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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for MTA3 |
 Gene summary |
| Gene information | Gene symbol | MTA3 | Gene ID | 57504 |
| Gene name | metastasis associated 1 family member 3 | |
| Synonyms | - | |
| Cytomap | 2p21 | |
| Type of gene | protein-coding | |
| Description | metastasis-associated protein MTA3metastasis associated gene family, member 3 | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context | - 21931736(CHD5, a Brain-Specific Paralog of Mi2 Chromatin Remodeling Enzymes, Regulates Expression of Neuronal Genes) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for MTA3 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000057935
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | UP | ENST00000493983.1 | MTA3-219:lncRNA:MTA3 | 2.782327e+00 | 8.773889e-01 | 3.595057e-04 | 2.182205e-03 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for MTA3 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_107699 | chr2 | 42697776:42697834:42704194:42704318:42707903:42708054 | 42704194:42704318 |
| exon_skip_115710 | chr2 | 42579107:42579200:42581785:42581908:42609458:42609584 | 42581785:42581908 |
| exon_skip_131531 | chr2 | 42579107:42579200:42640173:42640236:42644127:42644244 | 42640173:42640236 |
| exon_skip_144056 | chr2 | 42697776:42697834:42704197:42704318:42707903:42708054 | 42704197:42704318 |
| exon_skip_161196 | chr2 | 42579107:42579200:42609458:42609584:42644127:42644244 | 42609458:42609584 |
| exon_skip_166780 | chr2 | 42722889:42723035:42752234:42752307:42753374:42754060 | 42752234:42752307 |
| exon_skip_170747 | chr2 | 42579107:42579200:42581785:42581908:42609458:42609488 | 42581785:42581908 |
| exon_skip_173962 | chr2 | 42695765:42695839:42697776:42697834:42704194:42704318 | 42697776:42697834 |
| exon_skip_184637 | chr2 | 42609461:42609584:42640173:42640236:42644127:42644244 | 42640173:42640236 |
| exon_skip_200996 | chr2 | 42579107:42579200:42609458:42609584:42640173:42640236 | 42609458:42609584 |
| exon_skip_229439 | chr2 | 42697776:42697834:42698415:42698494:42704197:42704318 | 42698415:42698494 |
| exon_skip_236430 | chr2 | 42609458:42609584:42640173:42640236:42644127:42644244 | 42640173:42640236 |
| exon_skip_236905 | chr2 | 42659763:42659862:42682401:42682589:42695765:42695838 | 42682401:42682589 |
| exon_skip_271226 | chr2 | 42568746:42568773:42570437:42570504:42579107:42579200 | 42570437:42570504 |
| exon_skip_287177 | chr2 | 42659763:42659862:42682401:42682589:42695765:42695839 | 42682401:42682589 |
| exon_skip_34553 | chr2 | 42695765:42695839:42697776:42697834:42704197:42704318 | 42697776:42697834 |
| exon_skip_55506 | chr2 | 42570437:42570504:42579107:42579200:42609458:42609488 | 42579107:42579200 |
| exon_skip_57449 | chr2 | 42644127:42644244:42656200:42656302:42659763:42659776 | 42656200:42656302 |
| exon_skip_60305 | chr2 | 42656200:42656302:42659763:42659862:42682401:42682589 | 42659763:42659862 |
| exon_skip_72654 | chr2 | 42722891:42723035:42752234:42752307:42753374:42754060 | 42752234:42752307 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for MTA3 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000405094 | 42570437 | 42570504 | Frame-shift |
| ENST00000405094 | 42579107 | 42579200 | Frame-shift |
| ENST00000405094 | 42609458 | 42609584 | Frame-shift |
| ENST00000405094 | 42640173 | 42640236 | Frame-shift |
| ENST00000405094 | 42656200 | 42656302 | Frame-shift |
| ENST00000405094 | 42659763 | 42659862 | Frame-shift |
| ENST00000405094 | 42697776 | 42697834 | Frame-shift |
| ENST00000405094 | 42704194 | 42704318 | Frame-shift |
| ENST00000405094 | 42682401 | 42682589 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000405094 | 42579107 | 42579200 | Frame-shift |
| ENST00000405094 | 42609458 | 42609584 | Frame-shift |
| ENST00000405094 | 42640173 | 42640236 | Frame-shift |
| ENST00000405094 | 42682401 | 42682589 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000405094 | 42570437 | 42570504 | Frame-shift |
| ENST00000405094 | 42579107 | 42579200 | Frame-shift |
| ENST00000405094 | 42609458 | 42609584 | Frame-shift |
| ENST00000405094 | 42640173 | 42640236 | Frame-shift |
| ENST00000405094 | 42656200 | 42656302 | Frame-shift |
| ENST00000405094 | 42697776 | 42697834 | Frame-shift |
| ENST00000405094 | 42682401 | 42682589 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MTA3 |
p-ENSG00000057935_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000405094 | 1802 | 594 | 42682401 | 42682589 | 704 | 891 | 234 | 297 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000405094 | 1802 | 594 | 42682401 | 42682589 | 704 | 891 | 234 | 297 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000405094 | 1802 | 594 | 42682401 | 42682589 | 704 | 891 | 234 | 297 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9BTC8 | 234 | 297 | 1 | 594 | Chain | ID=PRO_0000083498;Note=Metastasis-associated protein MTA3 |
| Q9BTC8 | 234 | 297 | 148 | 259 | Domain | Note=ELM2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00512 |
| Q9BTC8 | 234 | 297 | 266 | 318 | Domain | Note=SANT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00624 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9BTC8 | 234 | 297 | 1 | 594 | Chain | ID=PRO_0000083498;Note=Metastasis-associated protein MTA3 |
| Q9BTC8 | 234 | 297 | 148 | 259 | Domain | Note=ELM2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00512 |
| Q9BTC8 | 234 | 297 | 266 | 318 | Domain | Note=SANT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00624 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9BTC8 | 234 | 297 | 1 | 594 | Chain | ID=PRO_0000083498;Note=Metastasis-associated protein MTA3 |
| Q9BTC8 | 234 | 297 | 148 | 259 | Domain | Note=ELM2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00512 |
| Q9BTC8 | 234 | 297 | 266 | 318 | Domain | Note=SANT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00624 |
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3'-UTR located exon skipping events that lost miRNA binding sites in MTA3 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for MTA3 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for MTA3 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MTA3 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for MTA3 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for MTA3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MTA3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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