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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for MICAL3 |
 Gene summary |
| Gene information | Gene symbol | MICAL3 | Gene ID | 57553 |
| Gene name | microtubule associated monooxygenase, calponin and LIM domain containing 3 | |
| Synonyms | MICAL-3 | |
| Cytomap | 22q11.21 | |
| Type of gene | protein-coding | |
| Description | [F-actin]-monooxygenase MICAL3[F-actin]-methionine sulfoxide oxidase MICAL3flavoprotein oxidoreductase MICAL3molecule interacting with CasL protein 3protein MICAL-3protein-methionine sulfoxide oxidase MICAL3 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MICAL3 | GO:0007010 | cytoskeleton organization | 24440334 |
| MICAL3 | GO:0030042 | actin filament depolymerization | 24440334 |
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Gene structures and expression levels for MICAL3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000243156
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MICAL3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_106857 | chr22 | 17822947:17823060:17827644:17827781:17831854:17831927 | 17827644:17827781 |
| exon_skip_110090 | chr22 | 17872747:17872854:17875447:17875554:17879346:17879402 | 17875447:17875554 |
| exon_skip_111248 | chr22 | 17827644:17827781:17831854:17832107:17841822:17842017 | 17831854:17832107 |
| exon_skip_117946 | chr22 | 17791202:17791301:17803811:17803861:17808844:17808937 | 17803811:17803861 |
| exon_skip_122931 | chr22 | 17871934:17872023:17884275:17884358:17885878:17885993 | 17884275:17884358 |
| exon_skip_140974 | chr22 | 17864899:17864986:17865924:17866012:17871837:17872023 | 17865924:17866012 |
| exon_skip_155368 | chr22 | 17810703:17810813:17812507:17812557:17816690:17816784 | 17812507:17812557 |
| exon_skip_160703 | chr22 | 17810703:17810813:17812507:17812557:17816690:17816776 | 17812507:17812557 |
| exon_skip_167200 | chr22 | 17891485:17891632:17893808:17893904:17895284:17895288 | 17893808:17893904 |
| exon_skip_174545 | chr22 | 17822030:17822170:17822947:17823060:17827644:17827781 | 17822947:17823060 |
| exon_skip_184013 | chr22 | 17819036:17819129:17821427:17821509:17822030:17822165 | 17821427:17821509 |
| exon_skip_229867 | chr22 | 17822947:17823060:17827644:17827781:17831854:17831863 | 17827644:17827781 |
| exon_skip_241073 | chr22 | 17871837:17872023:17884275:17884358:17885878:17886051 | 17884275:17884358 |
| exon_skip_260231 | chr22 | 17896949:17896981:17899448:17899548:17900842:17900997 | 17899448:17899548 |
| exon_skip_26431 | chr22 | 17900842:17900997:17901878:17901979:17902631:17902747 | 17901878:17901979 |
| exon_skip_269316 | chr22 | 17822947:17823060:17827644:17827781:17830067:17830154 | 17827644:17827781 |
| exon_skip_288902 | chr22 | 17816690:17816784:17817311:17819129:17821427:17821509 | 17817311:17819129 |
| exon_skip_289257 | chr22 | 17879346:17879402:17881205:17881303:17885878:17886051 | 17881205:17881303 |
| exon_skip_28998 | chr22 | 17889034:17889230:17891485:17891632:17893808:17893904 | 17891485:17891632 |
| exon_skip_296673 | chr22 | 17871934:17872023:17884275:17884358:17885878:17885989 | 17884275:17884358 |
| exon_skip_31936 | chr22 | 17822947:17823060:17826454:17826516:17831854:17831863 | 17826454:17826516 |
| exon_skip_37220 | chr22 | 17822947:17823060:17826454:17826516:17831854:17831927 | 17826454:17826516 |
| exon_skip_38234 | chr22 | 17822947:17823060:17827644:17827781:17831854:17831867 | 17827644:17827781 |
| exon_skip_40008 | chr22 | 17822030:17822170:17822947:17823060:17831854:17831863 | 17822947:17823060 |
| exon_skip_44818 | chr22 | 17822947:17823060:17826454:17826516:17831854:17831867 | 17826454:17826516 |
| exon_skip_47491 | chr22 | 17819036:17819129:17821427:17821509:17822030:17822170 | 17821427:17821509 |
| exon_skip_49137 | chr22 | 17896724:17896981:17899448:17899548:17900842:17900997 | 17899448:17899548 |
| exon_skip_5778 | chr22 | 17871837:17872023:17884275:17884358:17885878:17885993 | 17884275:17884358 |
| exon_skip_76056 | chr22 | 17827644:17827781:17830067:17830154:17831854:17831867 | 17830067:17830154 |
| exon_skip_81221 | chr22 | 17871934:17872023:17872747:17872854:17875447:17875554 | 17872747:17872854 |
| exon_skip_82202 | chr22 | 17822030:17822170:17822947:17823060:17831854:17831927 | 17822947:17823060 |
| exon_skip_83147 | chr22 | 17879346:17879402:17881205:17881303:17885878:17885993 | 17881205:17881303 |
| exon_skip_91866 | chr22 | 17831854:17832107:17841822:17842017:17864899:17864986 | 17841822:17842017 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for MICAL3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000441493 | 17841822 | 17842017 | Frame-shift |
| ENST00000441493 | 17899448 | 17899548 | Frame-shift |
| ENST00000441493 | 17822947 | 17823060 | In-frame |
| ENST00000441493 | 17827644 | 17827781 | In-frame |
| ENST00000441493 | 17901878 | 17901979 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000441493 | 17899448 | 17899548 | Frame-shift |
| ENST00000441493 | 17827644 | 17827781 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000441493 | 17817311 | 17819129 | Frame-shift |
| ENST00000441493 | 17821427 | 17821509 | Frame-shift |
| ENST00000441493 | 17831854 | 17832107 | Frame-shift |
| ENST00000441493 | 17841822 | 17842017 | Frame-shift |
| ENST00000441493 | 17865924 | 17866012 | Frame-shift |
| ENST00000441493 | 17891485 | 17891632 | Frame-shift |
| ENST00000441493 | 17893808 | 17893904 | Frame-shift |
| ENST00000441493 | 17899448 | 17899548 | Frame-shift |
| ENST00000441493 | 17822947 | 17823060 | In-frame |
| ENST00000441493 | 17827644 | 17827781 | In-frame |
| ENST00000441493 | 17901878 | 17901979 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MICAL3 |
p-ENSG00000243156_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000441493 | 9462 | 2002 | 17901878 | 17901979 | 943 | 1043 | 196 | 230 |
| ENST00000441493 | 9462 | 2002 | 17827644 | 17827781 | 3409 | 3545 | 1018 | 1064 |
| ENST00000441493 | 9462 | 2002 | 17822947 | 17823060 | 3547 | 3659 | 1064 | 1102 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000441493 | 9462 | 2002 | 17827644 | 17827781 | 3409 | 3545 | 1018 | 1064 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000441493 | 9462 | 2002 | 17901878 | 17901979 | 943 | 1043 | 196 | 230 |
| ENST00000441493 | 9462 | 2002 | 17827644 | 17827781 | 3409 | 3545 | 1018 | 1064 |
| ENST00000441493 | 9462 | 2002 | 17822947 | 17823060 | 3547 | 3659 | 1064 | 1102 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q7RTP6 | 196 | 230 | 1 | 2002 | Chain | ID=PRO_0000075846;Note=[F-actin]-monooxygenase MICAL3 |
| Q7RTP6 | 196 | 230 | 2 | 494 | Region | Note=Monooxygenase domain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VDP3 |
| Q7RTP6 | 1018 | 1064 | 949 | 2002 | Alternative sequence | ID=VSP_039488;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10718198,ECO:0000303|PubMed:15461802;Dbxref=PMID:10718198,PMID:15461802 |
| Q7RTP6 | 1018 | 1064 | 950 | 2002 | Alternative sequence | ID=VSP_042602;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q7RTP6 | 1018 | 1064 | 967 | 2002 | Alternative sequence | ID=VSP_039489;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 |
| Q7RTP6 | 1018 | 1064 | 1 | 2002 | Chain | ID=PRO_0000075846;Note=[F-actin]-monooxygenase MICAL3 |
| Q7RTP6 | 1018 | 1064 | 889 | 1138 | Compositional bias | Note=Glu-rich |
| Q7RTP6 | 1064 | 1102 | 949 | 2002 | Alternative sequence | ID=VSP_039488;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10718198,ECO:0000303|PubMed:15461802;Dbxref=PMID:10718198,PMID:15461802 |
| Q7RTP6 | 1064 | 1102 | 950 | 2002 | Alternative sequence | ID=VSP_042602;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q7RTP6 | 1064 | 1102 | 967 | 2002 | Alternative sequence | ID=VSP_039489;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 |
| Q7RTP6 | 1064 | 1102 | 1 | 2002 | Chain | ID=PRO_0000075846;Note=[F-actin]-monooxygenase MICAL3 |
| Q7RTP6 | 1064 | 1102 | 889 | 1138 | Compositional bias | Note=Glu-rich |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q7RTP6 | 1018 | 1064 | 949 | 2002 | Alternative sequence | ID=VSP_039488;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10718198,ECO:0000303|PubMed:15461802;Dbxref=PMID:10718198,PMID:15461802 |
| Q7RTP6 | 1018 | 1064 | 950 | 2002 | Alternative sequence | ID=VSP_042602;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q7RTP6 | 1018 | 1064 | 967 | 2002 | Alternative sequence | ID=VSP_039489;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 |
| Q7RTP6 | 1018 | 1064 | 1 | 2002 | Chain | ID=PRO_0000075846;Note=[F-actin]-monooxygenase MICAL3 |
| Q7RTP6 | 1018 | 1064 | 889 | 1138 | Compositional bias | Note=Glu-rich |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q7RTP6 | 196 | 230 | 1 | 2002 | Chain | ID=PRO_0000075846;Note=[F-actin]-monooxygenase MICAL3 |
| Q7RTP6 | 196 | 230 | 2 | 494 | Region | Note=Monooxygenase domain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8VDP3 |
| Q7RTP6 | 1018 | 1064 | 949 | 2002 | Alternative sequence | ID=VSP_039488;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10718198,ECO:0000303|PubMed:15461802;Dbxref=PMID:10718198,PMID:15461802 |
| Q7RTP6 | 1018 | 1064 | 950 | 2002 | Alternative sequence | ID=VSP_042602;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q7RTP6 | 1018 | 1064 | 967 | 2002 | Alternative sequence | ID=VSP_039489;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 |
| Q7RTP6 | 1018 | 1064 | 1 | 2002 | Chain | ID=PRO_0000075846;Note=[F-actin]-monooxygenase MICAL3 |
| Q7RTP6 | 1018 | 1064 | 889 | 1138 | Compositional bias | Note=Glu-rich |
| Q7RTP6 | 1064 | 1102 | 949 | 2002 | Alternative sequence | ID=VSP_039488;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:10718198,ECO:0000303|PubMed:15461802;Dbxref=PMID:10718198,PMID:15461802 |
| Q7RTP6 | 1064 | 1102 | 950 | 2002 | Alternative sequence | ID=VSP_042602;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q7RTP6 | 1064 | 1102 | 967 | 2002 | Alternative sequence | ID=VSP_039489;Note=In isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:17974005;Dbxref=PMID:15489334,PMID:17974005 |
| Q7RTP6 | 1064 | 1102 | 1 | 2002 | Chain | ID=PRO_0000075846;Note=[F-actin]-monooxygenase MICAL3 |
| Q7RTP6 | 1064 | 1102 | 889 | 1138 | Compositional bias | Note=Glu-rich |
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3'-UTR located exon skipping events that lost miRNA binding sites in MICAL3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MICAL3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MICAL3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| CDR | MSBB | IFG | exon_skip_225199 | 4.026609e-01 | 3.363623e-02 | chr22 | - | 17899448 | 17899548 | 17899842 | 17899949 | 17900842 | 17900997 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MICAL3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for MICAL3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | FUBP1 | exon_skip_117946 | -4.777588e-01 | 1.914512e-10 |
| CB | HNRNPF | exon_skip_117946 | -4.115038e-01 | 7.101315e-08 |
| HCC | FUBP3 | exon_skip_117946 | 4.008214e-01 | 6.407660e-12 |
| IFG | ELAVL4 | exon_skip_117946 | -6.194045e-01 | 5.706994e-04 |
| IFG | IGF2BP2 | exon_skip_49137 | 4.997898e-01 | 6.767771e-03 |
| PCC | ELAVL4 | exon_skip_117946 | -4.065654e-01 | 1.006969e-09 |
| PCC | G3BP2 | exon_skip_106857 | 4.629955e-01 | 3.979649e-12 |
| TC | ELAVL4 | exon_skip_117946 | -6.791834e-01 | 5.544557e-23 |
| TC | CELF1 | exon_skip_117946 | -5.271845e-01 | 7.966090e-13 |
| TC | HNRNPH2 | exon_skip_117946 | -4.887480e-01 | 5.490621e-11 |
| TC | ESRP1 | exon_skip_117946 | -4.799662e-01 | 1.344181e-10 |
| TC | SRSF2 | exon_skip_229867 | 4.281971e-01 | 1.798624e-08 |
| TC | ESRP1 | exon_skip_229867 | 4.724596e-01 | 3.223833e-10 |
| TC | NOVA1 | exon_skip_229867 | 6.260116e-01 | 1.109535e-18 |
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RelatedDrugs for MICAL3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MICAL3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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