906 | 97579043 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000258459 | 97507995 | 97508065 | Frame-shift |
| ENST00000359901 | 97507995 | 97508065 | Frame-shift |
| ENST00000258459 | 97513180 | 97513363 | Frame-shift |
| ENST00000359901 | 97513180 | 97513363 | Frame-shift |
| ENST00000258459 | 97551289 | 97551361 | Frame-shift |
| ENST00000359901 | 97551289 | 97551361 | Frame-shift |
| ENST00000258459 | 97576379 | 97576446 | Frame-shift |
| ENST00000359901 | 97576379 | 97576446 | Frame-shift |
| ENST00000258459 | 97578906 | 97579043 | In-frame |
| ENST00000359901 | 97578906 | 97579043 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ANKRD36B |
p-ENSG00000196912_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000258459 | 6003 | 1353 | 97578906 | 97579043 | 838 | 974 | 186 | 231 |
| ENST00000359901 | 4314 | 1353 | 97578906 | 97579043 | 594 | 730 | 186 | 231 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000258459 | 6003 | 1353 | 97578906 | 97579043 | 838 | 974 | 186 | 231 |
| ENST00000359901 | 4314 | 1353 | 97578906 | 97579043 | 594 | 730 | 186 | 231 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8N2N9 | 186 | 231 | 1 | 1353 | Chain | ID=PRO_0000243912;Note=Ankyrin repeat domain-containing protein 36B |
| Q8N2N9 | 186 | 231 | 1 | 1353 | Chain | ID=PRO_0000243912;Note=Ankyrin repeat domain-containing protein 36B |
| Q8N2N9 | 186 | 231 | 184 | 213 | Repeat | Note=ANK 6 |
| Q8N2N9 | 186 | 231 | 184 | 213 | Repeat | Note=ANK 6 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8N2N9 | 186 | 231 | 1 | 1353 | Chain | ID=PRO_0000243912;Note=Ankyrin repeat domain-containing protein 36B |
| Q8N2N9 | 186 | 231 | 1 | 1353 | Chain | ID=PRO_0000243912;Note=Ankyrin repeat domain-containing protein 36B |
| Q8N2N9 | 186 | 231 | 184 | 213 | Repeat | Note=ANK 6 |
| Q8N2N9 | 186 | 231 | 184 | 213 | Repeat | Note=ANK 6 |
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3'-UTR located exon skipping events that lost miRNA binding sites in ANKRD36B |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ANKRD36B |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ANKRD36B |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | MSBB | IFG | exon_skip_155858 | -4.513205e-01 | 1.592324e-02 | chr2 | - | 97507564 | 97507657 | 97507995 | 97508065 | 97509581 | 97509729 |
| CDR | MSBB | IFG | exon_skip_155858 | -5.339926e-01 | 3.424680e-03 | chr2 | - | 97507564 | 97507657 | 97507995 | 97508065 | 97509581 | 97509729 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ANKRD36B |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for ANKRD36B |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | DAZAP1 | exon_skip_265753 | -4.009902e-01 | 1.778286e-07 |
| CB | CNOT4 | exon_skip_265753 | -5.861587e-01 | 5.910676e-16 |
| CB | RBM45 | exon_skip_265753 | 5.915061e-01 | 2.762330e-16 |
| DLPFC | SRSF2 | exon_skip_155858 | 4.059256e-01 | 2.498271e-13 |
| FL | SRSF2 | exon_skip_155858 | 4.193056e-01 | 1.053072e-09 |
| FL | HNRNPL | exon_skip_155858 | 4.063606e-01 | 3.761338e-09 |
| HCC | DAZAP1 | exon_skip_155858 | -4.693888e-01 | 4.774465e-15 |
| HCC | RBM5 | exon_skip_155858 | -4.748810e-01 | 2.070567e-15 |
| IFG | DAZAP1 | exon_skip_155858 | -6.081360e-01 | 5.967412e-04 |
| IFG | CNOT4 | exon_skip_155858 | -5.392520e-01 | 3.064640e-03 |
| IFG | RBM5 | exon_skip_155858 | -6.455768e-01 | 2.073142e-04 |
| IFG | IGF2BP3 | exon_skip_155858 | -6.483264e-01 | 1.907644e-04 |
| IFG | RBM45 | exon_skip_155858 | -5.481705e-01 | 2.528081e-03 |
| IFG | EWSR1 | exon_skip_109737 | 5.023112e-01 | 1.050270e-02 |
| IFG | HNRNPD | exon_skip_125562 | -4.338984e-01 | 4.363713e-02 |
| IFG | RALYL | exon_skip_125562 | -4.355933e-01 | 4.273067e-02 |
| IFG | CPEB1 | exon_skip_125562 | -4.401131e-01 | 4.038510e-02 |
| IFG | NOVA1 | exon_skip_125562 | -5.182255e-01 | 1.348431e-02 |
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RelatedDrugs for ANKRD36B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ANKRD36B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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