ExonSkipAD: functional annotation of exon skipping event in human

Gene summary for PTK2

Gene summary

Gene information	Gene symbol	PTK2
	Gene ID	5747
	Gene name	protein tyrosine kinase 2
	Synonyms	FADK\|FAK\|FAK1\|FRNK\|PPP1R71\|p125FAK\|pp125FAK
	Cytomap	8q24.3
	Type of gene	protein-coding
	Description	focal adhesion kinase 1FADK 1FAK-related non-kinase polypeptidePTK2 protein tyrosine kinase 2focal adhesion kinase isoform FAK-Del33focal adhesion kinase-related nonkinaseprotein phosphatase 1 regulatory subunit 71
	Modification date	20200327
	UniProtAcc	A0A024R9H6, A0A1D5RMT1, B4DWJ1, E5RFW9, E5RG54, E5RG66, E5RG80, E5RG86, E5RGA6, E5RGP1, E5RH01, E5RH08, E5RH48, E5RHD8, E5RHK7, E5RI03, E5RI29, E5RI72, E5RII9, E5RIK4, E5RIR5, E5RJI4, E5RJN1, E5RJP0, E5RJQ2, E7ESA6, E9PEI4, H0YAS0, H0YB16, H0YB33, H0YB99, H0YBP1, H0YBZ1, I6L996, Q05397,
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
PTK2	GO:0007179	transforming growth factor beta receptor signaling pathway	24036928
PTK2	GO:0007229	integrin-mediated signaling pathway	24036928
PTK2	GO:0010763	positive regulation of fibroblast migration	26763945
PTK2	GO:0018108	peptidyl-tyrosine phosphorylation	10655584\|11331870
PTK2	GO:0022408	negative regulation of cell-cell adhesion	21703394
PTK2	GO:0030335	positive regulation of cell migration	11331870\|21703394
PTK2	GO:0033628	regulation of cell adhesion mediated by integrin	10655584
PTK2	GO:0046777	protein autophosphorylation	10655584\|11331870
PTK2	GO:0048013	ephrin receptor signaling pathway	10655584
PTK2	GO:0060396	growth hormone receptor signaling pathway	10925297
PTK2	GO:0090303	positive regulation of wound healing	26763945

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Gene structures and expression levels for PTK2

Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

ENSG00000169398

Differentially expressed gene analysis across multiple brain tissues between AD and control.

Tissue type

DEG direction

Base mean exp.

log2FC(AD/control)

P-value

Adj. p-value

Differentially expressed isoform analysis across multiple brain tissues between AD and control.

Tissue type	DEG direction	ENST	Transcript info.	Base mean exp.	log2FC(AD/control)	P-value	Adjc. p-value
PCC	UP	ENST00000523539.5	PTK2-246:protein_coding:PTK2	4.755620e+01	1.536037e+00	3.420264e-04	1.298133e-02
PG	UP	ENST00000523746.5	PTK2-250:lncRNA:PTK2	9.045822e+00	2.302815e+00	3.025255e-04	6.165914e-03
PG	UP	ENST00000523670.5	PTK2-247:nonsense_mediated_decay:PTK2	7.134847e+00	1.635052e+00	1.509230e-03	1.955225e-02
PG	UP	ENST00000519654.5	PTK2-215:protein_coding:PTK2	3.831781e+02	8.275894e-01	4.627850e-03	4.330686e-02
CB	DOWN	ENST00000517712.5	PTK2-206:protein_coding:PTK2	4.906989e+02	-8.342343e-01	3.580516e-10	1.873754e-08
CB	UP	ENST00000520151.5	PTK2-220:protein_coding:PTK2	1.251159e+00	2.098760e+00	5.240477e-07	8.646640e-06
CB	DOWN	ENST00000520460.1	PTK2-221:lncRNA:PTK2	5.631347e+00	-1.096117e+00	2.104340e-06	2.821360e-05
CB	DOWN	ENST00000519465.5	PTK2-213:protein_coding:PTK2	2.143305e+02	-1.660190e+00	1.849711e-04	1.245557e-03
CB	UP	ENST00000524357.5	PTK2-257:protein_coding:PTK2	1.246681e+00	1.163110e+00	9.766492e-04	5.062457e-03
TC	DOWN	ENST00000520460.1	PTK2-221:lncRNA:PTK2	1.002071e+01	-9.926751e-01	3.075199e-05	6.294822e-04
TC	UP	ENST00000520151.5	PTK2-220:protein_coding:PTK2	1.305513e+00	1.081537e+00	5.027941e-03	3.366055e-02

Landscape of isoform expressions across multiple brain tissues between AD and control.

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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for PTK2

Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap).

All exon skipping events in AD cohorts.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon
exon_skip_103559	chr8	140830472:140830526:140846260:140846322:140846599:140846678	140846260:140846322
exon_skip_108097	chr8	140735251:140735455:140739018:140739107:140743230:140743277	140739018:140739107
exon_skip_111153	chr8	140890543:140890769:140984078:140984155:141001125:141001196	140984078:140984155
exon_skip_112073	chr8	140717598:140717709:140718009:140718211:140718317:140718355	140718009:140718211
exon_skip_121223	chr8	140746834:140746860:140752232:140752316:140761165:140761258	140752232:140752316
exon_skip_125085	chr8	140864312:140864399:140890543:140890769:141001125:141001158	140890543:140890769
exon_skip_126563	chr8	140743290:140743330:140744652:140744767:140752232:140752316	140744652:140744767
exon_skip_126960	chr8	140764234:140764290:140789474:140789526:140793354:140793384	140789474:140789526
exon_skip_133990	chr8	140769575:140769592:140770716:140770799:140789474:140789526	140770716:140770799
exon_skip_135273	chr8	140674298:140674404:140675460:140675499:140686632:140686693	140675460:140675499
exon_skip_135874	chr8	140890637:140890769:140925661:140925749:140948666:140948723	140925661:140925749
exon_skip_136568	chr8	140879512:140879637:140890543:140890769:140925661:140925749	140890543:140890769
exon_skip_137221	chr8	140752232:140752316:140761165:140761262:140764234:140764260	140761165:140761262
exon_skip_14146	chr8	140746834:140746860:140761165:140761262:140764234:140764260	140761165:140761262
exon_skip_142075	chr8	140761222:140761262:140762368:140762388:140764234:140764260	140762368:140762388
exon_skip_149940	chr8	140800459:140800576:140803543:140803650:140818277:140818354	140803543:140803650
exon_skip_155804	chr8	140890637:140890769:140948666:140948723:141001125:141001158	140948666:140948723
exon_skip_158663	chr8	140674298:140674404:140675430:140675499:140686632:140686693	140675430:140675499
exon_skip_16000	chr8	140864312:140864399:140879471:140879637:140890543:140890597	140879471:140879637
exon_skip_164369	chr8	140659620:140659678:140664917:140664997:140668269:140668424	140664917:140664997
exon_skip_165220	chr8	140746834:140746860:140751903:140751987:140752232:140752316	140751903:140751987
exon_skip_168821	chr8	140830476:140830526:140846260:140846322:140846599:140846678	140846260:140846322
exon_skip_180378	chr8	140735251:140735455:140739018:140739107:140743230:140743330	140739018:140739107
exon_skip_180856	chr8	140664917:140664997:140668269:140668424:140674298:140674404	140668269:140668424
exon_skip_181421	chr8	140890637:140890769:140925661:140925749:141001125:141001158	140925661:140925749
exon_skip_185991	chr8	140659620:140659678:140664917:140664997:140668269:140668404	140664917:140664997
exon_skip_196150	chr8	140674298:140674404:140675430:140675499:140686632:140686694	140675430:140675499
exon_skip_197597	chr8	140879512:140879637:140890543:140890603:140925562:140925749	140890543:140890603
exon_skip_213560	chr8	140890584:140890769:140925661:140925749:141000880:141000926	140925661:140925749
exon_skip_213677	chr8	140746834:140746860:140752232:140752316:140761165:140761262	140752232:140752316
exon_skip_217482	chr8	140890543:140890769:140984078:140984155:141001125:141001158	140984078:140984155
exon_skip_220519	chr8	140743290:140743330:140744652:140744767:140746760:140746860	140744652:140744767
exon_skip_226102	chr8	140744747:140744767:140752232:140752316:140761165:140761262	140752232:140752316
exon_skip_226609	chr8	140746760:140746860:140751903:140751987:140752232:140752316	140751903:140751987
exon_skip_229608	chr8	140920890:140921132:140925562:140925749:141001125:141001158	140925562:140925749
exon_skip_239416	chr8	140925661:140925749:140948666:140948723:141001125:141001158	140948666:140948723
exon_skip_247901	chr8	140700943:140701022:140702570:140702707:140706119:140706168	140702570:140702707
exon_skip_249134	chr8	140675460:140675499:140686632:140686694:140700891:140701022	140686632:140686694
exon_skip_26144	chr8	140744747:140744767:140746760:140746860:140761165:140761262	140746760:140746860
exon_skip_263437	chr8	140744747:140744767:140746760:140746860:140752232:140752316	140746760:140746860
exon_skip_271549	chr8	140764234:140764290:140769575:140769592:140789474:140789526	140769575:140769592
exon_skip_276693	chr8	140764234:140764290:140769575:140769592:140770716:140770799	140769575:140769592
exon_skip_280082	chr8	140674298:140674404:140675460:140675499:140700891:140701022	140675460:140675499
exon_skip_283947	chr8	140846659:140846678:140864312:140864399:140879471:140879637	140864312:140864399
exon_skip_284875	chr8	140702698:140702707:140706119:140706205:140717598:140717709	140706119:140706205
exon_skip_287742	chr8	140890584:140890769:140948666:140948723:141001125:141001158	140948666:140948723
exon_skip_291141	chr8	140890584:140890769:140925661:140925749:141001125:141001158	140925661:140925749
exon_skip_293384	chr8	140864312:140864399:140879471:140879637:140890543:140890603	140879471:140879637
exon_skip_295354	chr8	140890543:140890769:140925661:140925749:141000880:141000926	140925661:140925749
exon_skip_30552	chr8	140744652:140744767:140746760:140746860:140752232:140752316	140746760:140746860
exon_skip_36696	chr8	140890584:140890769:140925661:140925749:141002014:141002110	140925661:140925749
exon_skip_40960	chr8	140668289:140668424:140669727:140669735:140674298:140674404	140669727:140669735
exon_skip_45349	chr8	140746760:140746860:140751903:140751987:140752232:140752313	140751903:140751987
exon_skip_52105	chr8	140668317:140668424:140669727:140669735:140674298:140674404	140669727:140669735
exon_skip_52962	chr8	140925689:140925749:140948666:140948723:141001125:141001158	140948666:140948723
exon_skip_57318	chr8	140674298:140674404:140675460:140675499:140686632:140686694	140675460:140675499
exon_skip_62097	chr8	140846659:140846678:140864312:140864399:140890543:140890603	140864312:140864399
exon_skip_63096	chr8	140890584:140890769:140925661:140925749:140948666:140948723	140925661:140925749
exon_skip_68410	chr8	140890543:140890769:140909549:140909621:140925562:140925749	140909549:140909621
exon_skip_68661	chr8	140846599:140846678:140864312:140864399:140890543:140890769	140864312:140864399
exon_skip_7175	chr8	140746834:140746860:140752232:140752316:140761165:140761194	140752232:140752316
exon_skip_80079	chr8	140744752:140744767:140746760:140746860:140752232:140752316	140746760:140746860
exon_skip_82262	chr8	140659620:140659678:140664917:140664997:140668269:140668418	140664917:140664997
exon_skip_83633	chr8	140800459:140800576:140803543:140803650:140818277:140818349	140803543:140803650
exon_skip_85368	chr8	140890637:140890769:140925661:140925749:141000880:141000926	140925661:140925749
exon_skip_93138	chr8	140761182:140761262:140762368:140762388:140764234:140764260	140762368:140762388

Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control.

Exon skipping information	Tissue type	Avg(PSIs) in AD	Avg(PSIs) in control	Difference (PSI)	Adj. p-value
exon_skip_291540	ROSMAP_PCC	2.969291e-01	3.984524e-01	-1.015232e-01	2.718630e-04
exon_skip_93138	MSBB_PG	3.950993e-01	5.259649e-01	-1.308656e-01	6.070008e-07
exon_skip_291540	MSBB_PG	2.353691e-01	3.407143e-01	-1.053452e-01	5.560751e-06

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Open reading frame (ORF) annotation in the exon skipping event for PTK2

Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000521059	140984078	140984155	3UTR-3UTR
ENST00000521059	140675460	140675499	Frame-shift
ENST00000522684	140675460	140675499	Frame-shift
ENST00000521059	140744652	140744767	Frame-shift
ENST00000522684	140744652	140744767	Frame-shift
ENST00000521059	140746760	140746860	Frame-shift
ENST00000522684	140746760	140746860	Frame-shift
ENST00000521059	140752232	140752316	Frame-shift
ENST00000522684	140752232	140752316	Frame-shift
ENST00000521059	140761165	140761262	Frame-shift
ENST00000522684	140761165	140761262	Frame-shift
ENST00000521059	140864312	140864399	Frame-shift
ENST00000522684	140864312	140864399	Frame-shift
ENST00000521059	140879471	140879637	Frame-shift
ENST00000522684	140879471	140879637	Frame-shift
ENST00000521059	140664917	140664997	In-frame
ENST00000522684	140664917	140664997	In-frame
ENST00000521059	140668269	140668424	In-frame
ENST00000522684	140668269	140668424	In-frame
ENST00000521059	140686632	140686694	In-frame
ENST00000522684	140686632	140686694	In-frame
ENST00000521059	140702570	140702707	In-frame
ENST00000522684	140702570	140702707	In-frame
ENST00000521059	140739018	140739107	In-frame
ENST00000522684	140739018	140739107	In-frame
ENST00000521059	140803543	140803650	In-frame
ENST00000522684	140803543	140803650	In-frame
ENST00000521059	140846260	140846322	In-frame
ENST00000522684	140846260	140846322	In-frame

Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000521059	140984078	140984155	3UTR-3UTR
ENST00000521059	140675460	140675499	Frame-shift
ENST00000522684	140675460	140675499	Frame-shift
ENST00000521059	140744652	140744767	Frame-shift
ENST00000522684	140744652	140744767	Frame-shift
ENST00000521059	140746760	140746860	Frame-shift
ENST00000522684	140746760	140746860	Frame-shift
ENST00000521059	140752232	140752316	Frame-shift
ENST00000522684	140752232	140752316	Frame-shift
ENST00000521059	140761165	140761262	Frame-shift
ENST00000522684	140761165	140761262	Frame-shift
ENST00000521059	140864312	140864399	Frame-shift
ENST00000522684	140864312	140864399	Frame-shift
ENST00000521059	140879471	140879637	Frame-shift
ENST00000522684	140879471	140879637	Frame-shift
ENST00000521059	140664917	140664997	In-frame
ENST00000522684	140664917	140664997	In-frame
ENST00000521059	140686632	140686694	In-frame
ENST00000522684	140686632	140686694	In-frame
ENST00000521059	140702570	140702707	In-frame
ENST00000522684	140702570	140702707	In-frame
ENST00000521059	140739018	140739107	In-frame
ENST00000522684	140739018	140739107	In-frame
ENST00000521059	140803543	140803650	In-frame
ENST00000522684	140803543	140803650	In-frame
ENST00000521059	140846260	140846322	In-frame
ENST00000522684	140846260	140846322	In-frame

Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000522684	140890543	140890769	3UTR-3CDS
ENST00000521059	140675460	140675499	Frame-shift
ENST00000522684	140675460	140675499	Frame-shift
ENST00000521059	140744652	140744767	Frame-shift
ENST00000522684	140744652	140744767	Frame-shift
ENST00000521059	140746760	140746860	Frame-shift
ENST00000522684	140746760	140746860	Frame-shift
ENST00000521059	140752232	140752316	Frame-shift
ENST00000522684	140752232	140752316	Frame-shift
ENST00000521059	140761165	140761262	Frame-shift
ENST00000522684	140761165	140761262	Frame-shift
ENST00000521059	140789474	140789526	Frame-shift
ENST00000522684	140789474	140789526	Frame-shift
ENST00000521059	140864312	140864399	Frame-shift
ENST00000522684	140864312	140864399	Frame-shift
ENST00000521059	140879471	140879637	Frame-shift
ENST00000522684	140879471	140879637	Frame-shift
ENST00000521059	140664917	140664997	In-frame
ENST00000522684	140664917	140664997	In-frame
ENST00000521059	140668269	140668424	In-frame
ENST00000522684	140668269	140668424	In-frame
ENST00000521059	140686632	140686694	In-frame
ENST00000522684	140686632	140686694	In-frame
ENST00000521059	140702570	140702707	In-frame
ENST00000522684	140702570	140702707	In-frame
ENST00000521059	140706119	140706205	In-frame
ENST00000522684	140706119	140706205	In-frame
ENST00000521059	140739018	140739107	In-frame
ENST00000522684	140739018	140739107	In-frame
ENST00000521059	140803543	140803650	In-frame
ENST00000522684	140803543	140803650	In-frame
ENST00000521059	140846260	140846322	In-frame
ENST00000522684	140846260	140846322	In-frame

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Infer the effects of exon skipping event on protein functional features for PTK2

p-ENSG00000169398_img4.png
boxplot

Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000521059	4422	1052	140846260	140846322	713	774	177	197
ENST00000522684	4972	1052	140846260	140846322	761	822	177	197
ENST00000521059	4422	1052	140803543	140803650	1050	1156	289	324
ENST00000522684	4972	1052	140803543	140803650	1098	1204	289	324
ENST00000521059	4422	1052	140739018	140739107	1918	2006	578	608
ENST00000522684	4972	1052	140739018	140739107	1966	2054	578	608
ENST00000521059	4422	1052	140702570	140702707	2412	2548	743	788
ENST00000522684	4972	1052	140702570	140702707	2460	2596	743	788
ENST00000521059	4422	1052	140686632	140686694	2682	2743	833	853
ENST00000522684	4972	1052	140686632	140686694	2730	2791	833	853
ENST00000521059	4422	1052	140668269	140668424	2892	3046	903	954
ENST00000522684	4972	1052	140668269	140668424	2940	3094	903	954
ENST00000521059	4422	1052	140664917	140664997	3048	3127	955	981
ENST00000522684	4972	1052	140664917	140664997	3096	3175	955	981

Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000521059	4422	1052	140846260	140846322	713	774	177	197
ENST00000522684	4972	1052	140846260	140846322	761	822	177	197
ENST00000521059	4422	1052	140803543	140803650	1050	1156	289	324
ENST00000522684	4972	1052	140803543	140803650	1098	1204	289	324
ENST00000521059	4422	1052	140739018	140739107	1918	2006	578	608
ENST00000522684	4972	1052	140739018	140739107	1966	2054	578	608
ENST00000521059	4422	1052	140702570	140702707	2412	2548	743	788
ENST00000522684	4972	1052	140702570	140702707	2460	2596	743	788
ENST00000521059	4422	1052	140686632	140686694	2682	2743	833	853
ENST00000522684	4972	1052	140686632	140686694	2730	2791	833	853
ENST00000521059	4422	1052	140664917	140664997	3048	3127	955	981
ENST00000522684	4972	1052	140664917	140664997	3096	3175	955	981

Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000521059	4422	1052	140846260	140846322	713	774	177	197
ENST00000522684	4972	1052	140846260	140846322	761	822	177	197
ENST00000521059	4422	1052	140803543	140803650	1050	1156	289	324
ENST00000522684	4972	1052	140803543	140803650	1098	1204	289	324
ENST00000521059	4422	1052	140739018	140739107	1918	2006	578	608
ENST00000522684	4972	1052	140739018	140739107	1966	2054	578	608
ENST00000521059	4422	1052	140706119	140706205	2325	2410	714	742
ENST00000522684	4972	1052	140706119	140706205	2373	2458	714	742
ENST00000521059	4422	1052	140702570	140702707	2412	2548	743	788
ENST00000522684	4972	1052	140702570	140702707	2460	2596	743	788
ENST00000521059	4422	1052	140686632	140686694	2682	2743	833	853
ENST00000522684	4972	1052	140686632	140686694	2730	2791	833	853
ENST00000521059	4422	1052	140668269	140668424	2892	3046	903	954
ENST00000522684	4972	1052	140668269	140668424	2940	3094	903	954
ENST00000521059	4422	1052	140664917	140664997	3048	3127	955	981
ENST00000522684	4972	1052	140664917	140664997	3096	3175	955	981

Lost protein functional features of individual exon skipping events in ROSMAP.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q05397	177	197	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	177	197	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	177	197	1	181	Alternative sequence	ID=VSP_004967;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	177	197	1	181	Alternative sequence	ID=VSP_004967;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	177	197	182	189	Alternative sequence	ID=VSP_004968;Note=In isoform 2%2C isoform 3 and isoform 4. EMRGNALE->MSDYWVVG;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	177	197	182	189	Alternative sequence	ID=VSP_004968;Note=In isoform 2%2C isoform 3 and isoform 4. EMRGNALE->MSDYWVVG;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	177	197	188	190	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	188	190	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	177	197	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	177	197	35	355	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00084
Q05397	177	197	35	355	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00084
Q05397	177	197	165	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	165	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	185	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	185	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	191	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	191	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	197	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	197	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	184	184	Sequence conflict	Note=R->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	177	197	184	184	Sequence conflict	Note=R->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	289	324	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	289	324	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	289	324	290	294	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	290	294	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	299	306	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	299	306	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	308	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	308	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	314	320	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	314	320	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	289	324	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	289	324	35	355	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00084
Q05397	289	324	35	355	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00084
Q05397	289	324	296	298	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	296	298	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	292	292	Natural variant	ID=VAR_041682;Note=H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=PMID:17344846
Q05397	289	324	292	292	Natural variant	ID=VAR_041682;Note=H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=PMID:17344846
Q05397	289	324	292	292	Natural variant	ID=VAR_041683;Note=H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=PMID:17344846
Q05397	289	324	292	292	Natural variant	ID=VAR_041683;Note=H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=PMID:17344846
Q05397	578	608	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	578	608	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	578	608	579	583	Alternative sequence	ID=VSP_004971;Note=In isoform 4. ASKGK->GKKSG;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	578	608	579	583	Alternative sequence	ID=VSP_004971;Note=In isoform 4. ASKGK->GKKSG;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	578	608	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	578	608	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	578	608	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	578	608	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	578	608	422	680	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q05397	578	608	422	680	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q05397	578	608	586	588	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4I4E
Q05397	578	608	586	588	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4I4E
Q05397	578	608	591	596	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4I4E
Q05397	578	608	591	596	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4I4E
Q05397	578	608	601	616	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4I4E
Q05397	578	608	601	616	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4I4E
Q05397	578	608	580	580	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19369195;Dbxref=PMID:19369195
Q05397	578	608	580	580	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19369195;Dbxref=PMID:19369195
Q05397	743	788	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	743	788	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	743	788	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	743	788	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	743	788	744	789	Alternative sequence	ID=VSP_057268;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q05397	743	788	744	789	Alternative sequence	ID=VSP_057268;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q05397	743	788	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	743	788	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	743	788	707	1052	Region	Note=Interaction with TGFB1I1
Q05397	743	788	707	1052	Region	Note=Interaction with TGFB1I1
Q05397	743	788	778	778	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	743	788	778	778	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	833	853	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	833	853	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	833	853	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	833	853	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	833	853	834	854	Alternative sequence	ID=VSP_004970;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	833	853	834	854	Alternative sequence	ID=VSP_004970;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	833	853	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	833	853	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	833	853	843	843	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q05397	833	853	843	843	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q05397	833	853	707	1052	Region	Note=Interaction with TGFB1I1
Q05397	833	853	707	1052	Region	Note=Interaction with TGFB1I1
Q05397	903	954	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	903	954	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	903	954	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	903	954	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	903	954	903	903	Alternative sequence	ID=VSP_042170;Note=In isoform 5. K->KPWR;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q05397	903	954	903	903	Alternative sequence	ID=VSP_042170;Note=In isoform 5. K->KPWR;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q05397	903	954	915	917	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	903	954	915	917	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	903	954	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	903	954	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	903	954	863	913	Compositional bias	Note=Pro-rich
Q05397	903	954	863	913	Compositional bias	Note=Pro-rich
Q05397	903	954	923	942	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	903	954	923	942	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	903	954	947	949	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	903	954	947	949	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	903	954	950	971	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	903	954	950	971	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	903	954	910	910	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:18691976,ECO:0000244\|PubMed:19369195,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163;Dbxref=PMID:1
Q05397	903	954	910	910	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:18691976,ECO:0000244\|PubMed:19369195,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163;Dbxref=PMID:1
Q05397	903	954	914	914	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:20068231;Dbxref=PMID:20068231
Q05397	903	954	914	914	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:20068231;Dbxref=PMID:20068231
Q05397	903	954	925	925	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:12387730,ECO:0000269\|PubMed:19339212;Dbxref=PMID:12387730,PMID:19339212
Q05397	903	954	925	925	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:12387730,ECO:0000269\|PubMed:19339212;Dbxref=PMID:12387730,PMID:19339212
Q05397	903	954	928	928	Mutagenesis	Note=Loss of interaction with TGFB1I1. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:9756887;Dbxref=PMID:9756887
Q05397	903	954	928	928	Mutagenesis	Note=Loss of interaction with TGFB1I1. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:9756887;Dbxref=PMID:9756887
Q05397	903	954	707	1052	Region	Note=Interaction with TGFB1I1
Q05397	903	954	707	1052	Region	Note=Interaction with TGFB1I1
Q05397	903	954	912	1052	Region	Note=Interaction with ARHGEF28;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q05397	903	954	912	1052	Region	Note=Interaction with ARHGEF28;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q05397	955	981	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	955	981	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	955	981	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	955	981	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	955	981	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	955	981	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	955	981	950	971	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	955	981	950	971	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	955	981	972	974	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	955	981	972	974	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	955	981	977	979	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	955	981	977	979	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	955	981	980	1006	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	955	981	980	1006	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	955	981	707	1052	Region	Note=Interaction with TGFB1I1
Q05397	955	981	707	1052	Region	Note=Interaction with TGFB1I1
Q05397	955	981	912	1052	Region	Note=Interaction with ARHGEF28;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q05397	955	981	912	1052	Region	Note=Interaction with ARHGEF28;Ontology_term=ECO:0000250;evidence=ECO:0000250

Lost protein functional features of individual exon skipping events in MSBB.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q05397	177	197	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	177	197	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	177	197	1	181	Alternative sequence	ID=VSP_004967;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	177	197	1	181	Alternative sequence	ID=VSP_004967;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	177	197	182	189	Alternative sequence	ID=VSP_004968;Note=In isoform 2%2C isoform 3 and isoform 4. EMRGNALE->MSDYWVVG;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	177	197	182	189	Alternative sequence	ID=VSP_004968;Note=In isoform 2%2C isoform 3 and isoform 4. EMRGNALE->MSDYWVVG;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	177	197	188	190	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	188	190	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	177	197	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	177	197	35	355	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00084
Q05397	177	197	35	355	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00084
Q05397	177	197	165	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	165	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	185	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	185	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	191	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	191	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	197	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	197	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	184	184	Sequence conflict	Note=R->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	177	197	184	184	Sequence conflict	Note=R->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	289	324	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	289	324	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	289	324	290	294	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	290	294	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	299	306	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	299	306	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	308	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	308	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	314	320	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	314	320	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	289	324	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	289	324	35	355	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00084
Q05397	289	324	35	355	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00084
Q05397	289	324	296	298	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	296	298	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	292	292	Natural variant	ID=VAR_041682;Note=H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=PMID:17344846
Q05397	289	324	292	292	Natural variant	ID=VAR_041682;Note=H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=PMID:17344846
Q05397	289	324	292	292	Natural variant	ID=VAR_041683;Note=H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=PMID:17344846
Q05397	289	324	292	292	Natural variant	ID=VAR_041683;Note=H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=PMID:17344846
Q05397	578	608	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	578	608	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	578	608	579	583	Alternative sequence	ID=VSP_004971;Note=In isoform 4. ASKGK->GKKSG;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	578	608	579	583	Alternative sequence	ID=VSP_004971;Note=In isoform 4. ASKGK->GKKSG;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	578	608	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	578	608	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	578	608	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	578	608	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	578	608	422	680	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q05397	578	608	422	680	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q05397	578	608	586	588	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4I4E
Q05397	578	608	586	588	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4I4E
Q05397	578	608	591	596	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4I4E
Q05397	578	608	591	596	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4I4E
Q05397	578	608	601	616	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4I4E
Q05397	578	608	601	616	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4I4E
Q05397	578	608	580	580	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19369195;Dbxref=PMID:19369195
Q05397	578	608	580	580	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19369195;Dbxref=PMID:19369195
Q05397	743	788	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	743	788	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	743	788	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	743	788	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	743	788	744	789	Alternative sequence	ID=VSP_057268;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q05397	743	788	744	789	Alternative sequence	ID=VSP_057268;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q05397	743	788	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	743	788	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	743	788	707	1052	Region	Note=Interaction with TGFB1I1
Q05397	743	788	707	1052	Region	Note=Interaction with TGFB1I1
Q05397	743	788	778	778	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	743	788	778	778	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	833	853	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	833	853	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	833	853	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	833	853	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	833	853	834	854	Alternative sequence	ID=VSP_004970;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	833	853	834	854	Alternative sequence	ID=VSP_004970;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	833	853	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	833	853	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	833	853	843	843	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q05397	833	853	843	843	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q05397	833	853	707	1052	Region	Note=Interaction with TGFB1I1
Q05397	833	853	707	1052	Region	Note=Interaction with TGFB1I1
Q05397	955	981	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	955	981	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	955	981	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	955	981	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	955	981	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	955	981	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	955	981	950	971	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	955	981	950	971	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	955	981	972	974	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	955	981	972	974	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	955	981	977	979	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	955	981	977	979	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	955	981	980	1006	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	955	981	980	1006	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	955	981	707	1052	Region	Note=Interaction with TGFB1I1
Q05397	955	981	707	1052	Region	Note=Interaction with TGFB1I1
Q05397	955	981	912	1052	Region	Note=Interaction with ARHGEF28;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q05397	955	981	912	1052	Region	Note=Interaction with ARHGEF28;Ontology_term=ECO:0000250;evidence=ECO:0000250

Lost protein functional features of individual exon skipping events in Mayo.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q05397	177	197	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	177	197	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	177	197	1	181	Alternative sequence	ID=VSP_004967;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	177	197	1	181	Alternative sequence	ID=VSP_004967;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	177	197	182	189	Alternative sequence	ID=VSP_004968;Note=In isoform 2%2C isoform 3 and isoform 4. EMRGNALE->MSDYWVVG;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	177	197	182	189	Alternative sequence	ID=VSP_004968;Note=In isoform 2%2C isoform 3 and isoform 4. EMRGNALE->MSDYWVVG;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	177	197	188	190	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	188	190	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	177	197	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	177	197	35	355	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00084
Q05397	177	197	35	355	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00084
Q05397	177	197	165	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	165	179	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	185	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	185	187	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	191	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	191	194	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	197	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	197	201	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	177	197	184	184	Sequence conflict	Note=R->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	177	197	184	184	Sequence conflict	Note=R->L;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	289	324	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	289	324	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	289	324	290	294	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	290	294	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	299	306	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	299	306	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	308	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	308	311	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	314	320	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	314	320	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	289	324	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	289	324	35	355	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00084
Q05397	289	324	35	355	Domain	Note=FERM;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00084
Q05397	289	324	296	298	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	296	298	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4NY0
Q05397	289	324	292	292	Natural variant	ID=VAR_041682;Note=H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=PMID:17344846
Q05397	289	324	292	292	Natural variant	ID=VAR_041682;Note=H->P;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=PMID:17344846
Q05397	289	324	292	292	Natural variant	ID=VAR_041683;Note=H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=PMID:17344846
Q05397	289	324	292	292	Natural variant	ID=VAR_041683;Note=H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:17344846;Dbxref=PMID:17344846
Q05397	578	608	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	578	608	1	692	Alternative sequence	ID=VSP_042168;Note=In isoform 6. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	578	608	579	583	Alternative sequence	ID=VSP_004971;Note=In isoform 4. ASKGK->GKKSG;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	578	608	579	583	Alternative sequence	ID=VSP_004971;Note=In isoform 4. ASKGK->GKKSG;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	578	608	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	578	608	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	578	608	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	578	608	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	578	608	422	680	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q05397	578	608	422	680	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Q05397	578	608	586	588	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4I4E
Q05397	578	608	586	588	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4I4E
Q05397	578	608	591	596	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4I4E
Q05397	578	608	591	596	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4I4E
Q05397	578	608	601	616	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4I4E
Q05397	578	608	601	616	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:4I4E
Q05397	578	608	580	580	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19369195;Dbxref=PMID:19369195
Q05397	578	608	580	580	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:19369195;Dbxref=PMID:19369195
Q05397	714	742	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	714	742	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	714	742	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	714	742	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	714	742	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	714	742	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	714	742	712	733	Compositional bias	Note=Pro-rich
Q05397	714	742	712	733	Compositional bias	Note=Pro-rich
Q05397	714	742	722	722	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19339212;Dbxref=PMID:19339212
Q05397	714	742	722	722	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:19339212;Dbxref=PMID:19339212
Q05397	714	742	732	732	Modified residue	Note=Phosphoserine%3B by CDK5;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P34152
Q05397	714	742	732	732	Modified residue	Note=Phosphoserine%3B by CDK5;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:P34152
Q05397	714	742	707	1052	Region	Note=Interaction with TGFB1I1
Q05397	714	742	707	1052	Region	Note=Interaction with TGFB1I1
Q05397	743	788	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	743	788	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	743	788	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	743	788	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	743	788	744	789	Alternative sequence	ID=VSP_057268;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q05397	743	788	744	789	Alternative sequence	ID=VSP_057268;Note=In isoform 7. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q05397	743	788	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	743	788	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	743	788	707	1052	Region	Note=Interaction with TGFB1I1
Q05397	743	788	707	1052	Region	Note=Interaction with TGFB1I1
Q05397	743	788	778	778	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	743	788	778	778	Sequence conflict	Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q05397	833	853	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	833	853	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	833	853	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	833	853	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	833	853	834	854	Alternative sequence	ID=VSP_004970;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	833	853	834	854	Alternative sequence	ID=VSP_004970;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	833	853	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	833	853	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	833	853	843	843	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q05397	833	853	843	843	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q05397	833	853	707	1052	Region	Note=Interaction with TGFB1I1
Q05397	833	853	707	1052	Region	Note=Interaction with TGFB1I1
Q05397	903	954	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	903	954	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	903	954	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	903	954	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	903	954	903	903	Alternative sequence	ID=VSP_042170;Note=In isoform 5. K->KPWR;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q05397	903	954	903	903	Alternative sequence	ID=VSP_042170;Note=In isoform 5. K->KPWR;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q05397	903	954	915	917	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	903	954	915	917	Beta strand	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	903	954	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	903	954	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	903	954	863	913	Compositional bias	Note=Pro-rich
Q05397	903	954	863	913	Compositional bias	Note=Pro-rich
Q05397	903	954	923	942	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	903	954	923	942	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	903	954	947	949	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	903	954	947	949	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	903	954	950	971	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	903	954	950	971	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	903	954	910	910	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:18691976,ECO:0000244\|PubMed:19369195,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163;Dbxref=PMID:1
Q05397	903	954	910	910	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:18691976,ECO:0000244\|PubMed:19369195,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163;Dbxref=PMID:1
Q05397	903	954	914	914	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:20068231;Dbxref=PMID:20068231
Q05397	903	954	914	914	Modified residue	Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:20068231;Dbxref=PMID:20068231
Q05397	903	954	925	925	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:12387730,ECO:0000269\|PubMed:19339212;Dbxref=PMID:12387730,PMID:19339212
Q05397	903	954	925	925	Modified residue	Note=Phosphotyrosine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269\|PubMed:12387730,ECO:0000269\|PubMed:19339212;Dbxref=PMID:12387730,PMID:19339212
Q05397	903	954	928	928	Mutagenesis	Note=Loss of interaction with TGFB1I1. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:9756887;Dbxref=PMID:9756887
Q05397	903	954	928	928	Mutagenesis	Note=Loss of interaction with TGFB1I1. V->G;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:9756887;Dbxref=PMID:9756887
Q05397	903	954	707	1052	Region	Note=Interaction with TGFB1I1
Q05397	903	954	707	1052	Region	Note=Interaction with TGFB1I1
Q05397	903	954	912	1052	Region	Note=Interaction with ARHGEF28;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q05397	903	954	912	1052	Region	Note=Interaction with ARHGEF28;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q05397	955	981	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	955	981	584	1052	Alternative sequence	ID=VSP_004972;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	955	981	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	955	981	707	1052	Alternative sequence	ID=VSP_004974;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8422239;Dbxref=PMID:8422239
Q05397	955	981	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	955	981	2	1052	Chain	ID=PRO_0000088077;Note=Focal adhesion kinase 1
Q05397	955	981	950	971	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	955	981	950	971	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	955	981	972	974	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	955	981	972	974	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	955	981	977	979	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	955	981	977	979	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	955	981	980	1006	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	955	981	980	1006	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:1K04
Q05397	955	981	707	1052	Region	Note=Interaction with TGFB1I1
Q05397	955	981	707	1052	Region	Note=Interaction with TGFB1I1
Q05397	955	981	912	1052	Region	Note=Interaction with ARHGEF28;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q05397	955	981	912	1052	Region	Note=Interaction with ARHGEF28;Ontology_term=ECO:0000250;evidence=ECO:0000250

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3'-UTR located exon skipping events that lost miRNA binding sites in PTK2

3'-UTR exon skipping evnets lost miRNA binding.

Tissue type	ENST	Exon skip start	Exon skip end	microRNA	Binding site by TargetScan	Binding type by TargetScan	Bdinding site by miRanda	Score of miRanda	Energy by miRanda
MSBB	ENST00000521059	140984078	140984155	hsa-miR-6879-3p	chr8:140984138-140984145	8mer-1a	chr8:140984123-140984145	149.00	-24.70
MSBB	ENST00000521059	140984078	140984155	hsa-miR-4755-3p	chr8:140984126-140984133	8mer-1a	chr8:140984116-140984134	159.00	-26.47
MSBB	ENST00000521059	140984078	140984155	hsa-miR-4638-5p	chr8:140984100-140984107	8mer-1a	chr8:140984086-140984107	148.00	-20.00
MSBB	ENST00000521059	140984078	140984155	hsa-miR-597-5p	chr8:140984140-140984147	8mer-1a	chr8:140984125-140984147	151.00	-22.57
MSBB	ENST00000521059	140984078	140984155	hsa-miR-500b-3p	chr8:140984136-140984143	8mer-1a	chr8:140984124-140984143	150.00	-24.61
ROSMAP	ENST00000521059	140984078	140984155	hsa-miR-6879-3p	chr8:140984138-140984145	8mer-1a	chr8:140984123-140984145	149.00	-24.70
ROSMAP	ENST00000521059	140984078	140984155	hsa-miR-4755-3p	chr8:140984126-140984133	8mer-1a	chr8:140984116-140984134	159.00	-26.47
ROSMAP	ENST00000521059	140984078	140984155	hsa-miR-4638-5p	chr8:140984100-140984107	8mer-1a	chr8:140984086-140984107	148.00	-20.00
ROSMAP	ENST00000521059	140984078	140984155	hsa-miR-597-5p	chr8:140984140-140984147	8mer-1a	chr8:140984125-140984147	151.00	-22.57
ROSMAP	ENST00000521059	140984078	140984155	hsa-miR-500b-3p	chr8:140984136-140984143	8mer-1a	chr8:140984124-140984143	150.00	-24.61

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SNVs in the skipped exons for PTK2

- Differential PSIs between mutated versus non-mutated samples.

- Depth of Coverage in the skipped exon of the mutated samples.

- Sashimi plot in the skipped exon of the mutated samples.

- Non-synonymous mutations located in the skipped exons.

Cancer type

Sample

ESID

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample

Skipped exon start

Skipped exon end

Mutation start

Mutation end

Mutation type

Reference seq

Mutation seq

AAchange

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AD stage-associated exon skippint events for PTK2

Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR).

AD stage info

Cohort

Tissue

SE id

Coefficient

P-value

Chromosome

Strand

E1 start

E1 end

Skipped start

Skipped end

E2 start

E2 end

ADstage

MSBB

IFG

exon_skip_255159

3.815418e-01

4.513465e-02

chr8

140764234

140764290

140764765

140764886

140769575

140769592

CDR

MSBB

IFG

exon_skip_287742

-3.789294e-01

4.675068e-02

chr8

140890584

140890769

140948666

140948723

141001125

141001158

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PTK2

sQTL information located at the skipped exons.

Tissue type	Exon skip ID	SNP id	Location	P-value	FDR
HCC	exon_skip_40960	rs10283368	chr8:140669718	1.691788e-04	1.417469e-02
HCC	exon_skip_40960	rs10088475	chr8:140660167	1.691788e-04	1.417469e-02
HCC	exon_skip_40960	rs11166992	chr8:140667371	1.691788e-04	1.417469e-02
HCC	exon_skip_40960	rs7009635	chr8:140584782	1.796464e-04	1.486747e-02
HCC	exon_skip_40960	rs11166990	chr8:140653873	1.818921e-04	1.500200e-02
HCC	exon_skip_40960	rs11166986	chr8:140646056	5.645139e-04	3.734306e-02
HCC	exon_skip_40960	rs938724	chr8:140647034	6.442232e-04	4.142267e-02

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Correlation with RNA binding proteins (RBPs) for PTK2

Correlated RBP and related information.

Tissue type	RBP name	Exon skip ID	Correlation coeifficient	P-value
CB	TRA2A	exon_skip_249134	-5.276967e-01	8.858608e-13
CB	HNRNPA2B1	exon_skip_249134	-4.442617e-01	4.463755e-09
CB	NUP42	exon_skip_142075	5.182890e-01	4.211922e-12
CB	FXR2	exon_skip_271549	4.006605e-01	2.393053e-07
CB	HNRNPA0	exon_skip_271549	4.905543e-01	9.201451e-11
CB	SRSF9	exon_skip_271549	4.374060e-01	1.263623e-08
CB	NUP42	exon_skip_133990	5.335283e-01	4.101059e-12
FL	MSI1	exon_skip_93138	-4.211769e-01	5.843960e-10
HCC	MSI1	exon_skip_93138	-6.176151e-01	4.199792e-30
HCC	MSI1	exon_skip_271549	-6.143648e-01	1.285027e-29
HCC	UNK	exon_skip_271549	-6.316825e-01	1.068616e-31
HCC	EWSR1	exon_skip_271549	-4.584024e-01	1.543836e-15
IFG	FXR2	exon_skip_271549	5.310027e-01	3.645052e-03
IFG	HNRNPA0	exon_skip_271549	4.094470e-01	3.048894e-02
IFG	RBM5	exon_skip_291540	-5.676312e-01	1.630125e-03
IFG	IGF2BP3	exon_skip_291540	-6.063436e-01	6.256624e-04
IFG	RBM3	exon_skip_291540	6.758950e-01	7.899854e-05
IFG	RBM47	exon_skip_291540	-6.203019e-01	4.295144e-04
IFG	UNK	exon_skip_291540	-4.618342e-01	1.335904e-02
IFG	PTBP1	exon_skip_291540	-6.655708e-01	1.110612e-04
IFG	ESRP2	exon_skip_291540	-5.615480e-01	1.875142e-03
IFG	RBM5	exon_skip_291141	4.619204e-01	1.333952e-02
IFG	TRA2A	exon_skip_291141	4.885433e-01	8.343905e-03
IFG	HNRNPA2B1	exon_skip_291141	4.811328e-01	9.542722e-03
PCC	HNRNPF	exon_skip_40960	-4.901452e-01	2.473417e-14
PCC	MSI1	exon_skip_93138	-4.434911e-01	8.971088e-12
PCC	MSI1	exon_skip_271549	-4.694901e-01	5.093734e-13
PCC	MSI1	exon_skip_291540	-4.692691e-01	5.948139e-13
PCC	RBM3	exon_skip_291540	4.439279e-01	1.332673e-11
PCC	PTBP1	exon_skip_291540	-6.518079e-01	6.627307e-27
PCC	NOVA1	exon_skip_293384	-4.031865e-01	1.424123e-09
PG	MSI1	exon_skip_93138	-4.636188e-01	1.761397e-12
PG	FXR2	exon_skip_271549	4.718232e-01	1.051804e-12
STG	MSI1	exon_skip_93138	-4.316927e-01	1.734956e-05
STG	FXR2	exon_skip_271549	5.107216e-01	2.312955e-07
STG	HNRNPA0	exon_skip_271549	4.825169e-01	1.275985e-06
TC	NUP42	exon_skip_93138	7.087230e-01	1.023412e-25
TC	FXR2	exon_skip_271549	5.370302e-01	2.932586e-13
TC	HNRNPA0	exon_skip_271549	7.132314e-01	5.227074e-26
TC	SRSF9	exon_skip_271549	4.597302e-01	1.087613e-09
TC	ESRP1	exon_skip_271549	5.267095e-01	9.937771e-13

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RelatedDrugs for PTK2

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Q05397	approved\|investigational	DB12010	Fostamatinib	small molecule	Q05397

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RelatedDiseases for PTK2

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in RPSMAP, MSBB, and Mayo
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	3'-UTR located exon skipping events lost miRNA binding sites
	SNVs in the skipped exons with depth of coverage
	AD stage-associated exon skipping events
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Correlation with RNA binding proteins (RBPs)
	Related drugs with this gene
	Related diseases with this gene

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