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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for DPP10 |
 Gene summary |
| Gene information | Gene symbol | DPP10 | Gene ID | 57628 |
| Gene name | dipeptidyl peptidase like 10 | |
| Synonyms | DPL2|DPPY|DPRP-3|DPRP3 | |
| Cytomap | 2q14.1 | |
| Type of gene | protein-coding | |
| Description | inactive dipeptidyl peptidase 10DPP Xdipeptidyl peptidase 10dipeptidyl peptidase IV-related protein 3dipeptidyl peptidase Xdipeptidyl peptidase-like protein 2dipeptidyl-peptidase 10 (inactive)dipeptidyl-peptidase 10 (non-functional) | |
| Modification date | 20200313 | |
| UniProtAcc | B4DKB5, | |
| Context | - 25025038(Dipeptidyl peptidase 10 (DPP10(789)): a voltage gated potassium channel associated protein is abnormally expressed in Alzheimer's and other neurodegenerative diseases.) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| DPP10 | GO:1903078 | positive regulation of protein localization to plasma membrane | 15671030 |
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Gene structures and expression levels for DPP10 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000175497
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | DOWN | ENST00000473362.1 | DPP10-210:retained_intron:DPP10 | 1.261161e+01 | -1.117603e+00 | 4.002935e-07 | 4.437008e-05 |
| PG | DOWN | ENST00000436732.5 | DPP10-208:protein_coding:DPP10 | 9.764150e+00 | -8.710211e-01 | 2.092561e-04 | 4.713578e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for DPP10 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_126340 | chr2 | 115836674:115836746:115840750:115840823:115842211:115842345 | 115840750:115840823 |
| exon_skip_135785 | chr2 | 115161602:115162028:115309239:115309353:115343817:115343912 | 115309239:115309353 |
| exon_skip_139298 | chr2 | 115499510:115499604:115525898:115525972:115689687:115689739 | 115525898:115525972 |
| exon_skip_205156 | chr2 | 115836157:115836256:115836507:115836565:115836674:115836682 | 115836507:115836565 |
| exon_skip_21536 | chr2 | 115753176:115753297:115762572:115762610:115768297:115768404 | 115762572:115762610 |
| exon_skip_223440 | chr2 | 114463395:114463426:114707117:114707174:115309239:115309353 | 114707117:114707174 |
| exon_skip_286180 | chr2 | 115791081:115791179:115791287:115791356:115814793:115814987 | 115791287:115791356 |
| exon_skip_291204 | chr2 | 114461603:114462140:114463395:114463426:114707117:114707174 | 114463395:114463426 |
| exon_skip_44106 | chr2 | 115162234:115162272:115309239:115309353:115343817:115343912 | 115309239:115309353 |
| exon_skip_55278 | chr2 | 115525898:115525972:115579114:115579266:115689687:115689739 | 115579114:115579266 |
| exon_skip_69272 | chr2 | 115753174:115753297:115762572:115762610:115768297:115768404 | 115762572:115762610 |
| exon_skip_90295 | chr2 | 114462031:114462140:114463395:114463426:114707117:114707174 | 114463395:114463426 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for DPP10 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000410059 | 115791287 | 115791356 | Frame-shift |
| ENST00000410059 | 115836507 | 115836565 | Frame-shift |
| ENST00000410059 | 115840750 | 115840823 | Frame-shift |
| ENST00000410059 | 115762572 | 115762610 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000410059 | 115791287 | 115791356 | Frame-shift |
| ENST00000410059 | 115836507 | 115836565 | Frame-shift |
| ENST00000410059 | 115762572 | 115762610 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000410059 | 115791287 | 115791356 | Frame-shift |
| ENST00000410059 | 115836507 | 115836565 | Frame-shift |
| ENST00000410059 | 115525898 | 115525972 | In-frame |
| ENST00000410059 | 115762572 | 115762610 | In-frame |
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Infer the effects of exon skipping event on protein functional features for DPP10 |
p-ENSG00000175497_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000410059 | 6295 | 796 | 115762572 | 115762610 | 1556 | 1593 | 358 | 371 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000410059 | 6295 | 796 | 115762572 | 115762610 | 1556 | 1593 | 358 | 371 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000410059 | 6295 | 796 | 115525898 | 115525972 | 848 | 921 | 122 | 147 |
| ENST00000410059 | 6295 | 796 | 115762572 | 115762610 | 1556 | 1593 | 358 | 371 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8N608 | 358 | 371 | 355 | 363 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WJL |
| Q8N608 | 358 | 371 | 1 | 796 | Chain | ID=PRO_0000122417;Note=Inactive dipeptidyl peptidase 10 |
| Q8N608 | 358 | 371 | 56 | 796 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8N608 | 358 | 371 | 355 | 363 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WJL |
| Q8N608 | 358 | 371 | 1 | 796 | Chain | ID=PRO_0000122417;Note=Inactive dipeptidyl peptidase 10 |
| Q8N608 | 358 | 371 | 56 | 796 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8N608 | 122 | 147 | 129 | 132 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WJL |
| Q8N608 | 122 | 147 | 136 | 147 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WJL |
| Q8N608 | 122 | 147 | 1 | 796 | Chain | ID=PRO_0000122417;Note=Inactive dipeptidyl peptidase 10 |
| Q8N608 | 122 | 147 | 138 | 138 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648 |
| Q8N608 | 122 | 147 | 143 | 143 | Modified residue | Note=Phosphotyrosine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:18669648;Dbxref=PMID:18669648 |
| Q8N608 | 122 | 147 | 56 | 796 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8N608 | 122 | 147 | 119 | 125 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WJL |
| Q8N608 | 358 | 371 | 355 | 363 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4WJL |
| Q8N608 | 358 | 371 | 1 | 796 | Chain | ID=PRO_0000122417;Note=Inactive dipeptidyl peptidase 10 |
| Q8N608 | 358 | 371 | 56 | 796 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in DPP10 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for DPP10 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for DPP10 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DPP10 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for DPP10 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| TC | RBM3 | exon_skip_21536 | 4.511827e-01 | 3.536340e-08 |
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RelatedDrugs for DPP10 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DPP10 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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