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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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3'-UTR located exon skipping events lost miRNA binding sites

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SNVs in the skipped exons with depth of coverage

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AD stage-associated exon skipping events

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Correlation with RNA binding proteins (RBPs)

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Related drugs with this gene

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Related diseases with this gene

Gene summary for KIDINS220

check button Gene summary
Gene informationGene symbol

KIDINS220

Gene ID

57498

Gene namekinase D interacting substrate 220
SynonymsARMS|SINO
Cytomap

2p25.1

Type of geneprotein-coding
Descriptionkinase D-interacting substrate of 220 kDaankyrin repeat-rich membrane-spanning proteinkinase D-interacting substrate 220kDa
Modification date20200313
UniProtAcc

A0A076N408,

A0A076N8A7,

A0A076NBC8,

A0A1W2PPB7,

A0A1W2PPY4,

E9PH70,

F8WAY8,

G1UI41,

H0Y8E4,

H7C584,

Q9ULH0,

Context- 27858709(Kidins220 Correlates with Tau in Alzheimer's Disease Brain and Cerebrospinal Fluid)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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Gene structures and expression levels for KIDINS220

check buttonSkipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

ENSG00000134313
check button Differentially expressed gene analysis across multiple brain tissues between AD and control.
Tissue typeDEG directionBase mean exp.log2FC(AD/control)P-valueAdj. p-value

check button Differentially expressed isoform analysis across multiple brain tissues between AD and control.
gencode gene structure
Tissue typeDEG directionENSTTranscript info.Base mean exp.log2FC(AD/control)P-valueAdjc. p-value
PGDOWNENST00000496383.5KIDINS220-210:protein_coding:KIDINS2203.476178e+02-1.005698e+005.047844e-075.262721e-05
CBUPENST00000488729.5KIDINS220-208:nonsense_mediated_decay:KIDINS2201.887786e+012.071025e+006.102676e-114.209786e-09
CBUPENST00000496383.5KIDINS220-210:protein_coding:KIDINS2204.526681e+018.228131e-012.036269e-041.351026e-03
TCUPENST00000488729.5KIDINS220-208:nonsense_mediated_decay:KIDINS2206.483720e+008.485320e-012.620607e-032.059732e-02

check button Landscape of isoform expressions across multiple brain tissues between AD and control.
gencode gene structure

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for KIDINS220

check button Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).
boxplot

check button All exon skipping events in AD cohorts.
Exon skip IDchrExons involved in exon skippingSkipped exon
exon_skip_107235chr28740152:8740184:8747145:8747201:8747887:87480008747145:8747201
exon_skip_11373chr28746457:8748000:8749371:8749421:8750112:87503358749371:8749421
exon_skip_114775chr28806271:8806369:8812395:8812493:8813237:88133358812395:8812493
exon_skip_122798chr28817618:8817716:8818695:8818793:8826986:88271298818695:8818793
exon_skip_137220chr28747887:8748000:8749371:8749421:8750112:87503358749371:8749421
exon_skip_15395chr28798202:8798300:8800400:8800498:8802930:88029718800400:8800498
exon_skip_161374chr28726887:8726943:8727189:8727267:8733444:87336808727189:8727267
exon_skip_168081chr28791060:8791224:8793810:8793987:8796771:87968698793810:8793987
exon_skip_211954chr28747887:8748000:8749371:8749421:8750112:87501328749371:8749421
exon_skip_238105chr28818695:8818793:8826986:8827129:8837480:88375968826986:8827129
exon_skip_239430chr28725560:8725599:8726887:8726943:8727189:87272678726887:8726943
exon_skip_259444chr28726887:8726943:8727189:8727267:8733444:87336738727189:8727267
exon_skip_282727chr28736868:8736999:8740152:8740184:8747145:87472018740152:8740184
exon_skip_30121chr28736868:8736999:8747887:8748000:8750112:87501328747887:8748000
exon_skip_3014chr28725560:8725599:8726887:8726943:8733444:87336808726887:8726943
exon_skip_31644chr28806271:8806369:8812395:8812496:8813237:88133358812395:8812496
exon_skip_80735chr28733609:8733680:8734655:8734753:8736868:87369998734655:8734753
exon_skip_85403chr28736868:8736999:8747887:8748000:8750112:87503358747887:8748000
exon_skip_9140chr28736868:8736999:8747145:8747201:8747887:87480008747145:8747201
exon_skip_93936chr28818695:8818793:8825743:8825913:8826986:88271298825743:8825913

check button Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.
Exon skipping informationTissue typeAvg(PSIs) in ADAvg(PSIs) in controlDifference (PSI)Adj. p-value


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Open reading frame (ORF) annotation in the exon skipping event for KIDINS220

check button Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000256707882698688271293UTR-3CDS
ENST0000025670787346558734753In-frame
ENST0000025670787471458747201In-frame

check button Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000256707882698688271293UTR-3CDS
ENST0000025670787938108793987Frame-shift
ENST0000025670787471458747201In-frame
ENST0000025670788004008800498In-frame
ENST0000025670788186958818793In-frame

check button Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000256707882698688271293UTR-3CDS
ENST0000025670787938108793987Frame-shift
ENST0000025670787346558734753In-frame
ENST0000025670787471458747201In-frame
ENST0000025670788123958812493In-frame
ENST0000025670788186958818793In-frame

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Infer the effects of exon skipping event on protein functional features for KIDINS220

p-ENSG00000134313_img4.png
boxplot

check button Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000025670773781771874714587472013711376611761194
ENST0000025670773781771873465587347533900399712391271

check button Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000025670773781771881869588187932913883668
ENST0000025670773781771880040088004989841081267299
ENST0000025670773781771874714587472013711376611761194

check button Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000025670773781771881869588187932913883668
ENST000002567077378177188123958812493588685135167
ENST0000025670773781771874714587472013711376611761194
ENST0000025670773781771873465587347533900399712391271

check button Lost protein functional features of individual exon skipping events in ROSMAP.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q9ULH01176119411228Alternative sequenceID=VSP_031861;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q9ULH01176119410311771Alternative sequenceID=VSP_031865;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
Q9ULH01176119411381194Alternative sequenceID=VSP_031866;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q9ULH01176119411771195Alternative sequenceID=VSP_031867;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
Q9ULH01176119411771ChainID=PRO_0000322119;Note=Kinase D-interacting substrate of 220 kDa
Q9ULH0117611947071771Topological domainNote=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q9ULH01239127110311771Alternative sequenceID=VSP_031865;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
Q9ULH01239127111771ChainID=PRO_0000322119;Note=Kinase D-interacting substrate of 220 kDa
Q9ULH0123912717071771Topological domainNote=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255

check button Lost protein functional features of individual exon skipping events in MSBB.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q9ULH0366811228Alternative sequenceID=VSP_031861;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q9ULH03668142Alternative sequenceID=VSP_031862;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q9ULH0366811771ChainID=PRO_0000322119;Note=Kinase D-interacting substrate of 220 kDa
Q9ULH036683766RepeatNote=ANK 2
Q9ULH036681499Topological domainNote=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q9ULH026729911228Alternative sequenceID=VSP_031861;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q9ULH026729911771ChainID=PRO_0000322119;Note=Kinase D-interacting substrate of 220 kDa
Q9ULH0267299268297RepeatNote=ANK 9
Q9ULH02672991499Topological domainNote=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q9ULH01176119411228Alternative sequenceID=VSP_031861;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q9ULH01176119410311771Alternative sequenceID=VSP_031865;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
Q9ULH01176119411381194Alternative sequenceID=VSP_031866;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q9ULH01176119411771195Alternative sequenceID=VSP_031867;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
Q9ULH01176119411771ChainID=PRO_0000322119;Note=Kinase D-interacting substrate of 220 kDa
Q9ULH0117611947071771Topological domainNote=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255

check button Lost protein functional features of individual exon skipping events in Mayo.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q9ULH0366811228Alternative sequenceID=VSP_031861;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q9ULH03668142Alternative sequenceID=VSP_031862;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q9ULH0366811771ChainID=PRO_0000322119;Note=Kinase D-interacting substrate of 220 kDa
Q9ULH036683766RepeatNote=ANK 2
Q9ULH036681499Topological domainNote=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q9ULH013516711228Alternative sequenceID=VSP_031861;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q9ULH0135167135135Alternative sequenceID=VSP_031863;Note=In isoform 3. L->LQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
Q9ULH013516711771ChainID=PRO_0000322119;Note=Kinase D-interacting substrate of 220 kDa
Q9ULH0135167136165RepeatNote=ANK 5
Q9ULH01351671499Topological domainNote=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q9ULH01176119411228Alternative sequenceID=VSP_031861;Note=In isoform 5. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
Q9ULH01176119410311771Alternative sequenceID=VSP_031865;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
Q9ULH01176119411381194Alternative sequenceID=VSP_031866;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334
Q9ULH01176119411771195Alternative sequenceID=VSP_031867;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
Q9ULH01176119411771ChainID=PRO_0000322119;Note=Kinase D-interacting substrate of 220 kDa
Q9ULH0117611947071771Topological domainNote=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q9ULH01239127110311771Alternative sequenceID=VSP_031865;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:17974005;Dbxref=PMID:17974005
Q9ULH01239127111771ChainID=PRO_0000322119;Note=Kinase D-interacting substrate of 220 kDa
Q9ULH0123912717071771Topological domainNote=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255


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3'-UTR located exon skipping events that lost miRNA binding sites in KIDINS220

check button 3'-UTR exon skipping evnets lost miRNA binding.
Tissue typeENSTExon skip startExon skip endmicroRNABinding site by TargetScanBinding type by TargetScanBdinding site by miRandaScore of miRandaEnergy by miRanda

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SNVs in the skipped exons for KIDINS220

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Depth of Coverage in the skipped exon of the mutated samples.

check button - Sashimi plot in the skipped exon of the mutated samples.

check button - Non-synonymous mutations located in the skipped exons.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange

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AD stage-associated exon skippint events for KIDINS220

check button Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).
AD stage infoCohortTissueSE idCoefficient P-valueChromosomeStrandE1 startE1 endSkipped startSkipped endE2 startE2 end
ADstageMSBBIFGexon_skip_347254.761874e-011.042053e-02chr2-880627188063698810661881077888123958812493
CDRMSBBIFGexon_skip_347253.890905e-014.071264e-02chr2-880627188063698810661881077888123958812493
CDRMSBBSTGexon_skip_854033.149922e-012.103061e-03chr2-873686887369998747887874800087501128750335

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for KIDINS220

check button sQTL information located at the skipped exons.
Tissue typeExon skip IDSNP idLocationP-valueFDR

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Correlation with RNA binding proteins (RBPs) for KIDINS220

check button Correlated RBP and related information.
Tissue typeRBP nameExon skip IDCorrelation coeifficientP-value
FLMSI1exon_skip_854035.295262e-018.880400e-16
FLRBM3exon_skip_85403-4.241515e-014.293819e-10
FLHNRNPKexon_skip_85403-4.630573e-015.714841e-12
FLNUP42exon_skip_85403-4.187096e-017.529250e-10
FLRALYLexon_skip_85403-5.674710e-012.346304e-18
FLNOVA1exon_skip_85403-4.921706e-011.548050e-13
HCCMSI1exon_skip_854035.719173e-011.113827e-24
HCCRBM6exon_skip_854036.304732e-014.184345e-31
HCCCNOT4exon_skip_854034.317434e-011.353767e-13
HCCPCBP1exon_skip_854034.433794e-012.471252e-14
HCCUNKexon_skip_854035.207598e-014.964156e-20
IFGRALYLexon_skip_91404.766348e-011.033844e-02
IFGIGF2BP2exon_skip_854034.345371e-012.085116e-02
IFGNUP42exon_skip_85403-4.451196e-011.761760e-02
IFGRALYLexon_skip_85403-5.618948e-011.860362e-03
IFGYBX2exon_skip_85403-4.176999e-012.698651e-02
IFGNOVA1exon_skip_85403-5.834064e-011.119376e-03
PCCMSI1exon_skip_854035.661041e-019.105579e-19
PCCRBM6exon_skip_854035.183563e-011.712181e-15
PGMSI1exon_skip_854034.121754e-017.475962e-10
PGRBM3exon_skip_85403-4.711076e-018.903741e-13
PGPCBP1exon_skip_85403-5.143983e-012.598315e-15
PGHNRNPKexon_skip_85403-4.816883e-012.304557e-13
PGNUP42exon_skip_85403-4.423702e-012.790306e-11
PGRALYLexon_skip_85403-6.726951e-011.697959e-28
PGNOVA1exon_skip_85403-5.498443e-011.132395e-17
STGIGF2BP2exon_skip_854034.190555e-012.906302e-05
STGHNRNPKexon_skip_85403-5.721338e-012.086353e-09
STGPCBP2exon_skip_85403-4.637821e-012.840966e-06
STGNUP42exon_skip_85403-6.396780e-015.125132e-12
STGRALYLexon_skip_85403-7.491501e-015.821658e-18
STGNOVA1exon_skip_85403-6.623696e-014.803242e-13
TCNUP42exon_skip_259444-4.386985e-011.428546e-07
TCRALYLexon_skip_259444-6.156257e-013.988044e-15
TCHNRNPH2exon_skip_259444-4.430533e-011.038358e-07
TCRBM6exon_skip_301214.215974e-015.172862e-08
TCNUP42exon_skip_30121-6.711069e-011.677335e-21
TCRALYLexon_skip_30121-8.582125e-017.102859e-46
TCYBX2exon_skip_30121-4.328583e-012.062926e-08
TCNOVA1exon_skip_30121-5.976310e-012.783625e-16

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RelatedDrugs for KIDINS220

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
UniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KIDINS220

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource