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| Open reading frame (ORF) annotation in the exon skipping event |
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| 3'-UTR located exon skipping events lost miRNA binding sites |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
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Gene summary for CORO1B |
 Gene summary |
| Gene information | Gene symbol | CORO1B | Gene ID | 57175 |
| Gene name | coronin 1B | |
| Synonyms | CORONIN-2 | |
| Cytomap | 11q13.2 | |
| Type of gene | protein-coding | |
| Description | coronin-1Bcoronin, actin binding protein, 1B | |
| Modification date | 20200313 | |
| UniProtAcc | ||
| Context |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CORO1B | GO:0016477 | cell migration | 16027158 |
| CORO1B | GO:0030036 | actin cytoskeleton organization | 18775315 |
| CORO1B | GO:0031529 | ruffle organization | 16027158 |
| CORO1B | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation | 17350576|18775315 |
| CORO1B | GO:0035767 | endothelial cell chemotaxis | 23667561 |
| CORO1B | GO:0042060 | wound healing | 23667561 |
| CORO1B | GO:0051017 | actin filament bundle assembly | 17456547 |
| CORO1B | GO:0090135 | actin filament branching | 18775315 |
| CORO1B | GO:1902463 | protein localization to cell leading edge | 17350576 |
| CORO1B | GO:2000394 | positive regulation of lamellipodium morphogenesis | 17350576 |
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Gene structures and expression levels for CORO1B |
| Skipped exons in the ROSMAP, MSBB, and Mayo based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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ENSG00000172725
| Differentially expressed gene analysis across multiple brain tissues between AD and control. |
| Tissue type | DEG direction | Base mean exp. | log2FC(AD/control) | P-value | Adj. p-value |
| Differentially expressed isoform analysis across multiple brain tissues between AD and control. |
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| Tissue type | DEG direction | ENST | Transcript info. | Base mean exp. | log2FC(AD/control) | P-value | Adjc. p-value |
| CB | DOWN | ENST00000539724.1 | CORO1B-205:lncRNA:CORO1B | 7.311415e+00 | -1.925789e+00 | 9.686255e-03 | 3.385038e-02 |
| TC | DOWN | ENST00000539724.1 | CORO1B-205:lncRNA:CORO1B | 7.514345e+00 | -3.223413e+00 | 3.485348e-05 | 6.964100e-04 |
| Landscape of isoform expressions across multiple brain tissues between AD and control. |
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Exon skipping events with PSIs in ROSMAP, MSBB, and Mayo for CORO1B |
| Landscape of individual exon skipping event across AD tissues and controls (PSI heatmap). |
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| All exon skipping events in AD cohorts. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon |
| exon_skip_108398 | chr11 | 67440231:67440263:67440335:67440439:67441125:67441244 | 67440335:67440439 |
| exon_skip_147100 | chr11 | 67438671:67438949:67439786:67439843:67440118:67440263 | 67439786:67439843 |
| exon_skip_212208 | chr11 | 67442428:67442630:67443404:67443465:67443753:67443821 | 67443404:67443465 |
| exon_skip_240350 | chr11 | 67440335:67440439:67440702:67440836:67441125:67441244 | 67440702:67440836 |
| exon_skip_260746 | chr11 | 67440335:67440439:67441125:67441244:67441333:67441514 | 67441125:67441244 |
| exon_skip_281726 | chr11 | 67438283:67438501:67438671:67438949:67439786:67439843 | 67438671:67438949 |
| exon_skip_286114 | chr11 | 67440231:67440263:67440335:67440439:67440702:67440836 | 67440335:67440439 |
| exon_skip_535 | chr11 | 67440231:67440263:67440335:67440484:67441125:67441244 | 67440335:67440484 |
| Differentially expressed PSI values of individual exon skipping events in multiple brain tissues between AD and control. |
| Exon skipping information | Tissue type | Avg(PSIs) in AD | Avg(PSIs) in control | Difference (PSI) | Adj. p-value |
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Open reading frame (ORF) annotation in the exon skipping event for CORO1B |
| Open reading frame (ORF) of individual exon skipping events in ROSMAP based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000393893 | 67443404 | 67443465 | 3UTR-3UTR |
| ENST00000341356 | 67439786 | 67439843 | Frame-shift |
| ENST00000393893 | 67439786 | 67439843 | Frame-shift |
| ENST00000341356 | 67438671 | 67438949 | In-frame |
| ENST00000393893 | 67438671 | 67438949 | In-frame |
| ENST00000341356 | 67440335 | 67440439 | In-frame |
| ENST00000393893 | 67440335 | 67440439 | In-frame |
| ENST00000341356 | 67441125 | 67441244 | In-frame |
| ENST00000393893 | 67441125 | 67441244 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in MSBB based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in Mayo based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000393893 | 67443404 | 67443465 | 3UTR-3UTR |
| ENST00000341356 | 67438671 | 67438949 | In-frame |
| ENST00000393893 | 67438671 | 67438949 | In-frame |
| ENST00000341356 | 67440335 | 67440439 | In-frame |
| ENST00000393893 | 67440335 | 67440439 | In-frame |
| ENST00000341356 | 67441125 | 67441244 | In-frame |
| ENST00000393893 | 67441125 | 67441244 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CORO1B |
p-ENSG00000172725_img4.png |
| Loci of skipped exons in ROSMAP across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000341356 | 1898 | 489 | 67441125 | 67441244 | 748 | 866 | 212 | 251 |
| ENST00000393893 | 1948 | 489 | 67441125 | 67441244 | 770 | 888 | 212 | 251 |
| ENST00000341356 | 1898 | 489 | 67440335 | 67440439 | 868 | 971 | 252 | 286 |
| ENST00000393893 | 1948 | 489 | 67440335 | 67440439 | 890 | 993 | 252 | 286 |
| ENST00000341356 | 1898 | 489 | 67438671 | 67438949 | 1177 | 1454 | 355 | 447 |
| ENST00000393893 | 1948 | 489 | 67438671 | 67438949 | 1199 | 1476 | 355 | 447 |
| Loci of skipped exons in MSBB across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in Mayo across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000341356 | 1898 | 489 | 67441125 | 67441244 | 748 | 866 | 212 | 251 |
| ENST00000393893 | 1948 | 489 | 67441125 | 67441244 | 770 | 888 | 212 | 251 |
| ENST00000341356 | 1898 | 489 | 67440335 | 67440439 | 868 | 971 | 252 | 286 |
| ENST00000393893 | 1948 | 489 | 67440335 | 67440439 | 890 | 993 | 252 | 286 |
| ENST00000341356 | 1898 | 489 | 67438671 | 67438949 | 1177 | 1454 | 355 | 447 |
| ENST00000393893 | 1948 | 489 | 67438671 | 67438949 | 1199 | 1476 | 355 | 447 |
| Lost protein functional features of individual exon skipping events in ROSMAP. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9BR76 | 212 | 251 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 212 | 251 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 212 | 251 | 211 | 256 | Repeat | Note=WD 5 |
| Q9BR76 | 212 | 251 | 211 | 256 | Repeat | Note=WD 5 |
| Q9BR76 | 252 | 286 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 252 | 286 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 252 | 286 | 211 | 256 | Repeat | Note=WD 5 |
| Q9BR76 | 252 | 286 | 211 | 256 | Repeat | Note=WD 5 |
| Q9BR76 | 252 | 286 | 257 | 296 | Repeat | Note=WD 6 |
| Q9BR76 | 252 | 286 | 257 | 296 | Repeat | Note=WD 6 |
| Q9BR76 | 355 | 447 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 355 | 447 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 355 | 447 | 411 | 411 | Natural variant | ID=VAR_035877;Note=In a colorectal cancer sample%3B somatic mutation. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs756117196,PMID:16959974 |
| Q9BR76 | 355 | 447 | 411 | 411 | Natural variant | ID=VAR_035877;Note=In a colorectal cancer sample%3B somatic mutation. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs756117196,PMID:16959974 |
| Lost protein functional features of individual exon skipping events in MSBB. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in Mayo. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9BR76 | 212 | 251 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 212 | 251 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 212 | 251 | 211 | 256 | Repeat | Note=WD 5 |
| Q9BR76 | 212 | 251 | 211 | 256 | Repeat | Note=WD 5 |
| Q9BR76 | 252 | 286 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 252 | 286 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 252 | 286 | 211 | 256 | Repeat | Note=WD 5 |
| Q9BR76 | 252 | 286 | 211 | 256 | Repeat | Note=WD 5 |
| Q9BR76 | 252 | 286 | 257 | 296 | Repeat | Note=WD 6 |
| Q9BR76 | 252 | 286 | 257 | 296 | Repeat | Note=WD 6 |
| Q9BR76 | 355 | 447 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 355 | 447 | 1 | 489 | Chain | ID=PRO_0000050922;Note=Coronin-1B |
| Q9BR76 | 355 | 447 | 411 | 411 | Natural variant | ID=VAR_035877;Note=In a colorectal cancer sample%3B somatic mutation. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs756117196,PMID:16959974 |
| Q9BR76 | 355 | 447 | 411 | 411 | Natural variant | ID=VAR_035877;Note=In a colorectal cancer sample%3B somatic mutation. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs756117196,PMID:16959974 |
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3'-UTR located exon skipping events that lost miRNA binding sites in CORO1B |
| 3'-UTR exon skipping evnets lost miRNA binding. |
| Tissue type | ENST | Exon skip start | Exon skip end | microRNA | Binding site by TargetScan | Binding type by TargetScan | Bdinding site by miRanda | Score of miRanda | Energy by miRanda |
| Mayo | ENST00000393893 | 67443404 | 67443465 | hsa-miR-1203 | chr11:67443449-67443456 | 8mer-1a | chr11:67443437-67443456 | 153.00 | -24.72 |
| ROSMAP | ENST00000393893 | 67443404 | 67443465 | hsa-miR-1203 | chr11:67443449-67443456 | 8mer-1a | chr11:67443437-67443456 | 153.00 | -24.72 |
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SNVs in the skipped exons for CORO1B |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Depth of Coverage in the skipped exon of the mutated samples. |
| - Sashimi plot in the skipped exon of the mutated samples. |
| - Non-synonymous mutations located in the skipped exons. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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AD stage-associated exon skippint events for CORO1B |
| Associated exon skipping events with Braak staging or Clinical Dementia Rating (CDR). |
| AD stage info | Cohort | Tissue | SE id | Coefficient | P-value | Chromosome | Strand | E1 start | E1 end | Skipped start | Skipped end | E2 start | E2 end |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CORO1B |
| sQTL information located at the skipped exons. |
| Tissue type | Exon skip ID | SNP id | Location | P-value | FDR |
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Correlation with RNA binding proteins (RBPs) for CORO1B |
| Correlated RBP and related information. |
| Tissue type | RBP name | Exon skip ID | Correlation coeifficient | P-value |
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RelatedDrugs for CORO1B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CORO1B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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