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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for BIRC6 |
 Gene summary |
| Gene information | Gene symbol | BIRC6 | Gene ID | 57448 |
| Gene name | baculoviral IAP repeat containing 6 | |
| Synonyms | APOLLON|BRUCE | |
| Cytomap | 2p22.3 | |
| Type of gene | protein-coding | |
| Description | baculoviral IAP repeat-containing protein 6BIR repeat-containing ubiquitin-conjugating enzymeRING-type E3 ubiquitin transferase BIRC6ubiquitin-conjugating BIR-domain enzyme apollon | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for BIRC6 |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000115760
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
 |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for BIRC6 |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
 |
| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_101732 | chr2 | 32433648:32433804:32435496:32435585:32436053:32436184 | 32435496:32435585 |
| exon_skip_102215 | chr2 | 32513079:32513154:32514990:32515770:32518254:32518397 | 32514990:32515770 |
| exon_skip_10706 | chr2 | 32479462:32479617:32481320:32481453:32482429:32482582 | 32481320:32481453 |
| exon_skip_107579 | chr2 | 32433650:32433804:32436053:32436184:32439508:32439686 | 32436053:32436184 |
| exon_skip_123765 | chr2 | 32388811:32388943:32392039:32392150:32395511:32395593 | 32392039:32392150 |
| exon_skip_126500 | chr2 | 32488588:32488714:32490041:32490151:32491425:32491558 | 32490041:32490151 |
| exon_skip_146150 | chr2 | 32603006:32603083:32607455:32607643:32611448:32611581 | 32607455:32607643 |
| exon_skip_189401 | chr2 | 32575291:32575366:32593915:32594060:32595034:32595144 | 32593915:32594060 |
| exon_skip_205545 | chr2 | 32433648:32433804:32436053:32436184:32439508:32439686 | 32436053:32436184 |
| exon_skip_209744 | chr2 | 32448795:32448928:32453808:32453942:32463194:32463282 | 32453808:32453942 |
| exon_skip_210401 | chr2 | 32477368:32477583:32478635:32478818:32479462:32479617 | 32478635:32478818 |
| exon_skip_219940 | chr2 | 32377588:32377769:32380153:32380290:32388750:32388943 | 32380153:32380290 |
| exon_skip_219947 | chr2 | 32597751:32597968:32599739:32599900:32603006:32603083 | 32599739:32599900 |
| exon_skip_222406 | chr2 | 32512933:32513154:32514990:32515770:32518254:32518397 | 32514990:32515770 |
| exon_skip_237149 | chr2 | 32448795:32448928:32453808:32453954:32463194:32463381 | 32453808:32453954 |
| exon_skip_263363 | chr2 | 32575291:32575366:32590806:32590978:32593915:32594046 | 32590806:32590978 |
| exon_skip_265055 | chr2 | 32485643:32485759:32487647:32487801:32488588:32488714 | 32487647:32487801 |
| exon_skip_270274 | chr2 | 32448795:32448928:32453808:32453954:32463194:32463282 | 32453808:32453954 |
| exon_skip_273033 | chr2 | 32471014:32471151:32473112:32473239:32476213:32476281 | 32473112:32473239 |
| exon_skip_27341 | chr2 | 32433650:32433804:32435496:32435585:32436053:32436184 | 32435496:32435585 |
| exon_skip_285615 | chr2 | 32593915:32594060:32595034:32595144:32597751:32597968 | 32595034:32595144 |
| exon_skip_295865 | chr2 | 32575291:32575366:32590806:32590978:32593915:32594060 | 32590806:32590978 |
| exon_skip_31323 | chr2 | 32401463:32401623:32406499:32406557:32414769:32416163 | 32406499:32406557 |
| exon_skip_32884 | chr2 | 32380153:32380290:32388750:32388943:32392039:32392150 | 32388750:32388943 |
| exon_skip_3318 | chr2 | 32443491:32443588:32445521:32445668:32448795:32448928 | 32445521:32445668 |
| exon_skip_35250 | chr2 | 32445521:32445668:32448795:32448928:32453808:32453942 | 32448795:32448928 |
| exon_skip_38894 | chr2 | 32401163:32401385:32401463:32401623:32406499:32406557 | 32401463:32401623 |
| exon_skip_39531 | chr2 | 32607455:32607643:32611448:32611582:32617725:32618876 | 32611448:32611582 |
| exon_skip_45980 | chr2 | 32463194:32463381:32464509:32464823:32465065:32465164 | 32464509:32464823 |
| exon_skip_50057 | chr2 | 32439508:32439686:32441329:32441462:32442065:32442226 | 32441329:32441462 |
| exon_skip_65599 | chr2 | 32493540:32493667:32499547:32500109:32501713:32501888 | 32499547:32500109 |
| exon_skip_71396 | chr2 | 32448795:32448928:32453808:32453942:32463194:32463381 | 32453808:32453942 |
| exon_skip_7834 | chr2 | 32401178:32401385:32401463:32401623:32406499:32406557 | 32401463:32401623 |
| exon_skip_79987 | chr2 | 32476213:32476344:32477368:32477583:32478635:32478818 | 32477368:32477583 |
| exon_skip_93860 | chr2 | 32507980:32508259:32509738:32509994:32510526:32510634 | 32509738:32509994 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for BIRC6 |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000421745 | 32388750 | 32388943 | Frame-shift |
| ENST00000421745 | 32392039 | 32392150 | Frame-shift |
| ENST00000421745 | 32401463 | 32401623 | Frame-shift |
| ENST00000421745 | 32406499 | 32406557 | Frame-shift |
| ENST00000421745 | 32441329 | 32441462 | Frame-shift |
| ENST00000421745 | 32445521 | 32445668 | Frame-shift |
| ENST00000421745 | 32448795 | 32448928 | Frame-shift |
| ENST00000421745 | 32487647 | 32487801 | Frame-shift |
| ENST00000421745 | 32514990 | 32515770 | Frame-shift |
| ENST00000421745 | 32593915 | 32594060 | Frame-shift |
| ENST00000421745 | 32380153 | 32380290 | In-frame |
| ENST00000421745 | 32435496 | 32435585 | In-frame |
| ENST00000421745 | 32453808 | 32453942 | In-frame |
| ENST00000421745 | 32464509 | 32464823 | In-frame |
| ENST00000421745 | 32477368 | 32477583 | In-frame |
| ENST00000421745 | 32490041 | 32490151 | In-frame |
| ENST00000421745 | 32595034 | 32595144 | In-frame |
| ENST00000421745 | 32607455 | 32607643 | In-frame |
| ENST00000421745 | 32611448 | 32611582 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000421745 | 32388750 | 32388943 | Frame-shift |
| ENST00000421745 | 32392039 | 32392150 | Frame-shift |
| ENST00000421745 | 32401463 | 32401623 | Frame-shift |
| ENST00000421745 | 32406499 | 32406557 | Frame-shift |
| ENST00000421745 | 32441329 | 32441462 | Frame-shift |
| ENST00000421745 | 32448795 | 32448928 | Frame-shift |
| ENST00000421745 | 32487647 | 32487801 | Frame-shift |
| ENST00000421745 | 32499547 | 32500109 | Frame-shift |
| ENST00000421745 | 32509738 | 32509994 | Frame-shift |
| ENST00000421745 | 32514990 | 32515770 | Frame-shift |
| ENST00000421745 | 32435496 | 32435585 | In-frame |
| ENST00000421745 | 32453808 | 32453942 | In-frame |
| ENST00000421745 | 32464509 | 32464823 | In-frame |
| ENST00000421745 | 32477368 | 32477583 | In-frame |
| ENST00000421745 | 32490041 | 32490151 | In-frame |
| ENST00000421745 | 32595034 | 32595144 | In-frame |
| ENST00000421745 | 32607455 | 32607643 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000421745 | 32388750 | 32388943 | Frame-shift |
| ENST00000421745 | 32392039 | 32392150 | Frame-shift |
| ENST00000421745 | 32401463 | 32401623 | Frame-shift |
| ENST00000421745 | 32406499 | 32406557 | Frame-shift |
| ENST00000421745 | 32441329 | 32441462 | Frame-shift |
| ENST00000421745 | 32448795 | 32448928 | Frame-shift |
| ENST00000421745 | 32478635 | 32478818 | Frame-shift |
| ENST00000421745 | 32481320 | 32481453 | Frame-shift |
| ENST00000421745 | 32487647 | 32487801 | Frame-shift |
| ENST00000421745 | 32499547 | 32500109 | Frame-shift |
| ENST00000421745 | 32509738 | 32509994 | Frame-shift |
| ENST00000421745 | 32514990 | 32515770 | Frame-shift |
| ENST00000421745 | 32593915 | 32594060 | Frame-shift |
| ENST00000421745 | 32380153 | 32380290 | In-frame |
| ENST00000421745 | 32435496 | 32435585 | In-frame |
| ENST00000421745 | 32453808 | 32453942 | In-frame |
| ENST00000421745 | 32464509 | 32464823 | In-frame |
| ENST00000421745 | 32490041 | 32490151 | In-frame |
| ENST00000421745 | 32595034 | 32595144 | In-frame |
| ENST00000421745 | 32599739 | 32599900 | In-frame |
| ENST00000421745 | 32607455 | 32607643 | In-frame |
| ENST00000421745 | 32611448 | 32611582 | In-frame |
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Infer the effects of exon skipping event on protein functional features for BIRC6 |
p-ENSG00000115760_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000421745 | 15720 | 4857 | 32380153 | 32380290 | 643 | 779 | 169 | 215 |
| ENST00000421745 | 15720 | 4857 | 32435496 | 32435585 | 3545 | 3633 | 1137 | 1166 |
| ENST00000421745 | 15720 | 4857 | 32453808 | 32453942 | 4754 | 4887 | 1540 | 1584 |
| ENST00000421745 | 15720 | 4857 | 32464509 | 32464823 | 5077 | 5390 | 1647 | 1752 |
| ENST00000421745 | 15720 | 4857 | 32477368 | 32477583 | 6988 | 7202 | 2284 | 2356 |
| ENST00000421745 | 15720 | 4857 | 32490041 | 32490151 | 8231 | 8340 | 2699 | 2735 |
| ENST00000421745 | 15720 | 4857 | 32595034 | 32595144 | 13637 | 13746 | 4501 | 4537 |
| ENST00000421745 | 15720 | 4857 | 32607455 | 32607643 | 14206 | 14393 | 4690 | 4753 |
| ENST00000421745 | 15720 | 4857 | 32611448 | 32611582 | 14395 | 14528 | 4753 | 4798 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000421745 | 15720 | 4857 | 32435496 | 32435585 | 3545 | 3633 | 1137 | 1166 |
| ENST00000421745 | 15720 | 4857 | 32453808 | 32453942 | 4754 | 4887 | 1540 | 1584 |
| ENST00000421745 | 15720 | 4857 | 32464509 | 32464823 | 5077 | 5390 | 1647 | 1752 |
| ENST00000421745 | 15720 | 4857 | 32477368 | 32477583 | 6988 | 7202 | 2284 | 2356 |
| ENST00000421745 | 15720 | 4857 | 32490041 | 32490151 | 8231 | 8340 | 2699 | 2735 |
| ENST00000421745 | 15720 | 4857 | 32595034 | 32595144 | 13637 | 13746 | 4501 | 4537 |
| ENST00000421745 | 15720 | 4857 | 32607455 | 32607643 | 14206 | 14393 | 4690 | 4753 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000421745 | 15720 | 4857 | 32380153 | 32380290 | 643 | 779 | 169 | 215 |
| ENST00000421745 | 15720 | 4857 | 32435496 | 32435585 | 3545 | 3633 | 1137 | 1166 |
| ENST00000421745 | 15720 | 4857 | 32453808 | 32453942 | 4754 | 4887 | 1540 | 1584 |
| ENST00000421745 | 15720 | 4857 | 32464509 | 32464823 | 5077 | 5390 | 1647 | 1752 |
| ENST00000421745 | 15720 | 4857 | 32490041 | 32490151 | 8231 | 8340 | 2699 | 2735 |
| ENST00000421745 | 15720 | 4857 | 32595034 | 32595144 | 13637 | 13746 | 4501 | 4537 |
| ENST00000421745 | 15720 | 4857 | 32599739 | 32599900 | 13966 | 14126 | 4610 | 4664 |
| ENST00000421745 | 15720 | 4857 | 32607455 | 32607643 | 14206 | 14393 | 4690 | 4753 |
| ENST00000421745 | 15720 | 4857 | 32611448 | 32611582 | 14395 | 14528 | 4753 | 4798 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NR09 | 169 | 215 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 1137 | 1166 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 1540 | 1584 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 1647 | 1752 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 1647 | 1752 | 1660 | 1668 | Compositional bias | Note=Poly-Ala |
| Q9NR09 | 1647 | 1752 | 1710 | 1710 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569 |
| Q9NR09 | 2284 | 2356 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 2284 | 2356 | 2319 | 2319 | Sequence conflict | Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9NR09 | 2699 | 2735 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 4501 | 4537 | 4536 | 4540 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4501 | 4537 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 4501 | 4537 | 4524 | 4533 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4690 | 4753 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 4690 | 4753 | 4688 | 4698 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4690 | 4753 | 4704 | 4707 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4690 | 4753 | 4711 | 4714 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4690 | 4753 | 4718 | 4738 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4690 | 4753 | 4741 | 4745 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4690 | 4753 | 4752 | 4777 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4690 | 4753 | 4576 | 4704 | Region | Note=Ubiquitin-conjugating |
| Q9NR09 | 4690 | 4753 | 4749 | 4751 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4753 | 4798 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 4753 | 4798 | 4752 | 4777 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4753 | 4798 | 4788 | 4810 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NR09 | 1137 | 1166 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 1540 | 1584 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 1647 | 1752 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 1647 | 1752 | 1660 | 1668 | Compositional bias | Note=Poly-Ala |
| Q9NR09 | 1647 | 1752 | 1710 | 1710 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569 |
| Q9NR09 | 2284 | 2356 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 2284 | 2356 | 2319 | 2319 | Sequence conflict | Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9NR09 | 2699 | 2735 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 4501 | 4537 | 4536 | 4540 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4501 | 4537 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 4501 | 4537 | 4524 | 4533 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4690 | 4753 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 4690 | 4753 | 4688 | 4698 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4690 | 4753 | 4704 | 4707 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4690 | 4753 | 4711 | 4714 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4690 | 4753 | 4718 | 4738 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4690 | 4753 | 4741 | 4745 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4690 | 4753 | 4752 | 4777 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4690 | 4753 | 4576 | 4704 | Region | Note=Ubiquitin-conjugating |
| Q9NR09 | 4690 | 4753 | 4749 | 4751 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9NR09 | 169 | 215 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 1137 | 1166 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 1540 | 1584 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 1647 | 1752 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 1647 | 1752 | 1660 | 1668 | Compositional bias | Note=Poly-Ala |
| Q9NR09 | 1647 | 1752 | 1710 | 1710 | Modified residue | Note=Phosphothreonine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569 |
| Q9NR09 | 2699 | 2735 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 4501 | 4537 | 4536 | 4540 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4501 | 4537 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 4501 | 4537 | 4524 | 4533 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4610 | 4664 | 4625 | 4625 | Active site | Note=Glycyl thioester intermediate;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00388 |
| Q9NR09 | 4610 | 4664 | 4608 | 4615 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4610 | 4664 | 4625 | 4631 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4610 | 4664 | 4642 | 4645 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4610 | 4664 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 4610 | 4664 | 4576 | 4704 | Region | Note=Ubiquitin-conjugating |
| Q9NR09 | 4610 | 4664 | 4634 | 4638 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4610 | 4664 | 4649 | 4652 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4690 | 4753 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 4690 | 4753 | 4688 | 4698 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4690 | 4753 | 4704 | 4707 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4690 | 4753 | 4711 | 4714 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4690 | 4753 | 4718 | 4738 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4690 | 4753 | 4741 | 4745 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4690 | 4753 | 4752 | 4777 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4690 | 4753 | 4576 | 4704 | Region | Note=Ubiquitin-conjugating |
| Q9NR09 | 4690 | 4753 | 4749 | 4751 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4753 | 4798 | 1 | 4857 | Chain | ID=PRO_0000122361;Note=Baculoviral IAP repeat-containing protein 6 |
| Q9NR09 | 4753 | 4798 | 4752 | 4777 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
| Q9NR09 | 4753 | 4798 | 4788 | 4810 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:3CEG |
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3'-UTR located exon skipping events that lost miRNA binding sites in BIRC6 |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for BIRC6 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for BIRC6 |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
| ADstage | MSBB | IFG | exon_skip_126500 | -3.977233e-01 | 3.608644e-02 | chr2 | + | 32488588 | 32488714 | 32490041 | 32490151 | 32491425 | 32491558 |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for BIRC6 |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for BIRC6 |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
| CB | DAZAP1 | exon_skip_265055 | -5.113591e-01 | 5.065960e-10 |
| CB | ELAVL1 | exon_skip_265055 | -4.718995e-01 | 1.447857e-08 |
| CB | U2AF2 | exon_skip_265055 | -5.974562e-01 | 6.206573e-14 |
| CB | PCBP1 | exon_skip_265055 | -4.638928e-01 | 2.718492e-08 |
| CB | RC3H1 | exon_skip_265055 | -4.659529e-01 | 2.315256e-08 |
| CB | FUBP1 | exon_skip_265055 | -5.151111e-01 | 3.600211e-10 |
| CB | KHSRP | exon_skip_265055 | -5.049662e-01 | 8.980351e-10 |
| CB | HNRNPC | exon_skip_265055 | -5.129615e-01 | 4.380577e-10 |
| CB | PTBP1 | exon_skip_265055 | -4.207059e-01 | 6.236786e-07 |
| CB | HNRNPF | exon_skip_265055 | -4.913856e-01 | 2.915824e-09 |
| IFG | ZC3H10 | exon_skip_295865 | 4.203406e-01 | 3.250949e-02 |
| STG | RBM3 | exon_skip_295865 | -4.002661e-01 | 2.822916e-04 |
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RelatedDrugs for BIRC6 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BIRC6 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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