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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for MIER1 |
 Gene summary |
| Gene information | Gene symbol | MIER1 | Gene ID | 57708 |
| Gene name | MIER1 transcriptional regulator | |
| Synonyms | ER1|MI-ER1 | |
| Cytomap | 1p31.3 | |
| Type of gene | protein-coding | |
| Description | mesoderm induction early response protein 1mesoderm induction early response 1 homologmesoderm induction early response 1, transcriptional regulator | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MIER1 | GO:0016575 | histone deacetylation | 28046085 |
| MIER1 | GO:0031937 | positive regulation of chromatin silencing | 12482978 |
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Gene structures and expression levels for MIER1 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000198160
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| STG | UP | ENST00000401041.5 | MIER1-208:protein_coding:MIER1 | 1.225552e+01 | 5.533223e+00 | 1.696726e-05 | 3.846551e-03 |
| CB | DOWN | ENST00000355977.10 | MIER1-202:protein_coding:MIER1 | 1.288847e+02 | -1.533485e+00 | 8.926504e-07 | 1.361211e-05 |
| TC | DOWN | ENST00000355977.10 | MIER1-202:protein_coding:MIER1 | 7.437728e+01 | -1.164008e+00 | 2.548561e-04 | 3.386168e-03 |
| TC | UP | ENST00000371014.5 | MIER1-205:protein_coding:MIER1 | 1.158642e+01 | 9.085713e-01 | 4.315815e-04 | 5.120902e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MIER1 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_101524 | chr1 | 66958911:66958983:66959679:66959743:66963088:66963160 | 66959679:66959743 |
| exon_skip_121401 | chr1 | 66940028:66940052:66946150:66946295:66958059:66958127 | 66946150:66946295 |
| exon_skip_125160 | chr1 | 66940186:66940222:66946150:66946295:66958059:66958220 | 66946150:66946295 |
| exon_skip_128341 | chr1 | 66924967:66925095:66926142:66926242:66940028:66940052 | 66926142:66926242 |
| exon_skip_134657 | chr1 | 66940028:66940052:66940186:66940222:66946150:66946295 | 66940186:66940222 |
| exon_skip_136347 | chr1 | 66959679:66959743:66963088:66963160:66970808:66970959 | 66963088:66963160 |
| exon_skip_20678 | chr1 | 66940028:66940052:66946150:66946295:66958059:66958074 | 66946150:66946295 |
| exon_skip_237210 | chr1 | 66971692:66971736:66972897:66972991:66976595:66976722 | 66972897:66972991 |
| exon_skip_267955 | chr1 | 66940028:66940052:66946150:66946295:66958059:66958132 | 66946150:66946295 |
| exon_skip_29907 | chr1 | 66926142:66926242:66928890:66928963:66940028:66940052 | 66928890:66928963 |
| exon_skip_31065 | chr1 | 66963088:66963160:66970808:66970959:66971655:66971736 | 66970808:66970959 |
| exon_skip_51657 | chr1 | 66971655:66971736:66972897:66972991:66976595:66976722 | 66972897:66972991 |
| exon_skip_75581 | chr1 | 66926142:66926242:66928887:66928963:66940028:66940052 | 66928887:66928963 |
| exon_skip_82061 | chr1 | 66940028:66940052:66946150:66946295:66958059:66958220 | 66946150:66946295 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for MIER1 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for MIER1 |
p-ENSG00000198160_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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3'-UTR located exon skipping events that lost miRNA binding sites in MIER1 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MIER1 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MIER1 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MIER1 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for MIER1 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | SRSF9 | exon_skip_134657 | 4.131297e-01 | 2.659254e-07 |
| CB | DAZAP1 | exon_skip_237210 | -4.134381e-01 | 1.601012e-07 |
| CB | TARDBP | exon_skip_237210 | -4.968328e-01 | 1.158618e-10 |
| CB | CNOT4 | exon_skip_237210 | -4.707318e-01 | 1.377047e-09 |
| CB | TRA2A | exon_skip_237210 | -4.183891e-01 | 1.098031e-07 |
| CB | FUBP1 | exon_skip_237210 | -4.852940e-01 | 3.551037e-10 |
| CB | NUP42 | exon_skip_237210 | 4.098973e-01 | 2.088899e-07 |
| HCC | PTBP1 | exon_skip_29907 | -4.108137e-01 | 1.382380e-09 |
| IFG | G3BP2 | exon_skip_134657 | 5.597403e-01 | 2.945634e-03 |
| PCC | G3BP2 | exon_skip_134657 | 4.607796e-01 | 2.212421e-12 |
| TC | G3BP2 | exon_skip_134657 | 5.489858e-01 | 4.196958e-13 |
| TC | NUP42 | exon_skip_134657 | 5.237360e-01 | 7.189595e-12 |
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RelatedDrugs for MIER1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MIER1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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