ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for ARHGAP21

Gene summary

Gene information	Gene symbol	ARHGAP21
	Gene ID	57584
	Gene name	Rho GTPase activating protein 21
	Synonyms	ARHGAP10
	Cytomap	10p12.1\|10p12.3
	Type of gene	protein-coding
	Description	rho GTPase-activating protein 21Rho-GTPase activating protein 10rho GTPase-activating protein 10rho-type GTPase-activating protein 21
	Modification date	20200320
	UniProtAcc	A0A087WW76, A0A1B0GTZ9, A0A1B0GV73, A0A1B0GW11, A0A2X0SF83, A0A452Q6Z5, E7ESW5, H0Y468, H0Y5T2, J3JSM9, L8EB25, Q5JSD8,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
ARHGAP21	GO:0051683	establishment of Golgi localization	20525016

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Gene structures and expression levels for ARHGAP21

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000107863

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
PG	UP	ENST00000376410.6	ARHGAP21-202:protein_coding:ARHGAP21	2.589513e+02	1.753513e+00	1.004783e-05	5.068453e-04
CB	UP	ENST00000418033.5	ARHGAP21-205:protein_coding:ARHGAP21	6.290927e+00	1.215945e+00	4.013230e-09	1.399998e-07

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ARHGAP21

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_125055	chr10	24621174:24621369:24622733:24622762:24629996:24630050	24622733:24622762
exon_skip_13165	chr10	24620879:24621369:24622733:24622762:24629996:24630050	24622733:24622762
exon_skip_13167	chr10	24589271:24589302:24590454:24590550:24591225:24591330	24590454:24590550
exon_skip_138676	chr10	24622733:24622762:24629996:24630050:24633402:24633480	24629996:24630050
exon_skip_142095	chr10	24629996:24630050:24633402:24633480:24635011:24635103	24633402:24633480
exon_skip_166997	chr10	24607745:24607903:24619473:24621369:24629996:24630050	24619473:24621369
exon_skip_186672	chr10	24589271:24589302:24591225:24591330:24591642:24591683	24591225:24591330
exon_skip_197044	chr10	24670339:24670397:24714297:24714378:24721837:24722019	24714297:24714378
exon_skip_207349	chr10	24586033:24586106:24589271:24589302:24591225:24591327	24589271:24589302
exon_skip_215890	chr10	24589271:24589302:24590206:24590479:24591225:24591327	24590206:24590479
exon_skip_215969	chr10	24607499:24607601:24607745:24607903:24619473:24621369	24607745:24607903
exon_skip_219554	chr10	24670339:24670397:24714297:24714378:24721837:24722225	24714297:24714378
exon_skip_220535	chr10	24594950:24595039:24595117:24595190:24595717:24595795	24595117:24595190
exon_skip_244649	chr10	24591225:24591330:24591642:24591683:24591887:24592012	24591642:24591683
exon_skip_268582	chr10	24620879:24621369:24629996:24630050:24633402:24633480	24629996:24630050
exon_skip_275099	chr10	24590206:24590479:24591225:24591330:24591642:24591683	24591225:24591330
exon_skip_277115	chr10	24589271:24589302:24590206:24590479:24591225:24591323	24590206:24590479
exon_skip_281452	chr10	24666985:24667009:24670218:24670397:24721837:24721866	24670218:24670397
exon_skip_33904	chr10	24670339:24670397:24714297:24714378:24721837:24721866	24714297:24714378
exon_skip_35768	chr10	24589271:24589302:24590454:24590550:24591225:24591323	24590454:24590550
exon_skip_38170	chr10	24586033:24586106:24589271:24589302:24590206:24590226	24589271:24589302
exon_skip_40655	chr10	24589271:24589302:24590206:24590479:24591225:24591330	24590206:24590479
exon_skip_58219	chr10	24635011:24635103:24666985:24667009:24670218:24670243	24666985:24667009
exon_skip_79947	chr10	24586033:24586106:24589271:24589302:24591225:24591330	24589271:24589302
exon_skip_99113	chr10	24635011:24635103:24666985:24667009:24670218:24670397	24666985:24667009

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information	Tissue type	Avg(PSIs) in AD	Avg(PSIs) in control	Difference (PSI)	Adj. p-value
exon_skip_277115	ROSMAP_DLPFC	2.118471e-01	3.319767e-01	-1.201296e-01	9.008826e-04
exon_skip_40655	MSBB_PG	1.840397e-01	3.305172e-01	-1.464775e-01	3.138208e-07
exon_skip_125055	MSBB_PG	6.456954e-01	7.656897e-01	-1.199943e-01	1.130170e-06
exon_skip_125055	Mayo_TC	5.592683e-01	6.862821e-01	-1.270138e-01	4.183163e-06

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Open reading frame (ORF) annotation in the exon skipping event for ARHGAP21

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000320481	24589271	24589302	Frame-shift
ENST00000396432	24589271	24589302	Frame-shift
ENST00000320481	24591225	24591330	Frame-shift
ENST00000396432	24591225	24591330	Frame-shift
ENST00000320481	24595117	24595190	Frame-shift
ENST00000396432	24595117	24595190	Frame-shift
ENST00000320481	24666985	24667009	Frame-shift
ENST00000396432	24666985	24667009	Frame-shift
ENST00000396432	24622733	24622762	In-frame
ENST00000320481	24670218	24670397	In-frame
ENST00000396432	24670218	24670397	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000320481	24591225	24591330	Frame-shift
ENST00000396432	24591225	24591330	Frame-shift
ENST00000320481	24633402	24633480	Frame-shift
ENST00000396432	24633402	24633480	Frame-shift
ENST00000396432	24607745	24607903	In-frame
ENST00000396432	24622733	24622762	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000320481	24589271	24589302	Frame-shift
ENST00000396432	24589271	24589302	Frame-shift
ENST00000320481	24591225	24591330	Frame-shift
ENST00000396432	24591225	24591330	Frame-shift
ENST00000320481	24595117	24595190	Frame-shift
ENST00000396432	24595117	24595190	Frame-shift
ENST00000320481	24629996	24630050	Frame-shift
ENST00000396432	24629996	24630050	Frame-shift
ENST00000320481	24633402	24633480	Frame-shift
ENST00000396432	24633402	24633480	Frame-shift
ENST00000320481	24666985	24667009	Frame-shift
ENST00000396432	24666985	24667009	Frame-shift
ENST00000320481	24591642	24591683	In-frame
ENST00000396432	24591642	24591683	In-frame
ENST00000396432	24622733	24622762	In-frame

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Infer the effects of exon skipping event on protein functional features for ARHGAP21

p-ENSG00000107863_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000396432	7184	1958	24670218	24670397	551	729	21	80
ENST00000396432	7184	1958	24622733	24622762	983	1011	165	174

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000396432	7184	1958	24622733	24622762	983	1011	165	174
ENST00000396432	7184	1958	24607745	24607903	2910	3067	807	860

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000396432	7184	1958	24622733	24622762	983	1011	165	174
ENST00000396432	7184	1958	24591642	24591683	4490	4530	1334	1347

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q5T5U3	21	80	50	53	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YUY
Q5T5U3	21	80	56	58	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YUY
Q5T5U3	21	80	79	81	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2YUY
Q5T5U3	21	80	1	1957	Chain	ID=PRO_0000305245;Note=Rho GTPase-activating protein 21
Q5T5U3	21	80	49	158	Domain	Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00143
Q5T5U3	21	80	35	35	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q6DFV3
Q5T5U3	21	80	56	56	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:20068231;Dbxref=PMID:20068231
Q5T5U3	165	174	165	174	Alternative sequence	ID=VSP_028298;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q5T5U3	165	174	1	1957	Chain	ID=PRO_0000305245;Note=Rho GTPase-activating protein 21

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q5T5U3	165	174	165	174	Alternative sequence	ID=VSP_028298;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q5T5U3	165	174	1	1957	Chain	ID=PRO_0000305245;Note=Rho GTPase-activating protein 21
Q5T5U3	807	860	1	1957	Chain	ID=PRO_0000305245;Note=Rho GTPase-activating protein 21
Q5T5U3	807	860	856	856	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q5T5U3	165	174	165	174	Alternative sequence	ID=VSP_028298;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q5T5U3	165	174	1	1957	Chain	ID=PRO_0000305245;Note=Rho GTPase-activating protein 21
Q5T5U3	1334	1347	1175	1957	Alternative sequence	ID=VSP_028301;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:17974005;Dbxref=PMID:17974005
Q5T5U3	1334	1347	1	1957	Chain	ID=PRO_0000305245;Note=Rho GTPase-activating protein 21
Q5T5U3	1334	1347	1146	1338	Domain	Note=Rho-GAP;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00172

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3'-UTR located exon skipping events that lost miRNA binding sites in ARHGAP21

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type

ENST

Exon skip start

Exon skip end

microRNA

Binding site by TargetScan

Binding type by TargetScan

Bdinding site by miRanda

Score of miRanda

Energy by miRanda

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SNVs in the skipped exons for ARHGAP21

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for ARHGAP21

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info	Cohort	Tissue	SE id	Coefficient	P-value	Chromosome	Strand	E1 start	E1 end	Skipped start	Skipped end	E2 start	E2 end
ADstage	MSBB	IFG	exon_skip_40655	-3.850754e-01	4.301955e-02	chr10	-	24589271	24589302	24590206	24590479	24591225	24591330
ADstage	MSBB	PG	exon_skip_40655	-4.152749e-01	4.050000e-10	chr10	-	24589271	24589302	24590206	24590479	24591225	24591330
ADstage	MSBB	PG	exon_skip_125055	-3.963320e-01	2.840000e-09	chr10	-	24621174	24621369	24622733	24622762	24629996	24630050
CDR	MSBB	PG	exon_skip_40655	-4.280667e-01	1.010000e-10	chr10	-	24589271	24589302	24590206	24590479	24591225	24591330
CDR	MSBB	PG	exon_skip_125055	-3.977187e-01	2.480000e-09	chr10	-	24621174	24621369	24622733	24622762	24629996	24630050

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ARHGAP21

sQTL information located at the skipped exons.

Tissue type

Exon skip ID

SNP id

Location

P-value

FDR

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Correlation with RNA binding proteins (RBPs) for ARHGAP21

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	SRSF9	exon_skip_296410	5.964635e-01	1.078154e-16
CB	SRSF11	exon_skip_40655	5.164609e-01	3.207601e-12
CB	TIA1	exon_skip_40655	6.743025e-01	1.986637e-22
CB	RBM3	exon_skip_40655	4.874700e-01	7.196747e-11
CB	FUBP3	exon_skip_40655	5.105246e-01	6.212315e-12
CB	PUM1	exon_skip_40655	4.271326e-01	1.967633e-08
CB	RALYL	exon_skip_40655	6.282553e-01	7.682470e-19
CB	PTBP3	exon_skip_40655	4.937314e-01	3.767090e-11
CB	SRSF9	exon_skip_40655	6.065270e-01	2.392786e-17
CB	HNRNPH2	exon_skip_40655	4.695195e-01	4.288243e-10
CB	EIF4B	exon_skip_40655	5.203540e-01	2.064789e-12
CB	NUP42	exon_skip_125055	5.993331e-01	7.056537e-17
CB	TIA1	exon_skip_74221	4.717548e-01	8.724214e-09
CB	FUBP3	exon_skip_74221	4.805756e-01	4.185633e-09
CB	NUP42	exon_skip_74221	4.510893e-01	4.504121e-08
DLPFC	DAZAP1	exon_skip_277115	6.898349e-01	1.153386e-35
DLPFC	ELAVL4	exon_skip_277115	8.699951e-01	5.745457e-76
DLPFC	ELAVL1	exon_skip_277115	5.712399e-01	1.901494e-22
DLPFC	SFPQ	exon_skip_277115	6.304366e-01	2.496411e-28
DLPFC	SRSF11	exon_skip_277115	-4.482110e-01	2.070349e-13
DLPFC	TIA1	exon_skip_277115	5.623831e-01	1.147884e-21
DLPFC	RBM5	exon_skip_277115	6.951014e-01	2.115204e-36
DLPFC	RBM3	exon_skip_277115	6.617249e-01	5.520099e-32
DLPFC	TRNAU1AP	exon_skip_277115	5.455429e-01	3.031741e-20
DLPFC	ILF2	exon_skip_277115	7.127678e-01	5.414724e-39
DLPFC	PCBP4	exon_skip_277115	4.470331e-01	2.433092e-13
DLPFC	TRA2A	exon_skip_277115	4.552305e-01	7.808718e-14
DLPFC	RC3H1	exon_skip_277115	6.136101e-01	1.570416e-26
DLPFC	SNRPA	exon_skip_277115	6.711292e-01	3.595626e-33
DLPFC	KHDRBS3	exon_skip_277115	8.033996e-01	3.471997e-56
DLPFC	RBM24	exon_skip_277115	7.365181e-01	8.387380e-43
DLPFC	FUBP3	exon_skip_277115	5.317934e-01	3.842928e-19
DLPFC	ENOX1	exon_skip_277115	7.635292e-01	1.136790e-47
DLPFC	KHSRP	exon_skip_277115	7.753247e-01	5.250578e-50
DLPFC	PUM1	exon_skip_277115	7.503582e-01	3.216436e-45
DLPFC	HNRNPA2B1	exon_skip_277115	5.456157e-01	2.990323e-20
DLPFC	PUF60	exon_skip_277115	7.719991e-01	2.470953e-49
DLPFC	RALYL	exon_skip_277115	7.915376e-01	1.851516e-53
DLPFC	PTBP3	exon_skip_277115	6.924348e-01	5.015319e-36
DLPFC	HNRNPL	exon_skip_277115	7.924322e-01	1.169741e-53
DLPFC	CELF1	exon_skip_277115	7.094968e-01	1.690837e-38
DLPFC	EWSR1	exon_skip_277115	7.502804e-01	3.321934e-45
DLPFC	SRSF1	exon_skip_277115	6.757847e-01	8.959988e-34
DLPFC	SRSF9	exon_skip_277115	7.227935e-01	1.491963e-40
DLPFC	HNRNPH2	exon_skip_277115	8.043798e-01	2.027285e-56
DLPFC	EIF4B	exon_skip_277115	7.437301e-01	4.830022e-44
DLPFC	ESRP1	exon_skip_277115	6.568517e-01	2.187406e-31
DLPFC	RBM41	exon_skip_277115	4.278013e-01	3.115014e-12
DLPFC	NOVA1	exon_skip_277115	7.651113e-01	5.628793e-48
FL	MSI1	exon_skip_40655	-5.779293e-01	4.891535e-19
FL	ELAVL4	exon_skip_40655	6.967456e-01	4.260179e-30
FL	SRSF11	exon_skip_40655	4.327600e-01	1.923577e-10
FL	SAMD4A	exon_skip_40655	-4.307640e-01	2.377858e-10
FL	TIA1	exon_skip_40655	5.157950e-01	7.456954e-15
FL	RBM3	exon_skip_40655	4.141167e-01	1.321770e-09
FL	ILF2	exon_skip_40655	5.625819e-01	6.381652e-18
FL	KHDRBS3	exon_skip_40655	6.918683e-01	1.545137e-29
FL	RBM24	exon_skip_40655	6.628014e-01	2.024335e-26
FL	FUBP1	exon_skip_40655	4.694313e-01	3.030769e-12
FL	ENOX1	exon_skip_40655	4.576301e-01	1.216814e-11
FL	PUM1	exon_skip_40655	5.012785e-01	5.397198e-14
FL	PUF60	exon_skip_40655	4.576619e-01	1.212353e-11
FL	RALYL	exon_skip_40655	6.942054e-01	8.360663e-30
FL	PTBP1	exon_skip_40655	-4.326957e-01	1.936807e-10
FL	HNRNPL	exon_skip_40655	5.271925e-01	1.473754e-15
FL	CELF1	exon_skip_40655	5.225971e-01	2.854307e-15
FL	SRSF1	exon_skip_40655	4.941563e-01	1.378041e-13
FL	SRSF9	exon_skip_40655	5.414200e-01	1.784524e-16
FL	HNRNPH2	exon_skip_40655	5.268562e-01	1.547309e-15
FL	EIF4B	exon_skip_40655	5.339887e-01	5.442682e-16
FL	ESRP1	exon_skip_40655	4.756526e-01	1.425221e-12
FL	NOVA1	exon_skip_40655	5.492255e-01	5.368052e-17
FL	NUP42	exon_skip_125055	4.387646e-01	1.008039e-10
FL	NOVA1	exon_skip_125055	4.631609e-01	6.385307e-12
HCC	DAZAP1	exon_skip_40655	-5.942406e-01	1.882211e-27
HCC	RBMS3	exon_skip_40655	-4.644323e-01	5.188754e-16
HCC	MSI1	exon_skip_40655	-6.189247e-01	2.938089e-30
HCC	SFPQ	exon_skip_40655	-6.012186e-01	3.205458e-28
HCC	RBM6	exon_skip_40655	-6.715747e-01	3.687595e-37
HCC	SRSF11	exon_skip_40655	-5.257722e-01	8.303959e-21
HCC	SAMD4A	exon_skip_40655	-6.175711e-01	4.250479e-30
HCC	TIA1	exon_skip_40655	-5.373112e-01	8.014485e-22
HCC	RBM5	exon_skip_40655	-6.403910e-01	6.557817e-33
HCC	IGF2BP2	exon_skip_40655	-4.508597e-01	4.490754e-15
HCC	TRNAU1AP	exon_skip_40655	-4.914732e-01	5.237429e-18
HCC	PCBP4	exon_skip_40655	-5.876225e-01	9.698706e-27
HCC	TRA2A	exon_skip_40655	-4.162252e-01	7.296409e-13
HCC	KHDRBS3	exon_skip_40655	-5.276349e-01	5.727787e-21
HCC	FUBP3	exon_skip_40655	-4.666914e-01	3.589114e-16
HCC	FUBP1	exon_skip_40655	-4.389515e-01	2.760690e-14
HCC	HNRNPA2B1	exon_skip_40655	-5.064744e-01	3.414160e-19
HCC	PTBP1	exon_skip_40655	-7.206608e-01	5.169508e-45
HCC	SRSF1	exon_skip_40655	-4.288072e-01	1.227383e-13
HCC	RBM41	exon_skip_40655	-4.625147e-01	7.079774e-16
HCC	HNRNPF	exon_skip_40655	-6.068462e-01	7.447787e-29
IFG	ELAVL4	exon_skip_40655	7.165660e-01	1.793881e-05
IFG	IGF2BP2	exon_skip_40655	-5.438766e-01	2.775362e-03
IFG	KHDRBS3	exon_skip_40655	6.717977e-01	9.057636e-05
IFG	RBM24	exon_skip_40655	5.259578e-01	4.044385e-03
IFG	PUM1	exon_skip_40655	4.113470e-01	2.965173e-02
IFG	RALYL	exon_skip_40655	7.094250e-01	2.368958e-05
IFG	HNRNPH2	exon_skip_40655	4.117027e-01	2.949709e-02
IFG	RBM41	exon_skip_40655	4.686197e-01	1.189396e-02
IFG	NOVA1	exon_skip_40655	5.219094e-01	4.391286e-03
IFG	NUP42	exon_skip_125055	4.702823e-01	1.155620e-02
IFG	RALYL	exon_skip_74221	-4.458622e-01	2.243578e-02
PCC	MSI1	exon_skip_215890	-4.260150e-01	6.859007e-11
PCC	ELAVL4	exon_skip_215890	6.015741e-01	1.498752e-22
PCC	RBM6	exon_skip_215890	-5.043207e-01	2.847354e-15
PCC	SAMD4A	exon_skip_215890	-5.870638e-01	2.628041e-21
PCC	TRNAU1AP	exon_skip_215890	-4.097596e-01	4.109100e-10
PCC	PCBP4	exon_skip_215890	-4.378911e-01	1.743560e-11
PCC	PUM1	exon_skip_215890	5.501968e-01	2.066745e-18
PCC	RALYL	exon_skip_215890	4.966600e-01	8.591616e-15
PCC	PTBP1	exon_skip_215890	-7.187371e-01	1.815837e-35
PCC	HNRNPF	exon_skip_215890	-6.092961e-01	3.073027e-23
PCC	ZNF326	exon_skip_125055	-4.078507e-01	5.038995e-10
PG	MSI1	exon_skip_40655	-5.203804e-01	6.707681e-16
PG	ELAVL4	exon_skip_40655	7.154360e-01	4.490369e-34
PG	ELAVL1	exon_skip_40655	4.229585e-01	1.771699e-10
PG	SAMD4A	exon_skip_40655	-4.424666e-01	1.976405e-11
PG	RBM3	exon_skip_40655	4.541392e-01	4.969086e-12
PG	IGF2BP2	exon_skip_40655	-4.509419e-01	7.290978e-12
PG	ILF2	exon_skip_40655	4.323710e-01	6.257327e-11
PG	KHDRBS3	exon_skip_40655	5.682699e-01	2.852008e-19
PG	RBM24	exon_skip_40655	5.696129e-01	2.252099e-19
PG	ENOX1	exon_skip_40655	4.135220e-01	4.872466e-10
PG	PUM1	exon_skip_40655	5.558448e-01	2.411595e-18
PG	PUF60	exon_skip_40655	5.175007e-01	1.029818e-15
PG	RALYL	exon_skip_40655	6.749177e-01	3.858010e-29
PG	HNRNPL	exon_skip_40655	4.708852e-01	6.241958e-13
PG	CELF1	exon_skip_40655	5.462477e-01	1.181463e-17
PG	HNRNPH2	exon_skip_40655	5.094004e-01	3.366337e-15
PG	NOVA1	exon_skip_40655	5.033940e-01	7.941025e-15
PG	NUP42	exon_skip_125055	4.187286e-01	2.799100e-10
PG	NOVA1	exon_skip_125055	4.667044e-01	1.058933e-12
STG	MSI1	exon_skip_40655	-5.294309e-01	4.859798e-08
STG	ELAVL4	exon_skip_40655	6.565867e-01	8.951492e-13
STG	IGF2BP2	exon_skip_40655	-4.481955e-01	6.632479e-06
STG	KHDRBS3	exon_skip_40655	5.757529e-01	1.564571e-09
STG	RBM24	exon_skip_40655	5.763235e-01	1.494685e-09
STG	PUM1	exon_skip_40655	4.310193e-01	1.610712e-05
STG	RALYL	exon_skip_40655	6.849584e-01	3.681054e-14
STG	PTBP1	exon_skip_40655	-4.170336e-01	3.204118e-05
STG	CELF1	exon_skip_40655	4.532483e-01	5.061612e-06
STG	SRSF9	exon_skip_40655	4.450780e-01	7.819449e-06
STG	HNRNPH2	exon_skip_40655	5.230345e-01	7.507774e-08
STG	NOVA1	exon_skip_40655	5.403859e-01	2.258842e-08
STG	NUP42	exon_skip_125055	5.193336e-01	1.131240e-07
STG	NOVA1	exon_skip_125055	5.342201e-01	4.148100e-08
TC	ELAVL4	exon_skip_277115	9.038872e-01	3.772163e-60
TC	RBM6	exon_skip_277115	-4.538390e-01	1.668167e-09
TC	RBM3	exon_skip_277115	4.046225e-01	1.116276e-07
TC	ILF2	exon_skip_277115	5.375307e-01	2.321184e-13
TC	KHDRBS3	exon_skip_277115	8.018930e-01	3.580844e-37
TC	RBM24	exon_skip_277115	8.302377e-01	5.985012e-42
TC	ENOX1	exon_skip_277115	4.127286e-01	5.845485e-08
TC	PUM1	exon_skip_277115	7.388563e-01	7.005611e-29
TC	RALYL	exon_skip_277115	9.046238e-01	2.116068e-60
TC	PTBP3	exon_skip_277115	5.978052e-01	7.070913e-17
TC	CELF1	exon_skip_277115	6.447922e-01	3.545355e-20
TC	EWSR1	exon_skip_277115	4.076159e-01	8.808258e-08
TC	SRSF9	exon_skip_277115	4.355815e-01	8.583023e-09
TC	HNRNPH2	exon_skip_277115	7.679199e-01	2.237054e-32
TC	ESRP1	exon_skip_277115	6.575740e-01	3.544996e-21
TC	NOVA1	exon_skip_277115	6.021366e-01	3.696809e-17
TC	ELAVL4	exon_skip_134950	6.757106e-01	9.574320e-22
TC	FXR2	exon_skip_134950	4.071406e-01	1.762157e-07
TC	KHDRBS3	exon_skip_134950	5.653318e-01	2.674765e-14
TC	RBM24	exon_skip_134950	5.554623e-01	9.192261e-14
TC	PUM1	exon_skip_134950	5.045295e-01	2.940976e-11
TC	RALYL	exon_skip_134950	6.516099e-01	7.446633e-20
TC	CELF1	exon_skip_134950	4.762257e-01	4.910695e-10
TC	HNRNPH2	exon_skip_134950	5.159896e-01	8.723376e-12
TC	ESRP1	exon_skip_134950	5.498007e-01	1.832704e-13
TC	NOVA1	exon_skip_134950	4.424330e-01	1.028151e-08
TC	NUP42	exon_skip_125055	4.922935e-01	3.797345e-11
TC	NOVA1	exon_skip_125055	5.920746e-01	1.643028e-16

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RelatedDrugs for ARHGAP21

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ARHGAP21

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for ARHGAP21

Gene structures and expression levels for ARHGAP21

Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ARHGAP21

Open reading frame (ORF) annotation in the exon skipping event for ARHGAP21

Infer the effects of exon skipping event on protein functional features for ARHGAP21

3'-UTR located exon skipping events that lost miRNA binding sites in ARHGAP21

SNVs in the skipped exons for ARHGAP21

AD stage-associated exon skippint events for ARHGAP21

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ARHGAP21

Correlation with RNA binding proteins (RBPs) for ARHGAP21

RelatedDrugs for ARHGAP21

RelatedDiseases for ARHGAP21