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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for ATP10D |
 Gene summary |
| Gene information | Gene symbol | ATP10D | Gene ID | 57205 |
| Gene name | ATPase phospholipid transporting 10D (putative) | |
| Synonyms | ATPVD | |
| Cytomap | 4p12 | |
| Type of gene | protein-coding | |
| Description | probable phospholipid-transporting ATPase VDATPase, class V, type 10DP4-ATPase flippase complex alpha subunit ATP10Dtype IV aminophospholipid transporting ATPase | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Gene structures and expression levels for ATP10D |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000145246
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| PG | UP | ENST00000505476.5 | ATP10D-205:lncRNA:ATP10D | 1.245372e+00 | 1.128616e+00 | 3.551956e-03 | 3.597734e-02 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for ATP10D |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_144294 | chr4 | 47546624:47546862:47554726:47554914:47557664:47558273 | 47554726:47554914 |
| exon_skip_227758 | chr4 | 47525557:47525642:47535509:47535615:47535902:47536033 | 47535509:47535615 |
| exon_skip_270469 | chr4 | 47576773:47576973:47580398:47580478:47581960:47582064 | 47580398:47580478 |
| exon_skip_281683 | chr4 | 47582031:47582064:47582869:47582961:47587019:47587206 | 47582869:47582961 |
| exon_skip_3543 | chr4 | 47576822:47576973:47580398:47580478:47581960:47582064 | 47580398:47580478 |
| exon_skip_78973 | chr4 | 47512504:47512830:47515476:47515670:47523012:47523216 | 47515476:47515670 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for ATP10D |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000273859 | 47535509 | 47535615 | Frame-shift |
| ENST00000273859 | 47515476 | 47515670 | In-frame |
| ENST00000273859 | 47554726 | 47554914 | In-frame |
| ENST00000273859 | 47580398 | 47580478 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000273859 | 47535509 | 47535615 | Frame-shift |
| ENST00000273859 | 47515476 | 47515670 | In-frame |
| ENST00000273859 | 47580398 | 47580478 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000273859 | 47535509 | 47535615 | Frame-shift |
| ENST00000273859 | 47515476 | 47515670 | In-frame |
| ENST00000273859 | 47580398 | 47580478 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ATP10D |
p-ENSG00000145246_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000273859 | 6672 | 1426 | 47515476 | 47515670 | 561 | 754 | 97 | 161 |
| ENST00000273859 | 6672 | 1426 | 47554726 | 47554914 | 1906 | 2093 | 545 | 608 |
| ENST00000273859 | 6672 | 1426 | 47580398 | 47580478 | 3838 | 3917 | 1189 | 1216 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000273859 | 6672 | 1426 | 47515476 | 47515670 | 561 | 754 | 97 | 161 |
| ENST00000273859 | 6672 | 1426 | 47580398 | 47580478 | 3838 | 3917 | 1189 | 1216 |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000273859 | 6672 | 1426 | 47515476 | 47515670 | 561 | 754 | 97 | 161 |
| ENST00000273859 | 6672 | 1426 | 47580398 | 47580478 | 3838 | 3917 | 1189 | 1216 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9P241 | 97 | 161 | 1 | 1426 | Chain | ID=PRO_0000046382;Note=Probable phospholipid-transporting ATPase VD |
| Q9P241 | 97 | 161 | 142 | 142 | Sequence conflict | Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9P241 | 97 | 161 | 1 | 97 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P241 | 97 | 161 | 119 | 121 | Topological domain | Note=Exoplasmic loop;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P241 | 97 | 161 | 143 | 321 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P241 | 97 | 161 | 98 | 118 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P241 | 97 | 161 | 122 | 142 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P241 | 545 | 608 | 553 | 747 | Alternative sequence | ID=VSP_006954;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q9P241 | 545 | 608 | 1 | 1426 | Chain | ID=PRO_0000046382;Note=Probable phospholipid-transporting ATPase VD |
| Q9P241 | 545 | 608 | 387 | 1113 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P241 | 1189 | 1216 | 1 | 1426 | Chain | ID=PRO_0000046382;Note=Probable phospholipid-transporting ATPase VD |
| Q9P241 | 1189 | 1216 | 1167 | 1195 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P241 | 1189 | 1216 | 1196 | 1216 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9P241 | 97 | 161 | 1 | 1426 | Chain | ID=PRO_0000046382;Note=Probable phospholipid-transporting ATPase VD |
| Q9P241 | 97 | 161 | 142 | 142 | Sequence conflict | Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9P241 | 97 | 161 | 1 | 97 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P241 | 97 | 161 | 119 | 121 | Topological domain | Note=Exoplasmic loop;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P241 | 97 | 161 | 143 | 321 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P241 | 97 | 161 | 98 | 118 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P241 | 97 | 161 | 122 | 142 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P241 | 1189 | 1216 | 1 | 1426 | Chain | ID=PRO_0000046382;Note=Probable phospholipid-transporting ATPase VD |
| Q9P241 | 1189 | 1216 | 1167 | 1195 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P241 | 1189 | 1216 | 1196 | 1216 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9P241 | 97 | 161 | 1 | 1426 | Chain | ID=PRO_0000046382;Note=Probable phospholipid-transporting ATPase VD |
| Q9P241 | 97 | 161 | 142 | 142 | Sequence conflict | Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q9P241 | 97 | 161 | 1 | 97 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P241 | 97 | 161 | 119 | 121 | Topological domain | Note=Exoplasmic loop;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P241 | 97 | 161 | 143 | 321 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P241 | 97 | 161 | 98 | 118 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P241 | 97 | 161 | 122 | 142 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P241 | 1189 | 1216 | 1 | 1426 | Chain | ID=PRO_0000046382;Note=Probable phospholipid-transporting ATPase VD |
| Q9P241 | 1189 | 1216 | 1167 | 1195 | Topological domain | Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9P241 | 1189 | 1216 | 1196 | 1216 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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3'-UTR located exon skipping events that lost miRNA binding sites in ATP10D |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
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SNVs in the skipped exons for ATP10D |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for ATP10D |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ATP10D |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
| HCC | exon_skip_270469 | rs4132384 | chr4:47525356 | 3.766162e-04 | 2.711338e-02 |
| HCC | exon_skip_227758 | rs6842801 | chr4:47563464 | 4.791300e-04 | 3.279809e-02 |
| HCC | exon_skip_227758 | rs6854584 | chr4:47566947 | 4.791300e-04 | 3.279809e-02 |
| HCC | exon_skip_270469 | rs4695243 | chr4:47532713 | 8.020721e-04 | 4.915291e-02 |
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Correlation with RNA binding proteins (RBPs) for ATP10D |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for ATP10D |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATP10D |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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